Dominant factors of the phosphorus regulatory network differ under various dietary phosphate loads in healthy individuals

References

• Wolfe‐ S, Switzer J, Kulp TR, et al. A bacterium that can grow by using arsenic instead of phosphorus. Science. 2011;332(6034):1163–1166.
   PubMed Web of Science ®Google Scholar
• Chande S, Bergwitz C. Role of phosphate sensing in bone and mineral metabolism. Nat Rev Endocrinol. 2018;14(11):637–655.
   PubMed Web of Science ®Google Scholar
• Hu MC, Shi M, Zhang J, et al. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. Faseb J. 2010;24(9):3438–3450.
   PubMed Web of Science ®Google Scholar
• Haarhaus M, Brandenburg V, Kalantar-Zadeh K, et al. Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD. Nat Rev Nephrol. 2017;13(7):429–442.
   PubMed Web of Science ®Google Scholar
• López I, Rodríguez-Ortiz ME, Almadén Y, et al. Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo. Kidney Int. 2011;80(5):475–482.
   PubMed Web of Science ®Google Scholar
• Quarles LD. Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism. Nat Rev Endocrinol. 2012;8(5):276–286.
   PubMed Web of Science ®Google Scholar
• Breslau NA. Normal and abnormal regulation of 1,25-(OH)2D synthesis. Am J Med Sci. 1988;296(6):417–425.
   PubMed Web of Science ®Google Scholar
• Nishida Y, Taketani Y, Yamanaka-Okumura H, et al. Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men. Kidney Int. 2006;70(12):2141–2147.
   PubMed Web of Science ®Google Scholar
• Hasegawa H, Nagano N, Urakawa I, et al. Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease. Kidney Int. 2010;78(10):975–980.
   PubMed Web of Science ®Google Scholar
• Antoniucci DM, Yamashita T, Portale AA. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J Clin Endocr Metab. 2006;91(8):3144–3149.
   PubMed Web of Science ®Google Scholar
• Dumitrescu EI, Hurlin C. Testing for Granger non-causality in heterogeneous panels. Econ Model. 2012;29(4):1450–1460.
   Web of Science ®Google Scholar
• Chen Y, Rangarajan G, Feng J, et al. Analyzing multiple nonlinear time series with extended Granger causality. Phys Lett. 2004;324(1):26–35.
   Web of Science ®Google Scholar
• Granger CWJ. Investigating causal relations by econometric models and cross-spectral methods. Econometrica. 1969;37(3):424–438.
   Web of Science ®Google Scholar
• Kleinberg S, Hripcsak G. A review of causal inference for biomedical informatics. J Biomed Inform. 2011;44(6):1102–1112.
   PubMed Web of Science ®Google Scholar
• Eichler M, Didelez V. Causal reasoning in graphical time series models. arXiv preprint. arXiv. 2012;1206:5246.
   Google Scholar
• Levin A, Lin CF, Chu CSJ. Unit root tests in panel data: asymptotic and finite-sample properties. J Econometrics. 2002;108(1):1–24.
   Web of Science ®Google Scholar
• Bakdash JZ, Marusich LR. Repeated measures correlation. Front Psychol. 2017;8:456.
   PubMed Web of Science ®Google Scholar
• Lopez L, Weber S. Testing for Granger causality in panel data. The Stata Journal. 2017;17(4):972–984.
   Web of Science ®Google Scholar
• Hagberg A, Schult D. Swart Networkx: Python software for the analysis of networks. Los Alamos: Mathematical Modeling and Analysis, Los Alamos National Laboratory; 2005.
   Google Scholar
• Kamiński M, Ding M, Truccolo WA, et al. Evaluating causal relations in neural systems: Granger causality, directed transfer function and statistical assessment of significance. Biol Cybern. 2001;85(2):145–157.
   PubMed Web of Science ®Google Scholar
• Spencer E, Martinet LE, Eskandar EN, et al. A procedure to increase the power of Granger-causal analysis through temporal smoothing. J Neurosci Methods. 2018;308:48–61.
   PubMed Web of Science ®Google Scholar
• Goebel R, Roebroeck A, Kim DS, et al. Investigating directed cortical interactions in time-resolved fMRI data using vector autoregressive modeling and Granger causality mapping. Magn Reson Imaging. 2003;21(10):1251–1261.
   PubMed Web of Science ®Google Scholar
• Bastos AM, Vezoli J, Bosman CA, et al. Visual areas exert feedforward and feedback influences through distinct frequency channels. Neuron. 2015;85(2):390–401.
   PubMed Web of Science ®Google Scholar
• Bacic D, Lehir M, Biber J, et al. The renal Na+/phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone. Kidney Int. 2006;69(3):495–503.
   PubMed Web of Science ®Google Scholar
• Saito H, Kusano K, Kinosaki M, et al. Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production. J Biol Chem. 2003;278(4):2206–2211.
   PubMed Web of Science ®Google Scholar
• Kilav R, Silver J, Naveh-Many T. Naveh-Many T. Parathyroid hormone gene expression in hypophosphatemic rats. J Clin Invest. 1995;96(1):327–333.
   PubMed Web of Science ®Google Scholar
• Sakwe AM, Larsson M, Rask L. Involvement of protein kinase C-alpha and -epsilon in extracellular Ca(2+) signalling mediated by the calcium sensing receptor. Exp Cell Res. 2004;297(2):560–573.
   PubMed Web of Science ®Google Scholar
• Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, et al. The parathyroid is a target organ for FGF23 in rats. J Clin Invest. 2007;117(12):4003–4008.
   PubMed Web of Science ®Google Scholar
• Kuro-O M. The Klotho proteins in health and disease. Nat Rev Nephrol. 2019;15(1):27–44.
   PubMed Web of Science ®Google Scholar
• Haruna Y, Kashihara N, Satoh M, et al. Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci USA. 2007;104(7):2331–2336.
   PubMed Web of Science ®Google Scholar
• Brownstein CA, Adler F, Nelson-Williams C, et al. A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism. Proc Natl Acad Sci USA. 2008;105(9):3455–3460.
   PubMed Web of Science ®Google Scholar
• Razzaque MS, Sitara D, Taguchi T, et al. Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process. Faseb J. 2006;20(6):720–722.
   PubMedGoogle Scholar
• Tsujikawa H, Kurotaki Y, Fujimori T, et al. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol. 2003;17(12):2393–2403.
   PubMedGoogle Scholar
• Yoshida T, Fujimori T, Nabeshima Y. Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology. 2002;143(2):683–689.
   PubMed Web of Science ®Google Scholar
• Imura A, Tsuji Y, Murata M, et al. alpha-Klotho as a regulator of calcium homeostasis. Science. 2007;316(5831):1615–1618.
   PubMed Web of Science ®Google Scholar
• Marsell R, Krajisnik T, Göransson H, et al. Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23. Nephrol Dial Transplant. 2008;23(3):827–833.
   PubMed Web of Science ®Google Scholar
• Forster RE, Jurutka PW, Hsieh JC, et al. Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells. Biochem Biophys Res Commun. 2011;414(3):557–562.
   PubMed Web of Science ®Google Scholar
• Zhang H, Li Y, Fan Y, et al. Klotho is a target gene of PPAR-gamma. Kidney Int. 2008;74(6):732–739.
   PubMed Web of Science ®Google Scholar
• Ito N, Findlay DM, Anderson PH, et al. Extracellular phosphate modulates the effect of 1α,25-dihydroxy vitamin D3 (1,25D) on osteocyte like cells. J Steroid Biochem Mol Biol. 2013;136:183–186.
   PubMed Web of Science ®Google Scholar
• Berndt TJ, Schiavi S, Kumar R. “Phosphatonins” and the regulation of phosphorus homeostasis. Am J Physiol-Renal. 2005;289(6):F1170–F1182.
   PubMed Web of Science ®Google Scholar
• Hernando N, Myakala K, Simona F, et al. Intestinal depletion of NaPi-IIb/Slc34a2 in Mice: renal and hormonal adaptation. J Bone Miner Res. 2015;30(10):1925–1937.
   PubMed Web of Science ®Google Scholar
• Hu MC, Shi M, Moe OW. Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters. Pflugers Arch. 2019;471(1):99–108.
   PubMed Web of Science ®Google Scholar
• Lavender AR, Pullman TN. Changes in inorganic phosphate excretion induced by renal arterial infusion of calcium. Am J Physiol. 1963;205(5):1025–1032.
   PubMedGoogle Scholar
• Ba J, Brown D, Friedman PA. Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transport. Am J Physiol-Renal. 2003;285(6):1233–1243.
   Web of Science ®Google Scholar
• Peacock M. Calcium metabolism in health and disease. Clin J Am Soc Nephro. 2010;5(Supplement 1):S23–S30.
   PubMedGoogle Scholar
• Ritter CS, Armbrecht HJ, Slatopolsky E, et al. 25-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells. Kidney Int. 2006;70(4):654–659.
   PubMed Web of Science ®Google Scholar