Pregnane X Receptor Polymorphisms and Risk of Inflammatory Bowel Disease: A Meta-Analysis

References

• Amre DK, Mack DR, Israel D, et al. (2008). Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn’s disease in Canadian children using a gene-wide haplotype-based approach. Inflamm Bowel Dis, 14, 1214–18.
   PubMed Web of Science ®Google Scholar
• Andersen V, Christensen J, Ernst A, et al. (2011). Polymorphisms in NF-kappaB, PXR, LXR, PPARgamma and risk of inflammatory bowel disease. World J Gastroenterol, 17, 197–206.
   PubMed Web of Science ®Google Scholar
• Banerjee M, Robbins D, Chen T. (2015). Targeting xenobiotic receptors PXR and CAR in human diseases. Drug Discov Today, 20, 618–28.
   PubMed Web of Science ®Google Scholar
• Boyapati RK, Kalla R, Satsangi J, Ho GT. (2016). Biomarkers in search of precision medicine in IBD. Am J Gastroenterol, 11, 1682-1690.
   Google Scholar
• Cheng J, Shah YM, Gonzalez FJ. (2012). Pregnane X receptor as a target for treatment of inflammatory bowel disorders. Trends Pharmacol Sci, 33, 323–30.
   PubMed Web of Science ®Google Scholar
• Cheng X, Klaassen CD. (2006). Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. Drug Metab Dispos, 34, 1863–67.
   PubMed Web of Science ®Google Scholar
• Dring MM, Goulding CA, Trimble VI, et al. (2006). The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease. Gastroenterology, 130, 341–48; quiz 592.
   PubMed Web of Science ®Google Scholar
• Festen EA, Weersma RK. (2014). How will insights from genetics translate to clinical practice in inflammatory bowel disease? Best Pract Res Clin Gastroenterol, 28, 387–97.
   Google Scholar
• Gabryel M, Skrzypczak-Zielinska M, Kucharski MA, et al. (2016). The impact of genetic factors on response to glucocorticoids therapy in IBD. Scand J Gastroenterol, 51, 654–65.
   PubMed Web of Science ®Google Scholar
• Glas J, Seiderer J, Fischer D, et al. (2011). Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease. Inflamm Bowel Dis, 17, 1917–24.
   PubMed Web of Science ®Google Scholar
• Grigoras CA, Ziakas PD, Jayamani E, Mylonakis E. (2015). ATG16L1 and IL23R variants and genetic susceptibility to crohn’s disease: mode of inheritance based on meta-analysis of genetic association studies. Inflamm Bowel Dis, 21, 768–76.
   PubMed Web of Science ®Google Scholar
• Hirata Y, Ihara S, Koike K. (2016). Targeting the complex interactions between microbiota, host epithelial and immune cells in inflammatory bowel disease. Pharmacol Res, 113, 574–84.
   PubMed Web of Science ®Google Scholar
• Ho GT, Soranzo N, Tate SK, et al. (2006). Lack of association of the pregnane X receptor (PXR/NR1I2) gene with inflammatory bowel disease: parallel allelic association study and gene wide haplotype analysis. Gut, 55, 1676–77.
   PubMed Web of Science ®Google Scholar
• Kile DA, MaWhinney S, Aquilante CL, et al. (2012). A population pharmacokinetic-pharmacogenetic analysis of atazanavir. AIDS Res Hum Retroviruses, 28, 1227–34.
   PubMed Web of Science ®Google Scholar
• Kliewer SA, Goodwin B, Willson TM. (2002). The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev, 23, 687–702.
   PubMed Web of Science ®Google Scholar
• Liu J, Liu YY, Liu J, et al. (2015). Association between CARD8 rs2043211 polymorphism and inflammatory bowel disease: a meta-analysis. Immunol Invest, 44, 253–64.
   PubMed Web of Science ®Google Scholar
• Martinez A, Marquez A, Mendoza J, et al. (2007). Role of the PXR gene locus in inflammatory bowel diseases. Inflamm Bowel Dis, 13, 1484–87.
   PubMed Web of Science ®Google Scholar
• McGovern DP, Kugathasan S, Cho JH. (2015). Genetics of inflammatory bowel diseases. Gastroenterology, 149, 1163–1176 e2.
   PubMed Web of Science ®Google Scholar
• Molodecky NA, Soon IS, Rabi DM, et al. (2012). Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology, 142, 46–54 e42; quiz e30.
   Google Scholar
• Ng SC, Bernstein CN, Vatn MH, et al., Epidemiology, Natural History Task Force of the International Organization of Inflammatory Bowel D. (2013). Geographical variability and environmental risk factors in inflammatory bowel disease. Gut, 62, 630–49.
   Google Scholar
• Ni H, Su B, Pan L, et al. (2015). Functional variants inPXRare associated with colorectal cancer susceptibility in Chinese populations. Cancer Epidemiol, 39, 972–77.
   PubMed Web of Science ®Google Scholar
• Pillai S. (2013). Rethinking mechanisms of autoimmune pathogenesis. J Autoimmun, 45, 97–103.
   PubMed Web of Science ®Google Scholar
• Rogler G, Vavricka S. (2015). Exposome in IBD: recent insights in environmental factors that influence the onset and course of IBD. Inflamm Bowel Dis, 21, 400–08.
   PubMed Web of Science ®Google Scholar
• Salem M, Ammitzboell M, Nys K, et al. (2015). ATG16L1: A multifunctional susceptibility factor in Crohn disease. Autophagy, 11, 585–94.
   PubMed Web of Science ®Google Scholar
• Schnitzler F, Friedrich M, Wolf C, et al. (2015). The NOD2 single nucleotide polymorphism rs72796353 (IVS4+10 A>C) is a predictor for perianal fistulas in patients with crohn’s disease in the absence of other NOD2 mutations. Plos One, 10, e0116044.
   PubMed Web of Science ®Google Scholar
• Shakhnovich V, Vyhlidal C, Friesen C, et al. (2016). Decreased Pregnane X receptor expression in children with active Crohn’s Disease. Drug Metab Dispos, 44, 1066–69.
   PubMed Web of Science ®Google Scholar
• Song GG, Lee YH. (2015). The polymorphisms K469E and G261R of intercellular adhesion molecule-1 and susceptibility to inflammatory bowel disease: a meta-analysis. Immunol Invest, 44, 361–72.
   PubMed Web of Science ®Google Scholar
• Stang A (2010). Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 25, 603–05.
   PubMed Web of Science ®Google Scholar
• Terc J, Hansen A, Alston L, Hirota SA. (2014). Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis. Eur J Pharm Sci, 55, 12–19.
   PubMed Web of Science ®Google Scholar
• Wang YM, Chai SC, Brewer CT, Chen T. (2014). Pregnane X receptor and drug-induced liver injury. Expert Opin Drug Metab Toxicol, 10, 1521–32.
   PubMed Web of Science ®Google Scholar
• Wang ZP, Zhao M, Qu QS, Miao SZ. (2016). Effect of pregnane X receptor polymorphisms on tacrolimus blood concentrations and the resulting adverse reactions in kidney transplantation recipients. Genet Mol Res, 3, 15.
   Google Scholar
• Xu AT, Lu JT, Ran ZH, Zheng Q. (2016). Exosome in intestinal mucosal immunity. J Gastroenterol Hepatol, 31, 1694–99.
   PubMed Web of Science ®Google Scholar
• Yamamoto-Furusho JK, Fonseca-Camarillo G. (2015). Genetic markers associated with clinical outcomes in patients with inflammatory bowel disease. Inflamm Bowel Dis, 21, 2683–95.
   PubMed Web of Science ®Google Scholar
• Zazuli Z, Barliana MI, Mulyani UA, et al. (2015). Polymorphism of PXR gene associated with the increased risk of drug-induced liver injury in Indonesian pulmonary tuberculosis patients. J Clin Pharm Ther, 40, 680–84.
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang Y, Ma Z, et al. (2015). Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor. Drug Des Devel Ther, 9, 6343–62.
   PubMed Web of Science ®Google Scholar