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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 48, 2019 - Issue 2
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Original Articles

Analysis of the Association of Polymorphisms rs5743708 in TLR2 and rs4986790 in TLR4 with Atopic Dermatitis Risk

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References

  • Ahmad-Nejad P, Mrabet-Dahbi S, Breuer K, et al. (2004). The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype. J Allergy Clin Immunol, 113, 565–567.
  • Ashbaugh AG, Kwatra SG. (2017). Atopic dermatitis disease complications. Adv Exp Med Biol, 1027, 47–55. doi:10.1007/978-3-319-64804-0_5
  • Athari SS, Athari SM, Beyzay F, et al. (2017). Critical role of Toll-like receptors in pathophysiology of allergic asthma. Eur J Pharmacol, 808, 21–27. doi:10.1016/j.ejphar.2016.11.047
  • Bagheri N, Azadegan-Dehkordi F, Rahimian G, et al. (2016). Altered Th17 cytokine expression in helicobacter pylori patients with TLR4 (D299G) polymorphism. Immunol Invest, 45, 161–171. doi:10.3109/08820139.2015.1122615
  • Batool M, Anwar MA, Choi S. (2016). Toll-like receptors targeting technology for the treatment of lymphoma. Expert Opin Drug Discov, 11, 1047–1059. doi:10.1080/17460441.2016.1233964
  • Bin L, Leung DY. (2016). Genetic and epigenetic studies of atopic dermatitis. Allergy Asthma Clin Immunol, 12, 52. doi:10.1186/s13223-016-0135-z
  • Brown J, Wang H, Hajishengallis GN, et al. (2011). TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res, 90, 417–427. doi:10.1177/0022034510381264
  • Brunner PM, Leung DYM, Guttman-Yassky E. (2018). Immunologic, microbial, and epithelial interactions in atopic dermatitis. Ann Allergy Asthma Immunol, 120, 34–41. doi:10.1016/j.anai.2017.09.055
  • Can C, Yazicioglu M, Gurkan H, et al. (2017). Lack of association between toll-like receptor 2 polymorphisms (R753Q and A-16934T) and atopic dermatitis in children from thrace region of Turkey. Balkan Med J, 34, 232–238. doi:10.4274/balkanmedj.2015.1253
  • David Boothe W, Tarbox JA, Tarbox MB. (2017). Atopic dermatitis: pathophysiology. Adv Exp Med Biol, 1027, 21–37. doi:10.1007/978-3-319-64804-0_3
  • Erridge C. (2010). Endogenous ligands of TLR2 and TLR4: agonists or assistants? J Leukoc Biol, 87, 989–999. doi:10.1189/jlb.1209775
  • Galli E, Ciucci A, Cersosimo S, et al. (2010). Eczema and food allergy in an Italian pediatric cohort: no association with TLR-2 and TLR-4 polymorphisms. Int J Immunopathol Pharmacol, 23, 671–675. doi:10.1177/039463201002300233
  • Guven M, Batar B, Mutlu T, et al. (2016). Toll-like receptors 2 and 4 polymorphisms in age-related macular degeneration. Curr Eye Res, 41, 856–861. doi:10.3109/02713683.2015.1067326
  • Kanagaratham C, Camateros P, Flaczyk A, et al. (2011). Polymorphisms in TOLL-like receptor genes and their roles in allergic asthma and atopy. Recent Pat Inflamm Allergy Drug Discov, 5, 45–56.
  • Kaufman BP, Guttman-Yassky E, Alexis AF. (2018). Atopic dermatitis in diverse racial and ethnic groups - variations in epidemiology, genetics, clinical presentation, and treatment. Exp Dermatol, 27, 340–357. doi:10.1111/exd.13514
  • Koponen P, Vuononvirta J, Nuolivirta K, et al. (2014). The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy. Pediatr Infect Dis J, 33, 463–466. doi:10.1097/INF.0000000000000253
  • Levchenko LY, Izmailova OV, Shlykova OA, et al. (2013). TLR4 896A/G gene polymorphism, rather than the TLR4 1196C/T and TLR2 2258G/A gene polymorphisms, determines the severe and aggravated course of atopic dermatitis in children. Cytol Genet, 47, 167–173. doi:10.3103/S0095452713030067
  • Li Y, Cheng H, Xiao FL, et al. (2017). Association of UBASH3A gene polymorphism and atopic dermatitis in the Chinese Han population. Genes Immun, 18, 158–162. doi:10.1038/gene.2017.15
  • Lowe AJ, Leung DYM, Tang MLK, et al. (2018). The skin as a target for prevention of the atopic march. Ann Allergy Asthma Immunol, 120, 145–151. doi:10.1016/j.anai.2017.11.023
  • Mastrorilli C, Caffarelli C, Hoffmann-Sommergruber K. (2017). Food allergy and atopic dermatitis: prediction, progression, and prevention. Pediatr Allergy Immunol, 28, 831–840. doi:10.1111/pai.12831
  • Niebuhr M, Langnickel J, Draing C, et al. (2008). Dysregulation of toll-like receptor-2 (TLR-2)-induced effects in monocytes from patients with atopic dermatitis: impact of the TLR-2 R753Q polymorphism. Allergy, 63, 728–734. doi:10.1111/j.1398-9995.2008.01721.x
  • Oh DY, Schumann RR, Hamann L, et al. (2009). Association of the toll-like receptor 2 A-16934T promoter polymorphism with severe atopic dermatitis. Allergy, 64, 1608–1615. doi:10.1111/j.1398-9995.2009.02066.x
  • Paternoster L, Standl M, Chen CM, et al. (2011). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet, 44, 187–192. doi:10.1038/ng.1017
  • Salpietro C, Rigoli L, Miraglia Del Giudice M, et al. (2011). TLR2 and TLR4 gene polymorphisms and atopic dermatitis in Italian children: a multicenter study. Int J Immunopathol Pharmacol, 24, 33–40. doi:10.1177/03946320110240S408
  • Silverberg JI. (2018). Associations between atopic dermatitis and other disorders. F1000Res, 7, 303. doi:10.12688/f1000research
  • Stemmler S, Hoffjan S. (2016). Trying to understand the genetics of atopic dermatitis. Mol Cell Probes, 30, 374–385. doi:10.1016/j.mcp.2016.10.004
  • Tyurin YA, Shamsutdinov AF, Kalinin NN, et al. (2017). Association of toll-like cell receptors TLR2 (p.Arg753GLN) and TLR4 (p.Asp299GLY) polymorphisms with indicators of general and local immunity in patients with atopic dermatitis. J Immunol Res, 2017, 8493545. doi:10.1155/2017/5974574
  • Wang XX, Chen T. (2018). Meta-analysis of the association of IL2RA polymorphisms rs2104286 and rs12722489 with multiple sclerosis risk. Immunol Invest, 47, 431–442. doi:10.1080/08820139.2018.1425699
  • Zhang B, Li XL, Zhao CR, et al. (2018a). Interleukin-6 as a predictor of the risk of cardiovascular disease: a meta-analysis of prospective epidemiological studies. Immunol Invest, 1–11, doi:10.1080/08820139.2018.1480034
  • Zhang G, Zhang J, Kuang M, et al. (2018b). The role of TNF alpha polymorphism and expression in susceptibility to nasal polyposis. Immunol Invest, 47, 360–371. doi:10.1080/08820139.2018.1433204

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