2,301
Views
4
CrossRef citations to date
0
Altmetric
Clinical Study

The effect of body mass index on the development of acute kidney injury and mortality in intensive care unit: is obesity paradox valid?

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 543-555 | Received 24 Aug 2020, Accepted 03 Mar 2021, Published online: 22 Mar 2021

References

  • Wang S, Liu X, Chen Q, et al. The role of increased body mass index in outcomes of sepsis: a systematic review and meta-analysis. BMC Anesthesiol. 2017;17(1):118.
  • Flegal KM, Carroll MD, Kuczmarski RJ, et al. Overweight and obesity in the United States: prevalence and trends, 1960–1994. Int J Obes Relat Metab Disord. 1998;22(1):39–47.
  • Flegal KM, Carroll MD, Ogden CL, et al. Prevalence and trends in obesity among US adults, 1999–2008. JAMA. 2010;303(3):235–241.
  • Macha M, Molina EJ, Franco M, et al. Pre-transplant obesity in heart transplantation: are there predictors of worse outcomes? Scand Cardiovasc J. 2009;43(5):304–310.
  • Schetz M, De Jong A, Deane AM, et al. Obesity in the critically ill: a narrative review. Intensive Care Med. 2019;45(6):757–769.
  • Robinson MK, Mogensen KM, Casey JD, et al. The relationship among obesity, nutritional status, and mortality in the critically ill. Crit Care Med. 2015;43(1):87–100.
  • Sakr Y, Madl C, Filipescu D, et al. Obesity is associated with increased morbidity but not mortality in critically ill patients. Intensive Care Med. 2008;34(11):1999–2009.
  • Shashaty MG, Stapleton RD. Physiological and management implications of obesity in critical illness. Ann Am Thorac Soc. 2014;11(8):1286–1297.
  • Wacharasint P, Fuengfoo P, Rangsin R, et al. Prevalence and impact of overweight and obesity in critically ill surgical patients: analysis of THAI-SICU study. J Med Assoc Thai. 2016;99(6):55–62.
  • Joffe A, Wood K. Obesity in critical care. Curr Opin Anaesthesiol. 2007;20(2):113–118.
  • Nasraway SA Jr, Albert M, Donnelly AM, et al. Morbid obesity is an independent determinant of death among surgical critically ill patients. Crit Care Med. 2006;34(4):964–970.
  • Goulenok C, Monchi M, Chiche JD, et al. Influence of overweight on ICU mortality: a prospective study. Chest. 2004;125(4):1441–1445.
  • Bercault N, Boulain T, Kuteifan K, et al. Obesity-related excess mortality rate in an adult intensive care unit: a risk-adjusted matched cohort study. Crit Care Med. 2004;32:998–1003.
  • Akinnusi ME, Pineda LA, El Solh AA. Effect of obesity on intensive care morbidity and mortality: a meta-analysis. Crit Care Med. 2008;36:151–158.
  • Oliveros H, Villamor E. Obesity and mortality in critically ill adults: a systematic review and meta-analysis. Obesity (Silver Spring). 2008;16(3):515–521.
  • Ni YN, Luo J, Yu H, et al. Can body mass index predict clinical outcomes for patients with acute lung injury/acute respiratory distress syndrome? Crit Care. 2017;21(1):36.
  • Schiffl H. Obesity and the survival of critically ill patients with acute kidney injury: a paradox within the paradox? Kidney Dis. 2020;6(1):13–21.
  • Druml W, Metnitz B, Schaden E, et al. Impact of body mass on incidence and prognosis of acute kidney injury requiring renal replacement therapy. Intensive Care Med. 2010;36(7):1221–1228.
  • Chao CT, Wu VC, Tsai HB, et al. Impact of body mass on outcomes of geriatric postoperative acute kidney injury patients. Shock. 2014;41(5):400–405.
  • Kim H, Kim H, Lee M, et al. The impact of disease severity on paradoxical association between body mass index and mortality in patients with acute kidney injury undergoing continuous renal replacement therapy. BMC Nephrol. 2018;19(1):32.
  • Pedersen AB, Gammelager H, Kahlert J, et al. Impact of body mass index on risk of acute kidney injury and mortality in elderly patients undergoing hip fracture surgery. Osteoporos Int. 2017;28(3):1087–1097.
  • Soto GJ, Frank AJ, Christiani DC, et al. Body mass index and acute kidney injury in the acute respiratory distress syndrome. Crit Care Med. 2012;40(9):2601–2608.
  • Danziger J, Chen KP, Lee J, et al. Obesity, acute kidney injury, and mortality in critical illness. Crit Care Med. 2016;44(2):328–334.
  • Gameiro J, Gonçalves M, Pereira M, et al. Obesity, acute kidney injury and mortality in patients with sepsis: a cohort analysis. Ren Fail. 2018;40(1):120–126.
  • Kidney International Supplements. 2012. 2, 1;
  • World Health Organization: Body mass index – BMI. [cited 2020 Aug 20]. Available from: http://www.euro.who.int/en/health-topics/disease-prevention/nutrition/a-healthy-lifestyle/body-mass-index-bmi.
  • Yap CH, Mohajeri M, Yii M. Obesity and early complications after cardiac surgery. Med J Aust. 2007;186(7):350–354.
  • Chagnac A, Weinstein T, Korzets A, et al. Glomerular hemodynamics in severe obesity. Am J Physiol Renal Physiol. 2000;278(5):F817–F822.
  • Chagnac A, Weinstein T, Herman M, et al. The effects of weight loss on renal function in patients with severe obesity. J Am Soc Nephrol. 2003;14(6):1480–1486.
  • Cheng CF, Lian WS, Chen SH, et al. Protective effects of adiponectin against renal ischemia-reperfusion injury via prostacyclin-PPARα-heme oxygenase-1 signaling pathway . J Cell Physiol. 2012;227(1):239–249.
  • Han DC, Isono M, Chen S, et al. Leptin stimulates type I collagen production in db/db mesangial cells: glucose uptake and TGF-beta type II receptor expression. Kidney Int. 2001;59(4):1315–1323.
  • Nakamura K, Fuster JJ, Walsh K. Adipokines: a link between obesity and cardiovascular disease. J Cardiol. 2014;63(4):250–259.
  • Ng PY, Eikermann M. The obesity conundrum in sepsis. BMC Anesthesiol. 2017;17(1):147.
  • Yamahara K, Kume S, Koya D. Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. J Am Soc Nephrol. 24(11):1769–1781.
  • Mullens W, Abrahams Z, Francis GS, et al. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol. 2009;53(7):589–596.
  • Kim IB, Prowle J, Baldwin I, et al. Incidence, risk factors and outcome associations of intra-abdominal hypertension in critically ill patients. Anaesth Intensive Care. 2012;40(1):79–89.
  • Glance LG, Wissler R, Mukamel DB, et al. Perioperative outcomes among patients with the modified metabolic syndrome who are undergoing noncardiac surgery. Anesthesiology. 2010;113(4):859–852.
  • Duane TM, Dechert T, Aboutanos MB, et al. Obesity and outcomes after blunt trauma. J Trauma. 2006;61:1218–1221.
  • Varon J, Marik P. Management of the obese critically ill patient. Crit Care Clin. 2001;17(1):187–200.
  • De Jong A, Wrigge H, Hedenstierna G, et al. How to ventilate obese patients in the ICU. Intensive Care Med. 2020;46(12):2423–2435.
  • Lee CK, Tefera E, Colice G. The effect of obesity on outcomes in mechanically ventilated patients in a medical intensive care unit. Respiration. 2014;87(3):219–226.
  • O’Brien JM, Philips GS, Ali NA, et al. The association between body mass index, processes of care, and outcomes from mechanical ventilation: a prospective cohort study. Crit Care Med. 2012;40(5):1456–1463.
  • Pepin J, Borel JC, Janssens JP. Obesity hypoventilation syndrome: an underdiagnosed and undertreated condition . Am J Respir Crit Care Med. 2012;186(12):1205–1207.
  • Chlif M, Keochkerian D, Choquet D, et al. Effects of obesity on breathing pattern, ventilatory neural drive and mechanics. Respir Physiol Neurobiol. 2009;168(3):198–202.
  • Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol (1985). 2010;108(1):206–211.
  • Pelosi P, Croci M, Ravagnan I, et al. Total respiratory system, lung, and chest wall mechanics in sedated-paralyzed postoperative morbidly obese patients. Chest. 1996;109(1):144–151.
  • Kress JP, Pohlman AS, Alverdy J, et al. The impact of morbid obesity on oxygen cost of breathing (VO(2RESP)) at rest. Am J Respir Crit Care Med. 1999;160(3):883–886.
  • De Jong A, Chanques G, Jaber S. Mechanical ventilation in obese ICU patients: from intubation to extubation. Crit Care. 2017;21(1):63.
  • Sakr Y, Elia C, Mascia L, et al. Being overweight or obese is associated with decreased mortality in critically ill patients: a retrospective analysis of a large regional Italian multicenter cohort. J Crit Care. 2012;27(6):714–721.
  • Gong MN, Bajwa EK, Thompson BT, et al. Body mass index is associated with the development of acute respiratory distress syndrome. Thorax. 2010;65(1):44–50.
  • Ju S, Lee TW, Yoo JW, et al. Body Mass Index as a predictor of acute kidney injury in critically ill patients: a retrospective single-center study. Tuberc Respir Dis. 2018;81(4):311–318.
  • Winkelman C, Maloney B, Kloos J. The impact of obesity on critical care resource use and outcomes. Crit Care Nurs Clin North Am. 2009;21(3):403–422.
  • Pepper DJ, Sun J, Welsh J, et al. Increased body mass index and adjusted mortality in ICU patients with sepsis or septic shock: a systematic review and meta-analysis. Crit Care. 2016;20(1):181.
  • Tocalini P, Vicente A, Amoza RL, et al. Asociación entre obesidad y mortalidad en pacientes adultos que reciben ventilación mecánica invasiva: una revisión sistemática y metaanálisis. Med Intens; 2018;44:18–26.
  • Wang H, Shi Y, Bai Z-H, et al. Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy. Ren Fail. 2019;41(1):726–732.
  • Falagas ME, Athanasoulia AP, Peppas G, et al. Effect of body mass index on the outcome of infections: a systematic review. Obes Rev. 2009;10(3):280–289.
  • Kim H, Kim J, Seo C, et al. Body mass index is inversely associated with mortality in patients with acute kidney injury undergoing continuous renal replacement therapy. Kidney Res Clin Pract. 2017;36(1):39–47.
  • Deng F, Peng M, Li J, et al. Nomogram to predict the risk of septic acute kidney injury in the first 24 h of admission: an analysis of intensive care unit data. Ren Fail. 2020;42(1):428–436.