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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 50, 2021 - Issue 4
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Review

Immunological Role of IgG Subclasses

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References

  • Aalberse RC, Schuurman J. 2002. IgG4 breaking the rules. Immunol. 105(1):9–19.
  • Abolhassani H, Gharib B, Shahinpour S, Masoom SN, Havaei A, Mirminachi B, Arandi N, Torabi-Sagvand B, Khazaei HA, Mohammadi J, et al. 2015. Autoimmunity in patients with selective IgA deficiency. J Investig Allergol Clin Immunol. 25(2):112–19.
  • Adjobimey T, Hoerauf A. 2010. Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation. Ann Trop Med Parasitol. 104(6):455–64.
  • Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P. 2015. Autoimmune thyroid disorders. Autoimmun Rev. 14(2):174–80.
  • Banerjee K, Klasse PJ, Sanders RW, Pereyra F, Michael E, Lu M, Walker BD, Moore JP. 2010. IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines. AIDS Res Hum Retroviruses. 26(4):445–58.
  • Bartoccioni E, Scuderi F, Minicuci GM, Marino M, Ciaraffa F, Evoli A. 2006. Anti-MuSK antibodies: correlation with myasthenia gravis severity. Neurology. 67(3):505–07.
  • Barton J, Barton C, Bertoli L, Shankar EM. 2019. Duration of frequent or severe respiratory tract infection in adults before diagnosis of IgG subclass deficiency. PLoS One. 14(5):e0216940.
  • Basile U, Gulli F, Gragnani L, Fognani E, Napodano C, Pocino K, Zignego AL, Rapaccini GL. 2017. IgG3 subclass: A possible trigger of mixed cryoglobulin cascade in hepatitis C virus chronic infection. Dig Liver Dis. 49(11):1233–39.
  • Basile U, Marino M, Napodano C, Pocino K, Alboini PE, Gulli F, Evoli A, Provenzano C, Bartoccioni E. 2018. Serological immunoglobulin-free light chain profile in myasthenia gravis patients. J Immunol Res. 2018:9646209.
  • Bernasconi L, Mundwiler E, Regenass S, Aubert V, Hammerer-Lercher A, Heijnen I. 2019. Variable and inaccurate serum IgG4 levels resulting from lack of standardization in IgG subclass assay calibration. Clin Chem Lab Med. 57(11):1777–83.
  • Bertoli LF, Pappas DG, Barton JC, Barton JC. 2014. Serum immunoglobulins in 28 adults with autoimmune sensorineural hearing loss: increased prevalence of subnormal immunoglobulin G1 and immunoglobulin G3. BMC Immunol. 15(1):43.
  • Bijl M, Dijstelbloem HM, Oost WW, Bootsma H, Derksen RHWM, Aten J, Limburg PC, Kallenberg CG. 2002. IgG subclass distribution of autoantibodies differs between renal and extra‐renal relapses in patients with systemic lupus erythematosus. Rheumatology (Oxford). 41(1):62–67.
  • Bournazos S, Woof JM, Hart SP, Dransfield I. 2009. Functional and clinical consequences of Fc receptor polymorphic and copy number variants. Clin Exp Immunol. 157(2):244–54.
  • Burtis C, Ashwood E, Brun D. 2012. Tietz Textbook of clinical chemistry and molecular diagnostics. 5th. Missouri (USA): Saunders Elsevier; 544–45.
  • Chen LF, Mo YQ, Ma JD, Luo L, Zheng DH, Dai L. 2014. Elevated serum IgG4 defines specific clinical phenotype of rheumatoid arthritis. Mediators Inflamm. 2014:635293.
  • Cho EH, Choi R, Kang ES, Park HD. 2018. Performance evaluation of serum IgG subclass quantification using a SPAPLUS turbidimetric analyzer and comparison with the BNII nephelometer. Scand J Clin Lab Invest. 78(6):496–500.
  • Crassini KR, Zhang E, Balendran S, Freeman JA, Best OG, Forsyth CJ, Mackinlay NJ, Han P, Stevenson WS, Mulligan SP. 2018. Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in chronic lymphocytic leukaemia. Br J Haematol. 181(1):97–101.
  • Dolscheid-Pommerich RC, Beinert S, Eichhorn L, Conrad R, Stoffel-Wagner B, Zur B. 2015. IgG subclass distribution in patients with monoclonal gammopathy. Clin Chim Acta. 444:167–69.
  • Eleftherios PD, Christopoulos TK. 1996. Immunoassay. San Diego: Academic Press; p. 363–87.
  • Engelhart S, Glynn RJ, Schur PH. 2017. Disease associations with isolated elevations of each of the four IgG subclasses. Semin Arthritis Rheum. 47(2):276–80.
  • Gulli F, Basile U, Gragnani L, Fognani E, Napodano C, Colacicco L, Miele L, De Matthaeis N, Cattani P, Zignego AL, et al. 2016. Autoimmunity and lymphoproliferation markers in naїve HCV-RNA positive patients without clinical evidences of autoimmune/lymphoproliferative disorders. Dig Liver Dis. 48(8):927–33.
  • Gulli F, Basile U, Gragnani L, Napodano C, Pocino K, Miele L, Santini SA, Zignego AL, Gasbarrini A, Rapaccini GL. 2018. IgG cryoglobulinemia. Eur Rev Med Pharmacol Sci. 22(18):6057–62.
  • Gulli F, Napodano C, Marino M, Ciasca G, Pocino K, Basile V, Visentini M, Stefanile A, Todi L, De Spirito M, et al. 2020. Serum immunoglobulin free light chain levels in systemic autoimmune rheumatic diseases. Clin Exp Immunol. 199(2):163–71.
  • Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N, et al. 2001. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 344(10):732–38.
  • Hamano H, Kawa S, Ochi Y, Unno H, Shiba N, Wajiki M, Nakazawa K, Shimojo H, Kiyosawa K. 2002. Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet. 359(9315):1403–04.
  • Horns F, Vollmers C, Croote D, Mackey SF, Swan GE, Dekker CL, Davis MM, Quake SR. 2016. Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching. Elife. 2:5.
  • Huijbers MG, Zhang W, Klooster R, Niks EH, Friese MB, Straasheijm KR, Thijssen PE, Vrolijk H, Plomp JJ, Vogels P, et al. 2013. MuSK IgG4 autoantibodies cause myasthenia Gravis by inhibiting binding between MuSK and Lrp4. Proc Natl Acad Sci U S A. 110(51):20783–88.
  • Hussain R, Jaferi W, Zuberi S, Baqai R, Abrar N, Ahmed A, Zaman V. 1997. Significantly increased IgG2 subclass antibody levels to Blastocystis hominis in patients with irritable bowel syndrome. Am J Trop Med Hyg. 56(3):301–06.
  • Hussain R, Poindexter RW, Ottesen EA. 1992. Control of allergic reactivity in human filariasis. Predominant localization of blocking antibody to the IgG4 subclass. J Immunol. 148(9):2731–37.
  • Jeannin P, Lecoanet S, Delneste Y, Gauchat JF, Bonnefoy JY. 1998. IgE versus IgG4 production can be differentially regulated by IL-10. J Immunol. 160(7):3555–61.
  • Kadelka C, Liechti T, Ebner H, Schanz M, Rusert P, Friedrich N, Stiegeler E, Braun DL, Huber M, Scherrer AU, et al. 2018. Swiss HIV cohort study distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity. J Exp Med. 215(6):1589–608.
  • Kamisawa T, Funata N, Hayashi Y, Eishi Y, Koike M, Tsuruta K, Okamoto A, Egawa N, Nakajima H. 2003. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 38(10):982–84.
  • Kapur R, Einarsdottir HK, Vidarsson G. 2014. IgG-effector functions: “the good, the bad and the ugly”. Immunol Lett. 160(2):139–44.
  • Kawano Y, Noma T, Yata J. 1994. Regulation of human IgG subclass production by cytokines. IFN-gamma and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2. J Immunol. 153(11):4948–58.
  • Klooster R, Plomp JJ, Huijbers MG, Niks EH, Straasheijm KR, Detmers FJ, Hermans PW, Sleijpen K, Verrips A, Losen M, et al. 2012. Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice. Brain. 135(4):1081–101.
  • Koneczny I. 2018. A New classification system for IgG4 autoantibodies. Front Immunol. 9:97.
  • Koneczny I, Stevens JA, De Rosa A, Huda S, Huijbers MG, Saxena A, Maestri M, Lazaridis K, Zisimopoulou P, Tzartos S, et al. 2017. IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients. J Autoimmun. 77:104–15.
  • Kotani T, Kato E, Hirai K, Kuma K, Ohtaki S. 1986. Immunoglobulin G subclasses of anti-thyroid peroxidase autoantibodies in human autoimmune thyroid diseases. Endocrinol Jpn. 33(4):505–10.
  • Kubo K, Yamamoto K. 2016. IgG4-related disease. Int J Rheum Dis. 19(8):747–62.
  • Kurtovic L, Agius PA, Feng G, Drew DR, Ubillos I, Sacarlal J, Aponte JJ, Fowkes FJI, Dobaño C, Beeson JG. 2019. Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure. BMC Med. 17(1):45.
  • Ladwig PM, Barnidge DR, Snyder MR, Katzmann JA, Murray DL. 2014. Quantification of serum IgG subclasses by use of subclass-specific tryptic peptides and liquid chromatography-tandem mass spectrometry. Clin Chem. 60(8):1080–88.
  • Leitao Filho FS, Ra SW, Mattman A, Schellenberg RS, Criner GJ, Woodruff PG, Lazarus SC, Albert R, Connett JE, Han MK, et al. 2018. Canadian Respiratory Research Network (CRRN). Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD. Respir Res. 19(1):30.
  • Liu H, May K. 2012. Disulfide bond structures of IgG molecules: structural variations, chemical modifications and possible impacts to stability and biological function. MAbs. 4(1):17–23.
  • Liu Y, Li J. 2011. Preferentially immunoglobulin (IgG) subclasses production in primary Sjögren’s syndrome patients. Clin Chem Lab Med. 50(2):345–49.
  • Liu Z, Deng C, Li P, Wang J, Ma L, Li Y, Xu Y, Puissant-Lubrano B. 2018. A reference interval for serum IgG subclasses in Chinese children. PLoS One. 13(3):e0192923.
  • Lowe D, Higgins R, Zehnder D, Briggs DC. 2013. Significant IgG subclass heterogeneity in HLA-specific antibodies: implications for pathogenicity, prognosis, and the rejection response. Hum Immunol. 74(5):666–72.
  • Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, et al. 2017. Mechanisms of autoantibody-induced pathology. Front Immunol. 8:603.
  • Ludwig‐Kraus B, Kraus FB. 2017. Similar but not consistent: revisiting the pitfalls of measuring IgG subclasses with different assays. J Clin Lab Anal. 31(6):e22146.
  • Lux A, Nimmerjahn F. 2013. Of mice and men: the need for humanized mouse models to study human IgG activity in vivo. J Clin Immunol. 33(S1):S4–S8.
  • Mahajan VS, Mattoo H, Deshpande V, Pillai SS, Stone JH. 2014. IgG4-related disease. Annu Rev Pathol. 9(1):315–47.
  • Marino M, Basile U, Spagni G, Napodano C, Iorio R, Gulli F, Todi L, Provenzano C, Bartoccioni E, Evoli A. 2020. Long-lasting rituximab-induced reduction of specific—but not total—IgG4 in MuSK-positive Myasthenia Gravis. Front Immunol. 11. doi:10.3389/fimmu.2020.00613
  • McAlister VC. 2019. Anti-donor immunoglobulin G subclass in liver transplantation. Hepatobiliary Surg Nutr. 8(2):125–28.
  • McConville J, Farrugia ME, Beeson D, Kishore U, Metcalfe R, Newsom-Davis J, Vincent A. 2004. Detection and characterization of MuSK antibodies in seronegative myasthenia gravis. Ann Neurol. 55(4):580–84.
  • Mishra R, Panda SK, Sahoo PK, Mishra S, Satapathy AK. 2019. Self-reactive IgG4 antibodies are associated with blocking of pathology in human lymphatic filariasis. Cell Immunol. 341:103927.
  • Molica S. 1994. Infections in chronic lymphocytic leukemia: risk factors, and impact on survival, and treatment. Leuk Lymphoma. 13(3–4):203–14.
  • Nezlin R. 2019. Dynamic aspects of the immunoglobulin structure. Immunol Invest. 48(8):771–80.
  • Niks EH, van Leeuwen Y, Leite MI, Dekker FW, Wintzen AR, Wirtz PW, Vincent A, van Tol MJ, Jol-van der Zijde CM, Verschuuren JJ. 2008. Clinical fluctuations in MuSK myasthenia gravis are related to antigen-specific IgG4 instead of IgG1. J Neuroimmunol. 195(1–2):151–56.
  • Nimmerjahn F, Ravetch JV. 2008. Anti-inflammatory actions of intravenous immunoglobulin. Annu Rev Immunol. 26(1):513–33.
  • Nirula A, Glaser SM, Kalled SL, Taylora FR, Liu Z, Deng C, Li P, Wang J, Ma L, Li Y. 2011. What is IgG4? A review of the biology of a unique immunoglobulin subtype. Curr Opin Rheumatol. 23(1):119–24.
  • Pagliari D, Cianci R, Rigante D. 2019a. Autoimmune pancreatitis in children: the impact of immune system in a challenging disease. Autoimmun Rev. 18(2):209–10.
  • Pagliari D, Cianci R, Rigante D. 2019b. The challenge of autoimmune pancreatitis: a portrayal from the pediatric perspective. Pancreas. 48(5):605–12.
  • Preud’homme JL, Hanson LA. 1990. IgG subclass deficiency. Immunodefic Rev. 2(2):129–49.
  • Punnonen J, Aversa G, Cocks BG, McKenzie AN, Menon S, Zurawski G, de Waal Malefyt R, de Vries JE. 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA. 90(8):3730–34.
  • Raibagkar P, Ferry JA, Stone JH. 2017. Is MuSK myasthenia gravis linked to IgG4-related disease? J Neuroimmunol. 305:82–83.
  • Reichert JM. 2014. Antibody Fc: linking Adaptive and Innate Immunity. MAbs. 6(3):619–21.
  • Roopenian DC, Akilesh S. 2007. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol. 7(9):715–25.
  • RTS, S Clinical Trials Partnership. 2015. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. Lancet. 386(9988):31–45.
  • Sarween N, Drayson MT, Hodson J, Knox EM, Plant T, Day CJ, Lipkin GW. 2018. Humoral immunity in late-onset Pre-eclampsia and linkage with angiogenic and inflammatory markers. Am J Reprod Immunol. 80(5):e13041.
  • Schauer U, Stemberg F, Rieger CH, Rieger CH, Borte M, Schubert S, Riedel F, Herz U, Renz H, Wick M, et al. 2003. IgG subclass concentrations in certified reference material 470 and reference values for children and adults determined with the binding site reagents. Clin Chem. 49(11):1924–29.
  • Schur PH. 1987. IgG subclasses-a review. Ann Allergy. 58(2):89–96.
  • Shiokawa M, Kodama Y, Kuriyama K, Yoshimura K, Tomono T, Morita T, Kakiuchi N, Matsumori T, Mima A, Nishikawa Y, et al. 2016. Pathogenicity of IgG in patients with IgG4-related disease. Gut. 65(8):1322–32.
  • Shiokawa M, Kodama Y, Sekiguchi K, Kuwada T, Tomono T, Kuriyama K, Yamazaki H, Morita T, Marui S, Sogabe Y, et al. 2018. Target antigen in autoimmune pancreatitis. Sci Transl Med. 10(453):eaaq0997.
  • Sigal LH. 2012. IgG subclasses. J Clin Rheumatol. 18(6):316–18.
  • Stone JH, Khosroshahi A, Deshpande V, Chan JK, Heathcote JG, Aalberse R, Azumi A, Bloch DB, Brugge WR, Carruthers MN, et al. 2012. Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations. Arthritis Rheum. 64(10):3061–67.
  • Takahashi H, Yamamoto M, Suzuki C, Naishiro Y, Shinomura Y, Imai K. 2010. The birthday of a new syndrome: igG4-related diseases constitute a clinical entity. Autoimmun Rev. 9(9):591–94.
  • Tan J, Jin X, Zhao R, Wei X, Liu Y, Kong X. 2015. Beneficial effect of T follicular helper cells on antibody class switching of B cells in prostate cancer. Oncol Rep. 33(3):1512–18.
  • Ubillos I, Ayestaran A, Nhabomba AJ, Dosoo D, Vidal M, Jiménez A, Jairoce C, Sanz H, Aguilar R, Williams NA, et al. 2018. Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children. BMC Med. 16(1):197.
  • Umehara H, Okazaki K, Kawano M, Mimori T, Chiba T. 2017. How to diagnose IgG4-related disease. Ann Rheum Dis. 76(11):e46.
  • Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Sumida T, Mimori T, Tanaka Y, et al. 2012a. Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team.A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol. 22(1):1–14.
  • Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, et al. 2012b. Comprehensive diagnostic criteria for IgG4-related disease (IgG4‐RD). Mod Rheumatol. 22(1):21–30.
  • Umetsu DT, Ambrosino DM, Quinti I, Siber GR, Geha RS. 1985. Recurrent sinopulmonary infection and impaired antibody response to bacterial capsular polysaccharide antigen in children with selective IgG-subclass deficiency. N Engl J Med. 313(20):1247–51.
  • Valenzuela NM, Schaub S. 2018. The Biology of IgG Subclasses and Their Clinical Relevance to Transplantation. Transplantation. 102:S7–S13.
  • Van der Gugten G, DeMarco ML, Chen LY, Chin A, Carruthers M, Holmes DT, Mattman A. 2018. Resolution of spurious immunonephelometric IgG subclass measurement discrepancies by LC-MS/MS. Clin Chem. 64(4):735–42.
  • Van der Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martínez-Martínez P, Vermeulen E, den Bleker TH, Wiegman L, Vink T, Aarden LA, et al. 2007. Anti-inflammatory activity of human IgG4 antibodies by dynamic fab arm exchange. Science. 317(5844):1554–57.
  • Vidarsson G, Dekkers G, Rispens T. 2014. IgG subclasses and allotypes: from structure to effector functions. Front Immunol. 5:520.
  • White MT, Verity R, Griffin JT, Asante KP, Owusu-Agyei S, Greenwood B, Drakeley C, Gesase S, Lusingu J, Ansong D, et al. 2015. Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial. Lancet Infect Dis. 15(12):1450–58.
  • Wilson C, Ebling R, Henig C, Adler T, Nicolaevski R, Barak M, Cazabon J, Maisin D, Lepoutre T, Gruson D, et al. 2013. Significant, quantifiable differences exist between IgG subclass standards WHO67/97 and ERM-DA470k and can result in different interpretation of results. Clin Biochem. 46(16–17):1751–55.
  • Wu J, Lin R, Huang J, Guan W, Oetting WS, Sriramarao P, Blumenthal MN. 2014. Functional Fcgamma receptor polymorphisms are associated with human allergy. PLoSOne. 9(2):e89196.
  • Xie LD, Gao Y, Li MR, Lu GZ, Guo XH. 2008. Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto’s thyroiditis with different thyroid functional status. Clin Exp Immunol. 154(2):172–76.
  • Yamazaki R, Kato J, Koda Y, Sakurai M, Tozawa K, Okayama M, Nakayama H, Watanuki S, Kikuchi T, Hasegawa N, et al. 2019. Impact of immunoglobulin G2 subclass level on late-onset bacterial infection after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 21(3):e13086.
  • Yamazaki R, Kikuchi T, Kato J, Sakurai M, Koda Y, Hashida R, Yamane Y, Abe R, Hasegawa N, Okamoto S, et al. 2018. Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: efficacy of immunoglobulin replacement. Transpl Infect Dis. 20(3):e12863.
  • Young E, Lock E, Ward DG, Cook A, Harding S, Wallis GL. 2014. Estimation of polyclonal IgG4 hybrids in normal human serum. Immunol. 142(3):406–13.
  • Zhang H, Li P, Wu D, Xu D, Hou Y, Wang Q, Li M, Li Y, Zeng X, Zhang F, et al. 2015. Serum IgG subclasses in autoimmune diseases. Med (Baltimore). 94(2):e387.

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