Corneal Collagen Cross-Linking Complications

REFERENCES

• Vazirani J, Basu S. Keratoconus: Current perspectives. Clin Ophthalmol. 2013;7:2019–2030.
   PubMedGoogle Scholar
• Godefrooij D, De Wit GA, Uiterwaal CS, Imhof SM, Wisse RPL. Age-specific incidence and prevalence of keratoconus: A nationwide registration study. Am J Ophthalmol. 2017;175:169–172. 10.1016/j.ajo.2016.12.015.
   PubMed Web of Science ®Google Scholar
• Spadea L, Cantera E, Cortes M, Conocchia NE, Stewart CW. Corneal ectasia after myopic laser in situ keratomileusis: A long-term study. Clin Ophthalmol. 2012;6:1801–1813. 10.2147/OPTH.S37249.
   PubMedGoogle Scholar
• Wagner H, Barr JT, Zadnik K. Collaborative Longitudinal Evaluation of Keratoconus (CLEK) study: Methods and findings to date. Cont Lens Anterior Eye. 2007;30(4):223–232. 10.1016/j.clae.2007.03.001.
   PubMedGoogle Scholar
• O’Brart DP, Patel P, Lascaratos G, et al. Corneal cross-linking to halt the progression of keratoconus and corneal ectasia: Seven-year follow-up. Am J Ophthalmol. 2015;160:1154–1163. 10.1016/j.ajo.2015.08.023.
   PubMed Web of Science ®Google Scholar
• Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res. 1998;66:97–103. 10.1006/exer.1997.0410.
   PubMed Web of Science ®Google Scholar
• Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T. Safety of UVA-riboflavin cross-linking of the cornea. Cornea. 2007;26(4):385–389. 10.1097/ICO.0b013e3180334f78.
   PubMed Web of Science ®Google Scholar
• Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a–induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135(5):620–627. 10.1016/S0002-9394(02)02220-1.
   PubMed Web of Science ®Google Scholar
• Chen X, Stojanovic A, Eidet J, Utheim T. Corneal collagen cross-linking (CXL) in thin corneas. Eye Vis. 2015;2:15. 10.1186/s40662-015-0025-3.
   PubMedGoogle Scholar
• Randleman JB, Khandelwal SS, Hafezi F. Corneal cross-linking. Surv Ophthalmol. 2015;60(6):509–623. 10.1016/j.survophthal.2015.04.002.
   PubMed Web of Science ®Google Scholar
• Ghanem VC, Ghanem RC, De Oliveira R. Postoperative pain after corneal collagen cross-linking. Cornea. 2013;32(1):20–24. 10.1097/ICO.0b013e31824d6fe3.
   PubMed Web of Science ®Google Scholar
• Abbouda A, Abicca I, Alió JL. Infectious keratitis following corneal crosslinking: A systematic review of reported cases: Management, visual outcome, and treatment proposed. Semin Ophthalmol. 2016;31(5):485–491.
   PubMed Web of Science ®Google Scholar
• Sharma N, Maharana P, Singh G, Titiyal JS. Pseudomonas keratitis after collagen crosslinking for keratoconus: Case report and review of literature. J Cataract Refract Surg. 2010;36:517–520. 10.1016/j.jcrs.2009.08.041.
   PubMed Web of Science ®Google Scholar
• Zamora KV, Males JJ. Polymicrobial keratitis after a collagen cross-linking procedure with postoperative use of a contact lens: A case report. Cornea. 2009;28:474–476. 10.1097/ICO.0b013e31818d381a.
   PubMed Web of Science ®Google Scholar
• Kymionis GD, Portaliou DM, Bouzoukis DI, et al. Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. J Cataract Refract Surg. 2007;33:1982–1984. 10.1016/j.jcrs.2007.06.036.
   PubMed Web of Science ®Google Scholar
• Yuksel N, Bilgihan K, Hondur AM. Herpetic keratitis after corneal collagen cross-linking with riboflavin and ultraviolet-A for progressive keratoconus. Int Ophthalmol. 2011;31:513–515. 10.1007/s10792-011-9489-x.
   PubMedGoogle Scholar
• Soeters N, Wisse RP, Godefrooij DA, Imhof SM, Tahzib NG. Transepithelial versus epithelium-off corneal cross-linking for the treatment of progressive keratoconus: A randomized controlled trial. Am J Ophthalmol. 2015;159(5):821–828. 10.1016/j.ajo.2015.02.005.
   PubMed Web of Science ®Google Scholar
• Koller T, Mrochen M, Seiler T. Complication and failure rates after corneal crosslinking. J Cataract Refract Surg. 2009;35:1358–1362. 10.1016/j.jcrs.2009.03.035.
   PubMed Web of Science ®Google Scholar
• Ghanem RC, Netto MV, Ghanem VC, Santhiago MR, Wilson SE. Peripheral sterile corneal ring infiltrate after riboflavin-UVA collagen cross-linking in keratoconus. Cornea. 2012;31:702–705. 10.1097/ICO.0b013e318226da53.
   PubMed Web of Science ®Google Scholar
• Wittig-Silva C, Whiting M, Lamoureux E, Lindsay RG, Sullivan LJ, Snibson GR. A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: Preliminary results. J Refract Surg. 2008;24:S720–S725.
   PubMed Web of Science ®Google Scholar
• Arora R, Jain P, Gupta D, Goyal JL. Sterile keratitis after corneal collagen crosslinking in a child. Cont Lens Anterior Eye. 2012;35(5):233–235. 10.1016/j.clae.2012.06.002.
   PubMed Web of Science ®Google Scholar
• Kanellopoulos AJ. Long term results of a prospective randomized bilateral eye comparison trial of higher fluence, shorter duration ultraviolet A radiation, and riboflavin collagen cross linking for progressive keratoconus. Clin Ophthalmol. 2012;6:97–101. 10.2147/OPTH.S27170.
   PubMedGoogle Scholar
• Mohamed-Noriega K, Butrón-Valdez K, Vazquez-Galvan J, Mohamed-Noriega J, Cavazos-Adame H, Mohamed-Hamsho J. Corneal melting after collagen cross-linking for keratoconus in a thin cornea of a diabetic patient treated with topical nepafenac: A case report with a literature review. Case Rep Ophthalmol. 2016;7:119–124. 10.1159/000444437.
   PubMed Web of Science ®Google Scholar
• Faschinger C, Kleinert R, Wedrich A. [Corneal melting in both eyes after simultaneous corneal cross-linking in a patient with keratoconus and Down syndrome] [in German]. Ophthalmologe. 2010;107:951–955. 10.1007/s00347-009-2127-6.
   PubMed Web of Science ®Google Scholar
• Labiris G, Kaloghianni E, Koukoula S, Zissimopoulos A, Kozobolis VP. Corneal melting after collagen cross-linking for keratoconus: A case report. J Med Case Rep. 2011;5:152. 10.1186/1752-1947-5-152.
   PubMedGoogle Scholar
• Mazzotta C, Balestrazzi A, Baiocchi S, Traversi C, Caporossi A. Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in keratoconus: In vivo confocal microscopic evaluation. Clin Experiment Ophthalmol. 2007;35:580–582. 10.1111/j.1442-9071.2007.01536.x.
   PubMed Web of Science ®Google Scholar
• Kim BZ, Jordan CA, McGhee CN, Patel DV. Natural history of corneal haze after corneal collagen crosslinking in keratoconus using Scheimpflug analysis. J Cataract Refract Surg. 2016;42(7):1053–1059. 10.1016/j.jcrs.2016.04.019.
   PubMed Web of Science ®Google Scholar
• Mazzotta C, Hafezi F, Kymionis G, et al. In vivo confocal microscopy after corneal collagen crosslinking. Ocul Surf. 2015;13:298–314. 10.1016/j.jtos.2015.04.007.
   PubMed Web of Science ®Google Scholar
• Raiskup F, Hoyer A, Spoerl E. Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus. J Refract Surg. 2009;25:S824–S828. 10.3928/1081597X-20090813-12.
   PubMed Web of Science ®Google Scholar
• Sharma A, Nottage JM, Mirchia K, Sharma R, Mohan K, Nirankari VS. Persistent corneal edema after collagen cross-linking for keratoconus. Am J Ophthalmol. 2012;154(6):922–926. 10.1016/j.ajo.2012.06.005.
   PubMed Web of Science ®Google Scholar
• Kymionis GD, Portaliou DM, Diakonis VF, Kounis GA, Panagopoulou SI, Grentzelos MA. Corneal collagen cross-linking with riboflavin and ultraviolet-A irradiation in patients with thin corneas. Am J Ophthalmol. 2012;153:24–28. 10.1016/j.ajo.2011.05.036.
   PubMed Web of Science ®Google Scholar
• Hafezi F, Mrochen M, Iseli HP, Seiler T. Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas. J Cataract Refract Surg. 2009;35(4):621–624. 10.1016/j.jcrs.2008.10.060.
   PubMed Web of Science ®Google Scholar
• Kymionis GD, Diakonis VF, Coskunseven E, Jankov M, Yoo SH, Pallikaris IG. Customized pachymetric guided epithelial debridement for corneal collagen cross linking. BMC Ophthalmol. 2009;9:1–4. 10.1186/1471-2415-9-10.
   PubMed Web of Science ®Google Scholar
• Cagil N, Sarac O, Can GD, Akcay E, Can ME. Outcomes of corneal collagen crosslinking using a customized epithelial debridement technique in keratoconic eyes with thin corneas. Int Ophthalmol. 2017;37(1):103–109. 10.1007/s10792-016-0234-3.
   PubMed Web of Science ®Google Scholar
• Jacob S, Kumar DA, Agarwal A, Basu S, Sinha P, Agarwal A. Contact lens-assisted collagen cross-linking (CACXL): A new technique for cross-linking thin corneas. J Refract Surg. 2014;30:366–372. 10.3928/1081597X-20140523-01.
   PubMed Web of Science ®Google Scholar
• Cummings AB, Sinjab MM, Hatch KM, et al. Combined Corneal Cross Linking and Other Procedures: Indications and Application Models. In M.M. Sinjab and A. Cummings (eds.), Corneal Collagen Cross Linking, 1st ed. Switzerland: Springer International Publishing, 2017: 87–165.
   Google Scholar
• Filippello M, Stagni E, O’Brart D. Transepithelial corneal collagen crosslinking: Bilateral study. J Cataract Refract Surg. 2012;38(2):283–291. 10.1016/j.jcrs.2011.08.030.
   PubMed Web of Science ®Google Scholar
• Spadea L, Mencucci R. Transepithelial corneal collagen cross-linking in ultrathin keratoconic corneas. Clin Ophthalmol. 2012;6:1785–1792. 10.2147/OPTH.S37335.
   PubMedGoogle Scholar
• Caporossi A, Mazzotta C, Paradiso AL, Baiocchi S, Marigliani D, Caporossi T. Transepithelial corneal collagen crosslinking for progressive keratoconus: 24-month clinical results. J Cataract Refract Surg. 2013;39:1157–1163. 10.1016/j.jcrs.2013.03.026.
   PubMed Web of Science ®Google Scholar
• Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: Long-term results. J Cataract Refract Surg. 2008;34(5):796–801. 10.1016/j.jcrs.2007.12.039.
   PubMed Web of Science ®Google Scholar
• Stulting D, Woolfson J, Trattler W, Rubinfeld R. Effective corneal collagen crosslinking without removal of the epithelium. Paper presented at the American Society of Cataract and Refractive Surgery Annual Meeting; May 5–9, 2017; Los Angeles, CA, USA.
   Google Scholar
• Vinciguerra P, Romano V, Rosetta P, et al. Transepithelial iontophoresis versus standard corneal collagen cross-linking: 1-year results of a prospective clinical study. J Refract Surg. 2016;32(10):672–678. 10.3928/1081597X-20160629-02.
   PubMed Web of Science ®Google Scholar
• Bikbova G, Bikbov M. Transepithelial corneal collagen crosslinking by iontophoresis of riboflavin. Acta Ophthalmol. 2014;92(1):e30–34. 10.1111/aos.12235.
   PubMed Web of Science ®Google Scholar
• Caruso C, Ostacolo C, Epstein RL, Barbaro G, Troisi S, Capobianco D. Transepithelial corneal cross-linking with vitamin E-enhanced riboflavin solution and abbreviated, low-dose UV-A: 24-month clinical outcomes. Cornea. 2016;35(2):145–150. 10.1097/ICO.0000000000000699.
   PubMed Web of Science ®Google Scholar
• Kymionis GD, Bouzoukis DI, Diakonis VF, Portaliou DM, Pallikaris AI, Yoo SH. Diffuse lamellar keratitis after corneal crosslinking in a patient with post-laser in situ keratomileusis corneal ectasia. J Cataract Refract Surg. 2007;33:2135–2137. 10.1016/j.jcrs.2007.06.070.
   PubMed Web of Science ®Google Scholar
• Yildirim A, Cakir H, Kara N, et al. Corneal collagen crosslinking for ectasia after laser in situ keratomileusis: Long-term results. J Cataract Refract Surg. 2014;40(1):1591–1596. 10.1016/j.jcrs.2014.01.042.
   PubMed Web of Science ®Google Scholar
• Agrawal V. Long-term results of cornea collagen cross-linking with riboflavin for keratoconus. Indian J Ophthalmol. 2013;61(8):433–434. 10.4103/0301-4738.116072.
   PubMed Web of Science ®Google Scholar
• Wisse RP, Godefrooij DA, Soeters N, Imhof SM, Van Der Lelij A. A multivariate analysis and statistical model for predicting visual acuity and keratometry one year after cross-linking for keratoconus. Am J Ophthalmol. 2014;157(3):519–525.e1–2. 10.1016/j.ajo.2013.11.001.
   PubMed Web of Science ®Google Scholar
• Hafezi F. Limitation of collagen cross-linking with hypoosmolar riboflavin solution: Failure in an extremely thin cornea. Cornea. 2011;30:917–919. 10.1097/ICO.0b013e31820143d1.
   PubMed Web of Science ®Google Scholar
• Sarac OB, Caglayan M, Cakmak H, Cagil N. Factors influencing progression of keratoconus 2 years after corneal collagen cross-linking in pediatric patients. Cornea. 2016;35(12):1503–1507. 10.1097/ICO.0000000000001051.
   PubMed Web of Science ®Google Scholar