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Laboratory Studies

Does Haloperidol Have Side Effects on Histological and Stereological Structure of the Rat Kidneys?

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Pages 573-581 | Received 25 Mar 2009, Accepted 17 May 2009, Published online: 09 Sep 2009

REFERENCES

  • Borc JJ, Larson DB, Lyons JS, Beardsley RS. Expenditures for psychotropic medications in the United States. Am J Psychiatry. 1991; 148: 644–647
  • Baldessarini RJ, Frankenburg FR. Clozapine: A novel antipsychotic agent. N Engl J Med. 1991; 324: 746–754
  • Levenson JL. Neuroleptic malignant syndrome. Am J Psychiatry. 1985; 142: 1137–1145
  • Sovner R, Dimascio A, Killam F. Psychopharmacology: A generation of progress. Extrapyrmidal syndromes and the other neurological side effects of psychotropic drugs, MA Lipton, F Killam. Raven Press, , New York 1978; 1021–1032, In:(eds.)
  • Vilner BJ, Bowen WD. Sigma receptor-active neuroleptics are cytotoxic to C6 glioma cells in culture. Eur J Pharmacol. 1993; 244: 199–201
  • Vilner BJ, De Costa BR, Bowen WD. Cytotoxic effects of sigma ligands: Sigma receptor-mediated alterations in cellular morphology and viability. J Neurosci. 1995; 15: 117–134
  • Behl C, Lezoulac'h F, Widmann M, Rupprecht R, Holsboer F. Oxidative stress-resistant cells are protected against haloperidol toxicity. Brain Res. 1996; 717: 193–195
  • Halici Z, Dursun H, Keles ON, et al. Effect of chronic treatment of haloperidol on the rat liver: A stereological and histopathological study. Naunyn Schmiedebergs Arch Pharmacol. 2009; 379: 253–261
  • Gepdiremen A, Aydin N, Halici Z, Sahin O, Unal B, Aydin MD, Bakuridze K. Chronic treatment of haloperidol causes vasoconstriction on basilar arteries of rats, dose dependently. Pharmacol Res. 2004; 50: 569–574
  • Sarsilmaz M, Kaplan S, Songur A, et al. Effects of postnatal formaldehyde exposure on pyramidal cell number, volume of cell layer in hippocampus and hemisphere in the rat: A stereological study. Brain Res. 2007; 1145: 157–167
  • Razga Z, Nyengaard JR. Estimation of the number of angiotensin II AT1 receptors in rat kidney afferent and efferent arterioles. Anal Quant Cytol Histol. 2007; 29: 208–216
  • Medeiros FJ, Aguila MB, Mandarim-de-Lacerda CA. Renal cortex remodeling in streptozotocin-induced diabetic spontaneously hypertensive rats treated with olive oil, palm oil and fish oil from Menhaden. Prostaglandins Leukot Essent Fatty Acids. 2006; 75: 357–365
  • Mayhew TM. Second-order stereology and ultrastructural examination of the spatial arrangements of tissue compartments within glomeruli of normal and diabetic kidneys. J Microsc. 1999; 195: 87–95
  • Bertram JF. Analyzing renal glomeruli with the new stereology. Int Rev Cytol. 1995; 161: 111–172
  • Chang WH, Jaw SS, Tsay L. Chronic haloperidol treatment with low doses may enhance the increase of homovanillic acid in rat brain. Eur J Pharmacol. 1989; 62: 151–156
  • Di Matteo V, Cacchio M, Di Giulio C, Di Giovanni G, Esposito E. Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT(2C) receptors in vivo. Pharmacol Biochem Behav. 2002; 71: 607–613
  • Cruz-Orive LM, Weibel ER. Recent stereological methods for cell biology: A brief survey. Am J Physiol. 1990; 258: 148–156
  • Gundersen HJ, Bagger P, Bendtsen TF, et al. The new stereological tools: Dissector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988; 96: 857–881
  • Tunc AT, Turgut M, Aslan H, et al. Neonatal pinealectomy induces Purkinje cell loss in the cerebellum of the chick: A stereological study. Brain Res. 2006; 1067: 95–102
  • Gundersen HJG, Jensen EB. The efficacy of systematic sampling in stereology and its prediction. J Microsc. 1987; 147: 229–263
  • Sterio DC. The unbiased estimation of number and sizes of arbitrary particles using the dissector. J Microsc. 1984; 134: 127–136
  • Unal B, Özbek E, Aydin MD, et al. Effect of haloperidol on the numerical density of neurons and nuclear height in the rat hippocampus: A stereological and histopathological study. Neurosci Res Commun. 2004; 34: 1–9
  • Kaplan S, Gokyar A, Unal B, et al. A simple technique for localizing consecutive fields for dissector pairs in light microscopy: Application to neuron counting in rabbit spinal cord following spinal cord injury. J Neurosci Methods. 2005; 145: 277–284
  • Cunha AR, Aguila MB, Mandarim-de-Lacerda CA. Effects of early postnatal hyperglycaemia on renal cortex maturity, endothelial nitric oxide synthase expression and nephron deficit in mice. Int J Exp Pathol. 2008; 89: 284–291
  • Piecha G, Koleganova N, Gross ML, Geldyyev A, Adamczak M, Ritz E. Regression of glomerulosclerosis in subtotally nephrectomized rats: Effects of monotherapy with losartan, spironolactone, and their combination. Am J Physiol Renal Physiol. 2008; 295: 137–144
  • Seitz DP, Gill SS. Neuroleptic malignant syndrome complicating antipsychotic treatment of delirium or agitation in medical and surgical patients: Case reports and a review of the literature. Psychosomatics. 2009; 50: 8–15
  • Sanai T, Matsui R, Hirano T, et al. Successful treatment of six patients with neuroleptic malignant syndrome associated with myoglobulinemic acute renal failure. Ren Fail. 2006; 28: 51–55
  • Sala MA, Valeri V, Matheus M, Marcos R, Monteiro RA, Rocha E. Stereological analysis of syncytiotrophoblast from human mature placenta. Arch Anat Microsc Morphol Exp. 1983; 72: 99–106
  • Marcos R, Monteiro RA, Rocha E. Design-based stereological estimation of hepatocyte number, by combining the smooth optical fractionator and immunocytochemistry with anti-carcinoembryonic antigen polyclonal antibodies. Liver Int. 2006; 26: 116–124

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