Sclerostin is involved in osteogenic transdifferentiation of vascular smooth muscle cells in chronic kidney disease-associated vascular calcification with non-canonical Wnt signaling

References

• Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet. 2020;395(10225):709–733.
   PubMed Web of Science ®Google Scholar
• Zhang L, Wang F, Wang L, et al. Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet. 2012;379(9818):815–822.
   PubMed Web of Science ®Google Scholar
• Liu ZH, Yu XQ, Yang JW, et al. Prevalence and risk factors for vascular calcification in Chinese patients receiving dialysis: baseline results from a prospective cohort study. Curr Med Res Opin. 2018;34(8):1491–1500.
   PubMed Web of Science ®Google Scholar
• Vervloet M, Cozzolino M. Vascular calcification in chronic kidney disease: different bricks in the wall? Kidney Int. 2017;91(4):808–817.
   PubMed Web of Science ®Google Scholar
• Chen W, Melamed ML. Vascular calcification in predialysis CKD: common and deadly. Clin J Am Soc Nephrol. 2015;10(4):551–553.
   PubMed Web of Science ®Google Scholar
• Okuno S, Ishimura E, Kitatani K, et al. Presence of abdominal aortic calcification is significantly associated with all-cause and cardiovascular mortality in maintenance hemodialysis patients. Am J Kidney Dis. 2007;49(3):417–425.
   PubMed Web of Science ®Google Scholar
• Wang XR, Yuan L, Shi R, et al. Predictors of coronary artery calcification and its association with cardiovascular events in patients with chronic kidney disease. Ren Fail. 2021;43(1):1172–1179.
   PubMed Web of Science ®Google Scholar
• (KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney Disease-Mineral and bone disorder (CKD-MBD). Kidney Int Suppl. 2017;7(1):1–59.
   PubMed Web of Science ®Google Scholar
• Lacolley P, Regnault V, Segers P, et al. Vascular smooth muscle cells and arterial stiffening: relevance in development, aging, and disease. Physiol Rev. 2017;97(4):1555–1617.
   PubMed Web of Science ®Google Scholar
• Dai L, Schurgers LJ, Shiels PG, et al. Early vascular ageing in chronic kidney disease: impact of inflammation, vitamin K, senescence and genomic damage. Nephrol Dial Transplant. 2020;35(2):ii31–ii37.
   PubMedGoogle Scholar
• Sanchis P, Ho CY, Liu Y, et al. Arterial "inflammaging" drives vascular calcification in children on dialysis. Kidney Int. 2019;95(4):958–972.
   PubMed Web of Science ®Google Scholar
• Düsing P, Zietzer A, Goody PR, et al. Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches. J Mol Med (Berl). 2021;99(3):335–348.
   PubMed Web of Science ®Google Scholar
• Kudryavtseva O, Aalkjaer C, Matchkov VV. Vascular smooth muscle cell phenotype is defined by Ca2+-dependent transcription factors. FEBS J. 2013;280(21):5488–5499.
   PubMed Web of Science ®Google Scholar
• Schunk SJ, Floege J, Fliser D, et al. WNT-β-catenin signalling - a versatile player in kidney injury and repair. Nat Rev Nephrol. 2021;17(3):172–184.
   PubMed Web of Science ®Google Scholar
• Voelkl J, Lang F, Eckardt KU, et al. Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia. Cell Mol Life Sci. 2019;76(11):2077–2091.
   PubMed Web of Science ®Google Scholar
• Lee MY, Garvey SM, Ripley ML, et al. Genome-wide microarray analyses identify the protein C receptor as a novel calcineurin/nuclear factor of activated T cells-dependent gene in vascular smooth muscle cell phenotypic modulation. Arterioscler Thromb Vasc Biol. 2011;31(11):2665–2675.
   PubMed Web of Science ®Google Scholar
• Furmanik M, Chatrou M, van Gorp R, et al. Reactive Oxygen-Forming Nox5 links vascular smooth muscle cell phenotypic switching and extracellular Vesicle-Mediated vascular calcification. Circ Res. 2020;127(7):911–927.
   PubMed Web of Science ®Google Scholar
• Malhotra R, Mauer AC, Lino Cardenas CL, et al. HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. Nat Genet. 2019;51(11):1580–1587.
   PubMed Web of Science ®Google Scholar
• Wang C, Tang Y, Wang Y, et al. Label-free quantitative proteomics identifies Smarca4 is involved in vascular calcification. Ren Fail. 2019;41(1):220–228.
   PubMed Web of Science ®Google Scholar
• Xiao Q, Tang Y, Xia J, et al. Ubiquitin-specific protease 47 is associated with vascular calcification in chronic kidney disease by regulating osteogenic transdifferentiation of vascular smooth muscle cells. Ren Fail. 2022;44(1):752–766.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–d613.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Bao YW, Yuan Y, Chen JH, et al. Kidney disease models: tools to identify mechanisms and potential therapeutic targets. Zool Res. 2018;39(2):72–86.
   PubMed Web of Science ®Google Scholar
• Ferrari GO, Ferreira JC, Cavallari RT, et al. Mineral bone disorder in chronic kidney disease: head-to-head comparison of the 5/6 nephrectomy and adenine models. BMC Nephrol. 2014;15:69.
   PubMed Web of Science ®Google Scholar
• Neven E, D’Haese PC. Vascular calcification in chronic renal failure: what have we learned from animal studies? Circ Res. 2011;108(2):249–264.
   PubMed Web of Science ®Google Scholar
• Ciceri P, Volpi E, Brenna I, et al. Combined effects of ascorbic acid and phosphate on rat VSMC osteoblastic differentiation. Nephrol Dial Transplant. 2012;27(1):122–127.
   PubMed Web of Science ®Google Scholar
• Bao S, Guo Y, Diao Z, et al. Genome-wide identification of lncRNAs and mRNAs differentially expressed in human vascular smooth muscle cells stimulated by high phosphorus. Ren Fail. 2020;42(1):437–446.
   PubMed Web of Science ®Google Scholar
• Voelkl J, Luong TT, Tuffaha R, et al. SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling. J Clin Invest. 2018;128(7):3024–3040.
   PubMed Web of Science ®Google Scholar
• Chen B, Zhao Y, Han D, et al. Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression. J Mol Cell Cardiol. 2019;135:10–21.
   PubMed Web of Science ®Google Scholar
• Proudfoot D. Calcium signaling and tissue calcification. Cold Spring Harb Perspect Biol. 2019;11(10):a035303.
   PubMed Web of Science ®Google Scholar
• Ishitani T, Kishida S, Hyodo-Miura J, et al. The TAK1-NLK mitogen-activated protein kinase Cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003;23(1):131–139.
   PubMed Web of Science ®Google Scholar
• Albanese I, Yu B, Al-Kindi H, et al. Role of noncanonical Wnt signaling pathway in human aortic valve calcification. Arterioscler Thromb Vasc Biol. 2017;37(3):543–552.
   PubMed Web of Science ®Google Scholar
• Xin H, Xin F, Zhou S, et al. The Wnt5a/Ror2 pathway is associated with determination of the differentiation fate of bone marrow mesenchymal stem cells in vascular calcification. Int J Mol Med. 2013;31(3):583–588.
   PubMed Web of Science ®Google Scholar
• van Amerongen R, Fuerer C, Mizutani M, et al. Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev Biol. 2012;369(1):101–114.
   PubMed Web of Science ®Google Scholar
• Liao R, Wang L, Li J, et al. Vascular calcification is associated with Wnt-signaling pathway and blood pressure variability in chronic kidney disease rats. Nephrology (Carlton). 2020;25(3):264–272.
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang L, Zhou Y, et al. Aberrant activation of Wnt pathways in arteries associates with vascular calcification in chronic kidney disease. Int Urol Nephrol. 2016;48(8):1313–1319.
   PubMed Web of Science ®Google Scholar
• De Maré A, D’Haese PC, Verhulst A. The role of sclerostin in bone and ectopic calcification. Int J Mol Sci. 2020;21(9):3199.
   PubMed Web of Science ®Google Scholar
• Zeng C, Guo C, Cai J, et al. Serum sclerostin in vascular calcification and clinical outcome in chronic kidney disease. Diab Vasc Dis Res. 2018;15(2):99–105.
   PubMed Web of Science ®Google Scholar
• Araújo M, Bacelar Marques ID, Graciolli FG, et al. Comparison of serum levels with bone content and gene expression indicate a contradictory effect of kidney transplantation on sclerostin. Kidney Int. 2019;96(5):1100–1104.
   PubMed Web of Science ®Google Scholar
• Morena M, Jaussent I, Dupuy AM, et al. Osteoprotegerin and sclerostin in chronic kidney disease prior to dialysis: potential partners in vascular calcifications. Nephrol Dial Transplant. 2015;30(8):1345–1356.
   PubMed Web of Science ®Google Scholar
• De Maré A, Opdebeeck B, Neven E, et al. Sclerostin protects against vascular calcification development in mice. J Bone Miner Res. 2022;37(4):687–699.
   PubMed Web of Science ®Google Scholar
• Claes KJ, Viaene L, Heye S, et al. Sclerostin: another vascular calcification inhibitor? J Clin Endocrinol Metab. 2013;98(8):3221–3228.
   PubMed Web of Science ®Google Scholar
• Brandenburg VM, Verhulst A, Babler A, et al. Sclerostin in chronic kidney disease-mineral bone disorder think first before you block it!. Nephrol Dial Transplant. 2019;34(3):408–414.
   PubMed Web of Science ®Google Scholar
• Evenepoel P, D'Haese P, Brandenburg V. Sclerostin and DKK1: new players in renal bone and vascular disease. Kidney Int. 2015;88(2):235–240.
   PubMed Web of Science ®Google Scholar
• Bruzzese A, Lacquaniti A, Cernaro V, et al. Sclerostin levels in uremic patients: a link between bone and vascular disease. Ren Fail. 2016;38(5):759–764.
   PubMed Web of Science ®Google Scholar
• Trionfini P, Benigni A, Remuzzi G. MicroRNAs in kidney physiology and disease. Nat Rev Nephrol. 2015;11(1):23–33.
   PubMed Web of Science ®Google Scholar
• Cai G, Cai G, Zhou H, et al. Mesenchymal stem cell-derived exosome miR-542-3p suppresses inflammation and prevents cerebral infarction. Stem Cell Res Ther. 2021;12(1):2.
   PubMed Web of Science ®Google Scholar
• Garros RF, Paul R, Connolly M, et al. MicroRNA-542 promotes mitochondrial dysfunction and SMAD activity and is elevated in intensive care unit-acquired weakness. Am J Respir Crit Care Med. 2017;196(11):1422–1433.
   PubMed Web of Science ®Google Scholar
• Li J, Bao H, Zhang K, et al. MiR-542-3p drives renal fibrosis by targeting AGO1 in vivo and in vitro. Life Sci. 2020;255:117845.
   PubMed Web of Science ®Google Scholar
• Li Q, Song S, Ni G, et al. Serum miR-542-3p as a prognostic biomarker in osteosarcoma. CBM. 2018;21(3):521–526.
   Google Scholar
• He T, Qi F, Jia L, et al. Tumor cell-secreted angiogenin induces angiogenic activity of endothelial cells by suppressing miR-542-3p. Cancer Lett. 2015;368(1):115–125.
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhu Y, Zhang C, et al. miR-542-3p prevents ovariectomy-induced osteoporosis in rats via targeting SFRP1. J Cell Physiol. 2018;233(9):6798–6806.
   PubMed Web of Science ®Google Scholar
• Qian DH, Gao P, Feng H, et al. Down-regulation of mir-542-3p promotes neointimal formation in the aging rat. Vascul Pharmacol. 2015;72:118–129.
   PubMed Web of Science ®Google Scholar
• Liu H, Wang H, Yang S, et al. Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting BMP7. Hum Genomics. 2019;13(1):67.
   PubMed Web of Science ®Google Scholar
• Li LJ, Huang Q, Zhang N, et al. miR-376b-5p regulates angiogenesis in cerebral ischemia. Mol Med Rep. 2014;10(1):527–535.
   PubMed Web of Science ®Google Scholar
• Chen Y, Xu Y, Deng Z, et al. MicroRNA expression profiling involved in doxorubicin-induced cardiotoxicity using high-throughput deep-sequencing analysis. Oncol Lett. 2021;22(1):560.
   PubMed Web of Science ®Google Scholar
• Li X, Wang X, Liu YS, et al. Downregulation of miR-3568 protects against ischemia/Reperfusion-Induced cardiac dysfunction in rats and apoptosis in H9C2 cardiomyocytes through targeting TRIM62. Front Pharmacol. 2020;11:17.
   PubMed Web of Science ®Google Scholar
• Ma M, Duan R, Shen L, et al. The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice. J Lipid Res. 2020;61(7):1052–1064.
   PubMed Web of Science ®Google Scholar
• Nguyen-Yamamoto L, Tanaka KI, St-Arnaud R, et al. Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification. JCI Insight. 2019;4(13):e126467.
   PubMed Web of Science ®Google Scholar