Serum YKL-40 and Serum Krebs von den Lungen-6 as Potential Predictive Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease

References

• Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., Combe, B., Costenbader, K. H., Dougados, M., Emery, P., Ferraccioli, G., Hazes, J. M., Hobbs, K., Huizinga, T. W., Kavanaugh, A., … Wolfe, F. (2010). 2010 rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative [published correction appears in Ann Rheum Dis. 2010 Oct;69(10): 1892]. Annals of the Rheumatic Diseases, 69(9), 1580–1588. https://doi.org/10.1136/ard.2010.138461
   PubMed Web of Science ®Google Scholar
• Bongartz, T., Nannini, C., Medina-Velasquez, Y. F., Achenbach, S. J., Crowson, C. S., Ryu, J. H., Vassallo, R., Gabriel, S. E., & Matteson, E. L. (2010). Incidence and mortality of interstitial lung disease in rheumatoid arthritis: A population-based study. Arthritis & Rheumatism, 62(6), 1583–1591. https://doi.org/10.1002/art.27405
   PubMed Web of Science ®Google Scholar
• Cano-Jiménez, E., Vázquez Rodríguez, T., Martín-Robles, I., Castillo Villegas, D., Juan García, J., Bollo de Miguel, E., Robles-Pérez, A., Ferrer Galván, M., Mouronte Roibas, C., Herrera Lara, S., Bermudo, G., García Moyano, M., Rodríguez Portal, J. A., Sellarés Torres, J., Narváez, J., & Molina-Molina, M. (2021, April 28). Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis. Scientific Reports, 11(1), 9184. https://doi.org/10.1038/s41598-021-88734-2
   PubMed Web of Science ®Google Scholar
• Chiu, Y. H., Chu, C. C., Lu, C. C., Liu, F.-C., Tang, S.-E., Chu, S.-J., Kuo, S.-Y., & Chen, H.-C. (2022, April 8). KL-6 as a biomarker of interstitial lung disease development in patients with Sjögren syndrome: A retrospective case–control study. Journal of Inflammation Research, 15, 2255–2262. https://doi.org/10.2147/JIR.S352085
   PubMed Web of Science ®Google Scholar
• Cui, B., Chen, Y., Luo, F., Lin, S., Liu, H., Huang, Y., Zhou, Y., Tian, Y., Yin, G., & Xie, Q. (2022). Clinical value of YKL-40 in patients with polymyositis/dermatomyositis: A cross-sectional study and a systematic review. Journal of Clinical Laboratory Analysis, 36(9), e24605. https://doi.org/10.1002/jcla.24605
   PubMed Web of Science ®Google Scholar
• d’Alessandro, M., Bergantini, L., Cameli, P., Vietri, L., Lanzarone, N., Alonzi, V., Pieroni, M., M Refini, R., Sestini, P., Bonella, F., & Bargagli, E. (2020). Krebs von den Lungen-6 as a biomarker for disease severity assessment in interstitial lung disease: A comprehensive review. Biomarkers in Medicine, 14(8), 665–674. https://doi.org/10.2217/bmm-2019-0545
   PubMed Web of Science ®Google Scholar
• Duru, S., Yüceege, M., & Ardıç, S. (2013). Chitinases and lung diseases. Tuberk Toraks, 61(1), 71–75. https://doi.org/10.5578/tt.3773
   PubMedGoogle Scholar
• Furuhashi, K., Suda, T., Nakamura, Y., Inui, N., Hashimoto, D., Miwa, S., Hayakawa, H., Kusagaya, H., Nakano, Y., Nakamura, H., & Chida, K. (2010). Increased expression of YKL-40, a chitinase-like protein, in serum and lung of patients with idiopathic pulmonary fibrosis. Respiratory Medicine, 104(8), 1204–1210. https://doi.org/10.1016/j.rmed.2010.02.026
   PubMed Web of Science ®Google Scholar
• Giménez Palleiro, A., Mazzini, S. P., & Franquet, T. (2022). Basic HRCT patterns in diffuse interstitial lung disease. Radiologia (English Edition), 64(Suppl 3), 215–226. https://doi.org/10.1016/j.rxeng.2022.12.001
   PubMedGoogle Scholar
• Goldin, J. G., Lynch, D. A., Strollo, D. C., Suh, R. D., Schraufnagel, D. E., Clements, P. J., Elashoff, R. M., Furst, D. E., Vasunilashorn, S., McNitt-Gray, M. F., Brown, M. S., Roth, M. D., & Tashkin, D. P. (2008). High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease. Chest, 134(2), 358–367. https://doi.org/10.1378/chest.07-2444
   PubMed Web of Science ®Google Scholar
• Graham, B. L., Steenbruggen, I., Miller, M. R., Barjaktarevic, I. Z., Cooper, B. G., Hall, G. L., Hallstrand, T. S., Kaminsky, D. A., McCarthy, K., McCormack, M. C., Oropez, C. E., Rosenfeld, M., Stanojevic, S., & Swanney, M. P. (2019). Standardization of spirometry 2019 update. An official American Thoracic Society and European Respiratory Society technical statement. American Journal of Respiratory and Critical Care Medicine, 200(8), e70–e88. https://doi.org/10.1164/rccm.201908-1590ST
   PubMed Web of Science ®Google Scholar
• Hozumi, H., Fujisawa, T., Enomoto, N., Nakashima, R., Enomoto, Y., Suzuki, Y., Kono, M., Karayama, M., Furuhashi, K., Murakami, A., Inui, N., Nakamura, Y., Mimori, T., & Suda, T. (2017). Clinical utility of YKL-40 in polymyositis/dermatomyositis-associated interstitial lung disease. The Journal of Rheumatology, 44(9), 1394–1401. https://doi.org/10.3899/jrheum.170373
   PubMed Web of Science ®Google Scholar
• Hyldgaard, C., Hilberg, O., Pedersen, A. B., Ulrichsen, S. P., Løkke, A., Bendstrup, E., & Ellingsen, T. (2017). A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: Comorbidity and mortality. Annals of the Rheumatic Diseases, 76(10), 1700–1706. https://doi.org/10.1136/annrheumdis-2017-211138
   PubMed Web of Science ®Google Scholar
• Inoue, Y., Barker, E., Daniloff, E., Kohno, N., Hiwada, K., & Newman, L. S. (1997). Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. American Journal of Respiratory and Critical Care Medicine, 156(1), 109–115. https://doi.org/10.1164/ajrccm.156.1.9612043
   PubMed Web of Science ®Google Scholar
• Jiang, D., Xiao, H., Dong, R., Geng, J., Xie, B., Ren, Y., & Dai, H. (2022). Krebs von den Lungen-6 levels in untreated idiopathic pulmonary fibrosis. The Clinical Respiratory Journal, 16(3), 234–243. https://doi.org/10.1111/crj.13475
   PubMed Web of Science ®Google Scholar
• Jiang, L., Wang, Y., Peng, Q., Shu, X., Wang, G., & Wu, X. (2019). Serum YKL-40 level is associated with severity of interstitial lung disease and poor prognosis in dermatomyositis with anti-MDA5 antibody. Clinical Rheumatology, 38(6), 1655–1663. https://doi.org/10.1007/s10067-019-04457-w
   PubMed Web of Science ®Google Scholar
• Johansen, J. S. (2006). Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer. Danish Medical Bulletin, 53(2), 172–209.
   PubMed Web of Science ®Google Scholar
• Juge, P. A., Lee, J. S., Ebstein, E., Furukawa, H., Dobrinskikh, E., Gazal, S., Kannengiesser, C., Ottaviani, S., Oka, S., Tohma, S., Tsuchiya, N., Rojas-Serrano, J., González-Pérez, M. I., Mejía, M., Buendía-Roldán, I., Falfán-Valencia, R., Ambrocio-Ortiz, E., Manali, E., Papiris, S. A., … Schwartz, D. A. (2018). MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease. New England Journal of Medicine, 379(23), 2209–2219. https://doi.org/10.1056/NEJMoa1801562
   PubMed Web of Science ®Google Scholar
• Kadura, S., & Raghu, G. (2021, June 23). Rheumatoid arthritis-interstitial lung disease: Manifestations and current concepts in pathogenesis and management. European Respiratory Review, 30(160), 210011. https://doi.org/10.1183/16000617.0011-2021
   PubMed Web of Science ®Google Scholar
• Kim, Y. J., Choe, J., Moon, S. J., & Song, J. W. (2022, March 29). Blood KL-6 predicts prognosis in primary Sjögren’s syndrome-associated interstitial lung disease. Scientific Reports, 12(1), 5343. https://doi.org/10.1038/s41598-022-09283-w
   PubMed Web of Science ®Google Scholar
• Kim, H. C., Choi, K. H., Jacob, J., Song, J. W., & Kuwana, M. (2020, March 12). Prognostic role of blood KL-6 in rheumatoid arthritis–associated interstitial lung disease. PLOS ONE, 15(3), e0229997. https://doi.org/10.1371/journal.pone.0229997
   PubMed Web of Science ®Google Scholar
• Kimura, H., Shimizu, K., Tanabe, N., Makita, H., Taniguchi, N., Kimura, H., Suzuki, M., Abe, Y., Matsumoto-Sasaki, M., Oguma, A., Takimoto-Sato, M., Takei, N., Matsumoto, M., Goudarzi, H., Sato, S., Ono, J., Izuhara, K., Hirai, T., Nishimura, M., & Konno, S. (2022). Further evidence for association of YKL-40 with severe asthma airway remodeling. Annals of Allergy, Asthma & Immunology, 128(6), 682–688.e5. https://doi.org/10.1016/j.anai.2022.03.016
   PubMed Web of Science ®Google Scholar
• Koduri, G., Norton, S., Young, A., Cox, N., Davies, P., Devlin, J., Dixey, J., Gough, A., Prouse, P., Winfield, J., & Williams, P. (2010). Interstitial lung disease has a poor prognosis in rheumatoid arthritis: Results from an inception cohort. Rheumatology (Oxford), 49(8), 1483–1489. https://doi.org/10.1093/rheumatology/keq035
   PubMed Web of Science ®Google Scholar
• Koduri, G., & Solomon, J. J. (2023). Identification, monitoring, and management of rheumatoid arthritis-associated interstitial lung disease. Arthritis and Rheumatology, 75(12), 2067–2077. https://doi.org/10.1002/art.42640
   PubMed Web of Science ®Google Scholar
• Kohno, N., Awaya, Y., Oyama, T., Yamakido, M., Akiyama, M., Inoue, Y., Yokoyama, A., Hamada, H., Fujioka, S., & Hiwada, K. (1993). KL-6, a mucin-like glycoprotein, in bronchoalveolar lavage fluid from patients with interstitial lung disease. The American Review of Respiratory Disease, 148(3), 637–642. https://doi.org/10.1164/ajrccm/148.3.637
   PubMedGoogle Scholar
• Lee, H. K., Kim, D. S., Yoo, B., Seo, J. B., Rho, J. Y., Colby, T. V., & Kitaichi, M. (2005). Histopathologic pattern and clinical features of rheumatoid arthritis-associated interstitial lung disease. Chest, 127(6), 2019–2027. https://doi.org/10.1378/chest.127.6.2019
   PubMed Web of Science ®Google Scholar
• Lee, J. S., Lee, E. Y., Ha, Y. J., Kang, E. H., Lee, Y. J., & Song, Y. W. (2019, February 14). Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease. Arthritis Research & Therapy, 21(1), 58. https://doi.org/10.1186/s13075-019-1835-9
   PubMedGoogle Scholar
• Lin, Y. J., Anzaghe, M., & Schülke, S. (2020, April 3). Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis. Cells, 9(4), 880. https://doi.org/10.3390/cells9040880
   PubMed Web of Science ®Google Scholar
• Long, X., He, X., Ohshimo, S., Griese, M., Sarria, R., Guzman, J., Costabel, U., & Bonella, F. (2017, February 23). Serum YKL-40 as predictor of outcome in hypersensitivity pneumonitis. The European Respiratory Journal, 49(2), 1501924. https://doi.org/10.1183/13993003.01924-2015
   PubMed Web of Science ®Google Scholar
• Majewski, S., Szewczyk, K., Jerczyńska, H., Miłkowska-Dymanowska, J., BiałBiałAs, A. J., Gwadera, Ł., & Piotrowski, W. J. (2022, February 10). Longitudinal and comparative measures of serum chitotriosidase and YKL-40 in patients with idiopathic pulmonary fibrosis. Frontiers in Immunology, 13, 760776. https://doi.org/10.3389/fimmu.2022.760776
   PubMed Web of Science ®Google Scholar
• Miao, Z. Y., Ran, J. J., Mou, D. C., Wu, S. S., Chen, Y. Q., Li, C., Chen, Y. H., Yang, M., & Xie, Q. B. (2023). YKL-40 promotes the expression of inflammatory factors in typeIIAlveolar epithelial cell model of A549 cell line. Journal of Sichuan University (Medical Sciences), 54(5), 954–958. https://doi.org/10.12182/20230960201
   Google Scholar
• Nishikawa, K. C., & Millis, A. J. (2003). gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Experimental Cell Research, 287(1), 79–87. https://doi.org/10.1016/s0014-4827(03)00069-7
   PubMed Web of Science ®Google Scholar
• Nordenbaek, C., Johansen, J. S., Halberg, P., Wiik, A., Garbarsch, C., Ullman, S., Price, P. A., & Jacobsen, S. (2005). High serum levels of YKL-40 in patients with systemic sclerosis are associated with pulmonary involvement. Scandinavian Journal of Rheumatology, 34(4), 293–297. https://doi.org/10.1080/03009740510018598
   PubMed Web of Science ®Google Scholar
• Olson, A. L., Swigris, J. J., Sprunger, D. B., Fischer, A., Fernandez-Perez, E. R., Solomon, J., Murphy, J., Cohen, M., Raghu, G., & Brown, K. K. (2011). Rheumatoid arthritis–interstitial lung disease–associated mortality. American Journal of Respiratory and Critical Care Medicine, 183(3), 372–378. https://doi.org/10.1164/rccm.201004-0622OC
   PubMed Web of Science ®Google Scholar
• Rehli, M., Krause, S. W., & Andreesen, R. (1997). Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. Genomics, 43(2), 221–225. https://doi.org/10.1006/geno.1997.4778
   PubMed Web of Science ®Google Scholar
• Sánchez-Díez, S., Munoz, X., Ojanguren, I., Romero-Mesones, C., Espejo, D., Villar, A., Gómez-Olles, S., & Cruz, M.-J. (2022). YKL-40 and KL-6 levels in serum and sputum of patients diagnosed with hypersensitivity pneumonitis. The Journal of Allergy and Clinical Immunology: In Practice, 10(9), 2414–2423. https://doi.org/10.1016/j.jaip.2022.06.031
   PubMed Web of Science ®Google Scholar
• Smolen, J. S., Aletaha, D., & McInnes, I. B. (2016). Rheumatoid arthritis [published correction appears in Lancet. 2016 Oct 22;388(10055): 1984]. Lancet, 388(10055), 2023–2038. https://doi.org/10.1016/S0140-6736(16)30173-8
   PubMed Web of Science ®Google Scholar
• Sofíudóttir, B. K., Harders, S. M. W., Lage-Hansen, P. R., Christensen, R., Munk, H. L., Sorensen, G. L., Davidsen, J. R., & Ellingsen, T. (2022, December 23). Using thoracic ultrasound to detect interstitial lung disease in patients with rheumatoid arthritis: A protocol for the diagnostic test accuracy AURORA study. British Medical Journal Open, 12(12), e067434. https://doi.org/10.1136/bmjopen-2022-067434
   PubMed Web of Science ®Google Scholar
• Stainer, A., Tonutti, A., De Santis, M., Amati, F., Ceribelli, A., Bongiovanni, G., Torrisi, C., Iacopino, A., Mangiameli, G., Aliberti, S., & Selmi, C. (2023, March 16). Unmet needs and perspectives in rheumatoid arthritis-associated interstitial lung disease: A critical review. Frontiers in Medicine, 10, 1129939. https://doi.org/10.3389/fmed.2023.1129939
   Web of Science ®Google Scholar
• Stock, C. J. W., Hoyles, R. K., Daccord, C., Kokosi, M., Visca, D., De Lauretis, A., Alfieri, V., Kouranos, V., Margaritopoulos, G., George, P. M., Molyneaux, P. L., Chua, F., Maher, T. M., Abraham, D. J., Ong, V., Donovan, J., Sestini, P., Denton, C. P., Wells, A. U., & Renzoni, E. A. (2021). Serum markers of pulmonary epithelial damage in systemic sclerosis-associated interstitial lung disease and disease progression. Respirology, 26(5), 461–468. https://doi.org/10.1111/resp.13988
   PubMed Web of Science ®Google Scholar
• Volkmann, E. R., Tashkin, D. P., Kuwana, M., Li, N., Roth, M. D., Charles, J., Hant, F. N., Bogatkevich, G. S., Akter, T., Kim, G., Goldin, J., Khanna, D., Clements, P. J., Furst, D. E., Elashoff, R. M., Silver, R. M., & Assassi, S. (2019). Progression of interstitial lung disease in systemic sclerosis: The importance of pneumoproteins Krebs von den Lungen 6 and CCL18. Arthritis and Rheumatology, 71(12), 2059–2067. https://doi.org/10.1002/art.41020
   PubMed Web of Science ®Google Scholar
• Zhang, H., Chen, L., Wu, L., Huang, J., Li, H., Wang, X., & Weng, H. (2020). Diagnostic and prognostic predictive values of circulating KL-6 for interstitial lung disease: A PRISMA-compliant systematic review and meta-analysis. Medicine, 99(16), e19493. https://doi.org/10.1097/MD.0000000000019493
   PubMed Web of Science ®Google Scholar
• Zhou, Y., Peng, H., Sun, H., Peng, X., Tang, C., Gan, Y., Chen, X., Mathur, A., Hu, B., Slade, M. D., Montgomery, R. R., Shaw, A. C., Homer, R. J., White, E. S., Lee, C.-M., Moore, M. W., Gulati, M., Geun Lee, C., Elias, J. A., & Herzog, E. L. (2014). Chitinase 3–like 1 suppresses injury and promotes fibroproliferative responses in mammalian lung fibrosis. Science Translational Medicine, 6(240), 240ra76. https://doi.org/10.1126/scitranslmed.3007096
   Web of Science ®Google Scholar