Antipsychotic drug use and associations with neuropsychiatric symptoms in persons with impaired cognition: a cross-sectional study

References

• Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The neuropsychiatric inventory: Comprehensive assessment of psychopathology in dementia. Neurology 1994;44:2308–14.
   PubMed Web of Science ®Google Scholar
• Steinberg M, Shao H, Zandi P, Lyketsos CG, Welsh-Bohmer KA, Norton MC, et al. Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: The Cache County study. Int J Geriatr Psychiatry 2008;23:170–7.
   PubMed Web of Science ®Google Scholar
• Selbaek G, Engedal K, Benth JS, Bergh S. The course of neuropsychiatric symptoms in nursing-home patients with dementia over a 53-month follow-up period. Int Psychogeriatr 2014;26:81–91.
   PubMed Web of Science ®Google Scholar
• Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: Results from the cardiovascular health study. JAMA 2002;288:1475–83.
   PubMed Web of Science ®Google Scholar
• Selbæk G, Kirkevold O, Engedal K. The prevalence of psychiatric symptoms and behavioural disturbances and the use of psychotropic drugs in Norwegian nursing homes. Int J Geriatr Psychiatry 2007;22:843–9.
   PubMed Web of Science ®Google Scholar
• Wergeland JN, Selbæk G, Høgset LD, Söderhamn U, Kirkevold Ø. Dementia, neuropsychiatric symptoms and the use of psychotropic drugs in older people using domiciliary care; A cross-sectional study. Int Psychogeriatr 2014;26:383–91.
   PubMed Web of Science ®Google Scholar
• Scarmeas N, Brandt J, Blacker D, Albert M, Hadjigeorgiou G, Dubois B, et al. Disruptive behavior as a predictor in Alzheimer disease. Arch Neurol 2007;64:1755–61.
   PubMed Web of Science ®Google Scholar
• Devanand DP. Psychosis, agitation, and antipsychotic treatment in dementia. Am J Psychiatry 2013;170:957–60.
   PubMed Web of Science ®Google Scholar
• Jennings L, Grossberg GT. Antipsychotics continue to have a place in the management of difficult behavior problems in patients with dementia. J Am Med Dir Assoc 2013;14:447–9.
   PubMed Web of Science ®Google Scholar
• Tan L, Tan L, Wang HF, Wang J, Tan CC, Tan MS, et al. Efficacy and safety of atypical antipsychotic drug treatment for dementia: A systematic review and meta-analysis. Alzheimers Res Ther 2015;7:20–20.
   PubMed Web of Science ®Google Scholar
• Gerhard T, Huybrechts K, Olfson M, Schneeweiss S, Bobo WV, Doraiswamy PM, et al. Comparative mortality risks of antipsychotic medications in community-dwelling older adults. Br J Psychiatry 2014;205:44–51.
   PubMed Web of Science ®Google Scholar
• Maust DT, Hyungjin MK, Seyfried LS, Chiang C, Kavanagh J, Scneider LS, et al. Antipsychotics, other psychotropics, and the risk of death in patients with dementia. JAMA Psychiatry 2015;2:438–45.
   Web of Science ®Google Scholar
• Maher AR, Maglione M, Bagley S, Suttorp M, Hu J-H, Ewing B, et al. Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA 2011;306:1359–69.
   PubMed Web of Science ®Google Scholar
• American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American geriatrics society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2015;63:2227–46.
   PubMed Web of Science ®Google Scholar
• Gustafsson M, Karlsson S, Lövheim H. Inappropriate long-term use of antipsychotic drugs is common among people with dementia living in specialized care units. BMC Pharmacol Toxicol 2013;14:10.
   PubMed Web of Science ®Google Scholar
• National Institute for Health and Clinical Excellence (NICE). Dementia. 2006 NICE guideline CG42.
   Google Scholar
• Brodaty H, Arasaratnam C. Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia. Am J Psychiatry 2012;169:946–53.
   PubMed Web of Science ®Google Scholar
• Steinberg M, Lyketsos CG. Atypical antipsychotic use in patients with dementia: Managing safety concerns. Am J Psychiatry 2012;169:900–6.
   PubMed Web of Science ®Google Scholar
• Sink KM, Holden KF, Yaffe K. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA 2005;293:596–608.
   PubMed Web of Science ®Google Scholar
• Jeste DV, Blazer D, Casey D, Meeks T, Salzman C, Schneider L, et al. ACNP white paper: update on use of antipsychotic drugs in elderly persons with dementia. Neuropsychopharmacology 2008;33:957–70.
   PubMed Web of Science ®Google Scholar
• Kamble P, Chen H, Sherer JT, Aparasu RR. Use of antipsychotics among elderly nursing home residents with dementia in the US: An analysis of national survey data. Drugs Aging 2009;26:483–92.
   PubMed Web of Science ®Google Scholar
• Azermai M, Elseviers M, Petrovics M, van Bortel L, Stichele RV. Assessment of antipsychotic prescribing in Belgian nursing homes. Int Psychogeriatr 2011;8:1240–8.
   Web of Science ®Google Scholar
• Chen Y, Briesacher B, Field T, Tjia J, Lau D, Gurwitz J. Unexplained variation across U.S. nursing homes in antipsychotic prescribing rates. Arch Intern Med 2010;170:89–95.
   PubMed Web of Science ®Google Scholar
• Zuidema SU, de Jonghe JF, Verhey FR, Koopmans RT. Psychotropic drug prescription in nursing home patients with dementia: Influence of environmental correlates and staff distress on physicians' prescription behavior. Int Psychogeriatr 2011;23:1632–9.
   PubMed Web of Science ®Google Scholar
• Foebel AD, Liperoti R, Onder G, Finne-Soveri H, Henrard JC, Lukas A, et al. Use of antipsychotic drugs among residents with dementia in European long-term care facilities: Results from the SHELTER study. J Am Med Dir Assoc 2014;15:911–7.
   PubMed Web of Science ®Google Scholar
• Gustafsson M, Sandman P-O, Karlsson S, Gustafson Y, Lövheim H. Association between behavioral and psychological symptoms and psychotropic drug use among old people with cognitive impairment living in geriatric care settings. Int Psychogeriatr 2013;25:1415–23.
   PubMed Web of Science ®Google Scholar
• Nijk RM, Zuidema SU, Koopmans RTCM. Prevalence and correlates of psychotropic drug use in Dutch nursing-home patients with dementia. Int Psychogeriatr 2009;21:485–93.
   PubMed Web of Science ®Google Scholar
• Okumura Y, Togoa T, Fujitaa J. Trends in use of psychotropic medications among patients treated with cholinesterase inhibitors in Japan from 2002 to 2010. Int Psychogeriatr 2014;27:407–15.
   PubMed Web of Science ®Google Scholar
• Lee KS, Kim S-H, Hwang H-J. Behavioral and psychological symptoms of dementia and antipsychotic drug use in the elderly with dementia in Korean long-term care facilities. Drugs Real World Outcomes 2015;2:363–8.
   PubMedGoogle Scholar
• Shah SM, Carey IM, Harris T, DeWilde S, Cook DG. Antipsychotic prescribing to older people living in care homes and the community in England and Wales. Int J Geriatr Psychiatry 2011;26:423–34.
   PubMed Web of Science ®Google Scholar
• Hartikainen S, Rahkonen T, Kautiainen H, Sulkava R. Use of psychotropics among home-dwelling nondemented and demented elderly. Int J Geriatr Psychiatry 2003;18:1135–41.
   PubMed Web of Science ®Google Scholar
• Laitinen M-L, Bell JS, Lavikainen P, Lönnroos E, Sulkava R, Hartikainen S. Nationwide study of antipsychotic use among community-dwelling persons with Alzheimer’s disease in Finland. Int Psychogeriatr 2011;23:1623–31.
   PubMed Web of Science ®Google Scholar
• Koponen M, Taipale H, Tanskanen A, Tolppanen AM, Tiihonen J, Ahonen R, et al. Long-term use of antipsychotics among community-dwelling persons with Alzheimer's disease: A nationwide register-based study. Eur Neuropsychopharmacol 2015;25:1706–13.
   PubMed Web of Science ®Google Scholar
• Lövheim H, Sandman P-O, Kallin K, Karlsson S, Gustafsson YG. Relationship between antipsychotic drug use and behavioral and psychological symptoms of dementia in old people with cognitive impairment living in geriatric care. Int Psychogeriatr 2006;18:713–26.
   PubMed Web of Science ®Google Scholar
• Kuronen M, Koponen H, Nykänen I, Karppi P, Hartikainen S. Use of anti-dementia drugs in home care and residential care and associations with neuropsychiatric symptoms: A cross-sectional study. BMC Geriatrics 2015;15:100.
   PubMed Web of Science ®Google Scholar
• Mahoney FI, Barthel M. Functional evaluation: The Barthel index. Md State Med J 1965;14:61–5.
   PubMedGoogle Scholar
• Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–98.
   PubMed Web of Science ®Google Scholar
• Aalten P, de Vugt ME, Lousberg R, Korten E, Jaspers N, Senden B, et al. Behavioral problems in dementia: A factor analysis of the neuropsychiatric inventory. Dem Geriatr Cogn Disord 2003;15:99–105.
   PubMed Web of Science ®Google Scholar
• WHO Collaborating Centre for Drugs Statistics Methodology. The Anatomical Therapeutic Chemical Classification System. Available at: http://www.whocc.no/atc_ddd_index [accessed 22 May 2013].
   Google Scholar
• StataCorp. 2013. Stata Statistical Software: Release 13. College Station, TX: StataCorp LP.
   Google Scholar
• de Mauleon A, Sourdet S, Renom-Guiteras A, Gillette-Guyonnet S, Leino-Kilpi H, Karlsson S, et al. Associated factors with antipsychotic use in long-term institutional care in eight European countries: Results from the RightTimePlaceCare study. J Am Med Dir Assoc 2014;15:812–8.
   PubMed Web of Science ®Google Scholar
• Alanen HM, Finne-Soveri H, Noro A. Use of antipsychotic medications among elderly residents in long-term institutional care: a three year follow-up. Int J Geriatr Psychiatry 2006;21:288–95.
   PubMed Web of Science ®Google Scholar
• Mintzer J, Burns A. Anticholinergic side-effects of drugs in elderly people. J R Soc Med 2000;93:457–62.
   PubMed Web of Science ®Google Scholar
• Kleijer BC, van Marum RJ, Frijters DH, Jansen PA, Ribbe MW, Egberts AC, et al. Variability between nursing homes in prevalence of antipsychotic use in patients with dementia. Int Psychogeriatr 2014;26:363–71.
   PubMed Web of Science ®Google Scholar
• Alanen HM, Finne-Soveri H, Fialova D, Topinkova E, Jonsson PV, Soerbye LW, et al. Use of antipsychotic medications in older home-care patients. Report from nine European countries. Aging Clin Exp Res 2008;20:260–5.
   PubMed Web of Science ®Google Scholar
• Puustinen J, Nurminen J, Vahlberg T, Lyles A, Isoaho R, Räihä I, et al. CNS medications as predictors of precipitous cognitive decline in the cognitively disabled aged: A longitudinal population-based study. Dem Ger Cogn Disord Extra 2012;2:57–68.
   PubMedGoogle Scholar
• Finnish Medical Society Duodecim, Helsinki. Current care: memory disorders (In Finnish with English summary) 2010. Available at http:/www.kaypahoito.fi [accessed 10.04.14].
   Google Scholar
• Taipale H, Koponen M, Tanskanen A, Tolppanen A-M, Tiihonen J, Hartikainen S. High prevalence of psychotropic drug use among persons with and without Alzheimer's disease in Finnish nationwide cohort. Eur Neuropsychopharmacol 2014;24:1729–37.
   PubMed Web of Science ®Google Scholar
• Alexopoulos GS, Streim J, Carpenter D, Docherty JP. Expert consensus panel for using antipsychotic drugs in older patients. Using antipsychotic agents in older patients. J Clin Psychiatry 2004;65:5–99.
   PubMed Web of Science ®Google Scholar
• Zuidema SU, Johansson A, Selbæk G, Murray M, Burns A, Ballard C, et al. A consensus guideline for antipsychotic drug use for dementia in care homes. Bridging the gap between scientific evidence and clinical practice. Int Psychogeriatr 2015;27:1849–59.
   PubMed Web of Science ®Google Scholar
• Declercq T, Petrovic M, Azermai M, Vander Stichele R, De Sutter AI, van Driel ML, et al. Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev 2013;3:CD007726.
   PubMed Web of Science ®Google Scholar
• Devanand DP, Mintzer J, Schullz SK, Andrews HF, Sultzer DL, de la Pena D, et al. Relapse risk after discontinuation of risperidone in Alzheimer’s disease. N Eng J Med 2012;367:1497–507.
   PubMed Web of Science ®Google Scholar