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Original

Psychiatric outcome studies (POS): Does treatment help the patients? A Popperian approach to research in clinical psychiatry

25th anniversary report from the Psychiatric Research Unit, Frederiksborg General Hospital, Denmark

Pages 4-34 | Published online: 12 Jul 2009

References

  • James W. The principles of psychology. Holt, New York 1890
  • Bech P. Stress og livskvalitet. København, PsykiatriFonden 1999
  • Phillips DC. Was William James telling the truth after all?. The Monist 1984; 68: 419–34
  • Bech P, Rafaelsen L, Christiansen J, Christrup H, Nyboe J, Rafaelsen OJ. Cannabis og alkohol: Virkning på simuleret bilkørsel. Nord Psykiatr Tidsskr 1971; 25: 350–6
  • Rafaelsen OJ, Bech P, Christiansen J, Christrup H, Nyboe J, Rafaelsen L. Cannabis and alcohol: Effects on simulated cardriving. Science 1973; 179: 920–3
  • Rafaelsen L, Christrup H, Bech P, Rafaelsen O J. Cannabis and alcohol: Effects on psychological tests. Nature 1973; 242: 117–18
  • Bech P. Cannabis and alcohol: Effects on simulated driving. In: Prag HM van, editor. Biochemical and pharmacological aspects of dependence and reports on marihuana research. Harlem; 1972.
  • Bech P. Depression: Influence on time estimation and time experience. Acta Psychiatr Scand 1975; 51: 42–50
  • Bech P. Rating scales for affective disorders: Their validity and consistency. Thesis. Acta Psychiatr Scand 1981; 64(Suppl 295)1–101
  • Bech P. The full story of lithium. A tribute to Mogens Schou 1918. Psychother Psychosom 2006; 75: 265–9
  • Reisby N, Gram LF, Bech P, Sihm F, Krautwald O, Elly J, et al. Clomipramine: Plasma levels and clinical effects. Commun Psychopharmacol 1979; 3: 341–51
  • Gram LF, Bech P, Reisby N, Nagy A, Christiansen J. Factors influencing pharmacokinetics and clinical effects of tricyclic antidepressants. Depressive disorders, S Garattini. Schattauer Verlag, Stuttgart 1978; 337–46
  • Gram LF, Reisby N, Ibsen I, Nagy A, Dencker SJ, Bech P, et al. Plasma levels and antidepressive effect of imipramine. Clin Pharmacol Ther 1976; 19: 318–24
  • Pedersen J, Ravnkilde J. Om videnskabelig metode. Lægevidenskabelig forskning. En introduktion, J Pedersen, B Havsteen. F.A.D.L.'s Forlag, København 1973; 1–11
  • Magee B. Popper. Fontana, London 1973
  • Stone AR. The interdisciplinary research team: A case study. Effective ingredients of successful psychotherapy, JD Frank, R Hoehn-Saric, RL Lieberman, AR Stone. Brunner-Mazel, New York 1978; 155–170
  • Frank JD. Persuasion and healing. Baltimore, MD: The Johns Hopkins University Press; 1961 ( Second, revised edition, 1973).
  • Bech P. Quality of life in psychosomatic research. A psychometric model. Psychopathology 1987; 20: 169–79
  • Danish University Antidepressant Group. Citalopram: Clinical effect profile in comparison with clomipramine. A controlled multicenter study. Psychopharmacology 1986;90:131–8.
  • Bech P, Haaber A, Joyce CRB and DUAG. Experiments on clinical observation and judgement in the assessment of depression: Profiled videotapes and judgement analysis. Psychol Med 1986;16:873–83.
  • Danish University Antidepressant Group (DUAG). Paroxetine: A selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. J Affect Dis 1990;18:289–99.
  • Bech P, Kastrup M, Rafaelsen OJ. Mini-compendium of rating scales for states of anxiety, depression, mania, schizophrenia with corresponding DSM-III syndromes. Acta Psychiatr Scand 1986; 73(Suppl 326)7–37
  • Bech P, Gram LF, Reisby N, Rafaelsen OJ. The WHO Depression Scale: Relationship to the Newcastle Scales. Acta Psychiatr Scand 1980; 62: 140–53
  • Klein DF. Endogenomorphic depression. Arch Gen Psychiatr 1974; 31: 447–54
  • Reisby N, Gram LF, Bech P, Nagy A, Petersen GO, Ortmann J, et al. Imipramine: Clinical effects and pharmacokinetic variability. Psychopharmacology 1977; 54: 263–72
  • Nielsen NP, Wiig EH, Warkentin S, Minthon L. Clinical utility of color-form naming in Alzheimer's disease: Preliminary evidence. Percept Mot Skills 2004; 93(3 Pt 2)1201–4
  • Bech P, Moses R, Gomis R. The effect of prandial glucose regulation with repaglinide on treatment satisfaction, wellbeing and health status in patients with pharmacotherapy-naïve Type 2 diabetes: A placebo-controlled, multicentre study. Qual Life Res 2003; 12: 413–25
  • Bech P, Gram LF, Kragh-Sørensen P, Reisby N, Vestergaard P. DUAG: Standardized assessment scales and effectiveness of antidepressants. Nord Psykiatr Tidsskr 1988; 42: 511–5
  • Bech P, Allerup P, Gram LF, Reisby N, Rosenberg R., Jacobsen O Nagy A. The Hamilton Depression Scale. Evaluation of objectivity using logistic models. Acta Psychiatr Scand 1981; 63: 290–9
  • Bech P, Gram LF, Dein E, Jacobsen O, Vitger J, Bolwig TG. Quantitative rating of depressive states. Acta Psychiatr Scand 1975; 51: 161–70
  • Bech P, Licht RW, Stage KB, Abildgaard W, Bech-Andersen G, Søndergaard S, et al. Rating scales for affective lidelser. Kompendium 2, revideret oplag. Psykiatrisk Forskningsenhed, Psykiatrisk Sygehus Hillerød, Frederiksborg Amt; 2005.
  • Healy D. Roland Kuhn (1912–2005). Hist Psychiatr 2006; 17: 253–5
  • Bech P. Pharmacological treatment of depressive disorders: A review. Depressive disorders. WPA Series Evidence and Experience in Psychiatry, M Maj, N Sartorius. John Wiley & Sons, Chichester 1999; 89–127
  • Kuhn R. The treatment of depressive states with G22355 (imipramine hydrochloride). Am J Psychiatry 1958; 115: 459–64
  • Bech P. The instrumental use of rating scales for depression. Pharmacopsychiatry 1984; 17: 22–8
  • Hardy MC, Lancrenon S, Lecrubier Y. Construction and validation of a new biaxial scale for the evaluation of manic states. Psychiatry Psychobiol 1986; 1: 221–31
  • Maier W, Philipp M, Heuser I, Schlegel S, Buller R, Wetzel H. Improving depression severity assessment—I. Reliability, internal validity and sensitivity to change of three observer depression scales. J Psychiatr Res 1988; 22: 3–12
  • Bech P, Allerup P, Reisby N, Gram LF. Assessment of symptom change from improvement curves on the Hamilton Depression Scale in trials with antidepressants. Psychopharmacology 1984; 84: 276–81
  • Paykel ES., Meyers JK, Lindenthal JJ, Tanner J. Suicidal feelings in the general population: A prevalence study. Br J Psychiatry 1974; 124: 460–9
  • Ghaemi SN. The concepts of psychiatry. A pluralistic approach to the mind and mental illness. Johns Hopkins University Press, Baltimore 2003
  • Borsboom D. Measuring the mind. Conceptual issues in contemporary psychometrics. Cambridge University Press, Cambridge 2005
  • Popper K. The logic of scientific discovery. Hutchinson, London 1959
  • Miller GA. The marginal number seven, plus or minus two: Some limits on our capacity for processing information. Psychol Rev 1956; 63: 81–96
  • Popper K. A world of propensities. Thoemmes, Bristol 1990
  • Gjerris A, Bech P, Bøjholm S., Bolwig TG, Kramp P, Clemmesen L, Andersen J, Jensen E, Rafaelsen OJ. The Hamilton Anxiety Scale: Evaluation of homogeneity and inter-observer reliability in patients with depressive disorders. J Affect Disord 1983; 5: 163–70
  • Bech P, Grosby H, Husum B, Rafaelsen L. Generalized Anxiety or Depression measured by the Hamilton Anxiety Scale and the Melancholia Scale in patients before and after cardiac surgery. Psychopathology 1984; 16: 253–63
  • Bech P, Allerup P, Maier W, Albus M, Lavori P, Ayuso JL. The Hamilton Scales and the Hopkins Symptom Checklist (SCL-90). A cross-national validity study in patients with panic disorders. Br J Psychiatry 1992; 160: 206–11
  • Kragh-Sørensen P, Holm P, Fynboe C, Schaumburg E, Andersen B, Bech P, et al. Bromazepam in generalized anxiety disorder. Psychopharmacology 1990; 100: 383–6
  • Bech P, Larsen JK, Andersen J. The BPRS: Psychometric developments. Psychopharmacol Bull. 1988; 24: 118–21
  • Andersen J, Larsen JK, Schultz V, Nielsen B M, Kørner A, Behnke K, et al. The Brief Psychiatric Rating Scale. Dimension schizophrenia—Reliability and construct validity. Psychopathology 1989; 22: 168–76
  • Crippa JA, Sanches RF, Hallak JE, Loureiro SR, Zuardi AW. Factor structure of Bech's version of the Brief Psychiatric Rating Scale in Brazilian patients. Braz J Med Biol Res 2002; 35: 1209–13
  • Wistedt B, Rasmussen A, Pedersen L, Malm U, Träskman-Bendz L, Wakelin J, et al. The development of an observer-scale for measuring social dysfunction and aggression. Pharmacopsychiatry 1990; 23: 249–52
  • Bang-Kittilsen A, Asserson S, Elgen K, Heldin L, Juel M, Nerdrum T, et al. Kvalitetskontroll av zuclopenthixol acetat hos psykotiske pasienter med aggressiv holdning eller atferd. Multisenterregistrering ved sju norske og svenske sykehus. Nord J Psychiatry 1995; 49(Suppl 35)79–93
  • Bech P, Allerup P, Gram LF, Kragh-Sørensen P, Rafaelsen OJ, Reisby N, et al. The Diagnostic Melancholia Scale (DMS): Dimensions of endogenous and reactive depression with relationship to the Newcastle Scales. J Affect Disord 1988; 14: 161–70
  • Kristensen CB, Rasmussen S, Dahl A, Lauritsen B, Lund K, Stubgaard M, et al. The withdrawal syndrome scale for alcohol and related psychoactive drugs: Total scores as guidelines for treatment with phenobarbital. Nord Psykiatr Tidsskr 1986; 40: 139–46
  • Bech P, Rasmussen S, Dahl A, Lauritsen B, Lund K. The Withdrawal Syndrome Scale for alcohol and related psychoactive drugs. Inter-observer reliability and construct validity. Nord Psykiatr Tidsskr 1989; 43: 291–4
  • Lam RW, Michalak EE, Swinson RP. Assessment scales in depression, mania and anxiety. Taylor and Francis, London 2005
  • Waskow IE, Parloff MD, editors. Psychotherapy change measures. Washington, DC: DHEW Publ No (ADM) 74-120, US Government Printing Office; 1975.
  • Ntasis C, Pakos E, Kyzas P, Iannidis JPA. Benzodiazepines for alcohol withdrawal. The Cochrane database of systematic reviews 2005, issue 3, Art No CD005063. DOI: 10. 1002/14651858. CD005063.pub2.
  • Bech P, Coppen A, editors. The Hamilton scales. Springer: Berlin; 1990. p. 72–9.
  • Strömgren E. Current status of psychiatric research in Denmark. Psychiatry and Psychychobiology 1987; 2: 128–34
  • Kielholz P, Adams C, Bech P. Depression and cognitive impairment in the elderly: A multicenter study. Eur Psychiatry 1995; 10: 61–74
  • Bech P, Gastpar M, Morozov PV. Clinical assessment scales for biological psychiatry to be used in WHO studies. Progr Neuro-Psychopharmacol Biol Psychiatry 1984; 8: 190–6
  • Bech P, Gastpar M, Mendlewicz J. The role of training courses in multicenter trials: WHO experiences. Developments in psychiatry, C Chagas, RG Josiassen, WH Bridger, KJ Weiss, D Stoff, GM Simpson. Amsterdam, Elsevier 1986; 7: 1513–15
  • Bech P, Eplov L, Gastpar M, Gentsch C, Mendlewicz J, Plenge P, et al. WHO pilot study on the validity of imipramine platelet receptor binding sites as a biological marker of endogenous depression. Pharmacopsychiatry 1988; 21: 147–50
  • Bech P, Gjerris A, Andersen J, Rafaelsen OJ. World Health Organization Schedule for Standardised Assessment of Depressive Disorders (WHO/SAD5). Item combinations and inter-observer reliability. Psychopathology 1984; 17: 244–52
  • Sartorius N, Ban TA, editors. Assessment of depression. Berlin: Springer; 1986.
  • Gjerris A, Bech P, Andersen J, Bøjholm S, Kramp P, Bolwig TG, . The Melancholia Scale, the Newcastle Scales, and the Eighth International Classification of Disease: Inter-observer reliability and diagnostic validity. Biological psychiatry, recent studies, depressive illness, G Burrows, TR Norman, KP Maguire, et al. John Libbey, London 1984; 121–5
  • Jørgensen B, Nørrelund N, Bech P, Jakobsen K. Smerter og depressive symptomer i almen praksis. Ugeskr Læger 1984; 146: 2868–72
  • Bech P, Jørgensen B, Nørrelund N, Loldrup D, Langemark M, Hansen HJ, et al. Pains as presentation symptoms of depression in liaison psychiatry as evidenced by outcome of clomipramine treatment. Nord Psykiatr Tidsskr 1989; 43: 291–4
  • Loldrup Poulsen D, Hansen HJ, Langemark M, Olesen J, Bech P. Discomfort or disability in patients with chronic pain syndrome. Psychother Psychosom 1987; 48: 60–2
  • Loldrup D, Langemark M, Hansen HJ, Olesen J, Bech P. Clomipramine and mianserin in chronic idiopathic pain syndrome. A placebo controlled study. Psychopharmacology 1989; 99: 1–7
  • Loldrup D, Langemark M, Hansen HJ, Kastrup M, Jeppesen K, Bonnevie O, et al. The validity of the Melancholia Scale (MES) in predicting outcome of antidepressants in chronic idiopathic pain disorders. Eur Psychiatry 1991; 6: 119–25
  • Mellerup ET, Bech P, Hansen H J, Langemark M, Loldrup D, Plenge P. Platelet 3H-imipramine binding in psychogenic pain patients. Psychiatry Res 1988; 26: 149–56
  • Bendtsen L, Jensen R. Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. Neurology 2004; 62: 1706–11
  • Bech P. Clinical effects of selective serotonin reuptake inhibitors. Clinical pharmacology in psychiatry, SG Dahl, LF Gram. Springer, Berlin 1989; 81–93
  • Gjerris A, Bech P, Broen-Christensen C, Geisler A, Klysner R, Rafaelsen OJ. Haloperidol plasma levels in relation to antimanic effect. Clinical pharmacology and psychiatry, E Usdin, S Dahl, LF Gram, O Lingjærde. MacMillan Press, London 1980; 227–32
  • Klysner R, Butler B, Vilmar T, Bech P. Empirical versus prospective pharmacokinetic dosing of perfenazine in schizophrenic and acute paranoid disorders. Preliminary findings. Nord Psykiatr Tidsskr 1986; 40: 473–7
  • Brøsen K, Gram LF, Klysner R, Bech P. Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics. Eur J Clin Pharmacol 1986; 30: 43–9
  • Brøsen K, Klysner R, Gram LF, Otton SV, Bech P, Bertilsson L. Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism. Eur J Clin Pharmacol 1986; 30: 679–84
  • Bech P, Ahlfors UG, Dencker SJ, Elgen K, Lingjærde O. UKU's bivirkningsskala—Skala til registrering af uønskede virkninger af psykofarmaka. Nord Psykiatr Tidsskr 1986; 40: 147–58
  • Lingjærde O, Ahlfors UG, Bech P, Dencker SJ, Elgen, K. The UKU Side Effect Rating Scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand 1987;76(Suppl 334).
  • Bech P. Rating scales for psychopathology, health status and quality of life. A compendium on documentation in accordance with the DSM-III-R and WHO systems. Berlin, Springer 1993
  • Lindstrom E, Lewander T, Malm U, Malt UF, Lublin H, Ahlfors UG. Patient-rated versus clinician-rated side effects of drug treatment in schizophrenia. Clinical validation of a self-rating version of the UKU Side Effect Rating Scale (UKU-SERS-Pat). Nord J Psychiatry 2001; 55(Suppl 44)5–69
  • Bech P. Quality-of-life measurements for patients taking which drugs? The clinical PCASEE Perspective. PharmacoEconomics 1995; 7: 141–51
  • Bech P, Tanghøj P, Andersen HF, Overø K. Citalopram dose–response revisited using an alternative psychometric approach to evaluate clinical effects of four fixed citalopram doses compared to placebo in patients with major depression. Psychopharmacol 2002; 163: 20–5
  • Bech P, Thomsen J, Prytz S, Vendsborg P B, Zilstorff K, Rafaelsen OJ. The profile and severity of lithium-induced side effects in mentally healthy subjects. Neuropsychobiol 1979; 5: 160–6
  • Bech P, Mellerup ET. Psychochemistry in psychiatry. Papers presented in memory of Ole J. Rafaelsen. Acta Psychiatr Scand 1988;78(Suppl 345).
  • Gjerris A, Hammer M, Vendsborg P, Christensen NJ, Rafaelsen OJ. Cerebrospinal fluid vasopressin—Changes in depression. Br J Psychiatry. 1985; 147: 696–701
  • Gjerris A. Baseline studies on transmitter substances in cerebrospinal fluid in depression. Acta Psychiatrica Scandinavica 1988; Suppl 346: 1–35
  • Dinan TG, O'Brien S, Lavelle E, Scott LV. Further neuroendocrine evidence of enhanced vasopressin V3 receptor responses in melancholic depression. Psychol Med 2004; 34: 169–72
  • Geisler A, Bech P, Johannesen M, Rafaelsen OJ. Cyclic AMP levels in cerebrospinal fluid in manic–melancholic patients. Neuropsychobiology 1976; 2: 211–20
  • Jørgensen OS, Bock E, Bech P, Rafaelsen OJ. Synaptic membrane protein D2 in cerebrospinal fluid of manic–melancholic patients. Acta Psychiatr Scand 1977; 56: 50–6
  • Bech P, Kirkegaard C, Bock E, Johannesen M, Rafaelsen OJ. Hormones, electrolytes, and cerebrospinal fluid proteins in manic–melancholic patients. Neuropsychobiol 1978; 4: 99–112
  • Booij L, van der Does W, Benkelfat C, Bremner JD, Cowen PJ, Fava M, et al. Predictors of mood response to acute tryptophan depletion. A reanalysis. Neuropsychopharmacol 2002; 27: 852–61
  • Kessing LV, Hansen HV, Hougaard E, Hvenegaard A, Albæk J. Forebyggende ambulant behandling ved svær affektiv lidelse (depression og mani)—En Medicinsk Teknologivurdering. København: Sundhedsstyrelsen, Center for Evaluering og Medicinsk Teknologivurdering, 2006. Medicinsk Teknologivurdering—puljeprojekter 2006; 6(9)
  • American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd edition (DSM-III). Washington, DC: American Psychiatric Association; 1980.
  • World Health Organization. Glossary of mental disorders and guide to their classification, 8th revision (ICD-8). Geneva: World Health Organization; 1974.
  • Bech P. Diagnostic and classification tradition of mental disorders in the twentieth century in Scandinavia. Sources of diagnosis in different cultures, N Sartorius. Bern, Hans Huber 1990; 153–69
  • Bech P, Jepsen, PW, editors. Diagnostiske kriterier for DSM-III. København: F.A.D.L.'s forlag; 1987.
  • Bech P, Hippius H, editors. Joining together clinical assessment systems for depression. Acta Psychiatr Scand 1986; 68 Suppl 310.
  • Bech P, Hjortsø S, Lund K, Vilmar T, Kastrup M. An integration of the DSM-III and ICD-8 by global severity assessments for measuring multidimensional outcomes in general hospital psychiatry. Acta Psychiatr Scand 1987; 75: 297–306
  • Loldrup Poulsen D, Zierau F, Eplov L, Jepsen PW, Kastrup M, Kijne B, et al. Integration of DSM-III and ICD-8 to be used in a consultations-liaison psychiatric service. Psychother Psychosom 1987; 48: 78–82
  • Bech P. Observer rating scales of anxiety and depression with reference to DSM-III for clinical studies in psychosomatic medicine. Adv Psychosom Med 1987; 17: 55–70
  • Bech P. DSM-III and ICD-9: Developments and levels of communicative validity. Psychometric and international perspective. Clinical update. Upjohn Company, Kalamazoo, MI 1987
  • Bech P. Methodological problems in assessing quality of life as outcome in psychopharmacology. A multi-axial approach. Methodology and evaluation of psychotropic drugs, O Benkert, K Rickels. Berlin, Springer 1990
  • Danish University Antidepressant Group. Moclobemide: A reversible MAO-A-inhibitor showing weaker antidepressant effect than clomipramine in a controlled multicenter study. J Affect Dis 1993;28:105–16.
  • Bech P. SBUs rapport om depressionsbehandling kan öka vårdkvaliteten. Måtte den bli läst!. Läkartidningen 2004; 101: 534–5
  • Danish University Antidepressant Group (DUAG). Clomipramine dose-effect study in patients with depression: Clinical end points and pharmacokinetics. Clin Pharmacol Ther 1999;66:152–65.
  • Vestergaard P, Gram LF, Kragh-Sørensen P, Bech P, Reisby N, Bolwig TG. Therapeutic potentials of recently introduced antidepressants. Danish University Antidepressant Group. Psychopharmacol Ser [Springer] 1993; 10: 190–8
  • Bech P. The Cronholm–Ottosson Depression Scale: The first depression scale designed to rate changes during treatment. Acta Psychiatr Scand 1991; 84: 439–45
  • Ottosson J-O. Experimental studies of the mode of action of electroconvulsive treatment. Acta Psychiatr Scand 1960; 35(Suppl 145)69–97
  • Frank JD. Methods of assessing the results of psychotherapy. The role of learning in psychotherapy; A Ciba Foundation symposium, R Porter. Churchill, London 1968; 38–60
  • Guy W. Early Clinical Drug Evaluation (ECDEU) assessment manual for psychopharmacology. Publication No. 76-338. National Institute of Mental Health, Rockville, MD 1976
  • Hamilton M, Shapiro CM. Depression. Measuring human problems, DF Peck, CM Shapiro. John Wiley, Chichester 1990; 25–65
  • Bjerrum H, Allerup P, Thunedborg K, Jakobsen K, Bech P. Treatment of generalized anxiety disorder: Comparison of a new beta-blocking drug (CGP361A), low-dose neuroleptic (flupenthixol), and placebo. Pharmacopsychiatry 1992; 5: 229–32
  • Bech P, Loldrup D, Garre K, Rasmussen K, Ærenlund Jensen H. Livskvalitetsmåling som effektstørrelse ved behandling af essentiel arteriel hypertension. Ugeskr Læger 1990; 152/6: 383–6
  • Bech P, Hjortsø S. Problems in measuring quality of life in schizophrenia. Nord Psykiatr Tidsskr 1990; 44: 77–9
  • Bech P. Measurement of psychological distress and well-being. Psychother Psychosom 1990; 54: 77–89
  • Bech P. Methods of evaluation of psychoactive drugs. Recenti Progressi Medicina 1989; 80: 706–11
  • Kelstrup, A., Bech P, Lund K, Vilmer T, Hjortsø S, Lauritsen, B. Brugernes evaluering af to psykiatriske afdelinger. Dansk Sygehus Institut; 1990.
  • Frimodt-Møller J, Loldrup Poulsen D, Kornerup HJ, Bech P. Quality of life, side effects and efficacy of lisinopril compared with metoprolol in patients with mild to moderate essential hypertension. J Hum Hypertension 1991; 5: 215–21
  • Bech P. Quality of life measurement in the medical setting. Int J Methods Psychiat Res 1992; 2: 139–44
  • Bech P. The clinical measurement of aggression. The science and psychiatry of violence, C Thompson, P Cowen. Butterworth Heinman, Oxford 1991; 186–96
  • European Rating Aggression Group (ERAG). Social dysfunction and aggression scale (SDAS-21) in generalized aggression and in aggressive attacks: A validity and reliability study. Int J Meth Psychiatr Res 1992;2:15–29.
  • Bech P, Gudex C, Staehr Johansen K. The WHO (Ten) Well-Being Index: Validation in Diabetes. Psychother Psychosom 1996; 65: 183–90
  • Bjørner JB, Kreiner S, Ware JE, Damsgaard MT, Bech P. Differential item functioning in the Danish translation of the SF-36. J Clin Epidemiol 1998; 51: 1189–202
  • The WHOQOL group. The development of the World Health Organisation Quality of Life Instrument (WHOQOL). Berlin: Springer; 1994.
  • Thunedborg K, Allerup P, Bech P, Joyce CRB. Development of the Repertory Grid for measurement of individual quality of life in clinical trials. Int J Meth Psychiatr Res 1993; 3: 48–58
  • Bech P. Methodological issues in individual quality of life assessment. Individual quality of life. Approaches to conceptualisation and assessment, CRB Joyce, HM McGee, CA O'Bolyle. Harwood Academic Publishers, Amsterdam 1999; 51–63
  • The WHOQOL Group. Development of the World Health Organization WHOQOL-BREF Quality of Life Assessment. Psychol Med 1998;28:551–8.
  • Bech P, Angst J. Quality of life in anxiety and social phobia. Clin Psychopharmacol 1996; 11(Suppl 3)16–20
  • Becker N, Bondegaard Thomsen A, Olsen AK, Sjøgren P, Bech P, Eriksen J. Pain epidemiology and health related quality of life in chronic non-malignant pain patients referred to a Danish multidisciplinary pain center. Pain 1997; 73: 393–400
  • Bech P. Health-related quality of life measurements in the assessment of pain clinic results. Acta Anaesthesiol Scand 1999; 43: 893–6
  • Becker N, Sjøgren P, Bech P, Olsen AK, Eriksen J. Treatment outcome of chronic non-malignant pain patients managed in a Danish multidisciplinary pain centre compared to general practice: A randomised controlled trial. Pain 2000; 84: 203–11
  • Bjerg Bendsen B, Bjerg Bendsen E, Lauritzen L, Vilmer T, Bech P. Post-stroke patients in rehabilitation. The relationship between biological impairment (CT scanning), physical disability and clinical depression. Eur Psychiatry 1997; 12: 399–404
  • Lauritzen L, Bjerg Bendsen B, Vilmer T, Bjerg Bendsen E, Lunde M, Bech P. Post-stroke depression: Combined treatment with imipramine or desipramine and mianserin. A controlled clinical study. Psychopharmacology 1994; 114: 119–22
  • Andersen G, Vestergaard K, Lauritzen L. Effective treatment of post-stroke depression with the selective serotonin reuptake inhibitor citalopram. Stroke 1994; 25: 1099–104
  • Bech P. Depressive syndrome in Parkinson's disease: Clinical manifestations. In: Wolters, E. Ch., Scheltens P, editors. Mental dysfunction in Parkinson's disease. Amsterdam: Vrije Universiteit; 1993.
  • Wermuth L, Sørensen PS, Timm S, Christensen B, Utzon NP, Boas J, et al. Depression in idiopathic Parkinson's disease treated with citalopram. A placebo-controlled study. Nord J Psychiatry 1998; 52: 163–9
  • Bech P, Wermuth L. Applicability and validity of the Major Depression Inventory in patients with Parkinson's disease. Nord Psykiatr Tidsskr 1998; 52: 305–9
  • Årsland D, Larsen JP, Lim NG, Wermuth L, Bech P. α2-Adrenoreceptor antagonism and serotonin reuptake inhibition in patients with Parkinson disease and depression. Nord J Psychiatry 2000; 54: 411–15
  • Middelboe T, Ovesen L, Mortensen EL, Bech P. Depressive symptoms in cancer patients undergoing chemotherapy. A psychometric analysis. Psychother Psychosom 1994; 61: 171–7
  • Groenvold M, Fayer PM, Sprangers MAG, Bjorner JB, Klee MC, Aaronson NK, et al. Anxiety in breast cancer patients at low risk of recurrence compared with the general population: A valid comparison?. J Clin Epidemiol 1999; 52: 523–30
  • Bech P, Stage KB, Nair NPV, Larsen JK, Kragh-Sørensen P, Gjerris A and DUAG. The major depression rating Scale (MDS). Inter-rater reliability and validity across different settings in randomized moclobemide trials. J Affect Disord 1997;42:39–48.
  • Kørner A, Lauritzen L, Bech P. A psychometric evaluation of dementia rating scales. Eur Psychiatry 1996; 11: 185–91
  • Bech P, Langemark M, Loldrup D, Krogh Rasmussen B., Krabbe A. Tension-type headache: Psychiatric aspects. Tension-type headache: Classification, mechanisms, and treatment, J Olesen, J Schoenen. Raven Press, New York 1993; 143–6
  • Bech P, Munk-Jensen N, Obel EB, Ulrich LG, Eiken P, Nielsen SP. Combined versus sequential hormonal replacement therapy: A double-blind, placebo-controlled study on quality of life-related outcome measures. Psychother Psychosom 1998; 67: 259–65
  • Beck AT. Cognitive therapy and emotional disorders. New American Library, New York 1979
  • Ehrenwald J. Psychotherapy: Myth and method. An integrative approach. Grune and Stratton, New York 1966
  • Jess P, Bech P, and the Hvidovre Ulcer Project Group. The validity of Eysenck's Neuroticism Dimension within the Minnesota Multiphasic Personality Inventory in patients with duodenal ulcer. Psychother Psychosom 1994;62:168–75.
  • Jess P, Jess T, Beck H, Bech P. Neuroticism in relation to recovery and persisting pain after laparoscopic cholecystectomy. Scand J Gastroenterol 1998; 33: 550–3
  • Bech P, Jørgensen B, Jeppesen K, Loldrup Poulsen D, Vanggard T. Personality in depression: Concordance between clinical assessment and questionnaires. Acta Psychiatr Scand 1986; 74: 263–8
  • Brodman K, Erdmann AJ, Lorge I, Wolff HG. The Cornell Medical Index. An adjunct to medical interview. JAMA 1949; 140: 530–4
  • Eysenck HJ, Eysenck SBG. Manual of the Eysenck Personality Questionnaire. Hodder and Stoughton, London 1985
  • Goldberg D. The detection of psychiatric illness by questionnaire. Oxford University Press, Oxford 1972
  • Parloff MB, Kelman HC, Frank JD. Comfort, effectiveness and self-awareness as criteria of improvement in psychotherapy. Am J Psychiatr 1954; 111: 343–51
  • Fava GA, Freyberger H, editors. Handbook of psychosomatic medicine. Madison: International Universities Press; 1998.
  • Larsen JK, Lund Y, Wilki L, Bech P, Rafaelsen OJ. Non-medical aspects of out-patient treatment of manic–melancholic patients. Nord Psykiatr Tidsskr 1983; 37: 331–7
  • Bech P. Pharmacological treatment of depressive disorders: A review. Depressive disorders. WPA Series Evidence and Experience in Psychiatry, M. Maj, N Sartorius. John Wiley & Sons, Chichester 1999; 89–127
  • Bech P. Clinical features of mood disorders and mania. New Oxford textbook of psychiatry, MG Gelder, JJ López-Ibor, N Andreasen. Oxford University Press, Oxford 2000; 682–8
  • Bech P, Cialdella P, Haugh M, Birkett MA, Hours A, Boissel JP, et al. A meta-analysis of randomised controlled trials of fluoxetine versus placebo and tricyclic antidepressants in the short-term treatment of major depression. Br J Psychiatry 2000; 176: 421–8
  • Gram LF. Fluoxetine. N Eng J Med 1994; 331: 1354–61
  • Bech P. A meta-analysis of the antidepressant properties of serotonin reuptake inhibitors. Int Rev Psychiatry 1990; 2: 207–11
  • Bech P, Raabæk Olsen L, Jarløv N, Hammer M, Schütze T, Breum L. A case of sequential anti-stress medication in a patient with major depression resistant to amine-reuptake inhibitors. Acta Psychiatr Scand 1999; 100: 76–8
  • Dam J, Ryde L, Svejsø J, Lauge N, Lauritsen B, Bech P. Morning fluoxetine plus evening mianserin versus vorning fluoxetine plus evening placebo in the acute treatment of Major Depression. Pharmacopsychiatry 1998; 31: 48–54
  • Gerlach J, Korsgaard S, Clemmesen P, Lund Lauersen A-M, Magelund G, Noring U, et al. The St. Hans Rating Scale for extrapyramidal syndromes: Reliability and validity. Acta Psychiatr Scand 1993; 87: 244–52
  • Bech P. Quality of life in the psychiatric patient. Mosby, London 1998
  • Mindham RHS, Howland C, Shepherd M. An evaluation of continuation therapy with tricyclic antidepressants in depressive illness. Psychol Med 1973; 3: 5–17
  • Frank E, Kupfer DJ, Perel JM. Three-year outcomes for maintenance therapies in recurrent depression. Arch Gen Psychiatry 1990; 47: 1093–99
  • Lauritzen L, Odgaard K, Clemmesen L, Lunde M, Öhrström J, Black C, Bech P. Relapse prevention of paroxetine in ECT treated patients with major depression. A comparison with imipramine and placebo in medium-term continuation therapy. Acta Psychiatr Scand 1996; 94: 241–51
  • American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 3rd edition, revised (DSM-III-R). WashingtonDC: American Psychiatric Association; 1987.
  • World Health Organization. International classification of diseases, 10th revision (ICD-10). Geneva: World Health Organization; 1993.
  • American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th edition (DSM-IV). Washington DC: American Psychiatric Association; 1994.
  • Olsen LR, Mortensen EL, Bech P. Prevalence of major depression and stress indicators in the Danish general population. Acta Psychiatr Scand. 2004; 109: 96–103
  • Christensen S, Bundgaard S, Bech P. Prævalens af middelsvær depression i almen praksis ved brug af PRIME-MD. Månedsskr Prakt Lægegern 1999; 77: 937–50
  • Stage KB, Bech P, Kragh-Sørensen P and the Danish University Antidepressant Group. Age-related adverse drug reactions to clomipramine. Acta Psychiatr Scand 2002;105:55–9.
  • Gram LF. Patterns of treatment and response during the acute phase and the continuation therapy in non-first episodes of major depression. Observations from the 6-month run-in phase of a randomized maintenance trial. Symposium: New targets in psychiatry. organized by the Danish Association of Psychiatrists, 20 April 2006, Copenhagen.
  • Nierenberg AA, Sonino N, editors. From clinical observations to clinimetrics: A tribute to Alvan R. Feinstein, MD. Psychother Psychosom 2004;73:131–3
  • Bech P. Modern psychometrics in clinimetrics: Impact on clinical trials of antidepressants. Psychother Psychosom 2004; 73: 134–8
  • Bagby RM, Ryder AG, Schuller DR, Marshall MB. The Hamilton Depression Rating Scale: Has the gold standard become a lead weight?. Am J Psychiatry 2004; 161: 2163–77
  • Kørner A et al. Rating scales for depression in the elderly. External and internal validity. J Clin Psychiatry ( in press).
  • Paykel ES. Use of the Hamilton Depression Scale in general practice. The Hamilton Scales, P Bech, A Coppen. Berlin, Springer 1990; 40–7
  • Ruhe H, Dekker JJ, Peen J, Holman R, de Jonghe F. Clinical use of the Hamilton Depression Scale: Is increased efficiency possible? A post hoc comparison of the Hamilton Depression Rating Scale, Maier and Bech subscales, Clinical Global Impression and Symptom Checklist-90 scores. Comprehens Psychiatry. 2005; 46: 417–27
  • O'Sullivan RL, Fava M, Agustin C, Baer L, Rosenbaum JF. Sensitivity of the six-item Hamilton Depression Scale. Acta Psychiatr Scand 1997; 95: 379–84
  • Snaith RP, Harrup FM, Newby DA, Teale C. Grade scores of the Montgomery-Åsberg Depression and the Clinical Anxiety Scales. Br J Psychiatry 1986; 148: 599–601
  • Bent-Hansen J, Lunde M, KLysner R. The validity of the depression rating scales in discrimination between citalopram and placebo in depression recurrence in the maintenance therapy of elderly unipolar patients with major depression. Pharmacophychiatry 2003; 36: 313–16
  • Licht RW, Qvitzau S, Allerup P, Bech P. Validation of the Bech–Rafaelsen Melancholia Scale and the Hamilton Depression Scale in patients with major depression: Is the total score a valid measure of illness severity?. Acta Psychiatr Scand 2005; 111: 144–9
  • Bech P. The Bech–Rafaelsen Melancholia Scale (MES) in clinical trials of therapies in depressive disorders: A 20-year review of its use as outcome measure. Acta Psychiatr Scand 2002; 106: 252–64
  • Kuhn R. The imipramine story. Discoveries in biological psychiatry, FJ Ayd, B Blackwell. Lippincott, Philadelphia 1970; 205–17
  • Bech P, Baastrup PC, de Bleeker E, Ropert P. Dimensionality, responsiveness and standardization of the Bech–Rafaelsen Mania Scale in the ultra-short therapy with antipsychotics in patients with severe manic episodes. Acta Psychiatr Scand 2001; 104: 25–30
  • Bech P. The Bech–Rafaelsen Mania Scale in clinical trials of therapies for bipolar disorder: 20-year review of its use as an outcome measure. CNS Drugs 2002; 16: 47–63
  • Bech P, Gex-Fabry M, Aubry J-M, Favre S, Bertschy G. Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states. Short communication. Nord J Psychiatry 2006; 60: 181–2
  • Bech P, Rafaelsen OJ, Kramp P. The mania rating scale: Scale construction and inter-observer agreement. Neuropharmacol 1978; 17: 430–1
  • Endicott J, Spitzer RL. A diagnostic interview. Arch Gen Psychiatry 1978; 35: 837–44
  • Young RC, Biggs JT, Ziegler VE, Meyer DA. A Rating scale for mania: Reliability, validity and sensitivity. Br J Psychiatry 1978; 133: 429–35
  • Licht RW. Limitations in randomised controlled trials evaluating clinical drug effects in mania. Eur Arch Psychiatry Clin Neurosci ;251 Suppl 2001; 2: 66–71
  • Bech P. Dimensions of depression and mania emerging in the : Shared with Max Hamilton and Ole Rafaelsen. From psychopharmacology to neuropsychopharmacology in the 1980s, TA Ban, D Healy, E Shorter. Animula Publishing House; 2002 p, Budapest 1980s; 122–6
  • Hautzinger M, Meyer TD. Diagnostik Affektive Störungen. Hogrefe-Verlag, Göttinger 2002
  • Dew MA, Switzer GE, Myaskovsky L. Rating Scales for mood disorders. Textbook of mood disorders, DJ Stein, DJ Kupfer, AF Schatzberg. American Psychiatry Publishing, Washington, DC 2006; 69–97
  • Goodwin FK, Jamison KR. Manic depressive illness. Oxford University Press, New York 1990
  • Bech P. The Bech–Rafaelsen Mania and Melancholia Scales in clinical trials: A 25-year review of their use as outcome measure in bipolar and unipolar patients. Focus on bipolar disorder research. Hauppauge, MC Brown. Nova Science Publishers, NY 2005; 131–54
  • Hartong EG. The prophylactic effect of lithium and carbamazapine in patients with bipolar disorder (thesis in Dutch). Nijmegen: University of Nijmegen; 2000.
  • Hartong EG, Moleman P, Hoogduin CA. Prophylactic efficacy of lithium versus carbamazepine in treatment-naive bipolar patients. J Clin Psychiatr 2003; 64: 144–51
  • Bech P, Lunde M, Undén M. An inventory for the measurement of generalised anxiety distress symptoms, the GAD-10 Inventory. Acta Psychiatr Belg 2005; 105: 111–18
  • Elberling TV, Rasmussen AK, Feldt-Rasmussen U, Hording M, Perrild H, Waldemar G. Impaired health-related quality of life in Graves’ disease. A prospective study. Eur J Endocrinol. 2004; 151: 549–55
  • Bech P. Dose–response relationship of pregabalin in patients with generalized anxiety disorder. A pooled analysis of four placebo-controlled trials. Pharmacopsychiatry 2007. In press.
  • Bech P. The impact of the SCL-90 on the validity of the DSM-IV neurotic or stress-related disorders. Acta Psychiatr Scand 2004; 110: 161–2
  • Olsen LR, Mortensen EL, Bech P. The SCL-90 and SCL-90R versions validated by item response theory models in a Danish community sample. Acta Psychiatr Scand 2004; 110: 225–9
  • Bech P, Hansen HV, Kessing LV. The internalising and externalising dimensions of affective symptoms in depressed (unipolar) and bipolar patients. Psychother Psychosom 2006; 75: 362–9
  • Fava M, McCall WV, Krystal A, Wessel T, Rubens R, Caron J, et al. Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder. Biol Psychiatry. 2006; 59: 1052–60
  • Williams JBW. Standardisation of the Hamilton Depression Rating Scale: Past, present and future. Eur Arch Psychiatry Clin Neurosci 2001; 251(Suppl 2)6–12
  • Brundtland GH, WHO. Coping with stress and depression in Europe. Mental health: A priority for world action. Brussels, 25 October 2001.
  • Bech P, Rasmussen N-A, Olsen LR, Noerholm V, Abildgaard W. The sensitivity and specificity of the Major Depression Inventory, using the Present State Examination as the index of diagnostic validity. J Affect Disord 2001; 66: 159–64
  • Olsen LR, Jensen DV, Noerholm V, Martiny K, Bech P. The internal and external validity of the Major Depression Inventory in measuring severity of depressive states. Psychol Med 2003; 33: 351–6
  • Fountoulakis KN, Iacovides A, Kleanthous S, Samolis S, Gougoulia K, Kaprinis SG, et al. Reliability, validity and psychometric properties of the Greek translation of the Major Depression Inventory. BMC Psychiatry 2003;3:2, www.biomedcentral.com/bmcpsychiatr/.
  • Olsen LR, Mortensen EL, Bech P. The relationship between depression, distress and perceived stress in the Danish general population. 2006 ( submitted).
  • Bech P. Male depression: Stress and aggression as pathways to major depression. Depression: Social and economic timebomb, A Dawson, A Tylee. BMJ Books, London 2001; 63–6
  • Zierau F, Bille A, Rutz W, Bech P. The Gotland Male Depression Scale: A validity study in patients with alcohol use disorder. Nord J Psychiatry 2002; 56: 265–71
  • Noerholm V, Groenvold M, Watt T, Bjorner JB, Rasmussen N-A, Bech P. Quality of life in the Danish general population—Normative data and validity of WHOQOL-BREF using Rasch and item response theory models. Qual Lif Res 2004; 13: 531–40
  • Vinberg MC, Bech P, Kyvik KO, Kessing LV. Quality of life in unaffected twins discordant for affective disorder. J Affect Disord 2006 ( in press).
  • Henkel V, Mergl R, Kohnen R, Maier W, Möller H-J, Hegerl U. Identifying depression in primary care: A comparison of different methods in a prospective cohort study. BMJ 2003; 326: 200–1
  • Henkel V, Mergel R, Coyne JC, Kohnem R, Möller H-J, Hegerl V. Screening for depression in primary care: Will one or two items suffice?. Eur Arch Psychiatry Clin Neurosci 2004; 254: 215–23
  • Bech P, Hackett D, Pitrosky B. Efficacy of venlafaxine on a derived self-rating scale of well being. Abstract. 12th AEP Congress 2003. Eur Psychiatry 2003;18(Suppl):S228.
  • Bech P, Olsen RL, Kjoller M, Rasmussen NK. Measuring well-being rather than the absence of distress symptoms: A comparison of the SH-36 Mental Health subscale and the WHO-Five Well-being Scale. Int J Meth Psychiatr Res 2003; 12: 85–91
  • Bech P, Andersen MB, Bech-Andersen G, Tønnesen S, Agnarsdottir E, Borg V. Work-related stress, depression and quality of life in Danish managers. Eu Psychiatry 2005; Suppl 3: 318–25
  • de Figueiredo JM, Frank JD. Subjective incompetence, the clinical hallmark of demoralization. Comprehens Psychiatry 1982; 23: 353–63
  • Cooper CL, Dewee P. Stress. A brief history. Blackwell, London 2004
  • Mangelli L, Fava GA, Grandi S. Assessing demoralization and depression in the setting of medical disease. J Clin Psychiatr 2005; 66: 391–4
  • Netterstrøm B, Bech P, Eller N. Erfaringer fra en stressklinik. Et pilotstudium. Ugeskr Læg 2007; 169: 89–176
  • Bech P. Social functioning. Should it become an endpoint in trials of antidepressants? Review article. CNS Drugs 2005; 19: 313–24
  • Hawthorne G, Kalfoss M, Bushnell D, Martiny K, Matschinger H, Winkler I, Bech-Andersen G. Screening for depression in older adults: A five country comparison using the WHO5. 2006 ( submitted).
  • Awata S, Bech P, Koizumi Y, Seki T, Kuriyama S, Hozawa A, et al. Validity and utility of the Japanese version of the WHO-Five Well-Being Index in the context of detecting suicidal ideation in elderly community residents. Int Psychogeriatr 2007; 19: 77–88
  • Rasmussen A, Lunde M, Poulsen DL, Sørensen K, Qvitzau S, Bech P. A double-blind, placebo-controlled study in the prevention of depression in stroke patients. Psychosomatics 2003; 44: 216–21
  • Sørensen C, Friis-Hasché E, Haghfelt T, Bech P. Postmyocardial infarction mortality in relation to depression: A systematic critical review. Psychother Psychosom 2005; 74: 69–80
  • Sørensen C, Brandes A, Hendricks O, Thrane J, Friis-Hasché E, Haghfelt T, et al. Psychosocial predictors of depression in patients with acute coronary syndrome. Acta Psychiatr Scand 2005; 111: 116–24
  • Bech P. A case report showing that subclinical hypothyroidism rather than hyperthyroidism stabilizes rapidly cycling bipolar illness. Psychother Psychosom 2000; 69: 110–11
  • Jorde R, Waterloo K, Storhaug H, Nyrnes A, Sundsfjord J, Jenssen TG. Neuropsychological function and symptoms in subjects with subclinical hypothyroidism and the effect of thyroxine treatment. J Clin Endocrinol Metab 2006; 91: 145–53
  • Maes M, Meltzer HY, Cosyns P. An evaluation of basal hypothalamic-pituitary-thyroid axis function in depression: Results of a large-scales and controlled study. Psychoneuroendocrinology 1993; 18: 607–20
  • Fountoulakis KN, Iacovides A, Grammaticos P, Kaprinis GS, Bech P. Thyroid function in clinical subtypes of major depression: An exploratory study. BMC Psychiatry 2004; 4: 6
  • Martiny K, Lunde M, Simonsen C, Clemmensen L, Poulsen DL, Solstad K, Bech P. Relapse prevention with citalopram in SAD patients responding to one week of bright light treatment. Acta Psychiatr Scand 2004; 109: 230–4
  • Elberling, TV, Bech P, Hørding M, Rasmussen ÅK, Perrild H, Feldt-Rasmussen U, Waldemar G. Affective symptoms in patients with Graves’ disease. A prospective study. Psychother psychosom 2007. In press.
  • Thomsen AF, Kvist TK, Andersen PK, Kessing LV. Increased risk of affective disorder following hospitalisation with hyperthyroidism—A register-based study. Eur J Endocrinol 2005; 152: 535–43
  • Bech P, Lucas M, Amir M, Bushnell D, Martin M, Buesching D, and the LIDO Group. Association between clinically depressed subgroups, type of treatment, and patient retention in the LIDO study. Psychol Med 2003;33:1051–9.
  • Moncrieff J, Kirsch I. Effecacy of antidepressants in adults. BMJ 2005; 331: 155–7
  • Fabre LF, Abuzzahab FS, Amin M, et al. Sertraline safety and efficacy in major depression: A double-blind fixed dose comparison with placebo. Biol Psychiatry 1995; 38: 592–602
  • Faries D, Herrera J, Rayamajhi J, DeBrota D, Demitrack M, Potter WZ. The responsiveness of the Hamilton Depression Rating Scale. J Psychiatr Res 2000; 34: 3–10
  • Bech P, Tanghøj P, Cialdella P, Friis Andersen H, Pedersen AG. Escitalopram dose–response revisited: An alternative psychometric approach to evaluate clinical effects of escitalopram compared to citalopram and placebo in patients with major depression. Int Neuropsychopharmacol 2004; 7: 283–90
  • Davidson J, Turnbull CD, Strickland R, Miller R, Graves K. The Montgomery–Åsberg Depression Scale: Reliability and validity. Acta Psychiatr Scand 1986; 73: 544–8
  • Bech P, Andersen HF, Wade A. Effective dose of escitalopram in moderate versus severe DSM-IV major depression. Pharmacopsychiatry 2006; 39: 128–34
  • Bech P, Kajdasz DK, Porsdal V. Dose–response relationship of duloxetine in placebo-controlled clinical trials in patients with major depressive disorder. Psychopharmacology 2006; 188: 273–80
  • Bobes J, Vieta E, Ballesteros J, González-Pinto A, Luque A, Ibarra N, Grupo Español de Estudios Psicométricos. Validity and reliability of the Spanish version of the Bech–Rafaelsen's mania MAS) and melancholia (MES) scales for bipolar disorders. Poster presented at the 19th ECNP Congress in Paris, September 2006.
  • Andersen TH, Bech P, Larsen N-E. Switching patients from olanzapine or risperidone to a combination treatment using perphenazine plus buspirone: Evaluation of antipsychotic efficacy and side-effects, including extrapyramidal effects and weight loss. Nord J Psychiatry 2005; 59: 205–8
  • Lieberman JA, Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO.; for the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators, et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. NEJM 2005;353:1209–23.
  • Demyttenaere K, Bruffaerts R, Albert A, Mesters P, Dewe W, Debruyckere K, Sangeleer M. Development of an antidepressant compliance questionnaire. Acta Psychiatr Scand 2004; 110: 201–7
  • Kessing LV, Hansen HV, Demyttenaere K, Bech P. Depressive and bipolar disorders: Patients’ attitudes and beliefs towards depression and antidepressants. Psychol Med 2005; 35: 1205–13
  • Kessing LV, Hansen HV, Bech P. Attitudes and beliefs among patients treated with mood stabilizers. Clin Pract Epidemiol Ment Health 2006;2:8, http://www.cpementalhealth.com/content/pdf/1745-0179-2-8.pdf.
  • Søndergaard MP, Jarden JO, Martiny K, Andersen G, Bech P. Dose response to adjunctive light therapy in citalopram-treated patients with post-stroke depression. Psychother Psychosom 2006; 75: 244–8
  • Bretlau LG, Lunde M, Lindberg L, Undén M, Dissing S, Bech P. Transcranial Magnetic Stimulation (rTMS) accelerates the response to escitalopram in patients with treatment-resistant major depression. A double-blind, randomised, sham-controlled trial. 2006. Submitted.
  • Benedetti F, Barbini B, Fulgosi MC, Colombo C, Dallaspezia S, Pontiggia A, et al. Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: Acute response and long-term remission rates. J Clin Psychiatry 2005; 66: 1535–40
  • Niklson IA, Reimitz PE. Baseline characteristics of major depressive disorder in clinical trials in Europe and the United States: Is there a difference?. J Psychiatr Res 2001; 35: 71–81
  • Wing JK, Beevor AS, Curtis RH, Park SB, Hadden S, Burns A. Health of the Nation Outcome Scales (HoNOS). Research and development. Br J Psychiatry 1998; 172: 11–18
  • Bech P, Bille J, Schutze T, Sondergaard S, Wiese M, Waarst S. Health of the Nations Outcomes Scale (HoNOS): Implementability, subscale structure and responsiveness in the daily psychiatric hospital routine over the first 18 months. Nord J Psychiatry 2003; 57: 285–90
  • Bech P, Bille J, Waarst S, Wiese M, Borberg L, Treufeldt P, Kessing L. Validity of HoNOS in identifying frequently hospitalised patients with ICD-10 mental disorders. Acta Psychiatr Scand 2006; 113: 485–91
  • Jepsen PW, Juel K, Bech P. 50 års registerefterundersøgelse af 112 patienter med klassisk neurosediagnose [A 50-years’ register follow-up of 112 patients with a classic diagnosis of neurosis, Danish]. Ugeskr Læg 2006 ( in press).
  • Rafaelsen OJ, Andersen J, Bech P, Clemmesen L. Gjerris A, Kastrup M, Kramp, P. @ Multi-Axial Classification of Depression: MULTICLAD-2 Case Record System. Acta Psychiatr Scand 1983; Suppl 310: 85–102
  • Sjövall B. Psychology of tension. An analysis of Pierre Janet's concept of “tension psycholique”. Stockholm: Scandinavian University Books; 1967.
  • Bech P. Papel de los psicofármacos en la mejoría de la calidad de vida de los pacientes psiquiatricos: Aspectos históricos. In: López-Munñoz F, Álamo C. Historia de la psicofarmacologia, Tomo III, sección XII; capitulo 68. Editorial Médica Panamericana; 2006.
  • Rickels K, Lipman RS, Garcia CR, Fisher E. Evaluating clinical improvement in anxious outpatients. Am J Psychiatry 1972; 128: 1005–9
  • Weissman MM, Bothwell S. Assessment of social adjustment by patient self-report. Arch Gen Psychiatry 1976; 33: 1111–15
  • Sheehan DV. The anxiety disease. Scribners, New York 1983
  • Heiligenstein JH, Ware JE, Jr, Beusterien KM, Roback PJ, Andrejasich C, Tollefson GD. Acute effects of fluoxetine versus placebo on functional health and well-being in late-life depression. Int Psychogeriatr 1995;7(Suppl):125–37.
  • Jamison R. An unquiet mind. A memoir of moods and madness. Knopf, New York 1995
  • Frank JD, Hoehn-Saric R, Imber SD, Lieberman BL, Stone AR. Effective ingredients of successful psychotherapy. Brünner/Mazel, New York 1978
  • Schou M, Juel-Nielsen N, Strömgren E, Voldby H. The treatment of manic psychoses by the administration of lithium salts. J Neurol Neurosurg Psychiatry 1954; 17: 250–60
  • Bech P. Quality of life in psychosomatic research. A psychometric model. Psychopathology 1987; 20: 169–79
  • Popper K. Unended quest. Fontana, London 1976
  • Bech P. Measurement issues. Biological psychiatry. II, H D'haenen, JA den Boer, P Willner. Wiley, New York 2002; 25–36
  • Bracken P, Thomas P. Postpsychiatry Mental Health in a post modern world. Oxford University Press, Oxford 2005

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