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Original Article

High neutrophil-lymphocyte ratio in schizophrenia independent of infectious and metabolic parameters

, , & ORCID Icon
Pages 336-340 | Received 03 Nov 2017, Accepted 24 Mar 2018, Published online: 12 Apr 2018

References

  • Tandon R, Keshavan MS, Nasrallah HA. Schizophrenia, “just the facts” what we know in 2008. 2. Epidemiology and etiology. Schizophr Res. 2008;102:1–18.
  • Yao JK, Reddy RD, Van Kammen DP. Oxidative damage and schizophrenia: an overview of the evidence and its therapeutic implications. CNS Drugs. 2001;15:287–310.
  • Karpiński P, Frydecka D, Sąsiadek MM, et al. Reduced number of peripheral natural killer cells in schizophrenia but not in bipolar disorder. Brain Behav Immun. 2016;54:194–200.
  • Turhan L, Batmaz S, Kocbiyik S, et al. The role of tumour necrosis factor alpha and soluble tumour necrosis factor alpha receptors in the symptomatology of schizophrenia. Nord J Psychiatry. 2016;70:342–350.
  • Schaffner KF. Variation and validation: the example of schizophrenia. World Psychiatry. 2016;15:39–40.
  • Potvin S, Stip E, Sepehry AA, et al. Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry. 2008;63:801–808.
  • Muller N, J Schwarz M. The role of immune system in schizophrenia. Curr Immunol Rev. 2010;6:213–220.
  • Zandi MS, Irani SR, Lang B, et al. Disease-relevant autoantibodies in first episode schizophrenia. J Neurol. 2011;258:686–688.
  • Klemettilä J-P, Kampman O, Seppälä N, et al. Resistin as an inflammatory marker in patients with schizophrenia treated with clozapine. Nord J Psychiatry. 2017;71:89–95.
  • Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102:5–14.
  • Guthrie GJ, Charles KA, Roxburgh CS, et al. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol. 2013;88:218–230.
  • Motomura T, Shirabe K, Mano Y, et al. Neutrophil–lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment. J Hepatol. 2013;58:58–64.
  • Kantola T, Klintrup K, Väyrynen J, et al. Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma. Br J Cancer. 2012;107:1729.
  • Azab B, Zaher M, Weiserbs KF, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol. 2010;106:470–476.
  • Chen Q, Yang L-X, Li X-D, et al. The elevated preoperative neutrophil-to-lymphocyte ratio predicts poor prognosis in intrahepatic cholangiocarcinoma patients undergoing hepatectomy. Tumor Biol. 2015;36:5283–5289.
  • Azab B, Jaglall N, Atallah JP, et al. Neutrophil-lymphocyte ratio as a predictor of adverse outcomes of acute pancreatitis. Pancreatology. 2011;11:445–452.
  • Azab B, Camacho-Rivera M, Taioli E. Average values and racial differences of neutrophil lymphocyte ratio among a nationally representative sample of United States subjects. PLoS One. 2014;9:e112361.
  • Dickerson F, Stallings C, Origoni A, et al. C-reactive protein is associated with the severity of cognitive impairment but not of psychiatric symptoms in individuals with schizophrenia. Schizophr Res. 2007;93:261–265.
  • Fan X, Pristach C, Liu EY, et al. Elevated serum levels of C-reactive protein are associated with more severe psychopathology in a subgroup of patients with schizophrenia. Psychiatry Res. 2007;149:267–271.
  • Miller BJ, Culpepper N, Rapaport MH. C-reactive protein levels in schizophrenia: a review and meta-analysis. Clin Schizophr Relat Psychoses. 2013;7:223–230.
  • Yilmaz H, Yalcin KS, Namuslu M, et al. Neutrophil-lymphocyte ratio (NLR) could be better predictor than C-reactive protein (CRP) for liver fibrosis in non-alcoholic steatohepatitis (NASH). Ann Clin Lab Sci. 2015;45:278–286.
  • Kuyumcu ME, Yesil Y, Oztürk ZA, et al. The evaluation of neutrophil-lymphocyte ratio in Alzheimer’s disease. Dement Geriatr Cogn Disord. 2012;34:69–74.
  • Demircan F, Gözel N, Kılınç F, et al. The impact of red blood cell distribution width and neutrophil/lymphocyte ratio on the diagnosis of major depressive disorder. Neurol Ther. 2016;5:27–33.
  • Mayda H, Ahsen A, Bağcioğlu E, et al. Effect of increased neutrophil-to-lymphocyte ratio (NLR) and decreased mean platelet volume (MPV) values on inflammation in acute mania. Noro Psikiyatr Ars. 2016;53:317
  • Semiz M, Yildirim O, Canan F, et al. Elevated neutrophil/lymphocyte ratio in patients with schizophrenia. Psychiat Danub. 2014;26:220–225.
  • Özdin S, Sarisoy G, Böke Ö. A comparison of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in schizophrenia and bipolar disorder patients–a retrospective file review. Nord J Psychiat. 2017;71:509–512.
  • Kay SR, Fiszbein A, Opfer LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261.
  • Kostakoğlu E, Batur S, Tiryaki A, et al. Pozitif ve negatif sendrom Ölçeğinin (PANSS) Türkçe uyarlamasının geçerlik ve güvenilirliği. Türk Psikoloji Dergisi. 1999;14:23–32. Dergisi
  • Busner J, Steven DT. The clinical global impressions scale: applying a research tool in clinical practice Psychiatry (Edgmont). 2007;4:28–37.
  • Expert Panel on Detection E. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285:2486.
  • Kinney DK, Hintz K, Shearer EM, et al. A unifying hypothesis of schizophrenia: abnormal immune system development may help explain roles of prenatal hazards, post-pubertal onset, stress, genes, climate, infections, and brain dysfunction. Med Hypotheses. 2010;74:555–563.
  • Monji A, Kato T, Kanba S. Cytokines and schizophrenia: microglia hypothesis of schizophrenia. Psychiatry Clin Neurosci. 2009;63:257–265.
  • Zhang XY, Zhou DF, Zhang PY, et al. Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology. Schizophr Res. 2002;57:247–258.
  • Lin A, Kenis G, Bignotti S, et al. The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6. Schizophr Res. 1998;32:9–15.
  • Katila H, Appelberg B, Hurme M, et al. Plasma levels of interleukin-1β and interleukin-6 in schizophrenia, other psychoses, and affective disorders. Schizophr Res. 1994;12:29–34.
  • Spangelo BL, Judd AM, Isakson PC, et al. Interleukin-6 stimulates anterior pituitary hormone release in vitro. Endocrinology. 1989;125:575–577.
  • Prajapati JH, Sahoo S, Nikam T, et al. Association of high density lipoprotein with platelet to lymphocyte and neutrophil to lymphocyte ratios in coronary artery disease patients. J Lipids. 2014;2014:686791.
  • Aydin M, Yilmaz A, Donma MM, et al. Neutrophil/lymphocyte ratio in obese adolescents. North Clin Istanb. 2015;2:87
  • Yilmaz H, Ucan B, Sayki M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr. 2015;9:299–304.
  • Liu X, Zhang Q, Wu H, et al. Blood neutrophil to lymphocyte ratio as a predictor of hypertension. Am J Hyperten. 2015;28:1339–1346.
  • Kulaksizoglu B, Kulaksizoglu S. Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia. Neuropsyc Dis Treat. 2016;12:1999.
  • Harvey PD, Koren D, Reichenberg A, et al. Negative symptoms and cognitive deficits: what is the nature of their relationship? Schizophr Bullet. 2005;32:250–258.

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