The randomised Oslo study of renal denervation vs. Antihypertensive drug adjustments: efficacy and safety through 7 years of follow-up

References

• Krum H, Schlaich M, Whitbourn R, et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009;373(9671):1275–1281.
   PubMed Web of Science ®Google Scholar
• Kiuchi MG, Esler MD, Fink GD, et al. Renal denervation update from the international sympathetic nervous system summit: JACC state-of-the-art review. J Am Coll Cardiol. 2019;73(23):3006–3017.
   PubMed Web of Science ®Google Scholar
• Symplicity HTNI, Esler MD, Krum H, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (the symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376(9756):1903–1909.
   PubMed Web of Science ®Google Scholar
• Kandzari DE, Bhatt DL, Brar S, et al. Predictors of blood pressure response in the SYMPLICITY HTN-3 trial. Eur Heart J. 2015;36(4):219–227.
   PubMed Web of Science ®Google Scholar
• Townsend RR, Mahfoud F, Kandzari DE, et al. Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial. Lancet. 2017;390(10108):2160–2170.
   PubMed Web of Science ®Google Scholar
• Kandzari DE, Bohm M, Mahfoud F, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. Lancet. 2018;391(10137):2346–2355.
   PubMed Web of Science ®Google Scholar
• Weber MA, Mahfoud F, Schmieder RE, et al. Renal denervation for treating hypertension: current scientific and clinical evidence. JACC Cardiovasc Interv. 2019;12(12):1095–1105.
   PubMed Web of Science ®Google Scholar
• Coppolino G, Pisano A, Rivoli L, et al. Renal denervation for resistant hypertension. Cochrane Database Syst Rev. 2017;2:CD011499
   PubMedGoogle Scholar
• Mahfoud F, Bohm M, Schmieder R, et al. Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY registry. Eur Heart J. 2019;40:3474–3482.
   PubMed Web of Science ®Google Scholar
• Fadl Elmula FE, Jin Y, Yang WY, et al. Meta-analysis of randomized controlled trials of renal denervation in treatment-resistant hypertension. Blood Press. 2015;24(5):263–274.
   PubMed Web of Science ®Google Scholar
• Kario K, Ogawa H, Okumura K, et al. SYMPLICITY HTN-Japan - first randomized controlled trial of catheter-based renal denervation in Asian patients. Circ J. 2015;79(6):1222–1229.
   PubMed Web of Science ®Google Scholar
• Fadl Elmula FE, Hoffmann P, Larstorp AC, et al. Adjusted drug treatment is superior to renal sympathetic denervation in patients with true treatment-resistant hypertension. Hypertension. 2014;63(5):991–999.
   PubMed Web of Science ®Google Scholar
• Fadl Elmula FE, Hoffmann P, Fossum E, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension after witnessed intake of medication before qualifying ambulatory blood pressure. Hypertension. 2013;62(3):526–532.
   PubMed Web of Science ®Google Scholar
• Hjornholm U, Larstorp ACK, Andersen MH, et al. Directly observed therapy prior to ambulatory blood pressure measurement (DOT-HTN) in uncontrolled hypertensive patients – effect on blood pressure, safety and patient perception. Blood Press. 2019;28(5):327–335.
   PubMed Web of Science ®Google Scholar
• Faini A, Omboni S, Tifrea M, et al. Cardiac index assessment: validation of a new non-invasive very low current thoracic bioimpedance device by thermodilution. Blood Press. 2014;23(2):102–108.
   PubMed Web of Science ®Google Scholar
• Mancia G, De Backer G, Dominiczak A, et al. ESH-ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Blood Press. 2007;16(3):135–232.
   PubMed Web of Science ®Google Scholar
• Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC practice guidelines for the management of arterial hypertension. Blood Press. 2014;23(1):3–16.
   PubMed Web of Science ®Google Scholar
• Williams B, Mancia G, Spiering W, et al. 2018 Practice Guidelines for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. Blood Press. 2018;27(6):314–340.
   PubMed Web of Science ®Google Scholar
• Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604–612.
   PubMed Web of Science ®Google Scholar
• Stevens PE, Levin A, Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group M. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158(11):825–830.
   PubMed Web of Science ®Google Scholar
• Inker LA, Schmid CH, Tighiouart H, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367(1):20–29.
   PubMed Web of Science ®Google Scholar
• Cleophas TJ, Zwinderman AH, van Ouwerkerk BM. Methods for analysing cardiovascular studies with repeated measures. Neth Heart J. 2009;17(11):429–433.
   PubMed Web of Science ®Google Scholar
• Xu W, Goldberg SI, Shubina M, et al. Optimal systolic blood pressure target, time to intensification, and time to follow-up in treatment of hypertension: population based retrospective cohort study. BMJ. 2015;350(9):h158–h158.
   PubMedGoogle Scholar
• Tsujimoto T, Kajio H. Intensive Blood Pressure Treatment for Resistant Hypertension. Hypertension. 2019;73(2):415–423.
   PubMed Web of Science ®Google Scholar
• Lamb EJ, Tomson CR, Roderick PJ, et al. Estimating kidney function in adults using formulae. Ann Clin Biochem. 2005;42(Pt 5):321–345.
   PubMedGoogle Scholar
• Stevens LA, Coresh J, Greene T, et al. Assessing kidney function-measured and estimated glomerular filtration rate. N Engl J Med. 2006;354(23):2473–2483.
   PubMed Web of Science ®Google Scholar
• Weinstein JR, Anderson S. The aging kidney: physiological changes. Adv Chronic Kidney Dis. 2010;17(4):302–307.
   PubMed Web of Science ®Google Scholar
• Hommos MS, Glassock RJ, Rule AD. Structural and functional changes in human kidneys with healthy aging. J Am Soc Nephrol. 2017;28(10):2838–2844.
   PubMed Web of Science ®Google Scholar
• Glassock RJ, Winearls C. Ageing and the glomerular filtration rate: truths and consequences. Trans Am Clin Climatol Assoc. 2009;120:419–428.
   PubMedGoogle Scholar
• Mennuni S, Rubattu S, Pierelli G, et al. Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage. J Hum Hypertens. 2014;28(2):74–79.
   PubMed Web of Science ®Google Scholar
• Chung M, Leitz FH, Maier G, et al. Rising multiple-dose pharmacokinetics of labetalol in hypertensive patients. J Clin Pharmacol. 1986;26(4):248–252.
   PubMed Web of Science ®Google Scholar
• de Jager RL, van Maarseveen EM, Bots ML, et al. Medication adherence in patients with apparent resistant hypertension: findings from the SYMPATHY trial. Br J Clin Pharmacol. 2018;84(1):18–24.
   PubMed Web of Science ®Google Scholar
• Gupta P, Patel P, Strauch B, et al. Biochemical screening for nonadherence is associated with blood pressure reduction and Improvement in adherence. Hypertension. 2017;70(5):1042–1048.
   PubMed Web of Science ®Google Scholar
• Fadl Elmula FE, Rebora P, Talvik A, et al. A randomized and controlled study of noninvasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients. J Hypertens. 2015;33(12):2534–2545.
   PubMed Web of Science ®Google Scholar
• McCambridge J, Witton J, Elbourne DR. Systematic review of the Hawthorne effect: new concepts are needed to study research participation effects. J Clin Epidemiol. 2014;67(3):267–277.
   PubMed Web of Science ®Google Scholar