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The potential role of interleukin-37 in infectious diseases

Role of IL-37 in HIV-1, viral myocarditis, HCV, HBV, tuberculosis, leprosy, pneumonia, listeria, aspergillosis, candidiasis, and eumycetoma infection

ORCID Icon, , &
Pages 3-10 | Received 17 Apr 2019, Accepted 01 Oct 2019, Published online: 21 Oct 2019

References

  • Dinarello CA. Keep up the heat on IL-1. Blood 2012;120(13):2538–2539. doi:10.1182/blood-2012-08-445254.
  • Dinarello CA. Why not treat human cancer with interleukin-1 blockade? Cancer Metastasis Rev 2010;29(2):317–329. doi:10.1007/s10555-010-9229-0.
  • Wang M, Wang B, Ma Z, et al. Detection of the novel IL-1 family cytokines by QAH-IL1F-1 assay in rheumatoid arthritis. Cell Mol Biol (Noisy-le-grand) 2016;62(4):31–34.
  • Dinarello CA. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011;117(14):3720–3732. doi:10.1182/blood-2010-07-273417.
  • Dinarello CA, Nold-Petry C, Nold M, et al. Suppression of innate inflammation and immunity by interleukin-37. Eur J Immunol 2016;46(5):1067–1081. doi:10.1002/eji.201545828.
  • Jia H, Liu J, Han B. Reviews of interleukin-37: functions, receptors, and roles in diseases. Biomed Res Int 2018;2018:1. doi:10.1155/2018/3058640.
  • Quirk S, Agrawal DK. Immunobiology of IL-37: mechanism of action and clinical perspectives. Expert Rev Clin Immunol 2014;10(12):1703–1709. doi:10.1586/1744666X.2014.971014.
  • Banchereau J, Pascual V, O'garra A. From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nat Immunol 2012;13(10):925. doi:10.1038/ni.2406.
  • Nold MF, Nold-Petry CA, Zepp JA, et al. IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol 2010;11(11):1014. doi:10.1038/ni.1944.
  • Cavalli G, Dinarello CA. Suppression of inflammation and acquired immunity by IL-37. Immunol Rev 2018;281(1):179–190. doi:10.1111/imr.12605.
  • Belladonna ML, Grohmann U. Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agents. Biotechnol Genet Eng Rev 2013;29(2):149–174. doi:10.1080/02648725.2013.801228.
  • Boraschi D, Lucchesi D, Hainzl S, et al. IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur Cytokine Netw 2011;22:127–147. doi:10.1684/ecn.2011.0288.
  • Bulau A-M, Nold MF, Li S, et al. Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. Proc Natl Acad Sci USA 2014;111(7):2650–2655. doi:10.1073/pnas.1324140111.
  • Nold-Petry CA, Lo CY, Rudloff I, et al. IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol 2015;16(4):354. doi:10.1038/ni.3103.
  • Garlanda C, Anders H-J, Mantovani A. TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization. Trends Immunol 2009;30(9):439–446. doi:10.1016/j.it.2009.06.001.
  • Garlanda C, Riva F, Bonavita E, et al. Negative regulatory receptors of the IL-1 family. Semin Immunol 2013;25(6):408–415. doi:10.1016/j.smim.2013.10.019.
  • Barry J, Loh Z, Collison A, et al. Absence of Toll–IL-1 receptor 8/single immunoglobulin IL-1 receptor-related molecule reduces house dust mite–induced allergic airway inflammation in mice. Am J Respir Cell Mol Biol 2013;49(3):481–490. doi:10.1165/rcmb.2012-0425OC.
  • Boraschi D, Italiani P, Weil S, et al. The family of the interleukin-1 receptors. Immunol Rev 2018;281(1):197–232. doi:10.1111/imr.12606.
  • Li S, Neff CP, Barber K, et al. Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8. Proc Natl Acad Sci USA 2015;112(8):2497–2502. doi:10.1073/pnas.1424626112.
  • Luo Y, Cai X, Liu S, et al. Suppression of antigen-specific adaptive immunity by IL-37 via induction of tolerogenic dendritic cells. Proc Natl Acad Sci USA 2014;111(42):15178–15183. doi:10.1073/pnas.1416714111.
  • Wiercinska-Drapalo A, Flisiak R, Jaroszewicz J, et al. Increased plasma transforming growth factor-beta1 is associated with disease progression in HIV-1-infected patients. Viral Immunol 2004;17:109–113. doi:10.1089/088282404322875502.
  • Garba ML, Pilcher CD, Bingham AL, et al. HIV antigens can induce TGF-beta(1)-producing immunoregulatory CD8+ T cells. J Immunol 2002;168(5):2247–2254. doi:10.4049/jimmunol.168.5.2247.
  • Hojen JF, Rasmussen TA, Andersen KL, Winckelmann AA, et al. Interleukin-37 expression is increased in chronic HIV-1-infected individuals and is associated with inflammation and the size of the total viral reservoir. Mol Med 2015;21:337–345. doi:10.2119/molmed.2015.00031.
  • An B, Liu X, Li G, et al. Interleukin-37 ameliorates Coxsackievirus B3-induced viral myocarditis by modulating the Th17/regulatory T cell immune response. J Cardiovasc Pharmacol 2017;69(5):305–313. doi:10.1097/FJC.0000000000000476.
  • Huang Z, Gao C, Chi X, et al. IL-37 expression is upregulated in patients with tuberculosis and induces macrophages towards an M2-like phenotype. Scand J Immunol 2015;82(4):370–379. doi:10.1111/sji.12326.
  • Hoebe K, Janssen E, Beutler B. The interface between innate and adaptive immunity. Nat Immunol 2004;5(10):971–974. doi:10.1038/ni1004-971.
  • Shuai X, Wei-Min L, Tong YL, et al. Expression of IL-37 contributes to the immunosuppressive property of human CD4 + CD25+ regulatory T cells. Sci Rep 2015;5(1):14478. doi:10.1038/srep14478.
  • Schauer AE, Klassert TE, von Lachner C, et al. IL-37 causes excessive inflammation and tissue damage in murine pneumococcal pneumonia. J Innate Immun 2017;9(4):403–418. doi:10.1159/000469661.
  • Zhao M, Hu Y, Shou J, et al. IL-37 impairs host resistance to Listeria infection by suppressing macrophage function. Biochem Biophys Res Commun 2017;485(2):563–568. doi:10.1016/j.bbrc.2016.11.002.
  • Moretti S, Bozza S, Oikonomou V, et al. IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis. PLoS Pathog 2014;10(11):e1004462. doi:10.1371/journal.ppat.1004462.
  • Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence 2013;4(2):119–128. doi:10.4161/viru.22913.
  • van de Veerdonk FL, Gresnigt MS, Oosting M, et al. Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37. Front Microbiol 2015;5(762):1–6. doi:10.3389/fmicb.2014.00762.
  • Zhao L, Fu Z. Roles of host immunity in viral myocarditis and dilated cardiomyopathy. J Immunol Res 2018;2018:1. doi:10.1155/2018/5301548.
  • Spartalis M, Tzatzaki E, Spartalis E, et al. Parvovirus B19 myocarditis of fulminant evolution. Cardiol Res 2017;8(4):172–175. doi:10.14740/cr580w.
  • Fairweather D, Frisancho-Kiss S, Rose NR. Viruses as adjuvants for autoimmunity: evidence from Coxsackievirus-induced myocarditis. Rev Med Virol 2005;15(1):17–27. doi:10.1002/rmv.445.
  • Frisancho-Kiss S, Davis SE, Nyland JF, et al. Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease. J Immunol 2007;178(11):6710–6714. doi:10.4049/jimmunol.178.11.6710.
  • Jung MK, Shin E-C. Regulatory T cells in hepatitis B and C virus infections. Immune Netw 2016;16(6):330–336. doi:10.4110/in.2016.16.6.330.
  • Li C, Ji H, Cai Y, et al. Serum interleukin-37 concentrations and HBeAg seroconversion in chronic HBV patients during telbivudine treatment. J Interferon Cytokine Res 2013;33(10):612–618. doi:10.1089/jir.2013.0001.
  • Ding S-X, Ma J-B, Hu Y-R, et al. Outcomes of interferon/ribavirin therapy in patients with HCV defined by expression of plasma soluble human leukocyte antigen-G but not IL-37. Med Sci Monit 2016;22:1398–1402. doi:10.12659/MSM.895971.
  • Yates TA, Khan PY, Knight GM, et al. The transmission of Mycobacterium tuberculosis in high burden settings. Lancet Infect Dis 2016;16(2):227–238. doi:10.1016/S1473-3099(15)00499-5.
  • Allam G, Mohamed IA, Alswat KA, et al. Association of IL-37 gene polymorphisms with susceptibility to tuberculosis in Saudi subjects. Microbiol Immunol 2016;60(11):778–786. doi:10.1111/1348-0421.12444.
  • Flynn JL, Chan J, Triebold KJ, et al. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 1993;178(6):2249–2254. doi:10.1084/jem.178.6.2249.
  • Cooper AM, Magram J, Ferrante J, et al. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J Exp Med 1997;186(1):39–45. doi:10.1084/jem.186.1.39.
  • Murray PJ, Young RA. Increased antimycobacterial immunity in interleukin-10-deficient mice. Infect Immun 1999;67(6):3087–3095.
  • Beamer GL, Flaherty DK, Assogba BD, et al. Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice. J Immunol 2008;181(8):5545–5550. doi:10.4049/jimmunol.181.8.5545.
  • Fulton S, Cross J, Toossi Z, et al. Regulation of interleukin-12 by interleukin-10, transforming growth factor-β, tumor necrosis factor-α, and interferon-γ in human monocytes infected with Mycobacterium tuberculosis H37Ra. J Infect Dis 1998;178(4):1105–1114. doi:10.1086/515698.
  • Toossi Z, Gogate P, Shiratsuchi H, et al. Enhanced production of TGF-beta by blood monocytes from patients with active tuberculosis and presence of TGF-beta in tuberculous granulomatous lung lesions. J Immunol 1995;154(1):465–473.
  • Gonzalez-Juarrero M, Shim TS, Kipnis A, et al. Dynamics of macrophage cell populations during murine pulmonary tuberculosis. J Immunol 2003;171(6):3128–3135. doi:10.4049/jimmunol.171.6.3128.
  • Mariani F, Goletti D, Ciaramella A, et al. Macrophage response to Mycobacterium tuberculosis during HIV infection: relationships between macrophage activation and apoptosis. CMM 2001;1(2):209–216. doi:10.2174/1566524013363933.
  • Benoit M, Desnues B, Mege JL. Macrophage polarization in bacterial infections. J Immunol 2008;181(6):3733–3739. doi:10.4049/jimmunol.181.6.3733.
  • Murray PJ, Wynn TA. Obstacles and opportunities for understanding macrophage polarization. J Leukoc Biol 2011;89(4):557–563. doi:10.1189/jlb.0710409.
  • Schreiber T, Ehlers S, Heitmann L, et al. Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity. J Immunol 2009;183(2):1301–1312. doi:10.4049/jimmunol.0803567.
  • Hajishengallis G, Lambris JD. Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol 2011;11(3):187–200. doi:10.1038/nri2918.
  • Zhang JA, Liu GB, Zheng BY, et al. Tuberculosis-sensitized monocytes sustain immune response of interleukin-37. Mol Immunol 2016;79:14–21. doi:10.1016/j.molimm.2016.09.018.
  • Jozefowski S, Sobota A, Pawlowski A, et al. Mycobacterium tuberculosis lipoarabinomannan enhances LPS-induced TNF-alpha production and inhibits NO secretion by engaging scavenger receptors. Microb Pathog 2011;50:350–359. doi:10.1016/j.micpath.2011.03.001.
  • Mahon RN, Sande OJ, Rojas RE, et al. Mycobacterium tuberculosis ManLAM inhibits T-cell-receptor signaling by interference with ZAP-70, Lck and LAT phosphorylation. Cell Immunol 2012;275(1–2):98–105. doi:10.1016/j.cellimm.2012.02.009.
  • Geijtenbeek TB, Van Vliet SJ, Koppel EA, et al. Mycobacteria target DC-SIGN to suppress dendritic cell function. J Exp Med 2003;197(1):7–17. doi:10.1084/jem.20021229.
  • Huang Z, Zhao GW, Gao CH, et al. Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis induces IL-37 production via upregulating ERK1/2 and p38 in human type II alveolar epithelial cells. Int J Clin Exp Med 2015; 8:7279–7287.
  • Guo XG, Ji TX, Xia Y, et al. Autophagy protects type II alveolar epithelial cells from Mycobacterium tuberculosis infection. Biochem Biophys Res Commun 2013;432(2):308–313. doi:10.1016/j.bbrc.2013.01.111.
  • Mazurek J, Ignatowicz L, Kallenius G, et al. Divergent effects of mycobacterial cell wall glycolipids on maturation and function of human monocyte-derived dendritic cells. PLoS One 2012;7(8):e42515. doi:10.1371/journal.pone.0042515.
  • Jarnicki AG, Conroy H, Brereton C, et al. Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics. J Immunol 2008;180(6):3797–3806. doi:10.4049/jimmunol.180.6.3797.
  • Talhari C, Talhari S, Penna GO. Clinical aspects of leprosy. Clin Dermatol 2015;33(1):26–37. doi:10.1016/j.clindermatol.2014.07.002.
  • de Sousa JR, Prudente RL, Dias Junior LB, et al. IL-37 and leprosy: a novel cytokine involved in the host response to Mycobacterium leprae infection. Cytokine 2018;106:89–94. doi:10.1016/j.cyto.2017.10.016.
  • O'Brien KL, Wolfson LJ, Watt JP, et al. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 2009;374:893–902. doi:10.1016/S0140-6736(09)61204-6.
  • Calbo E, Alsina M, Rodriguez-Carballeira M, et al. The impact of time on the systemic inflammatory response in pneumococcal pneumonia. Eur Respir J 2010;35(3):614–618. doi:10.1183/09031936.00052709.
  • Charlier C, Perrodeau E, Leclercq A, et al. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. Lancet Infect Dis 2017;17:510–519.
  • Kosmidis C, Denning DW. The clinical spectrum of pulmonary aspergillosis. Thorax 2015;70(3):270–277. doi:10.1136/thoraxjnl-2014-206291.
  • Kritas SK, Gallenga CE, D Ovidio C, et al. Impact of mold on mast cell-cytokine immune response. J Biol Regul Homeost Agents 2018;32(4):763–768.
  • Sun Y, Abbondante S, Karmakar M, et al. Neutrophil caspase-11 is required for cleavage of caspase-1 and secretion of IL-1beta in Aspergillus fumigatus infection. J Immunol 2018;201(9):2767–2775. doi:10.4049/jimmunol.1701195.
  • Gallenga C, Pandolfi F, Caraffa A, et al. Interleukin-1 family cytokines and mast cells: activation and inhibition. J Biol Regul Homeost Agents 2019;33(1):1–6.
  • Tettamanti L, Kritas S, Gallenga C, et al. IL-33 mediates allergy through mast cell activation: potential inhibitory effect of certain cytokines. J Biol Regul Homeost Agents 2018;32(5):1061–1065.
  • Kwok SC, Schelenz S, Wang X, et al. In vitro effect of DNA topoisomerase inhibitors on Candida albicans. Med Mycol 2010;48(1):155–160. doi:10.3109/13693780903114934.
  • Fahal A, Mahgoub el S, El Hassan AM, et al. Mycetoma in the Sudan: an update from the Mycetoma Research Centre, University of Khartoum, Sudan. PLoS Negl Trop Dis 2015;9(3):e0003679. doi:10.1371/journal.pntd.0003679.
  • Abushouk A, Nasr A, Masuadi E, et al. The role of interleukin-1 cytokine family (IL-1beta, IL-37) and interleukin-12 cytokine family (IL-12, IL-35) in eumycetoma infection pathogenesis. PLoS Negl Trop Dis 2019;13(4):e0007098. doi:10.1371/journal.pntd.0007098.

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