Association between frailty and adverse outcomes in patients undergoing maintenance hemodialysis: a systematic review and meta-analysis

References

• Zhang L, Zhao MH, Zuo L, et al. China kidney disease network (CK-NET) 2015 annual data report. Kidney Int Suppl. 2019;9(1):1–13. doi: 10.1016/j.kisu.2018.11.001.
   Web of Science ®Google Scholar
• Fang W, Fuxu W, Hongwei Z. Progress of clinical research on protein energy consumption in maintenance hemodialysis patients. Chinese Blood Purif. 2019;18(02):127–130. doi: 10.3969/j.issn.1671-4091.2019.02.013.
   Google Scholar
• Wei Q, Zhaohua ZOU, Zihan Y, et al. Construction of risk prediction model for patients with maintenance hemodialysis with frailty and pre-frailty. Nurs Res. 2024;38(02):233–239. doi: 10.12102/j.issn.1009-6493.2024.02.007.
   Google Scholar
• Chen X, Mao G, Leng SX. Frailty syndrome: an overview. Clin Interv Aging. 2014;9:433–441. doi: 10.2147/CIA.S45300.
   PubMed Web of Science ®Google Scholar
• Lu YW, Chang CC, Chou RH, et al. Sex differences in the frailty phenotype and mortality in the I-Lan longitudinal aging study cohort. BMC Geriatr. 2024;24(1):182. doi: 10.1186/s12877-024-04785-w.
   PubMed Web of Science ®Google Scholar
• Xu J, Xu W, Qiu Y, et al. Association of prefrailty and frailty with all-cause mortality, acute exacerbation, and hospitalization in patients with chronic obstructive pulmonary disease: a meta-analysis. J Am Med Dir Assoc. 2023;24(7):937–944.e933. doi: 10.1016/j.jamda.2023.03.032.
   PubMed Web of Science ®Google Scholar
• Sawa R, Doi T, Tsutsumimoto K, et al. Overlapping status of frailty and fear of falling: an elevated risk of incident disability in community-dwelling older adults. Aging Clin Exp Res. 2023;35(9):1937–1944. doi: 10.1007/s40520-023-02474-z.
   PubMedGoogle Scholar
• Dandan W, Kanfei Y, Xuanxue Z. Comparison of performance of three machine learning algorithms for ­predicting fateful risk in maintenance hemodialysis ­patients. Nurs Res. 2024;38(01):8–16. doi: 10.12102/j.issn.1009-6493.2024.01.002.
   Google Scholar
• Lee HJ, Son YJ. Prevalence and associated factors of frailty and mortality in patients with end-stage renal disease undergoing hemodialysis: a systematic review and meta-analysis. Int J Environ Res Public Health. 2021;18(7):3471. doi: 10.3390/ijerph18073471.
   PubMed Web of Science ®Google Scholar
• Yoneki K, Kitagawa J, Hoshi K, et al. Association between frailty and bone loss in patients undergoing maintenance hemodialysis. J Bone Miner Metab. 2019;37(1):81–89. doi: 10.1007/s00774-017-0898-4.
   PubMed Web of Science ®Google Scholar
• Tonelli M, Wiebe N, Gill JS, et al. Frailty and clinical outcomes in patients treated with hemodialysis: a prospective cohort study. Kidney Med. 2023;5(8):100684. doi: 10.1016/j.xkme.2023.100684.
   PubMedGoogle Scholar
• Lee SW, Lee A, Yu MY, et al. Is frailty a modifiable risk factor of future adverse outcomes in elderly patients with incident end-stage renal disease? J Korean Med Sci. 2017;32(11):1800–1806. doi: 10.3346/jkms.2017.32.11.1800.
   PubMed Web of Science ®Google Scholar
• Soldati A, Poggi MM, Azzolino D, et al. Frailty index and adverse outcomes in older patients in haemodialysis. Arch Gerontol Geriatr. 2022;101:104673. doi: 10.1016/j.archger.2022.104673.
   PubMed Web of Science ®Google Scholar
• Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev. 2021;10(1):89. doi: 10.1186/s13643-021-01626-4.
   PubMed Web of Science ®Google Scholar
• Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–156. doi: 10.1093/gerona/56.3.m146.
   PubMed Web of Science ®Google Scholar
• Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging. 2012;16(7):601–608. doi: 10.1007/s12603-012-0084-2.
   PubMed Web of Science ®Google Scholar
• Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal. 2001;1:323–336. doi: 10.1100/tsw.2001.58.
   PubMedGoogle Scholar
• Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007;62(7):722–727. doi: 10.1093/gerona/62.7.722.
   PubMed Web of Science ®Google Scholar
• Gilbert T, Neuburger J, Kraindler J, et al. Development and validation of a Hospital Frailty Risk Score focusing on older people in acute care settings using electronic hospital ­records: an observational study. Lancet. 2018;391(10132):1775–1782. doi: 10.1016/S0140-6736(18)30668-8.
   PubMed Web of Science ®Google Scholar
• Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–605. doi: 10.1007/s10654-010-9491-z.
   PubMed Web of Science ®Google Scholar
• Ma LL, Wang YY, Yang ZH, et al. Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better? Mil Med Res. 2020;7(1):7. doi: 10.1186/s40779-020-00238-8.
   PubMed Web of Science ®Google Scholar
• Shulin W. Longitudinal study of frailty and short-term adverse outcomes in elderly patients with maintenance hemodialysis [dissertation]. Shandong University of Chinese Medicine; 2021. doi: 10.27282/d.cnki.gsdzu.2021.000313.
   Google Scholar
• Yoshikoshi S, Yamamoto S, Suzuki Y, et al. Association between physical frailty and sleep disturbances among patients on hemodialysis: a cross-sectional study. Nephron. 2024;148(3):152–159. doi: 10.1159/000533418.
   PubMed Web of Science ®Google Scholar
• Imamura K, Yamamoto S, Suzuki Y, et al. Prevalence, overlap, and prognostic impact of multiple frailty domains in older patients on hemodialysis. Arch Gerontol Geriatr. 2023;114:105082. doi: 10.1016/j.archger.2023.105082.
   PubMed Web of Science ®Google Scholar
• Jafari M, Anwar S, Kour K, et al. T scores, FRAX, frailty phenotype, falls, and its relationship to fractures in patients on maintenance hemodialysis. Can J Kidney Health Dis. 2021;8:20543581211041184. doi: 10.1177/20543581211041184.
   Google Scholar
• Yang Y, Yang H, Diao Z, et al. Frailty and adverse outcomes after SARS-CoV-2 infection in elderly patients on maintenance hemodialysis: a cohort study. Clin Interv Aging. 2023;18:1937–1948. doi: 10.2147/CIA.S429226.
   PubMed Web of Science ®Google Scholar
• Guojuan Z, Jianyun X, Lili S, et al. Influence of frailty on prognosis of elderly hemodialysis patients. International Journal of Urology. 2023;43(5):874–877. doi: 10.3760/cma.j.cn431460-20220321-00223.
   Google Scholar
• Luo CM, Hsieh MY, Cheng CH, et al. Association of frailty with thrombosis of hemodialysis vascular access: a prospective Taiwanese cohort study. Am J Kidney Dis. 2022;80(3):353–363.e351. doi: 10.1053/j.ajkd.2021.12.017.
   PubMed Web of Science ®Google Scholar
• Guo Y, Tian R, Ye P, et al. Frailty in older patients undergoing hemodialysis and its association with all-cause mortality: a prospective cohort study. Clin Interv Aging. 2022;17:265–275. doi: 10.2147/CIA.S357582.
   PubMed Web of Science ®Google Scholar
• Chen CH, Hsieh YL, Chuang SY, et al. The impact of frailty on the outcomes of hemodialysis vascular access. Acta Cardiol Sin. 2022;38(1):29–38. doi: 10.6515/ACS.202201_38(1).20210711A.
   PubMed Web of Science ®Google Scholar
• Chi CY, Lee SY, Chao CT, et al. Frailty as an independent risk factor for depression in patients with end-stage ­renal disease: a cross-sectional study. Front Med. 2022;9:799544. doi: 10.3389/fmed.2022.799544.
   Web of Science ®Google Scholar
• Li Y, Zhang D, Ma Q, et al. The impact of frailty on prognosis in elderly hemodialysis patients: a prospective ­cohort study. Clin Interv Aging. 2021;16:1659–1667. doi: 10.2147/CIA.S329665.
   PubMed Web of Science ®Google Scholar
• Fu W, Zhang A, Ma L, et al. Severity of frailty as a significant predictor of mortality for hemodialysis patients: a prospective study in China. Int J Med Sci. 2021;18(14):3309–3317. doi: 10.7150/ijms.51569.
   PubMed Web of Science ®Google Scholar
• Du LY, Hu X, Wang XH, et al. Frailty in 380 patients with maintenance hemodialysis and its influence on prognosis. J Nurs. 2018;25(20):37–41. doi: 10.16460/j.issn1008-9969.2018.20.037.
   Google Scholar
• Lin Z, Zhenghong W, Yi W, et al. Incidence of frailty in maintenance hemodialysis patients and its effect on falls. Modern Clin Care. 2017;16(11):9–13. doi: 10.3969/j.issn.1671-8283.2017.11.003.
   Google Scholar
• Yadla M, John JP, Mummadi M. A study of clinical ­assessment of frailty in patients on maintenance hemodialysis supported by cashless government scheme. Saudi J Kidney Dis Transpl. 2017;28(1):15–22. doi: 10.4103/1319-2442.198102.
   PubMedGoogle Scholar
• Hamiduzzaman A, Wu R, Murray V, et al. Comparing the Fried frailty phenotype versus the Veterans Affairs frailty index among dialysis dependent patients. Hemodial Int. 2023;27(4):444–453. doi: 10.1111/hdi.13101.
   PubMed Web of Science ®Google Scholar
• Santos D, Ferreira LGS, Pallone JM, et al. Association between frailty and depression among hemodialysis patients: a cross-sectional study. Sao Paulo Med J. 2022;140(3):406–411. doi: 10.1590/1516-3180.2021.0556.R1.14092021.
   PubMed Web of Science ®Google Scholar
• Woo K, Gascue L, Norris K, et al. Patient frailty and functional use of hemodialysis vascular access: a retrospective study of the US renal data system. Am J Kidney Dis. 2022;80(1):30–45. doi: 10.1053/j.ajkd.2021.10.011.
   PubMed Web of Science ®Google Scholar
• Sy J, McCulloch CE, Johansen KL. Depressive symptoms, frailty, and mortality among dialysis patients. Hemodial Int. 2019;23(2):239–246. doi: 10.1111/hdi.12747.
   PubMed Web of Science ®Google Scholar
• Johansen KL, Delgado C, Kaysen GA, et al. Frailty among patients receiving hemodialysis: evolution of components and associations with mortality. J Gerontol A Biol Sci Med Sci. 2019;74(3):380–386. doi: 10.1093/gerona/gly206.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick J, Sozio SM, Jaar BG, et al. Frailty, body composition and the risk of mortality in incident hemodialysis patients: the predictors of arrhythmic and cardiovascular risk in end stage renal disease study. Nephrol Dial Transplant. 2019;34(2):346–354. doi: 10.1093/ndt/gfy124.
   PubMed Web of Science ®Google Scholar
• Johansen KL, Dalrymple LS, Glidden D, et al. Association of performance-based and self-reported function-based definitions of frailty with mortality among patients ­receiving hemodialysis. Clin J Am Soc Nephrol. 2016;11(4):626–632. doi: 10.2215/CJN.03710415.
   PubMed Web of Science ®Google Scholar
• Delgado C, Shieh S, Grimes B, et al. Association of self-reported frailty with falls and fractures among ­patients new to dialysis. Am J Nephrol. 2015;42(2):134–140. doi: 10.1159/000439000.
   PubMed Web of Science ®Google Scholar
• McAdams-DeMarco MA, Suresh S, Law A, et al. Frailty and falls among adult patients undergoing chronic ­hemodialysis: a prospective cohort study. BMC Nephrol. 2013;14(1):224. doi: 10.1186/1471-2369-14-224.
   PubMedGoogle Scholar
• McAdams-DeMarco MA, Law A, Salter ML, et al. Frailty as a novel predictor of mortality and hospitalization in individuals of all ages undergoing hemodialysis. J Am Geriatr Soc. 2013;61(6):896–901. doi: 10.1111/jgs.12266.
   PubMed Web of Science ®Google Scholar
• Barbosa EMS, Pereira AG, Mori V, et al. Comparison ­between FRAIL Scale and Clinical Frailty Scale in predicting hospitalization in hemodialysis patients. J Nephrol. 2023;36(3):687–693. doi: 10.1007/s40620-022-01532-5.
   PubMed Web of Science ®Google Scholar
• Stavert B, Monaro S, Naganathan V, et al. Frailty predicts increased risk of reintervention in the 2 years after ­arteriovenous fistula creation. J Vasc Access. 2023;24(6):1428–1437. doi: 10.1177/11297298221088756.
   PubMed Web of Science ®Google Scholar
• Bloomfield K, Wu Z, Chan L, et al. Frailty prevalence in Aotearoa New Zealand haemodialysis patients and its association with hospitalisations. N Z Med J. 2021;134(1546):95–108.
   PubMed Web of Science ®Google Scholar
• Anderson BM, Qasim M, Correa G, et al. Self-reported health change in haemodialysis recipients modulates the effect of frailty upon mortality and hospital admissions: outcomes from a large prospective UK cohort. Nephrol Dial Transplant. 2023;38(5):1297–1308. doi: 10.1093/ndt/gfac287.
   PubMed Web of Science ®Google Scholar
• Anderson BM, Qasim M, Correa G, et al. Cognitive ­impairment, frailty, and adverse outcomes among prevalent hemodialysis recipients: results from a large prospective cohort study in the United Kingdom. Kidney Med. 2023;5(4):100613. doi: 10.1016/j.xkme.2023.100613.
   PubMedGoogle Scholar
• López-Montes A, Martínez-Villaescusa M, Pérez-Rodríguez A, et al. Frailty, physical function and affective status in elderly patients on hemodialysis. Arch Gerontol Geriatr. 2020;87:103976. doi: 10.1016/j.archger.2019.103976.
   PubMed Web of Science ®Google Scholar
• Zanotto T, Mercer TH, van der Linden ML, et al. The relative importance of frailty, physical and cardiovascular function as exercise-modifiable predictors of falls in haemodialysis patients: a prospective cohort study. BMC Nephrol. 2020;21(1):99. doi: 10.1186/s12882-020-01759-z.
   PubMed Web of Science ®Google Scholar
• Garcia-Canton C, Rodenas A, Lopez-Aperador C, et al. Frailty in hemodialysis and prediction of poor short-term outcome: mortality, hospitalization and visits to hospital emergency services. Ren Fail. 2019;41(1):567–575. doi: 10.1080/0886022X.2019.1628061.
   PubMed Web of Science ®Google Scholar
• Oki R, Hamasaki Y, Tsuji S, et al. Clinical frailty assessment might be associated with mortality in incident dialysis patients. Sci Rep. 2022;12(1):17651. doi: 10.1038/s41598-022-22483-8.
   PubMed Web of Science ®Google Scholar
• Chao CT, Chiang CK, Huang JW, et al. Self-reported frailty among end-stage renal disease patients: a potential predictor of dialysis access outcomes. Nephrology (Carlton). 2017;22(4):333–334. doi: 10.1111/nep.12961.
   PubMed Web of Science ®Google Scholar
• Mansur HN, Lovisi JC, Colugnati FA, et al. Association of frailty with endothelial dysfunction and its possible impact on negative outcomes in Brazilian predialysis patients with chronic kidney disease. BMC Nephrol. 2015;16(1):157. doi: 10.1186/s12882-015-0150-1.
   PubMedGoogle Scholar
• Chan JS, Hsiao PJ, Chiang WF, et al. The role of oxidative stress markers in predicting acute thrombotic occlusion of haemodialysis vascular access and progressive stenotic dysfunction demanding angioplasty. Antioxidants. 2021;10(4):569. doi: 10.3390/antiox10040569.
   Web of Science ®Google Scholar
• Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107(3):499–511. doi: 10.1161/01.cir.0000052939.59093.45.
   PubMed Web of Science ®Google Scholar
• Shiu YT, Rotmans JI, Geelhoed WJ, et al. Arteriovenous conduits for hemodialysis: how to better modulate the pathophysiological vascular response to optimize vascular access durability. Am J Physiol Renal Physiol. 2019;316(5):F794–f806. doi: 10.1152/ajprenal.00440.2018.
   PubMed Web of Science ®Google Scholar
• Deng MG, Liu F, Liang Y, et al. Association between frailty and depression: a bidirectional Mendelian randomization study. Sci Adv. 2023;9(38):eadi3902. doi: 10.1126/sciadv.adi3902.
   PubMed Web of Science ®Google Scholar
• Majd M, Saunders EFH, Engeland CG. Inflammation and the dimensions of depression: a review. Front Neuroendocrinol. 2020;56:100800. doi: 10.1016/j.yfrne.2019.100800.
   PubMed Web of Science ®Google Scholar
• Anderson BM, Qasim M, Correa G, et al. Depression is associated with frailty and lower quality of life in haemodialysis recipients, but not with mortality or hospitalization. Clin Kidney J. 2023;16(2):342–354. doi: 10.1093/ckj/sfac241.
   PubMed Web of Science ®Google Scholar
• Potter GG, McQuoid DR, Whitson HE, et al. Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions. Int J Geriatr Psychiatry. 2016;31(5):466–474. doi: 10.1002/gps.4351.
   PubMed Web of Science ®Google Scholar
• Panza F, Lozupone M, Solfrizzi V, et al. Different cognitive frailty models and health- and cognitive-related outcomes in older age: from epidemiology to prevention. J Alzheimers Dis. 2018;62(3):993–1012. doi: 10.3233/JAD-170963.
   PubMed Web of Science ®Google Scholar
• Kennard AL, Rainsford S, Glasgow NJ, et al. Use of frailty assessment instruments in nephrology populations: a scoping review. BMC Geriatr. 2023;23(1):449. doi: 10.1186/s12877-023-04101-y.
   PubMed Web of Science ®Google Scholar
• Shannon OM, Ashor AW, Scialo F, et al. Mediterranean diet and the hallmarks of ageing. Eur J Clin Nutr. 2021;75(8):1176–1192. doi: 10.1038/s41430-020-00841-x.
   PubMed Web of Science ®Google Scholar
• Joshi S, Kalantar-Zadeh K, Chauveau P, et al. Risks and benefits of different dietary patterns in CKD. Am J Kidney Dis. 2023;81(3):352–360. doi: 10.1053/j.ajkd.2022.08.013.
   PubMed Web of Science ®Google Scholar
• Wu PY, Chen KM, Tsai WC. The Mediterranean dietary pattern and inflammation in older adults: a systematic review and meta-analysis. Adv Nutr. 2021;12(2):363–373. doi: 10.1093/advances/nmaa116.
   PubMed Web of Science ®Google Scholar
• Hansrivijit P, Oli S, Khanal R, et al. Mediterranean diet and the risk of chronic kidney disease: A systematic ­review and meta-analysis. Nephrology. 2020;25(12):913–918. doi: 10.1111/nep.13778.
   PubMed Web of Science ®Google Scholar
• Valdivielso JM, Jacobs-Cachá C, Soler MJ. Sex hormones and their influence on chronic kidney disease. Curr Opin Nephrol Hypertens. 2019;28(1):1–9. doi: 10.1097/MNH.0000000000000463.
   PubMed Web of Science ®Google Scholar
• Mauvais-Jarvis F, Bairey Merz N, Barnes PJ, et al. Sex and gender: modifiers of health, disease, and medicine. Lancet. 2020;396(10250):565–582. doi: 10.1016/S0140-6736(20)31561-0.
   PubMed Web of Science ®Google Scholar
• Vinson AJ, Zhang X, Dahhou M, et al. A multinational ­cohort study uncovered sex differences in excess mortality after kidney transplant. Kidney Int. 2023;103(6):1131–1143. doi: 10.1016/j.kint.2023.01.022.
   PubMed Web of Science ®Google Scholar