1999 World Health Organization – International Society of Hypertension Guidelines for the Management of Hypertension

References

• Uemura K, Pisa Z. Trends in cardiovascular disease mortality in industrialised countries since 1950. Wld Hlth Statist Quart 1988; 41: 155–68.
   PubMedGoogle Scholar
• Burt VL, Cutler JA, Higgins M, Horan MJ, Labarthe D, Whelton P, Brown C, Roccella EJ. Trends in the prevalence, awareness, treatment, and control of hyperten-sion in the adult US population. Data from the Health Examination Surveys, 1960 to 1991. Hypertension 1995; 26: 60–9.
   Google Scholar
• Marques-Vidal P, Tuomilehto J. Hypertension awareness, treatment and control in the community: is the "rule of halves" still valid? J Hum Hyperters 1997; 11: 213–20.
   Google Scholar
• Colhoun HM, Dong W, Poulter NR. Blood pressure screening, management and control in England: results from the health survey for England 1994. J Hypertens 1998; 16: 747–52.
   Google Scholar
• Murray CJL, Lopez AD, eds. The Global Burden of Disease. A comprehensive assessment of mortality, and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. World Health Organisation. Harvard University Press, 1996.
   Google Scholar
• WHO Expert Committee. Hypertension control. WHO Technical Report Series no. 862. Geneva: World Health Organisation 1996.
   Google Scholar
• Eastern Stroke and Coronary Heart Disease Collaborative Research Group. Blood pressure, cholesterol and stroke in Eastern Asia. Lancet 1998; 352: 1801–7.
   Google Scholar
• MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, Abbott R, Godwin J, Dyer A, Stamler J. Blood pressure, stroke, and coronary heart disease. Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 1990; 335: 765–74.
   Google Scholar
• Prospective Studies Collaboration. Cholesterol, diastolic blood pressure, and stroke: 13,000 strokes in 45,000 people in 45 prospective cohorts. Lancet 1995; 346: 1647–53.
   PubMed Web of Science ®Google Scholar
• Kannel WB, Castelli WP, McNamara PM, McKee PA, Feinleib M. Role of blood pressure in the development of congestive heart failure. The Framingham Study. N Engl J Med 1972; 287: 781–7.
   Google Scholar
• Klag MJ, Whelton PK, Randall BL, Neaton JD, Brancati FL, Ford CE, Shulman NB, Stamler J. Blood pressure and end-stage renal disease in men. N Engl J Med 1996; 334: 13–8.
   PubMed Web of Science ®Google Scholar
• Rodgers A, Neal B, MacMahon S. The effects of blood pressure lowering in individuals with cerebrovascular disease: an overview of randomised controlled trials. Neurol Rev Int 1997; 2: 12–5.
   Google Scholar
• Flack J, Neaton J, Grimm R, Shih J, Cutler J, Ensrud K, MacMahon S, for the Multiple Risk Factor Intervention Trial Research Group. Blood pressure and mortality among men with prior myocardial infarction. Circulation 1995; 92: 2437–45.
   Google Scholar
• Neal B, Clark T, MacMahon S, Rodgers A, Baigent C, Collins obotATAC. Blood pressure and the risk of recurrent vascular disease. Am J Hypertens 1998; 11(4 (part 2)): 25A.
   Google Scholar
• Irie K, Yamaguchi T, Minematsu K, Omae T. The J-curve phenomenon in stroke recurrence. Stroke 1993; 24: 18/1/I 9.
   Google Scholar
• Cruickshank JM, Thorp JM, Zacharias FJ. Benefits and potential harm of lowering high blood pressure. Lancet 1987; 14: 581–4.
   Google Scholar
• Benetos A, Safar M, Rudnichi A, Smulyan H, Richard JL, Ducimetieere P, Guize L. Pulse pressure: a predictor of long-term cardiovascular mortality in a French male population. Hypertension 1997; 30: 1410–5.
   Google Scholar
• Madhavan S, Ooi WL, Cohen H, Alderman MH. Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarction. Hypertension 1994; 23: 395–401.
   PubMed Web of Science ®Google Scholar
• Safar ME, London GM, Asmar R, Frohlich ED. Recent advances on large arteries in hypertension. Hypertension 1998; 32: 156–61.
   PubMed Web of Science ®Google Scholar
• Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME, London GM. Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension 1998; 32: 570–4.
   PubMed Web of Science ®Google Scholar
• Safar ME, Girerd X, Laurent S. Structural changes of large conduit arteries. J Hypertens 1996; 14: 545–55.
   Google Scholar
• Giannattasio C, Failla M, Mangoni AA, Scandola L, Fraschnin NGM. Evaluation of arterial compliance in humans. Chin Exp Hypertens 1996; 18: 347–62.
   PubMed Web of Science ®Google Scholar
• World Health Organization World Health Statistics Annual. Geneva: World Health Organization, 1995.
   Google Scholar
• The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991; 325: 293–302.
   PubMed Web of Science ®Google Scholar
• UK-TIA Study Group. The United Kingdom transient ischemic attack (UK-TIA) aspirin trial: final results. J Neurol Neurosurg Psychiat 1991; 54: 1044–54.
   PubMed Web of Science ®Google Scholar
• The LIPID Study Group. Prevention of mortality and cardiovascular events with pravastatin in 9,014 patients with coronary heart disease and broad range of cholesterol levels. N Engl J Med 1998; 339: 1349–57
   PubMed Web of Science ®Google Scholar
• The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med 1992; 327: 685–91.
   PubMed Web of Science ®Google Scholar
• Wong ND, Levy D, Kannel WB. Prognostic significance of the electrocardiogram after Q wave myocardial infarction. The Framingham Study. Circulation 1990; 81: 780–9.
   PubMedGoogle Scholar
• MacMahon S, Collins G, Rautaharju P, Cutler J, Neaton J, Prineas R, Crow R, Stamler J, for the Multiple Risk Factor Intervention Trial Research Group. Electrocardiographic left ventricular hypertrophy and effects of antihypertensive drug therapy in hypertensive participants in the Multiple Risk Factor Intervention Trial. Am J Cardiol 1989; 63: 202–10.
   Google Scholar
• Levy D, Garrison R, Savage D, Kannel W, Castelli W. Prognostic implications of echocardiographically deter-mined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990; 322: 1561–6.
   Google Scholar
• Salonen JT, Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler & Throm 1991; 11: 1245–9.
   PubMed Web of Science ®Google Scholar
• Zanchetti A, Agatiti RE, Dal PC, Lernetti G, Magnami B, Pessina A, for the VHAS Investigators. The Verapamil in Hypertension and Atherosclerosis Study (VHAS): results of long-term randomised treatment with either verapamil or chlorthalidone on carotid intima-media thickness. J Hypertens 1998; 16: 1667–76.
   Google Scholar
• Shulman NB, Ford CE, Hall WD, Blaufox MD, Simon D, Longford HG, Schneider KA, on behalf of the Hyperten-sion Detection and Follow-up Program Group. Prognostic value of serum creatinine and effect of treatment of hypertension on renal function. Hypertension 1989; 13(Suppl 1): 90–3.
   Google Scholar
• Samuelsson O, Wilhelmsen L, Elmfeldt D, Pennert K, Wedel H, Wikstrand J, Berglund G. Predictors of cardiovascular morbidity in treated hypertension: Results from the Primary Preventive Trial in Goteborg, Sweden. J Hypertens 1985; 3: 167–76.
   Google Scholar
• US Renal Data System USRDS 1997 Annual Report. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases, 1997.
   Google Scholar
• Gall M-A, Borch-Johnsen B, Hougaard P, Nielsen FS, Parving H-H. Albuminuria and poor glycemlc, control predict mortality in NIDDM. Diabetes 1995; 44: 1303–9.
   PubMed Web of Science ®Google Scholar
• Stamler J, Vaccaro O, Neaton JD, Wentworth D, for the Multiple Risk Factor Intervention Trial Research Group. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993; 16: 43/1 /14.
   Google Scholar
• Abbott RD, Donahue RP, MacMahon SW, Reed DM, Yano K. Diabetes and the risk of stroke: The Honolulu Heart Project. JAMA 1987; 257: 949–52.
   Google Scholar
• Despres J-P, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani SP-JL. Hyperinsulinemia is an independent risk factor for ischemic heart disease. N Engl J Med 1996; 334: 952–7.
   Google Scholar
• Gerstein HC, Yusuf S. Dysglycaemia and risk of cardiovascular disease. Lancet 1996; 347: 949–50.
   PubMed Web of Science ®Google Scholar
• Doll R, Peto R, Wheatley K, Gray R, Sutherland T. Mortality in relation to smoking: 40 years' observations on male British doctors. BMJ 1994; 309: 901–11.
   Google Scholar
• Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ 1994; 308: 367–73.
   Google Scholar
• Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, Jacobs DR, Bangdiwala S, Tyroler HA. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American stu-dies. Circulation 1989; 79: 8–15.
   Google Scholar
• Rimm EB, Stampfer MJ, Ciovannucci E, Ascherio A, Spiegelman D, Colditz GA, Willett WC. Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men. Am J Epidemiol 1995; 141: 1117–27.
   Google Scholar
• Stampfer MJ, Sacks FM, Salvini S, Willett WC, Hennekens CH. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N Engl J Med 1991; 325: 373–81.
   Google Scholar
• Stern MP, Haffner SM. Body fat distribution and hyperinsulinemia as risk factors for diabetes and cardio-vascular disease. Arteriosclerosis 1986; 6: 123–30.
   PubMedGoogle Scholar
• Woodward M, Lowe GDO, Rumley A, Tunstall-Pedoe H. Fibrinogen as a risk factor for coronary heart disease and mortality in middle-aged men and women. The Scottish Heart Health Study. Eur Heart J 1998; 19: 55–62.
   Google Scholar
• Ernst E, Resch KL. Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature. Ann Intern Med 1993; 118: 956–63.
   PubMed Web of Science ®Google Scholar
• Rimm ER, Klatsky A, Grobbee D, Stampher MJ. Review of moderate alcohol consuption and reduced risk of coronary heart disease: is the effect due to beer, wine or spirits? BMJ 1996; 312: 731–6.
   PubMed Web of Science ®Google Scholar
• Thun MJ, Peto R, Lopez AD, Monaco JH, Henley SJ, CW H, Doll R. Alcohol consumption and mortality among middle-aged and elderly US adults. N Engl J Med 1997; 337: 1705–14.
   Google Scholar
• Wannamethee SG, Shaper AG. Patterns of alcohol intake and risk of stroke in middle-aged British men. Stroke 1996; 27: 1033–9.
   PubMed Web of Science ®Google Scholar
• Leon AS, Myers MJ, Connell J, for the MRFIT Research Group. Leisure time physical activity and the 16-year risks of mortality from coronary heart disease and all-causes in the Multiple Risk Factor Intervention Trial (MRFIT). Int J Sports Med 1997; 18\(Suppl 3): 5208–15.
   Google Scholar
• Arakawa K. Effect of exercise on hypertension and associated complications. Hypertens Res 1996; 19(Suppl): S87–91.
   Google Scholar
• Grodstein F, Stampfer JJ, Colditz GA, Willett WC, Manson JE, Joffe M, Rosner B, Fuchs C, Hankinson SE, Hunter DJ, Hennekens CH, Speizer FE. Postmenopausal hormone therapy and mortality. N Engl J Med 1997; 336: 1769–75.
   PubMed Web of Science ®Google Scholar
• Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/ progestin Replacement Study (HERS). JAMA 1998; 280: 605–13.
   Google Scholar
• Davey-Smith G, Neaton JD, Wentworth D, Stamler R, Stamler J. Socioeconomic differentials in mortality risk among men screened for the Multiple Risk Factor Intervention Trial: I. White men. Am J Pub Health 1996; 86: 486–96.
   Google Scholar
• Whitlock G, MacMahon S, Vander Hoorn S, Davis P, Jackson R, Norton R. Socioeconomic distribution of smoking in a population of 10,529 New Zealanders. NZ Med J 1997; 110: 327–30.
   PubMed Web of Science ®Google Scholar
• Sheth T, Bosch J, Chen J, Anand S, Nargundkar M, Nair C, Yusuf S. Ethnic differences in socioeconomic status and mortality. 50th annual meeting of the Canadian Cardiovascular Society. Can J Cardiol 1997; 13(Suppl C): 89C.
   Google Scholar
• Tipene-Leach D, Stewart A, Beaglehole R. Coronary heart disease mortality in Auckland Maori and European. NZ Med J 1991; 104: 55–7.
   Google Scholar
• Lee EJ, Cowan LD, Welty TK, Sievers M, Howard WJ, Oopik A, Wang W, Yeh J, Devereux RB, Rhoades ER, Fabsitz RR, Go O, Howard By. All-cause mortality and cardiovascular disease mortality in three American Indian populations, aged 45-74 years, 1984-1988. The Strong Heart Study. Am J Epidemiol 1998; 147: 995–1008.
   Google Scholar
• Broderick J, Brott T, Kothari R, Miller R, Khoury J, Pancioli A, Gebel J, Mills D, Minneci L, Shukla R. The Greater Cincinnati/Northern Kentucky Stroke Study. Preliminary first-ever and total incidence rates of stroke among blacks. Stroke 1998; 29: 415–21.
   Google Scholar
• Klag MJ, Whelton PK, Randall BL, Neaton JD, Brancati FL, Stamler J. End-stage renal disease in African-American and white men. JAMA 1997; 277: 1293–8.
   PubMed Web of Science ®Google Scholar
• Cappuccio FP. Ethnicity and cardiovascular risk: varia-tions in people of African ancestry and South Asian origin. J Hum Hyperters 1997; 11: 571–6.
   PubMed Web of Science ®Google Scholar
• Sheth T, Nair C, Nargundkar M, Anand S, Yusuf S. Cardiovascular and cancer mortality among Whites, South Asians, and Chinese in Canada from 1979 to 1993: an analysis of 2.6 million deaths. Can Med Assoc J 1998: in press.
   Google Scholar
• WHO-MONICA Project. Tunstall-Pedoe H, Kuulasmaa K, Amouyel P. Arveiler D, Rajakangas AM, Pajak A. Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circula-tion 1994; 90: 583–612.
   Google Scholar
• WHO-MONICA Project. Stegmayr B, Asplund K, Kuu-lasmaa K, Rajakangas A-M, Thorvaldsen P, Tuomilehto J. Stroke incidence and mortality correlated to stroke risk factors in the WHO MONICA Project. An ecological study of 18 populations. Stroke 1997; 28: 1367–74.
   Google Scholar
• Yao C, Wu Z, Wu Y. The changing pattern of cardio-vascular diseases in China. Wld Hlth Statist Quart 1993; 46: 113–8.
   Google Scholar
• Collins R, Peto R, MacMahon S, Herbert P, Fiebach NH, Eberlein KA, Godwin J, Qizibash N, Taylor JO, Hennekens CH. Blood pressure, stroke, and coronary heart disease. Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 1990; 335: 827–39.
   Google Scholar
• Collins R, MacMahon S. Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease. Br Med Bull 1994; 50: 272–98.
   PubMed Web of Science ®Google Scholar
• MacMahon S, Rodgers A. The effects of antihypertensive treatment on vascular disease: reappraisal of the evidence in 1994. J Vase Med Biol 1993; 4: 265–71.
   Google Scholar
• Messerli FH, Grossman E, Goldbourt U. Are beta-blockers efficacious as first-line therapy for hypertension in the elderly? A systematic review. JAMA 1998; 279: 1903–7.
   Google Scholar
• Medical Research Council Working Party. MRC trial of treatment of mild hypertension: principal results. BMJ 1985; 291: 97–104.
   PubMed Web of Science ®Google Scholar
• Medical Research Council Working Party. Medical Research Council trial of treatment of hypertension in older adults: principal results. BMJ 1992; 304: 405–12.
   PubMed Web of Science ®Google Scholar
• The IPPPSH Collaborative Group. Cardiovascular risk and risk factors in a randomised trial of treatment based on the beta-blocker oxprenolol: the international prospective primary prevention study in hypertension (IPPPSH). J Hypertens 1985; 3: 379–92.
   PubMed Web of Science ®Google Scholar
• Wilhelmsen L, Berglund G, Elmfeld D, Fitzsimons T, Holzgreve H, Hosie J, Hörnkvist P-E, Pennert K, Tuomilehto J, Wedel H, on behalf of the Heart Attack Primary Prevention in Hypertension Trial Research Group. Beta-blockers versus diuretics in hypertensive men. Main results from the HAPPHY trial. J Hypertens 1987; 5: 561–72.
   Google Scholar
• Kostis JB, Davis BR, Cutler JRH G, Berge KG, Cohen JD, Lacy CR, Perry HM, Blaufox MD, Wassertheil-Smoller S, Black HR, Schron E, Berkson DM, Curb JD, McFate Smith W, McDonald R, Applegate WB for the SHEP Cooperative Research Group. Prevention of heart failure by antihypertensive drug treatment in older persons with isolated systolic hypertension. JAMA 1997; 278: 212–6.
   Google Scholar
• Yusuf S, Thomas T, Abbott RD. Changes in hypertension treatment and in congestive heart failure mortality in the United States. Hypertension 1989; 13(Suppl I): 1–74–9.
   Google Scholar
• SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991; 265: 3255–64.
   Google Scholar
• Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG, Birkenhager WH, Bulpitt CJ, De Leeuw PW, Dollery CT, Fletcher AE, Forette F, Leonetti G, Nachev C, O'Brien ET, Rosenfeld J, Rodicio JL, Tuomilehto J, Zanchetti A, for the Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. Lancet 1997; 350: 757–64.
   Google Scholar
• Gong L, Zhang W, Zhu Y, Zhu J, 11 collaborating centres in the Shanghai area, Kong D, Page V, Ghadirian P, LeLorier J, Hamet P. Shanghai trial of nifedipine in the elderly (STONE). J Hypertens 1996; 14: 1237–45.
   Google Scholar
• Liu L, Wang JG, Gong L, Liu G, Staessen JA for the Systolic Hypertension in China (Syst-China) Collaborative Group. Comparison of active treatment and placebo for older Chinese patients with isolated systolic hypertension. J Hypertens 1998; 16: 1823–9.
   Google Scholar
• Hans son L, Lindholm LH, Niskanen L, Lanke J, Hedner T, Niklason A, Luomannmaki K, Dahlöf B, de Faire U, Morlin C, Karlberg BE, Wester PO, Björck J-E, for the CAPPP Study Group. Principal results of the Captopril Prevention Project (CAPPP). Lancet 1999; 353: 611–6.
   Google Scholar
• UK Prospective Diabetes Study Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. BMJ 1998; 317: 713–20.
   Google Scholar
• Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, Menard J, Julius S, Rahn KB, Wedel H, Westerling S, for the HOT Study Group. Effects of intensive blood pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998; 351: 1755–62.
   Google Scholar
• UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and micro-vascular complications in type 2 diabetes: UKPDS 38. BMJ 1998; 317: 703–13.
   Google Scholar
• Ad Hoc Subcommittee of the Liaison Committee of the World Health Organisation and the International Society of Hypertension. Effects of calcium antagonists on the risks of coronary heart disease, cancer and bleeding. J Hypertens 1997; 15: 105–15.
   PubMed Web of Science ®Google Scholar
• Lever AF, Hole DJ, Gillis CR, McCallum IR, McInnes GT, MacKinnon PL, Meredith PA, Murray LS, Reid JL, Robertson JVVK. Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer? Lancet 1998; 352: 179–84.
   PubMed Web of Science ®Google Scholar
• Forette F, Seux MC, Thijs L, Staessen JA. Antihyperten-sive treatment and prevention of dementia in older patients with isolated systolic hypertension: the Syst-Eur results. J Hypertens 1998; 16\(Suppl 2): S22 (abstract 29Z21).
   Google Scholar
• Mancia G, Sega R, Milesi C, Cesana G, Zanchetti A. Blood pressure control in the hypertensive population. Lancet 1997; 349: 454–7.
   Google Scholar
• Tao S, Wu X, Duan X, Fang W, Hao J, Fan D, Wang W, Li Y. Hypertension prevalence and status of awareness, treatment and control in china. Chin Med J 1995; 108: 483–9.
   PubMed Web of Science ®Google Scholar
• Isles CG, Walker LM, Beevers GD, Brown I, Cameron HL, Clarke J, Hawthorne V, Hole D, Lever AF, Robertson JWK, Wapshaw JA. Mortality in patients of the Glasgow Blood Pressure Clinic. J Hypertens 1986; 4: 141–56.
   Google Scholar
• Gamble G, MacMahon S, Culpan A, Ciobo C, Whalley G, Sharpe N. Atherosclerosis and left ventricular hypertro-phy: persisting problems in treated hypertensive patients. J Hypertens 1998; 16: 1389–95. BLOOD PRESSURE 1999
   PubMed Web of Science ®Google Scholar
• Tang JL, Armitage JM, Lancaster T, Silagy CA, Fowler GH, Neil HAW. Systematic review of dietary intervention trials to lower blood total cholesterol in free-living subjects. BMJ 1998; 316: 1213–20.
   PubMed Web of Science ®Google Scholar
• Scandinavian Simvastatin Survival Study Group. Rando-mised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383–9.
   PubMed Web of Science ®Google Scholar
• Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ, for the West of Scotland Coronary Prevention Study group. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med 1995; 333: 1301–7.
   Google Scholar
• Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG, Brown L, Warnica JVV, Arnold JMO, Wun CC, Davis BR, Braunwald E, for the Cholesterol and Recurrent Events Trial Investigators. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 1996; 335: 1001–9.
   Google Scholar
• Downs JR, Clearfield M, Weis S, Whitney E, Shapiro DR, Beere PA, Langendorfer A, Stein EA, Kruyer W, Gotto AM, for the AFCAPS/TexCAPS Research Group. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Athero-sclerosis Prevention Study. JAMA 1998; 279: 1615–22.
   Google Scholar
• UK Prospective Diabetes Study (UKPDS) Group. Inten-sive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352: 837–53.
   Google Scholar
• UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352: 854–65.
   Google Scholar
• Antiplatelet Trialists' Collaboration. Collaborative over-view of randomised trials of antiplatelet therapy - I: Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 1994; 308: 81–106.
   Google Scholar
• Hennekens CH, Buring JE, Peto R. Antioxidant vitamins - benefits no yet proved. N Engl J Med 1994; 330: 1080–1.
   Google Scholar
• Mancia G, Parati G, Di Rienzo M, Zanchetti A. Blood pressure variability. In: Zanchetti A, Mancia G, eds. Handbook of hypertension; pathophysiology of hyperten-sion. Amsterdam: Elsevier Science, 1997; 17: 117–69.
   Google Scholar
• Laragh JH, Brenner BM, eds. Hypertension: pathophysiol-ogy, diagnosis and management. 2nd ed. New York: Raven Press, 1995; 2: 1897–952.
   Google Scholar
• Swales JD, ed. Textbook of hypertension. London: Blackwell, 1994: 989–1008.
   Google Scholar
• Ohkubo T, Imai Y, Tsuji I, Nagai K, Kato J, Kikuchi N, Nishiyama A, Aihara A, Sekino M, Kikuya M, Ito S, Satoh H, Hisamichi S. Home blood pressure measurement has a stronger predictive power for mortality than dose screen-ing blood pressure measurement: a population-based observation in Ohasama, Japan. J Hypertens 1998; 16: 971–5.
   Google Scholar
• Mancia G, Di Rienzo M, Parati G. Ambulatory blood pressure monitoring use in hypertension research and clinical practice. Hypertension 1993; 21: 510–24.
   PubMed Web of Science ®Google Scholar
• Mancia G, Sega R, Bravi D, De Vito G, Valagussa F, Cesana G, Zanchetti A. Ambulatory blood pressure normality: results from the PAMELA Study. J Hypertens 1995; 13: 1377–90.
   Google Scholar
• Wood D, Backer G, Faergeman O, Graham I, Mancia G, Pyorala K. Prevention of coronary heart disease in clinical practice. Recommendations of the Second Joint Task Force of the European Society of Cardiology, European Atherosclerosis Society and European Society of Hyper-tension. Eur Heart J 1998; 19: 1434–503.
   Google Scholar
• Zanchetti A, Bond MG, Henning M, Neiss A, Mancia G, Dal Palu C, Hansson L, Magnani B, Rahn K-H, Reid J, Rodicio J, Safar M, Eckes L, Ravinetto Ron behalf of the ELSA Investigators. Risk factors associated with altera-tions in carotid intima-media thickness in hypertension: baseline data from the European Lacidipine Study on Atherosclerosis. J Hypertens 1998; 16: 949–61.
   Google Scholar
• Fagard RH, Staessen JA, Thijs L. Prediction of cardiac structure and function by repeated clinic and ambulatory blood pressure. Hypertension 1997; 29: 22–9.
   Google Scholar
• Perloff D, Sokolow M, Cowan R, Juster R. Prognostic value of ambulatory blood pressure measurement. J Hypertens 1989; 7(Suppl 3): 53–10.
   Google Scholar
• Verdecchia P, Porcellati C, Shillaci G, Borgioni C, Ciucci A, Battistelli M. Ambulatory blood pressure: an indepen-dent predictor of prognosis in essential hypertension. Hypertension 1994; 24: 793–801.
   PubMed Web of Science ®Google Scholar
• Redon J, Campos C, Narciso ML, JL R, Pasquale JM, Ruilope LM. Prognostic value of ambulatory blood pressure monitoring in refractory hypertension: a prospec-tive study. Hypertension 1998; 31: 712–8.
   PubMed Web of Science ®Google Scholar
• Ohkubo T, Imai Y, Tsuji I, Nagai K, Ito S, Satoh H, Hisamichi S. Reference values for 24-hour ambulatory blood pressure monitoring based on a prognostic criterion: Ohasama study. Hypertension 1998; 32: 255–9.
   Google Scholar
• Mancia G, Zanchetti A, Agebiti-Rosei E, Benemio G, De Cesaris R, Fogari R, Pessino A, Porcellati C, Salvetti A, Trimarco B, for the SAMPLE Study Group. Ambulatory blood pressure is superior to clinic blood pressure in predicting treatment-induced regression of left ventricular hypertrophy. Circulation 1997; 95: 1464–70.
   Google Scholar
• Mancia G, Omboni S, Parati G. Assessment of antihy-pertensive treatment by ambulatory blood pressure. J Hypertens 1997; 15(Suppl 2): S43–50.
   Google Scholar
• Pickering TG, James GD, Boddie C, Harshfield GA, Blank S. How common is white coat hypertension? JAMA 1988; 259: 225–8.
   Google Scholar
• Mancia G, Zanchetti A. Editors' corner: white-coat hypertension: misnomers, misconceptions and misunder-standings. What should we do next? J Hypertens 1996; 14: 1049–52.
   Google Scholar
• Parati G, Ulian L, Santicciu C, Omboni S, Mancia G. Difference between clinic and daytime blood pressure is not a measure of the white coat effect. Hypertension 1998; 31: 1185–9.
   Google Scholar
• Mancia G, Parati G, Pomidossi G, Grassi G, Casadei R, Zanchetti A. Alerting reaction and rise in blood pressure during measurement by physician and nurse. Hypertension 1987; 9: 209–15.
   PubMed Web of Science ®Google Scholar
• Joint National Committee on Detection Evaluation and Treatment of High Blood Pressure. The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (INC V). Arch Intern Med 1993; 153: 154–83.
   PubMed Web of Science ®Google Scholar
• Joint National Committee on Detection Evaluation and Treatment of High Blood Pressure. The sixth report of the Joint National Committee on Prevention, Detection, and Treatment of High Blood Pressure (JNC VI). Arch Intern Med 1997; 157: 2413–46.
   PubMed Web of Science ®Google Scholar
• The Guidelines Subcommittee of the WHO-ISH Mild Hypertension Liaison Committee. 1993 Guidelines for the Management of Mild Hypertension. Memorandum from a World Health Organization-International Society of Hy-pertension Meeting. J Hypertens 1993; 11: 905–18.
   Google Scholar
• Chalmers J, Zanchetti A. Reply to a critique of the 1996 World Health Organisation expert committee report on hypertension. J Hypertens 1997; 15: 684–5.
   Web of Science ®Google Scholar
• Lindholm L, Ejlertsson G, Schersten B. High risk of cerebrovascular morbidity in well treated male hyperten-sives: a retrospective study of 40-59 year old hyperten-sives in a Swedish primary care district. Acta Med Scand 1984; 216: 251–9.
   Google Scholar
• Silagy C, Mant D, Fowler G, Lodge M. Meta-analysis on efficacy of nicotine replacement therapies in smoking cessation. Lancet 1994; 343: 139–42.
   PubMed Web of Science ®Google Scholar
• Stamler J. Epidemiologic findings on body mass and blood pressure in adults. Ann Epidemiol 1991; 1: 347–62.
   PubMedGoogle Scholar
• Reid CM, Dart AM, Dwar EM, Jennings GL. Interactions between the effects of exercise and weight loss on risk factors, cardiovascular haemodynamics and left ventricu-lar structure in overweight subjects. J Hypertens 1994; 12: 291–301.
   PubMed Web of Science ®Google Scholar
• Puddey 116, Parker M, Beiling LJ, Vandongen R, Masarei JRL. Effects of alcohol and caloric restrictions on blood pressure and serum lipids in overweight men. Hyperten-sion 1992; 20: 533–41.
   Google Scholar
• Whelton PK, Appel LJ, Espeland MA, Applegate WB, Ettinger WH, Kostis JB, Kumanyiaka S, Lacy CR, Johnson KC, Folmar S, Cutler JA, for TONE Collabora-tive Research Group. Sodium reduction and weight loss in the treatment of hypertension in older persons. A randomized controlled trial of nonpharmacologic inter-ventions in the Elderly (TONE). JAMA 1998; 279: 839–46.
   Google Scholar
• Puddey 116, Beilin LJ, Rakic V. Alcohol, hypertension and the cardiovascular system: a critical appraisal. Addiction Biol 1997; 2: 159–70.
   Google Scholar
• Puddey 116, Beilin LJ, Vandongen R. Regular alcohol use raises blood pressure in treated hypertensive subjects. A randomized controlled trial. Lancet 1987; i: 647–51.
   Google Scholar
• Law MR. Epidemiological evidence on salt and blood pressure. Am J Hypertens 1997; 10: 42S–5.
   Google Scholar
• Cutler JA, Follman D, Alexander PS. Randomised controlled trials of sodium reduction: An overview. Am J Chin Nutr 1997; 65 (Suppl): 643S–51.
   Google Scholar
• Rouse IL, Armstrong BK, Beilin U. The relationship of blood pressure to diet and lifestyle in two religious populations. J Hypertens 1983; 1: 65–71.
   Google Scholar
• Margetts BM, Beilin LJ, Vandongen R, Armstrong BK. Vegetarian diet in mild hypertension: A randomized controlled trial. BMJ 1986; 293: 1468–71.
   PubMed Web of Science ®Google Scholar
• Appel LJ, Moore TJ, Obarzanek E, Vollmer WI\4, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Cutler JA, Whindhauser MM, Lin PH, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med 1997; 336: 1117–24.
   PubMed Web of Science ®Google Scholar
• Bao DG, Mori TA, Burke V, Puddey IB, Beilin U. Effects of dietary fish and weight reduction on ambulatory blood pressure in overweight hypertensives. Hypertension 1998; 32: 710–7.
   Google Scholar
• Jennings GL. Exercise and blood pressure: Walk, run or swim? J Hypertens 1997; 15: 567–9.
   PubMed Web of Science ®Google Scholar
• Arakawa K. Antihypertensive mechanism of exercise. J Hypertens 1993; 11: 223–9.
   PubMed Web of Science ®Google Scholar
• Fagard RH. The role of exercise in blood pressure control: supportive evidence. J Hypertens 1995; 13: 1223–7.
   PubMed Web of Science ®Google Scholar
• Puddey 116, Cox K. Exercise lowers blood pressure - sometimes? Or did Pheidippides have hypertension? J Hypertens 1995; 13: 1229–33.
   Google Scholar
• Beilin U. Stress coping, lifestyle and hypertension: A paradigm for research prevention and non-pharmacologi-cal management of hypertension. Chin Exp Hypertens 1997; 19: 739–52.
   PubMed Web of Science ®Google Scholar
• Lindquist TL, Beilin LJ, Knuiman MW. Influence of lifestyle, coping and job stress on blood pressure in men and women. Hypertension 1997; 29: 1–7.
   Google Scholar
• Nyklicek I, Vingerhoets JJM, Van Heck GL. Hypertension and objective and self-reported stressor exporuse: A review. J Psychosom Res 1996; 40: 585–601.
   Google Scholar
• Pickering TG, Devereux RB, James GD, Gerin W, Landsbergis P, Schnall PL, Schawartz JE. Environmental influences on blood pressure and the role of job strain. J Hypertens 1996; 14(Suppl 5): 5179–85.
   Google Scholar
• Parati G, Pomidossi G, Albini F, Malaspina D, Mancia G. Relationship of 24 hour blood pressure mean and variability to severity of target organ damage in hyperten-sion. Hypertension 1987; 5: 93–8.
   Google Scholar
• Frattola A, Parati G, Cuspidi G, Albini F, Mancia G. Prognostic value of 24 hour blood pressure variability. J Hypertens 1993; 11: 1133–7.
   Google Scholar
• Siscovick D, Raghunathan T, Psaty B, Keopsell T, Wicklund K, Xiphong Lin M, Cobb L, Rantaharju P, Copass M, Wagner E. Diuretic therapy for hypertension and the risk of primary cardiac arrest. N Engl J Med 1994; 330: 1852–7.
   Google Scholar
• Hoes A, Grobbee D, Lubsen J, Man in't Veld A, Van der Does E, Hofman A. Diuretics, beta-blockers, and the risk of sudden cardiac death in hypertensive patients. Ann Intern Med 1995; 123: 481–87.
   Google Scholar
• Doughty R, Rodgers A, Sharpe N, MacMahon S. Effects of beta-blocker therapy on mortality in patients with heart failure. Eur Heart J 1997; 18: 560–5.
   PubMed Web of Science ®Google Scholar
• Yasue H, Kugiyama K. Coronary spasm: Japanese View. Coronary Artery Dis 1990; 1: 668–73.
   Web of Science ®Google Scholar
• Garg R, Yusuf S, for the Collaborative Group on ACE Inhibitor Trials. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. JAMA 1995; 273: 1450–6.
   Google Scholar
• Lewis EJ, Hunsicker LG, Bain RP, Rohde RD for the Collaborative Study Group. The effect of angiotensin converting enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 1993; 329: 1456–62.
   Google Scholar
• Israili Z, Hall W. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy. A review of the literature and pathophysiology. Ann Intern Med 1992; 117: 234 /12.
   Web of Science ®Google Scholar
• Johnston C. Angiotensin receptor antagonists: focus on losartan. Lancet 1995; 346: 1403–7.
   PubMed Web of Science ®Google Scholar
• Neaton JD, Grimm RH, Prineas RJ, Stamler J, Grandits GA, Elmer PJ, Cutler JA, Flack JM, Schoenberger JA, McDonald R, Lewis CE, Liebson PR, for the Treatment of Mild Hypertension Study Research Group. Treatment of Mild Hypertension Study. Final results. JAMA 1993; 270: 713–24.
   Google Scholar
• Brown MA, Whitworth JA Pregnancy. In: Bennett WM, McCarron DA, eds. Contemporary Issues in nephrology: Pharmacology and management of hypertension. New York: Churchill Livingstone, 1994; 28: 89–116.
   Google Scholar
• Cooper RS, Liao Y, Rotimi C. Is hypertension more severe among US Blacks, or is severe hypertension more common? Ann Epidemiol 1996; 6: 173–80.
   Google Scholar
• Bullen C, Tipene-Leach D, Vander Hoorn S, Jackson R, Norton R, MacMahon S. Ethnic differences in blood pressure: findings from the Fletcher Challenge-University of Auckland University Heart and Health Study. NZ Med J 1996; 109: 395–7.
   PubMed Web of Science ®Google Scholar
• World Health Organization-International Society of Hy-pertension Blood Pressure Lowering Treatment Trialists' Collaboration. Protocol for prospective collaborative overviews of major randomized trials of blood pressure lowering treatments. J Hypertens 1998; 16: 127–37.
   Google Scholar
• National High Blood Pressure Education Program Work-ing Group. National High Blood Pressure Education Program Working Group Report on High Blood Pressure in Pregnancy. Amn J Obstet Gynecol 1990; 163: 1689–712.
   Web of Science ®Google Scholar
• Australasian Society for the Study of Hypertension in Pregnancy. Management of hypertension in pregnancy: executive summary. Med J Aust 1993; 158: 700–2.
   PubMed Web of Science ®Google Scholar
• Collins R, Yusuf S, Peto R. Overview of randomised trials of diuretics in pregnancy. BMJ Clin Res Ed 1985; 290: 17–23.
   PubMed Web of Science ®Google Scholar
• CLASP Collaborative Group. CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet 1994; 343: 619–29.
   PubMed Web of Science ®Google Scholar
• MacMahon S, Rodgers A. The effects of blood pressure reduction in older patients: an overview of five rando-mized controlled trials in elderly hypertensives. J Clin Exp Hypertens 1993; 15: 967–78.
   PubMed Web of Science ®Google Scholar
• Dahlöf B, Lindholm LH, Hansson L, Scherstén B, Ekbom T, Wester PO. Morbidity and mortality in the Swedish trial in old patients with hypertension (STOP-Hypertension). Lancet 1991; 338: 1281–5.
   Google Scholar
• Staessen JA, Fagard R, Thijs L, Celis H, Birkenhager WH, CJ B, de Leeuw PW, Fletcher AE, Babarskiene M-R, Forette F, Kocemba J, Laks T, Leonetti G, Nachev G, Petrie JC, Tuomilehto J, Vanhanen H, Webster J, Yodfat Y, Zanchetti A, for the Systolic Hypertension in Europe Trial Investigators. Subgroup and per-protocol analysis of the randomized European Trial on Isolated Systolic Hypertension in the Elderly. Arch Intern Med 1998; 158: 1681–91.
   Google Scholar
• The INDANA (INdividual Data ANalysis of Antihyper-tensive interventional trials) Project Collaborators, Guey-ffier F, Boissel J-P, Boutitie F, Pocock S, Coope J, Cutler J, Ekbom T, Fagard R, Friedman L, Kerlikowske K, Perry M, Prineas R, Schron E. Effect of antihypertensive treatment in patients having already suffered from stroke. Gathering the evidence. Stroke 1997; 28: 2557–62.
   Google Scholar
• PROGRESS Management Committee. Blood pressure lowering for the secondary prevention of stroke: rationale and design for PROGRESS. J Hypertens 1996; 14(Suppl 2): S41–6.
   PubMedGoogle Scholar
• Yusuf S, Peto R, Lewis J, Collins R, Sleight P. Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985; 27: 335–71.
   Google Scholar
• Lonn EM, Yusuf S, Jha P, Montague TJ, Teo KK, Benedict CR, Pitt B. Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection. Circulation 1994; 90: 2056–69.
   Google Scholar
• The HOPE Study Investigators. The HOPE (Heart Outcome Prevention Evaluation) Study: the design of a large, simple randomised trial of an angiotensin converting enzyme inhibitor (ramipril) and vitamin E in patients at high risk of cardiovascular events. Can J Cardiol 1996; 12: 127–37.
   PubMed Web of Science ®Google Scholar
• Brown MA, Whitworth JA. Hypertension in human renal disease. J Hypertens 1992; 10: 701–12.
   PubMed Web of Science ®Google Scholar
• Iseki K, Ikemiya Y, Fukiyama K. Blood pressure and risk of end-stage renal disease in a screened cohort. Kidney Int 1996; 49(S55): 569–71.
   Google Scholar
• Ritz E, Rambausek M, Hasslacher C, Mann J. Pathogen-esis of hypertension in renal. Am J Nephrol 1989; 9: 85–90.
   PubMed Web of Science ®Google Scholar
• Krolewski AS, Canessa M, Warran JH, Laffel LMB, Christlich AR, Knowler WC, Rand LI. Predisposition to hypertension and susceptibility to renal disease in insulin dependent diabetes mellitus. N Engl J Med 1988; 318: 140–5.
   Google Scholar
• Bergstrom J, Alvestrand A, Bucht H, Gutierrez A. Progression of chronic renal failure in man is retarded with more frequent clinical follow-ups and better blood pressure control. Clin Nephrol 1986; 25: 1–6.
   PubMed Web of Science ®Google Scholar
• 'hie BU, Whitworth JA, Shahinfar S, Cnaan A, Kincaid-Smith PS, Becker GJ. Angiotensin converting enzyme inhibition in non-diabetic progressive renal insufficiency: a controlled double-blind trial. Am J Kidney Dis 1996; 27: 489–95.
   Google Scholar
• Peterson JC, Adler S, Bukart JM, Greene T, Hebert LA, Hunsicker LG, King AJ, Klahr S, Massry SG, Seifter JL, for the Modification of Diet in Renal Disease (MDRD) Study Group. Blood pressure control, proteinuria and the progression of renal disease. Ann Intern Med 1995; 123: 754–62.
   Google Scholar
• Simonson DC. Eitology and prevalence of hypertension in diabetic patients. Diabetes Care 1988; 11: 821–7.
   PubMed Web of Science ®Google Scholar
• Epstein M, Sowers JR. Diabetes mellitus and hyperten-sion. Hypertension 1992; 19: 403–18.
   PubMed Web of Science ®Google Scholar
• Reaven GM, Lithell H, Lansberg L. Hypertension and associated metabolic abnormalities. The role of insulin resistance and the sympathoadrenal system. N Engl J Med 1996; 334: 374–81.
   Google Scholar
• Haffner SM. Insulin and blood pressure: fact or fantasy? J Clin Endocrinol Metab 1993; 76: 541–2.
   PubMed Web of Science ®Google Scholar
• Grossman E, Messerli FH. Diabetic and hypertensive heart disease. Ann Intern Med 1996; 125: 304–10.
   PubMed Web of Science ®Google Scholar
• Borch-Johnson K, Nissen R, Nerup J. Blood pressure after 40 years of insulin-dependent diabetes. Nephron 1985; 4: 11–2.
   Google Scholar
• Mogensen CE. Long-term antihypertensive treatment inhibiting progression of diabetic nephropathy. BMJ 1982; 285: 685–8.
   PubMed Web of Science ®Google Scholar
• Knowler WC, Bennett PH, Ballintine EJ. Increased incidence of retinopathy in diabetics with elevated blood pressure. N Engl J Med 1980; 302: 645–50.
   Google Scholar
• Chaturvedi N, Sjolie A-K, Stephenson JM, Abrahamian H, Keipes M, Castellarin A, Rogulja-Pepenok Z, Fuller JH, and the EUCLID Study Group. Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes. Lancet 1998; 351: 28–31.
   Google Scholar
• Su HY, Sheu WH, Chin HM, Jeng CY, Chen YD, Reaven GM. Effect of weight loss on blood pressure and insulin resistance in normotensive and hypertensive obese in-dividuals. Am J Hypertens 1995; 8: 1067–71.
   PubMed Web of Science ®Google Scholar
• Lithell HO. Hyperinsulinemia, insulin resistance, and the treatment of hypertension. Am J Hypertens 1996; 9: 150S–4.
   Google Scholar
• Kjekshus J, Gilpin E, Cali G, Blackey AR, Henning H, Ross J. Diabetic patients and beta-blockers after acute myocardial infarction. Eur Heart J 1990; 11: 43–50.
   PubMed Web of Science ®Google Scholar
• Tatti P, Pahor M, Byington RP, Di Mauro P, Guarisco R, Strollo G, Strollo F. Outcome results of the Fosinopril versus Amlodipine cardiovascular events randomized trial (FACET) in patients with hypertension and NIDDM. Diabetes Care 1998; 21: 597–603.
   Google Scholar
• Estacio RO, Jeffers BW, Hiatt WR, Biggerstaff SL, Gifford N, Schrier RW. The effect of nisoldipine as compared to enalapril on cardiovascular outcomes in patients with non-insulin-dependent diabetes and hyper-tension. N Engl J Med 1998; 338: 645–52.
   PubMed Web of Science ®Google Scholar
• Ruilope LM, Garcia-Robles R. How far should blood pressure be reduced in diabetic hypertensive patients? J Hypertens 1997; 15\(suppl 2): S63–5.
   Google Scholar
• Lomas J. Words without action? The production, dis-semination and impact of consensus recommendations. Ann Rev Publ Health 1991; 12: 41–65.
   PubMed Web of Science ®Google Scholar
• Davis DA, Thomson MA, Oxman AD, Haynes RB. Evidence for the effectiveness of CME. A review of 50 randomised controlled trials. JAMA 1992; 268: 1111–7.
   Google Scholar
• Oxman AD, Thomson MA, Davis DA, Haynes RB. No magic bullets: a systematic review of 102 trials of interventions to improve professional practice. Can Med Assoc J 1995; 153: 1423–31.
   PubMed Web of Science ®Google Scholar
• Grol R, Dalhuijsen J, Thomas S, in 't Veld C, Rutten G, Mokkink H. Atrributes of clinical guidelines that influence use of guidelines in general practice: observational study. BMJ 1998; 317: 858–61.
   Google Scholar