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Blood Pressure Volume 26, 2017 - Issue 6
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Editorial

Renal denervation in hypertension: is it the end or the beginning of a SPYRAL?

Michel BurnierService of Nephrology and Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, SwitzerlandCorrespondence[email protected]
,
Krzysztof NarkiewiczDepartment of Hypertension and Diabetology, Medical University of Gdansk, Poland
,
Sverre E. KjeldsenDepartment of Cardiology, University of Oslo, Ullevaal Hospital, Oslo, Norway
&
Suzanne OparilVascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, AL, USA
Pages 319-320 | Received 26 Sep 2017, Accepted 27 Sep 2017, Published online: 04 Oct 2017

References

  • Schlaich MP, Sobotka PA, Krum H, et al. Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med. 2009;361:932–934.
  • Symplicity HTNI, Esler MD, Krum H, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:1903–1909.
  • Persu A, Jin Y, Azizi M, et al. Blood pressure changes after renal denervation at 10 European expert centers. J Hum Hypertens. 2014;28:150–156.
  • Burnier M, Wuerzner G, Struijker-Boudier H, et al. Measuring, analyzing, and managing drug adherence in resistant hypertension. Hypertension. 2013;62:218–225.
  • Berra E, Azizi M, Capron A, et al. Evaluation of adherence should become an integral part of assessment of patients with apparently treatment-resistant hypertension. Hypertension. 2016;68:297–306.
  • Bhatt DL, Kandzari DE, O’Neill WW, et al. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014;370:1393–1401.
  • Mahfoud F, Bohm M, Azizi M, et al. Proceedings from the European clinical consensus conference for renal denervation: considerations on future clinical trial design. Eur Heart J. 2015;36:2219–2227.
  • Townsend RR, Mahfoud F, Kandzari DE, et al. Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial. Lancet. 2017; [Epub ahead of print 25 Aug]. Available from: http://dx.doi.org/10.1016/S0140-6736(17)32281-X

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