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Hemodialysis and Peritoneal Dialysis

Medication burden in patients with dialysis-dependent CKD: a systematic review

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Article: 2353341 | Received 01 Dec 2023, Accepted 06 May 2024, Published online: 04 Jun 2024

References

  • KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024;105(4):684–701. doi:10.1016/j.kint.2023.10.018.
  • Schmidt IM, Hübner S, Nadal J, et al. Patterns of medication use and the burden of polypharmacy in patients with chronic kidney disease: the German Chronic Kidney Disease Study. Clin Kidney J. 2019;12(5):663–672. doi:10.1093/ckj/sfz046.
  • Chiu YW, Teitelbaum I, Misra M, et al. Pill burden, adherence, hyperphosphatemia, and quality of life in maintenance dialysis patients. Clin J Am Soc Nephrol. 2009;4(6):1089–1096. doi:10.2215/cjn.00290109.
  • Manley HJ, Garvin CG, Drayer DK, et al. Medication prescribing patterns in ambulatory haemodialysis patients: comparisons of USRDS to a large not-for-profit dialysis provider. Nephrol Dial Transplant. 2004;19(7):1842–1848. doi:10.1093/ndt/gfh280.
  • Cardone KE, Bacchus S, Assimon MM, et al. Medication-related problems in CKD. Adv Chronic Kidney Dis. 2010;17(5):404–412. doi:10.1053/j.ackd.2010.06.004.
  • Schmid H, Hartmann B, Schiffl H. Adherence to prescribed oral medication in adult patients undergoing chronic hemodialysis: a critical review of the literature. Eur J Med Res. 2009;14(5):185–190. doi:10.1186/2047-783x-14-5-185.
  • Mohammed MA, Moles RJ, Chen TF. Medication-related burden and patients’ lived experience with medicine: a systematic review and metasynthesis of qualitative studies. BMJ Open. 2016;6(2):e010035. doi:10.1136/bmjopen-2015-010035.
  • Lo CK, Mertz D, Loeb M. Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments. BMC Med Res Methodol. 2014;14(1):45. doi:10.1186/1471-2288-14-45.
  • AHRQ Methods for Effective Health Care. Methods guide for effectiveness and comparative effectiveness reviews. Rockville (MD): Agency for Healthcare Research and Quality (US); 2008.
  • Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med. 2015;8(1):2–10. doi:10.1111/jebm.12141.
  • Rodrigues H, Cobucci R, Oliveira A, et al. Burnout syndrome among medical residents: a systematic review and meta-analysis. PLOS One. 2018;13(11):e0206840. doi:10.1371/journal.pone.0206840.
  • Altman D, Machin D, Bryant T, et al. Statistics with confidence. 2nd ed. London: BMJ Books; 2000. p. 28–31.
  • Higgins JPT, Li T, Jj D. Chapter 6: choosing effect measures and computing estimates of effect. In: Cochrane handbook for systematic reviews of interventions. Cochrane; 2023. Available from: https://training.cochrane.org/handbook/current/chapter-06#section-6-5-2
  • Iwashita Y, Ohya M, Kunimoto S, et al. A survey of drug burden in patients undergoing maintenance hemodialysis in Japan. Intern Med. 2018;57(20):2937–2944. doi:10.2169/internalmedicine.0108-17.
  • Cirevalli P, Nimmanapalli HD, Parlapalli LK, et al. Pill burden, drug class distribution and financial burden for buying medicines in different modalities of chronic kidney disease patients: cross-sectional study. Int J Pharm Pharm Sci. 2018;10(6):165–170. doi:10.22159/ijpps.2018v10i6.26186.
  • Al-Mansouri A, Hamad AI, Al-Ali FS, et al. Pill-burden and its association with treatment burden among patients with advanced stages of chronic kidney disease. Saudi Pharm J. 2023;31(5):678–686. doi:10.1016/j.jsps.2023.03.008.
  • Parker K, Bull-Engelstad I, Aasebø W, et al. Medication regimen complexity and medication adherence in elderly patients with chronic kidney disease. Hemodial Int. 2019;23(3):333–342. doi:10.1111/hdi.12739.
  • George JS, Joseph R, Thomas ETA, et al. Active deprescribing program in chronic kidney disease patients undergoing haemodialysis. Nephrology. 2021;26(11):890–897. doi:10.1111/nep.13936.
  • Murali K, Mullan J, Roodenrys S, et al. Medication non-adherence in patients with kidney disease: importance of depression, health literacy and pill burden. Nephrology. 2021;26(Suppl. 2):24. doi:10.1111/nep.13930.
  • Paik JM, Zhuo M, York C, et al. Medication burden and prescribing patterns in patients on hemodialysis in the USA, 2013–2017. Am J Nephrol. 2021;52(12):919–928. doi:10.1159/000520028.
  • Parker K, Nikam M, Jayanti A, et al. Medication burden in CKD-5D: impact of dialysis modality and setting. Clin Kidney J. 2014;7(6):557–561. doi:10.1093/ckj/sfu091.
  • Gupta V, Jasani R, Kumar R, et al. Pill burden and PILL adherence in dialysis patients. Indian J Nephrol. 2017;27:S93.
  • Van Oosten MJM, Logtenberg SJJ, Hemmelder MH, et al. Polypharmacy and medication use in patients with chronic kidney disease with and without kidney replacement therapy compared to matched controls. Clin Kidney J. 2021;14(12):2497–2523. doi:10.1093/ckj/sfab120.
  • Gnjidic D, Hilmer SN, Blyth FM, et al. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012;65(9):989–995. doi:10.1016/j.jclinepi.2012.02.018.
  • Ghimire S, Peterson GM, Castelino RL, et al. Medication regimen complexity and adherence in haemodialysis patients: an exploratory study. Am J Nephrol. 2016;43(5):318–324. doi:10.1159/000446450.
  • Beddhu S, Bruns FJ, Saul M, et al. A simple comorbidity scale predicts clinical outcomes and costs in dialysis patients. Am J Med. 2000;108(8):609–613. doi:10.1016/s0002-9343(00)00371-5.
  • Scott IA, Hilmer SN, Reeve E, et al. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern Med. 2015;175(5):827–834. doi:10.1001/jamainternmed.2015.0324.
  • World Health Organization. The top 10 causes of death; 2020 [cited 2023 Oct 10]. Available from: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death
  • Tinoco MS, Groia-Veloso RCS, Santos J, et al. Medication regimen complexity of coronary artery disease patients. Einstein. 2021;19:eAO5565. doi:10.31744/einstein_journal/2021AO5565.
  • Noteboom B, Jenkins S, Maiorana A, et al. Comorbidities and medication burden in patients with chronic obstructive pulmonary disease attending pulmonary rehabilitation. J Cardiopulm Rehabil Prev. 2014;34(1):75–79. doi:10.1097/hcr.0000000000000036.
  • Negewo NA, Gibson PG, Wark PA, et al. Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD. Int J Chron Obstruct Pulmon Dis. 2017;12:2929–2942. doi:10.2147/copd.S136256.
  • Laville SM, Metzger M, Stengel B, et al. Evaluation of the adequacy of drug prescriptions in patients with chronic kidney disease: results from the CKD-REIN cohort. Br J Clin Pharmacol. 2018;84(12):2811–2823. doi:10.1111/bcp.13738.
  • Marienne J, Laville SM, Caillard P, et al. Evaluation of changes over time in the drug burden and medication regimen complexity in ESRD patients before and after renal transplantation. Kidney Int Rep. 2021;6(1):128–137. doi:10.1016/j.ekir.2020.10.011.
  • Cobretti MR, Page RL2nd, Linnebur SA, et al. Medication regimen complexity in ambulatory older adults with heart failure. Clin Interv Aging. 2017;12:679–686. doi:10.2147/cia.S130832.
  • Wright EA, Steinhubl SR, Jones JB, et al. Medication burden in patients with acute coronary syndromes. Am J Manage Care. 2017;23(4):e106–e112.
  • Federman AD, O'Conor R, Wolf MS, et al. Associations of medication regimen complexity with COPD medication adherence and control. Int J Chron Obstruct Pulmon Dis. 2021;16:2385–2392. doi:10.2147/copd.S310630.
  • He J, Whelton PK. Epidemiology and prevention of hypertension. Med Clin North Am. 1997;81(5):1077–1097. doi:10.1016/s0025-7125(05)70568-x.
  • Zimmerman DL, Ruzicka M, Hebert P, et al. Short daily versus conventional hemodialysis for hypertensive patients: a randomized cross-over study. PLOS One. 2014;9(5):e97135. doi:10.1371/journal.pone.0097135.
  • Levin NW, Kotanko P, Eckardt KU, et al. Blood pressure in chronic kidney disease stage 5D-report from a kidney disease: improving global outcomes controversies conference. Kidney Int. 2010;77(4):273–284. doi:10.1038/ki.2009.469.
  • Bucharles SGE, Wallbach KKS, Moraes TP, et al. Hypertension in patients on dialysis: diagnosis, mechanisms, and management. J Bras Nefrol. 2019;41(3):400–411. doi:10.1590/2175-8239-jbn-2018-0155.
  • Scialla JJ, Kendrick J, Uribarri J, et al. State-of-the-art management of hyperphosphatemia in patients with CKD: an NKF-KDOQI controversies perspective. Am J Kidney Dis. 2021;77(1):132–141. doi:10.1053/j.ajkd.2020.05.025.
  • Gray K, Ficociello LH, Hunt AE, et al. Phosphate binder pill burden, adherence, and serum phosphorus control among hemodialysis patients converting to sucroferric oxyhydroxide. Int J Nephrol Renovasc Dis. 2019;12:1–8. doi:10.2147/IJNRD.S182747.
  • Kalantar-Zadeh K, Parameswaran V, Ficociello LH, et al. Real-world scenario improvements in serum phosphorus levels and pill burden in peritoneal dialysis patients treated with sucroferric oxyhydroxide. Am J Nephrol. 2018;47(3):153–161. doi:10.1159/000487856.
  • Kidney Disease: improving Global Outcomes (KDIGO) CKD-MBD Work Group. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-Mineral and bone disorder (CKD-MBD). Kidney Int Suppl. 2009;2009(113):S1–S130. doi:10.1038/ki.2009.188.
  • McIntyre C, McQuillan R, Bell C, et al. Targeted deprescribing in an outpatient hemodialysis unit: a quality improvement study to decrease polypharmacy. Am J Kidney Dis. 2017;70(5):611–618. doi:10.1053/j.ajkd.2017.02.374.
  • Sleight P, Pouleur H, Zannad F. Benefits, challenges, and registerability of the polypill. Eur Heart J. 2006;27(14):1651–1656. doi:10.1093/eurheartj/ehi841.
  • Jerath A, Panckhurst J, Parotto M, et al. Safety and efficacy of volatile anesthetic agents compared with standard intravenous midazolam/propofol sedation in ventilated critical care patients: a meta-analysis and systematic review of prospective trials. Anesth Analg. 2017;124(4):1190–1199. doi:10.1213/ane.0000000000001634.
  • Lehmann J, Riedl D, Sztankay M, et al. The attitude towards polypills questionnaire (APPQ): a phase I–III development and validation study in patients with cerebrovascular disease. Eur J Neurol. 2021;28(12):4039–4050. doi:10.1111/ene.15088.
  • Tesfaye WH, Peterson GM, Castelino RL, et al. Medication regimen complexity and hospital readmission in older adults with chronic kidney disease. Ann Pharmacother. 2019;53(1):28–34. doi:10.1177/1060028018793419.
  • Colavecchia AC, Putney DR, Johnson ML, et al. Discharge medication complexity and 30-day heart failure readmissions. Res Social Adm Pharm. 2017;13(4):857–863. doi:10.1016/j.sapharm.2016.10.002.