Publication Cover
Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 46, 2017 - Issue 8
221
Views
15
CrossRef citations to date
0
Altmetric
Original Articles

Regulatory roles of micro-RNAs in T cell autoimmunity

, , &

References

  • Alevizos I, Illei GG. (2010a). MicroRNAs as biomarkers in rheumatic diseases. Nat Rev Rheumatol, 6, 391–98.
  • Alevizos I, Illei GG. (2010b). MicroRNAs in Sjögren’s syndrome as a prototypic autoimmune disease. Autoimmun Rev, 9, 618–21.
  • Alsaleh G, Suffert G, Semaan N, et al. (2009). Bruton’s tyrosine kinase is involved in miR-346-related regulation of IL-18 release by lipopolysaccharide-activated rheumatoid fibroblast-like synoviocytes. J Immunol, 182, 5088–97.
  • Amado T, Schmolka N, Metwally H, et al. (2015). Cross‐regulation between cytokine and microRNA pathways in T cells. Eur J Immunol, 45, 1584–1595.
  • Benderska N, Dittrich A-L, Knaup S, et al. (2015). miRNA-26b overexpression in ulcerative colitis-associated carcinogenesis. Inflamm Bowel Dis, 21, 2039.
  • Bhaumik D, Scott G, Schokrpur S, et al. (2008). Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells. Oncogene, 27, 5643–47.
  • Boldin M, Chang K. (2006). NF—kappaB· dependent induction of microRNA miR 一 146. an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci US, 103, 12481–86.
  • Boldin MP, Taganov KD, Rao DS, et al. (2011). miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med, 208, 1189–201.
  • Carissimi C, Fulci V, Macino G. (2009). MicroRNAs: novel regulators of immunity. Autoimmun Rev, 8, 520–24.
  • Ceribelli A, Yao B, Dominguez-Gutierrez PR, et al. (2011). MicroRNAs in systemic rheumatic diseases. Arthritis Res Ther, 13, 229.
  • Chatzikyriakidou A, Voulgari P, Georgiou I, Drosos A. (2010). The role of microRNA‐146a (miR‐146a) and its target IL‐1R‐associated kinase (IRAK1) in psoriatic arthritis susceptibility. Scand J Immunol, 71, 382–85.
  • Chong MM, Rasmussen JP, Rudensky AY, Littman DR. (2008). The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med, 205, 2005–17.
  • Churov AV, Oleinik EK, Knip M. (2015). MicroRNAs in rheumatoid arthritis: altered expression and diagnostic potential. Autoimmun Rev, 14, 1029–37.
  • Cox MB, Cairns MJ, Gandhi KS, et al. (2010). MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood. PloS One, 5, e12132.
  • De La Torre NG, Fernández-Durango R, Gómez R, et al. (2015). Expression of angiogenic MicroRNAs in endothelial progenitor cells from type 1 diabetic patients with and without diabetic retinopathy MicroRNA expression in EPCs from DM1 patients. Invest Ophthalmol Vis Sci, 56, 4090–98.
  • Demircan K, Yasar Z, Yüksel S, et al. (2014). AB0067 IL-17F gene polymorphism correlated with longer disease duration of rheumatoid arthritis patients. Ann Rheum Dis, 73, 826.
  • Deng X, Su Y, Wu H, et al. (2015). The role of microRNAs in autoimmune diseases with skin involvement. Scand J Immunol, 81, 153–65.
  • Ding S, Liang Y, Zhao M, et al. (2012). Decreased microRNA‐142‐3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus. Arthritis Rheum, 64, 2953–63.
  • Du C, Liu C, Kang J, et al. (2009). MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol, 10, 1252–59.
  • Ebert PJ, Jiang S, Xie J, et al. (2009). An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol, 10, 1162–69.
  • Escobar TM, Kanellopoulou C, Kugler DG, et al. (2014). miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity, 40, 865–79.
  • Fox R, Kang H-I. (1992). Pathogenesis of Sjogren’s syndrome. Rheum Dis Clin North Am, 18, 517–38.
  • Fu G, Rybakin V, Brzostek J, et al. (2014). Fine-tuning T cell receptor signaling to control T cell development. Trends Immunol, 35, 311–18.
  • Fulci V, Scappucci G, Sebastiani GD, et al. (2010). miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis. Hum Immunol, 71, 206–11.
  • Gandhi R. (2015). miRNA in multiple sclerosis: search for novel biomarkers. Mult Scler J, 21, 1095–1103.
  • Ha M, Kim VN. (2014). Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol, 15, 509–24.
  • He L, Thomson JM, Hemann MT, et al. (2005). A microRNA polycistron as a potential human oncogene. Nature, 435, 828–33.
  • Hezova R, Slaby O, Faltejskova P, et al. (2010). microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients. Cell Immunol, 260, 70–74.
  • Hickson LJ, Crowson CS, Gabriel SE, et al. (2014). Development of reduced kidney function in rheumatoid arthritis. Am J Kidney Dis, 63, 206–13.
  • Hillen M, Blokland S, Chouri E, et al. (2016). THU0268 decreased expression of MIR-130A and MIR-708 in type-1 classical dendritic cells of Sjögren’s syndrome patients indicates their dysregulation. Ann Rheum Dis, 75, 284.
  • Holmdahl R, Malmström V, Burkhardt H. (2014). Autoimmune priming, tissue attack and chronic inflammation—the three stages of rheumatoid arthritis. Eur J Immunol, 44, 1593–99.
  • Honardoost MA, Kiani-Esfahani A, Ghaedi K, et al. (2014). miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing–remitting multiple sclerosis. Gene, 544, 128–33.
  • Huffaker TB, O’Connell RM. (2015). miR-155-SOCS1 as a functional axis: satisfying the burden of proof. Immunity, 43, 3–4.
  • Jernås M, Malmeström C, Axelsson M, et al. (2013). MicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS). BMC Immunol, 14, 1.
  • Ji Y, Wrzesinski C, Yu Z, et al. (2015). miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines. Proc Natl Acad Sci, 112, 476–81.
  • Jindra PT, Bagley J, Godwin JG, Iacomini J. (2010). Costimulation-dependent expression of microRNA-214 increases the ability of T cells to proliferate by targeting Pten. J Immunol, 185, 990–97.
  • Junker A, Krumbholz M, Eisele S, et al. (2009). MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain, 132, 3342–52.
  • Kaga H, Komatsuda A, Omokawa A, et al. (2015). Down-regulated expression of miR-155, miR-17, and miR-181b, and up-regulated expression of activation-induced cytidine deaminase and interferon-α in PBMCs from patients with SLE. Mod Rheumatol, 25, 865–870.
  • Kanellopoulou C, Muljo SA, Kung AL, et al. (2005). Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev, 19, 489–501.
  • Keller A, Leidinger P, Lange J, et al. (2009). Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PloS One, 4, e7440.
  • Kelly CA, Saravanan V, Nisar M, et al. (2014). Rheumatoid arthritis-related interstitial lung disease: associations, prognostic factors and physiological and radiological characteristics—a large multicentre UK study. Rheumatology, 53, 1676–82.
  • Kim KM, Park SJ, Jung SH, et al. (2012). miR‐182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1. J Bone Mineral Res, 27, 1669–79.
  • Kohlhaas S, Garden OA, Scudamore C, et al. (2009). Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol, 182, 2578–82.
  • Lai M, Xiao C. (2015). Functional interactions among members of the miR-17–92 cluster in lymphocyte development, differentiation and malignant transformation. Int Immunopharmacol, 28, 854–858.
  • Lamers I, Kelchtermans S, Baert I, et al. (2014). Upper limb assessment in multiple sclerosis: a systematic review of outcome measures and their psychometric properties. Arch Phys Med Rehab, 95, 1184–1200.
  • Lawrie CH, Soneji S, Marafioti T, et al. (2007). Microrna expression distinguishes between germinal center B cell‐like and activated B cell‐like subtypes of diffuse large B cell lymphoma. Int J Cancer, 121, 1156–61.
  • Li H, Xie H, Liu W, et al. (2009). A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest, 119, 3666.
  • Li L, Chen XP, Li YJ. (2010). MicroRNA‐146a and Human Disease. Scand J Immunol, 71, 227–31.
  • Lindberg R, Hoffmann F, Kuhle J, Kappos L. (2010a). Circulating microRNAs as indicators for disease course of multiple sclerosis. Mult. Scler, 16, S41–S196.
  • Lindberg RL, Hoffmann F, Mehling M, et al. (2010b). Altered expression of miR‐17‐5p in CD4+ lymphocytes of relapsing–remitting multiple sclerosis patients. Eur J Immunol, 40, 888–98.
  • Liston A, Lu L-F, O’Carroll D, et al. (2008). Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med, 205, 1993–2004.
  • Lu L-F, Boldin MP, Chaudhry A, et al. (2010). Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell, 142, 914–29.
  • Lu L-F, Gasteiger G, Yu I-S, et al. (2015). A single miRNA-mRNA interaction affects the immune response in a context-and cell-type-specific manner. Immunity, 43, 52–64.
  • Lu L-F, Thai T-H, Calado DP, et al. (2009). Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity, 30, 80–91.
  • Lu MC, Lai NS, Chen HC, et al. (2013). Decreased microRNA (miR)‐145 and increased miR‐224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis. Clin Exp Immunol, 171, 91–99.
  • Luo X, Yang W, Ye D-Q, et al. (2011). A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus. PLoS genetics, 7, e1002128.
  • Lv M, Zhang X, Jia H, et al. (2012). An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways. Leukemia, 26, 769–77.
  • Magni S, Comani GB, Elli L, et al. (2014). miRNAs affect the expression of innate and adaptive immunity proteins in celiac disease. Am J Gastroenterol, 109, 1662.
  • Mansoori B, Mohammadi A, Shir Jang S, Baradaran B. (2016). Mechanisms of immune system activation in mammalians by small interfering RNA (siRNA). Artificial Cells, Nanomedicine, Biotechnol, 44, 1589–96.
  • Mansoori B, Shotorbani SS, Baradaran B. (2014). RNA interference and its role in cancer therapy. Adv Phar Bull, 4, 313.
  • Mehta A, Baltimore D. (2016). MicroRNAs as regulatory elements in immune system logic. Nat Rev Immunol, 16, 279–94.
  • Melnik BC, John SM, Schmitz G. (2014). Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy. J Transl Med, 12, 43.
  • Meng X, Kaufmann S. (2014). Bim regulation miRrors microRNA 17∼ 92 cluster expression in endothelial cells in vivo. Cell Death Differ, 21, 1665–66.
  • Miyaki S, Nakasa T, Otsuki S, et al. (2009). MicroRNA‐140 is expressed in differentiated human articular chondrocytes and modulates interleukin‐1 responses. Arthritis Rheum, 60, 2723–30.
  • Mohammadi A, Mansoori B, Baradaran B. (2016). The role of microRNAs in colorectal cancer. Biomed Pharmacother, 84, 705–13.
  • Mohammadi A, Mansoori B, Baradaran B. (2017). Regulation of miRNAs by herbal medicine: an emerging field in cancer therapies. Biomed Pharmacother, 86, 262–70.
  • Mraz M, Chen L, Rassenti LZ, et al. (2014). miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1. Blood, 124, 84–95.
  • Nagata Y, Nakasa T, Mochizuki Y, et al. (2009). Induction of apoptosis in the synovium of mice with autoantibody‐mediated arthritis by the intraarticular injection of double‐stranded MicroRNA‐15a. Arthritis Rheum, 60, 2677–83.
  • Nakamachi Y, Kawano S, Takenokuchi M, et al. (2009). MicroRNA‐124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast‐like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum, 60, 1294–304.
  • Nakasa T, Miyaki S, Okubo A, et al. (2008). Expression of microRNA‐146 in rheumatoid arthritis synovial tissue. Arthritis Rheum, 58, 1284–92.
  • Nakasa T, Shibuya H, Nagata Y, et al. (2011). The inhibitory effect of microRNA‐146a expression on bone destruction in collagen‐induced arthritis. Arthritis Rheum, 63, 1582–90.
  • Niimoto T, Nakasa T, Ishikawa M, et al. (2010). MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients. BMC Musculoskelet Disord, 11, 209.
  • O’Connell RM, Rao DS, Baltimore D. (2012). microRNA regulation of inflammatory responses. Annu Rev Immunol, 30, 295–312.
  • O’connell RM, Rao DS, Chaudhuri AA, Baltimore D. (2010). Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol, 10, 111–22.
  • Oertli M, Engler DB, Kohler E, et al. (2011). MicroRNA-155 is essential for the T cell-mediated control of Helicobacter pylori infection and for the induction of chronic Gastritis and Colitis. J Immunol, 187, 3578–86.
  • Pan W, Zhu S, Yuan M, et al. (2010). MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol, 184, 6773–81.
  • Paraskevi A, Theodoropoulos G, Papaconstantinou I, et al. (2012). Circulating MicroRNA in inflammatory bowel disease. J Crohn’s Colitis, 6, 900–04.
  • Pauley KM, Cha S, Chan EK. (2009). MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun, 32, 189–94.
  • Pauley KM, Satoh M, Chan AL, et al. (2008). Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther, 10, R101.
  • Perez P, Teos L, Tandon M, et al. (2015). Downregulation of Microrna-183 in Sjögren’s syndrome minor salivary glands; implications in the control of ezrin expression and salivary gland function. Scand J Immunol, 81, 426.
  • Quinn SR, O’Neill LA. (2011). A trio of microRNAs that control Toll-like receptor signalling. Int Immunol, 23, 421–25.
  • Rao DS, O’Connell RM, Chaudhuri AA, et al. (2010). MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1. Immunity, 33, 48–59.
  • Regev K, Healy B, Paul A, et al. (2016). A comprehensive evaluation of serum microRNAs as potential biomarkers in multiple sclerosis (P1. 390). Neurology, 86, 390.
  • Richmond TK, Tili E, Chiabai M, et al. (2015). Functional interaction of Mir-155, a pro-inflammatory microRNA, and quaking in the innate immune response. J Allergy Clin Immunol, 135, AB97.
  • Rodriguez A, Vigorito E, Clare S, et al. (2007). Requirement of bic/microRNA-155 for normal immune function. Science, 316, 608–11.
  • Runtsch MC, Hu R, Alexander M, et al. (2015). MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis. Oncotarget, 6, 28556.
  • Sernyak MJ, Leslie DL, Alarcon RD, et al. (2002). Association of diabetes mellitus with use of atypical neuroleptics in the treatment of schizophrenia. Am J Psychiatry, 159, 561–566.
  • Severin ME, Lee PW, Liu Y, et al. (2016). MicroRNAs targeting TGFβ signalling underlie the regulatory T cell defect in multiple sclerosis. Brain: aww084.
  • Shi H, Zheng LY, Zhang P, Yu CQ. (2014). miR‐146a and miR‐155 expression in PBMCs from patients with Sjögren’s syndrome. J Oral Pathol Med, 43, 792–97.
  • Simpson LJ, Ansel KM. (2015). MicroRNA regulation of lymphocyte tolerance and autoimmunity. J Clin Investig, 125, 2242.
  • Simpson N, Gatenby PA, Wilson A, et al. (2010). Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum, 62, 234–44.
  • Stanczyk J, Ospelt C, Karouzakis E, et al. (2011). Altered expression of microRNA‐203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheum, 63, 373–81.
  • Stanczyk J, Pedrioli DML, Brentano F, et al. (2008). Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum, 58, 1001–09.
  • Stittrich A-B, Haftmann C, Sgouroudis E, et al. (2010). The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol, 11, 1057–62.
  • Takahashi H, Kanno T, Nakayamada S, et al. (2012). TGF-[beta] and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat Immunol, 13, 587–95.
  • Tang X, Tang R, Xu Y, et al. (2014). MicroRNA networks in regulatory T cells. J Physiol Biochem, 70, 869–75.
  • Tecchio C, Micheletti A, Cassatella MA. (2014). Neutrophil-derived cytokines: facts beyond expression. Front Immunol, 5, 1–7.
  • Thamilarasan M, Koczan D, Hecker M, et al. (2012). MicroRNAs in multiple sclerosis and experimental autoimmune encephalomyelitis. Autoimmun Rev, 11, 174–79.
  • Tomankova T, Petrek M, Gallo J, Kriegova E. (2012). MicroRNAs: emerging regulators of immune‐mediated diseases. Scand J Immunol, 75, 129–41.
  • Van Keimpema M, Grüneberg LJ, Mokry M, et al. (2014). FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells. Blood, 124, 3431.
  • Vigorito E, Perks KL, Abreu-Goodger C, et al. (2007). microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity, 27, 847–59.
  • Wissink EM, Smith NL, Spektor R, et al. (2015). MicroRNAs and their targets are differentially regulated in adult and neonatal mouse CD8+ T cells. Genetics: Genetics, 115, 179176.
  • Yu D. (2014). MicroRNAs in Tfh cells: micromanaging inflammaging. Immunity, 41, 509–11.
  • Yu D, Tan AH-M, Hu X, et al. (2007). Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature, 450, 299–303.
  • Zampetaki A, Mayr M. (2015). Sweet dicer impairment of Micro-RNA processing by diabetes. Circ Res, 117, 116–18.
  • Zhang Y, Jin Y, Lin Y, et al. (2015). Adipose-derived mesenchymal stem cells ameliorate ulcerative colitis through miR-1236 negatively regulating the expression of retinoid-related orphan receptor gamma. DNA Cell Biol, 34, 618–25.
  • Zhao X, Tang Y, Qu B, et al. (2010). MicroRNA‐125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus. Arthritis Rheum, 62, 3425–35.
  • Zhou Q, Haupt S, Kreuzer JT, et al. (2015). Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis. Ann Rheum Dis, 74, 1265–74.
  • Zhou X, Jeker LT, Fife BT, et al. (2008). Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med, 205, 1983–91.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.