Efficacy and safety of artificial tears containing Artemia salina extract with dinucleotides for dry eye

References

• Craig JP, Nichols KK, Akpek EK et al. TFOS DEWS II definition and classification report. The ocular surface. Ocul Surf 2017; 15: 276–283. doi:10.1016/j.jtos.2017.05.008.
   PubMed Web of Science ®Google Scholar
• Stapleton F, Alves M, Bunya VY et al. TFOS DEWS II epidemiology report. The ocular surface. Ocul Surf 2017; 15: 334–365. doi:10.1016/j.jtos.2017.05.003.
   PubMed Web of Science ®Google Scholar
• Jones L, Downie LE, Korb D et al. TFOS DEWS II management and therapy report. The ocular surface. Ocul Surf 2017; 15: 575–628. doi:10.1016/j.jtos.2017.05.006.
   PubMed Web of Science ®Google Scholar
• Carracedo G, Crooke A, Guzman-Aranguez A et al. The role of dinucleoside polyphosphates on the ocular surface and other eye structures. Prog Retin Eye Res 2016; 55: 182–205. doi:10.1016/j.preteyeres.2016.07.001.
   PubMed Web of Science ®Google Scholar
• Guzman-Aranguez A, Santano C, Martin-Gil A et al. Nucleotides in the eye: focus on functional aspects and therapeutic perspectives. J Pharmacol Exp Ther 2013; 345: 331–341. doi:10.1124/jpet.112.202473.
   PubMed Web of Science ®Google Scholar
• Pintor J, Sanchez-Nogueiro J, Irazu M et al. Immunolocalisation of P2Y receptors in the rat eye. Purinergic Signal 2004; 1: 83–90. doi:10.1007/s11302-004-5072-5.
   PubMedGoogle Scholar
• Pintor J, Peral A, Hoyle CH et al. Effects of diadenosine polyphosphates on tear secretion in New Zealand white rabbits. J Pharmacol Exp Ther 2002; 300: 291–297. doi:10.1124/jpet.300.1.291.
   PubMed Web of Science ®Google Scholar
• Yerxa BR, Douglass JG, Elena PP et al. Potency and duration of action of synthetic P2Y2 receptor agonists on Schirmer scores in rabbits. Adv Exp Med Biol 2002; 506: 261–265.
   PubMed Web of Science ®Google Scholar
• Dominguez-Godinez CO, Martin-Gil A, Carracedo G et al. In vitro and in vivo delivery of the secretagogue diadenosine tetraphosphate from conventional and silicone hydrogel soft contact lenses. J Optom 2013; 6: 205–211. doi:10.1016/j.optom.2013.07.004.
   Google Scholar
• Dominguez-Godinez C, Carracedo G, Pintor J. Diquafosol delivery from silicone hydrogel contact lenses: improved effect on tear secretion. J Ocul Pharmacol Ther 2018; 34: 170–176. doi:10.1089/jop.2016.0193.
   PubMed Web of Science ®Google Scholar
• Fujihara T, Murakami T, Nagano T et al. INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model. J Ocul Pharmacol Ther 2002; 18: 363–370. doi:10.1089/10807680260218524.
   PubMed Web of Science ®Google Scholar
• Endo KI, Sakamoto A, Fujisawa K. Diquafosol tetrasodium elicits total cholesterol release from rabbit meibomian gland cells via P2Y(2) purinergic receptor signalling. Sci Rep 2021; 11: 6989. doi:10.1038/s41598-021-86433-6.
   PubMed Web of Science ®Google Scholar
• Pintor J, Bautista A, Carracedo G et al. UTP and diadenosine tetraphosphate accelerate wound healing in the rabbit cornea. Ophthalmic Physiol Opt 2004; 24: 186–193. doi:10.1111/j.1475-1313.2004.00182.x.
   PubMed Web of Science ®Google Scholar
• Mediero A, Peral A, Pintor J. Dual roles of diadenosine polyphosphates in corneal epithelial cell migration. Invest Ophthalmol Vis Sci 2006; 47: 4500–4506. doi:10.1167/iovs.06-0209.
   PubMed Web of Science ®Google Scholar
• Loma P, Guzman-Aranguez A, Perez de Lara MJ et al. Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability. Br J Pharmacol 2015; 172: 1045–1058. doi:10.1111/bph.12972.
   PubMed Web of Science ®Google Scholar
• Loma P, Guzman-Aranguez A, Perez de Lara MJ et al. Diadenosine tetraphosphate improves adrenergic anti-glaucomatous drug delivery and efficiency. Exp Eye Res 2015; 134: 141–147. doi:10.1016/j.exer.2015.02.014.
   PubMed Web of Science ®Google Scholar
• Peral A, Loma P, Yerxa B et al. Topical application of nucleotides increase lysozyme levels in tears. Clin Ophthalmol 2008; 2: 261–267. doi:10.2147/OPTH.S3752.
   PubMedGoogle Scholar
• Loma P, Guzman-Aranguez A, Perez de Lara MJ et al. Lactoferrin levels in tears are increased by the topical application of diadenosine tetraphosphate. Curr Eye Res 2016; 41: 1150–1152. doi:10.3109/02713683.2015.1113431.
   PubMed Web of Science ®Google Scholar
• Zhao X, Xia S, Chen Y. Comparison of the efficacy between topical diquafosol and artificial tears in the treatment of dry eye following cataract surgery: a meta-analysis of randomized controlled trials. Medicine (Baltimore) 2017; 96: e8174. doi:10.1097/MD.0000000000008174.
   PubMed Web of Science ®Google Scholar
• Nam K, Kim HJ, Yoo A. Efficacy and safety of topical 3% diquafosol ophthalmic solution for the treatment of multifactorial dry eye disease: meta-analysis of randomized clinical trials. Ophthalmic Res 2019; 61: 188–198. doi:10.1159/000492896.
   PubMed Web of Science ®Google Scholar
• Carpena-Torres C, Pintor J, Huete-Toral F et al. Preclinical development of artificial tears based on an extract of artemia salina containing dinucleotides in rabbits. Curr Eye Res 2021; 46: 174–178. doi:10.1080/02713683.2020.1789665.
   PubMed Web of Science ®Google Scholar
• Gilmour SJ, Warner AH. The presence of guanosine 5’-diphospho-5’-guanosine and guanosine 5’-triphospho-5’-adenosine in brine shrimp embryos. J Biol Chem 1978; 253: 4960–4965. doi:10.1016/S0021-9258(17)34641-0.
   PubMed Web of Science ®Google Scholar
• Carpena-Torres C, Pintor J, Huete-Toral F et al. Efficacy of artificial tears based on an extract of artemia salina containing dinucleotides in a rabbit dry eye model. Int J Mol Sci 2021; 22: 22. doi:10.3390/ijms222111999.
   Web of Science ®Google Scholar
• Lopez-de la Rosa A, Pinto-Fraga J, Blazquez Arauzo F et al. Safety and efficacy of an artificial tear containing 0.3% hyaluronic acid in the management of moderate-to-severe dry eye disease. Eye & Contact Lens: Science & Clinical Practice 2016; 43: 383–388. doi:10.1097/ICL.0000000000000284.
   Web of Science ®Google Scholar
• Tang F, Wang J, Tang Z et al. Accuracy of McMonnies questionnaire as a screening tool for Chinese ophthalmic outparticipants. PloS One 2016; 11: e0153047. doi:10.1371/journal.pone.0153047.
   PubMed Web of Science ®Google Scholar
• Mediero A, Guzman-Aranguez A, Crooke A et al. Corneal re-epithelialization stimulated by diadenosine polyphosphates recruits RhoA/ROCK and ERK1/2 pathways. Invest Ophthalmol Visual Sci 2008; 49: 4982–4992. doi:10.1167/iovs.07-1583.
   PubMed Web of Science ®Google Scholar
• Crooke A, Mediero A, Guzman-Aranguez A et al. Silencing of P2Y2 receptor delays Ap4A-corneal re-epithelialization process. Mol Vis 2009; 15: 1169–1178.
   PubMed Web of Science ®Google Scholar
• Mediero A, Crooke A, Guzman-Aranguez A et al. Phospholipase C/Protein Kinase C pathway is essential for corneal re-epithelialization induced by Ap(4)A. Curr Eye Res 2011; 36: 1108–1115. doi:10.3109/02713683.2011.614371.
   PubMed Web of Science ®Google Scholar
• Peral A, Pintor J. Ocular mucin visualization by confocal laser scanning microscopy. Cornea 2008; 27: 395–401. doi:10.1097/ICO.0b013e31816092dd.
   PubMed Web of Science ®Google Scholar