Insomnia symptoms are associated with elevated C-reactive protein in young adults

References

• Ayas, N. T., White, D. P., Al-Delaimy, W. K., Manson, J. E., Stampfer, M. J., Speizer, F. E., … Hu, F. B. (2003). A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care, 26, 380–384.
   PubMed Web of Science ®Google Scholar
• Ayas, N. T., White, D. P., Manson, J. E., Stampfer, M. J., Speizer, F. E., Malhotra, A., … Hu, F. B. (2003). A prospective study of sleep duration and coronary heart disease in women. Archives of Internal Medicine, 163, 205–209.
   PubMed Web of Science ®Google Scholar
• Bastien, C. H., Vallieres, A., & Morin, C. M. (2001). Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Medicine, 2, 297–307.
   PubMed Web of Science ®Google Scholar
• Belsley, D. A., Kuh, E., & Welsch, R. E. (1980). Regression diagnostics: Identifying influential data and sources of collinearity. Hoboken, NJ: John Wiley & Sons, Inc.
   Google Scholar
• Benschop, R. J., Geenen, R., Mills, P. J., Naliboff, B. D., Kiecolt-Glaser, J. K., Herbert, T. B., … Cacioppo, J. T. (1998). Cardiovascular and immune responses to acute psychological stress in young and old women: A meta analysis. Psychosomatic Medicine, 60, 290–296.
   PubMed Web of Science ®Google Scholar
• Blake, G., & Ridker, P. (2002). Inflammatory biomarkers and cardiovascular risk prediction. Journal of Internal Medicine, 252, 283–294.
   PubMed Web of Science ®Google Scholar
• Bolger, N., & Schilling, E. A. (1991). Personality and the problems of everyday life: The role of neuroticism in exposure and reactivity to daily stressors. Journal of Personality, 59, 354–386.
   Web of Science ®Google Scholar
• Breslau, N., Roth, T., Rosenthal, L., & Andreski, P. (1996). Sleep disturbance and psychiatric disorders: A longitudinal epidemiological study of young adults. Biological Psychiatry, 39, 411–418.
   PubMed Web of Science ®Google Scholar
• Buysse, D. J., Angst, J., Gamma, A., Ajdacic, V., Eich, D., & Rössler, W. (2008). Prevalence, course, and comorbidity of insomnia and depression in young adults. Sleep, 31, 473–480.
   PubMed Web of Science ®Google Scholar
• Buysse, D. J., Cheng, Y., Germain, A., Moul, D. E., Franzen, P. L., Fletcher, M., … Monk, T. H. (2010). Night-to-night sleep variability in older adults with and without chronic insomnia. Sleep Medicine, 11, 56–64.
   PubMed Web of Science ®Google Scholar
• Calkins, A. W., Hearon, B. A., Capozzoli, M. C., & Otto, M. W. (2013). Psychosocial predictors of sleep dysfunction: The role of anxiety sensitivity, dysfunctional beliefs, and neuroticism. Behavioral Sleep Medicine, 11, 133–143.
   PubMed Web of Science ®Google Scholar
• Cappuccio, F. P., D'Elia, L., Strazzullo, P., & Miller, M. A. (2010). Quantity and quality of sleep and incidence of type 2 diabetes: A systematic review and meta-analysis. Diabetes Care, 33, 414–420.
   PubMed Web of Science ®Google Scholar
• Chien, K.-L., Chen, P.-C., Hsu, H.-C., Su, T.-C., Sung, F.-C., Chen, M.-F., … Lee, Y.-T. (2010). Habitual sleep duration and insomnia and the risk of cardiovascular events and all-cause death: Report from a community-based cohort. Sleep, 33, 177–184.
   PubMed Web of Science ®Google Scholar
• Clark, L. A., & Watson, D. (1995). Constructing validity: Basic issues in objective scale development. Psychological Assessment, 7, 309.
   Web of Science ®Google Scholar
• Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Lawrence Earlbaum Associates.
   Google Scholar
• Danesh, J., Wheeler, J. G., Hirschfield, G. M., Eda, S., Eiriksdottir, G., Rumley, A., … Gudnason, V. (2004). C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. New England Journal of Medicine, 350, 1387–1397.
   PubMed Web of Science ®Google Scholar
• Drake, C., Richardson, G., Roehrs, T., Scofield, H., & Roth, T. (2004). Vulnerability to stress-related sleep disturbance and hyperarousal. Sleep, 27, 285–291.
   PubMed Web of Science ®Google Scholar
• Drake, C. L., Friedman, N. P., Wright, K. P., & Roth, T. (2011). Sleep reactivity and insomnia: Genetic and environmental influences. Sleep, 34, 1179–1188.
   PubMed Web of Science ®Google Scholar
• Drake, C. L., Pillai, V., & Roth, T. (2014). Stress and sleep reactivity: A prospective investigation of the stress-diathesis model of insomnia. Sleep, 37, 1295–1304.
   PubMed Web of Science ®Google Scholar
• Elovainio, M., Aalto, A. M., Kivimaki, M., Pirkola, S., Sundvall, J., Lonnqvist, J., … Reunanen, A. (2009). Depression and C-reactive protein: population-based Health 2000 Study. Psychosomatic Medicine, 71, 423–430.
   PubMed Web of Science ®Google Scholar
• Fernandez-Mendoza, J., Baker, J. H., Vgontzas, A. N., Gaines, J., Liao, D., … Bixler, E. O. (2017). Insomnia symptoms with objective short sleep duration are associated with systemic inflammation in adolescents. Brain, Behavior, and Immunity, 61, 110–116.
   PubMed Web of Science ®Google Scholar
• Fernandez-Mendoza, J., Shaffer, M. L., Olavarrieta-Bernardino, S., Vgontzas, A. N., Calhoun, S. L., Bixler, E. O., … Vela-Bueno, A. (2014). Cognitive-emotional hyperarousal in the offspring of parents vulnerable to insomnia: A nuclear family study. Journal of Sleep Research, 23, 489–498.
   PubMed Web of Science ®Google Scholar
• Fernandez-Mendoza, J., Vela-Bueno, A., Vgontzas, A. N., Ramos-Platon, M. J., Olavarrieta-Bernardino, S., Bixler, E. O., … De la Cruz-Troca, J. J. (2010). Cognitive-emotional hyperarousal as a premorbid characteristic of individuals vulnerable to insomnia. Psychosomatic Medicine, 72, 397–403.
   PubMed Web of Science ®Google Scholar
• Fernandez-Mendoza, J., & Vgontzas, A. N. (2013). Insomnia and its impact on physical and mental health. Current Psychiatry Reports, 15, 418.
   PubMed Web of Science ®Google Scholar
• Fernandez-Mendoza, J., Vgontzas, A. N., Liao, D., Shaffer, M. L., Vela-Bueno, A., Basta, M., … Bixler, E. O. (2012). Insomnia with objective short sleep duration and incident hypertension: The Penn State Cohort. Hypertension, 60, 929–935.
   PubMed Web of Science ®Google Scholar
• Festa, A., D'Agostino, R. J., Williams, K., Karter, A. J., Mayer-Davis, E. J., Tracy, R. P., … Haffner, S. M. (2001). The relation of body fat mass and distribution to markers of chronic inflammation. International Journal of Obesity and Related Metabolic Disorders, 25, 1407–1415.
   PubMed Web of Science ®Google Scholar
• Ford, D. E., & Erlinger, T. P. (2004). Depression and C-reactive protein in US adults: Data from the Third National Health and Nutrition Examination Survey. Archives of Internal Medicine, 164, 1010–1014.
   PubMedGoogle Scholar
• Ford, D. E., & Kamerow, D. B. (1989). Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? Journal of the American Medical Association, 262, 1479–1484.
   PubMed Web of Science ®Google Scholar
• Gasperi, M., Herbert, M., Schur, E., Buchwald, D., & Afari, N. (2017). Genetic and environmental influences on sleep, pain, and depression symptoms in a community sample of twins. Psychosomatic Medicine, 79, 646–654.
   PubMed Web of Science ®Google Scholar
• Gurtman, C. G., McNicol, R., & McGillivray, J. A. (2014). The role of neuroticism in insomnia. Clinical Psychologist, 18, 116–124.
   Web of Science ®Google Scholar
• Hann, D., Winter, K., & Jacobsen, P. (1999). Measurement of depressive symptoms in cancer patients: Evaluation of the Center for Epidemiological Studies Depression scale (CES-D). Journal of Psychosomatic Research, 46, 437–443.
   PubMed Web of Science ®Google Scholar
• Hohagen, F., Kappler, C., Schramm, E., Riemann, D., Weyerer, S., & Berger, M. (1994). Sleep onset insomnia, sleep maintaining insomnia and insomnia with early morning awakening–temporal stability of subtypes in a longitudinal study on general practice attenders. Sleep, 17, 551–554.
   PubMed Web of Science ®Google Scholar
• Irwin, M. R. (2015). Why sleep is important for health: A psychoneuroimmunology perspective. Annual Review of Psychology, 66, 143–172.
   PubMed Web of Science ®Google Scholar
• Irwin, M. R., Olmstead, R., & Carroll, J. E. (2016). Sleep disturbance, sleep duration, and inflammation: A systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biological Psychiatry, 80, 40–52.
   PubMed Web of Science ®Google Scholar
• Kohler-Forsberg, O., Buttenschon, H. N., Tansey, K. E., Maier, W., Hauser, J., Dernovsek, M. Z., … Mors, O. (2017). Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression. Brain, Behavior, and Immunity, 62, 344–350.
   PubMed Web of Science ®Google Scholar
• Krishnan, V., & Collop, N. A. (2006). Gender differences in sleep disorders. Current Opinion in Pulmonary Medicine, 12, 383–389.
   PubMed Web of Science ®Google Scholar
• Li, L., Wu, C., Gan, Y., Qu, X., & Lu, Z. (2016). Insomnia and the risk of depression: A meta-analysis of prospective cohort studies. BMC Psychiatry, 16, 375.
   PubMed Web of Science ®Google Scholar
• Lichstein, K. L., Durrence, H. H., Riedel, B. W., Taylor, D. J., & Bush, A. J. (2004). Epidemiology of sleep: Age, gender, and ethnicity. New York, NY, Psychology Press.
   Google Scholar
• Lind, M. J., & Gehrman, P. R. (2016). Genetic pathways to insomnia. Brain Sciences, 6, 64.
   PubMed Web of Science ®Google Scholar
• Marsland, A. L., Bachen, E. A., Cohen, S., Rabin, B., & Manuck, S. B. (2002). Stress, immune reactivity and susceptibility to infectious disease. Physiology & Behavior, 77, 711–716.
   PubMed Web of Science ®Google Scholar
• Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Price, N., Dinges, D. F., … Mullington, J. M. (2001). Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects. Clinical Chemistry, 47, 426–430.
   PubMed Web of Science ®Google Scholar
• Meng, L., Zheng, Y., & Hui, R. (2013). The relationship of sleep duration and insomnia to risk of hypertension incidence: A meta-analysis of prospective cohort studies. Hypertension Research, 36, 985–995.
   PubMed Web of Science ®Google Scholar
• Mezuk, B., Diez Roux, A. V., & Seeman, T. (2010). Evaluating the buffering vs. direct effects hypotheses of emotional social support on inflammatory markers: The Multi-Ethnic Study of Atherosclerosis. Brain, Behavior, and Immunity, 24, 1294–1300.
   PubMed Web of Science ®Google Scholar
• Millar, K., Lloyd, S. M., McLean, J. S., Batty, G. D., Burns, H., Cavanagh, J., … Tannahill, C. (2013). Personality, socio-economic status and inflammation: Cross-sectional, population-based study. PLoS ONE, 8, e58256.
   PubMed Web of Science ®Google Scholar
• Miller, G. E., Stetler, C. A., Carney, R. M., Freedland, K. E., & Banks, W. A. (2002). Clinical depression and inflammatory risk markers for coronary heart disease. American Journal of Cardiology, 90, 1279–1283.
   PubMed Web of Science ®Google Scholar
• Morin, C. M. (1993). Insomnia: Psychological assessment and management. New York: Guilford Press.
   Google Scholar
• Morin, C. M., Bélanger, L., LeBlanc, M., Ivers, H., Savard, J., Espie, C. A., … Grégoire, J. P. (2009). The natural history of insomnia: A population-based 3-year longitudinal study. Archives of Internal Medicine, 169, 447–453.
   PubMed Web of Science ®Google Scholar
• Morin, C. M., LeBlanc, M., Daley, M., Gregoire, J. P., & Mérette, C. (2006). Epidemiology of insomnia: Prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors. Sleep Medicine, 7, 123–130.
   PubMed Web of Science ®Google Scholar
• Mortensen, R. F. (2001). C-reactive protein, inflammation, and innate immunity. Immunologic Research, 24, 163–176.
   PubMed Web of Science ®Google Scholar
• Nakao, A. (2014). Temporal regulation of cytokines by the circadian clock. Journal of Immunology Research, 2014, 1–4.
   Google Scholar
• Niles, A. N., Smirnova, M., Lin, J., & O'Donovan, A. (2018). Gender differences in longitudinal relationships between depression and anxiety symptoms and inflammation in the health and retirement study. Psychoneuroendocrinology, 95, 149–157.
   PubMed Web of Science ®Google Scholar
• Nilsonne, G., Lekander, M., Åkerstedt, T., Axelsson, J., & Ingre, M. (2016). Diurnal variation of circulating interleukin-6 in humans: A meta-analysis. PLoS One, 11, e0165799.
   PubMed Web of Science ®Google Scholar
• O'Connor, M. F., Bower, J. E., Cho, H. J., Creswell, J. D., Dimitrov, S., Hamby, M. E., … Irwin, M. R. (2009). To assess, to control, to exclude: Effects of biobehavioral factors on circulating inflammatory markers. Brain, Behavior, and Immunity, 23, 887–897.
   PubMed Web of Science ®Google Scholar
• Ohayon, M. (2002). Epidemiology of insomnia: What we know and what we still need to learn. Sleep Medicine Reviews, 6, 97–111.
   PubMed Web of Science ®Google Scholar
• Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., III, Criqui, M., … Vinicor, F. (2003). Markers of inflammation and cardiovascular disease: Application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation, 107, 499–511.
   PubMed Web of Science ®Google Scholar
• R Core Team. (2017). R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
   Google Scholar
• Radloff, L. S. (1977). The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385–401.
   Web of Science ®Google Scholar
• Reuben, D. B., Cheh, A. I., Harris, T. B., Ferrucci, L., Rowe, J. W., Tracy, R. P., … Seeman, T. E. (2002). Peripheral blood markers of inflammation predict mortality and functional decline in high‐functioning community‐dwelling older persons. Journal of the American Geriatrics Society, 50, 638–644.
   PubMed Web of Science ®Google Scholar
• Ridker, P., Rifai, N., Stampfer, M., & Hennekens, C. (2000). Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation, 101, 1767–1772.
   PubMed Web of Science ®Google Scholar
• Ridker, P. M. (2003). Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation, 107, 363–369.
   PubMed Web of Science ®Google Scholar
• Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., … Nissen, C. (2010). The hyperarousal model of insomnia: A review of the concept and its evidence. Sleep Medicine Reviews, 14, 19–31.
   PubMed Web of Science ®Google Scholar
• Rosenkranz, M. A., Jackson, D. C., Dalton, K. M., Dolski, I., Ryff, C. D., Singer, B. H., … Davidson, R. J. (2003). Affective style and in vivo immune response: Neurobehavioral mechanisms. Procedings of the National Academy of Science, 100, 11148–11152.
   PubMed Web of Science ®Google Scholar
• Sato, T. (2005). The Eysenck personality questionnaire brief version: Factor structure and reliability. Journal of Psychology, 139, 545–552.
   PubMed Web of Science ®Google Scholar
• Slavish, D. C., Sliwinski, M. J., Smyth, J. M., Lipton, R. B., Katz, M. J., & Graham-Engeland, J. E. (2018). Neuroticism, rumination, negative affect, and sleep: Examining between- and within-person associations. Personality and Individual Differences, 123, 217–222.
   PubMed Web of Science ®Google Scholar
• Sofi, F., Cesari, F., Casini, A., Macchi, C., Abbate, R., & Gensini, G. F. (2014). Insomnia and risk of cardiovascular disease: A meta-analysis. European Journal of Preventive Cardiology, 21, 57–64.
   PubMed Web of Science ®Google Scholar
• Spielman, A. J., Caruso, L. S., & Glovinsky, P. B. (1987). A behavioral perspective on insomnia treatment. The Psychiatry Clinics of North America, 10, 541–553.
   PubMed Web of Science ®Google Scholar
• Stanley, D. (2017). apaTables: Create American Psychological Association (APA) Style Tables (Version 1.5.1) [R package]. Retrieved from https://github.com/dstanley4/apaTables
   Google Scholar
• Steptoe, A., Hamer, M., & Chida, Y. (2007). The effects of acute psychological stress on circulating inflammatory factors in humans: A review and meta-analysis. Brain, Behavior, and Immunity, 21, 901–912.
   PubMed Web of Science ®Google Scholar
• Suarez, E. C. (2008). Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: Evidence for gender disparity. Brain, Behavior, and Immunity, 22, 960–968.
   PubMed Web of Science ®Google Scholar
• Suh, S., Nowakowski, S., Bernert, R. A., Ong, J. C., Siebern, A. T., Dowdle, C. L., … Manber, R. (2012). Clinical significance of night-to-night sleep variability in insomnia. Sleep Medicine, 13, 469–475.
   PubMed Web of Science ®Google Scholar
• Sutin, A. R., Terracciano, A., Deiana, B., Naitza, S., Ferrucci, L., Uda, M., … Costa, P. T. J. (2010). High neuroticism and low conscientiousness are associated with interleukin-6. Psychological Medicine, 40, 1485–1493.
   PubMed Web of Science ®Google Scholar
• Tabachnick, B. G., & Fidell, L. S. (2007). Using multivariate statistics (5th ed.). Boston, MA: Allyn and Bacon.
   Google Scholar
• Taylor, D. J., Lichstein, K. L., Durrence, H. H., Reidel, B. W., & Bush, A. J. (2005). Epidemiology of insomnia, depression, and anxiety. Sleep, 28, 1457–1464.
   PubMed Web of Science ®Google Scholar
• Taylor, D. J., Mallory, L. J., Lichstein, K. L., Durrence, H. H., Riedel, B. W., … Bush, A. J. (2007). Comorbidity of chronic insomnia with medical problems. Sleep, 30, 213–218.
   PubMed Web of Science ®Google Scholar
• Uchino, B. N., Ruiz, J. M., Smith, T. W., Smyth, J. M., Taylor, D. J., Allison, M., … Ahn, C. (2016). Ethnic/racial differences in the association between social support and levels of C-reactive proteins in the North Texas Heart Study. Psychophysiology, 53, 64–70.
   PubMed Web of Science ®Google Scholar
• van de Laar, M., Verbeek, I., Pevernagie, D., Aldenkamp, A., & Overeem, S. (2010). The role of personality traits in insomnia. Sleep Medicine Reviews, 14, 61–68.
   PubMed Web of Science ®Google Scholar
• Woloshin, S., & Schwartz, L. M. (2005). Distribution of C-reactive protein values in the United States. New England Journal of Medicine, 352, 1611–1613.
   PubMed Web of Science ®Google Scholar
• Zoccola, P. M., Figueroa, W. S., Rabideau, E. M., Woody, A., & Benencia, F. (2014). Differential effects of poststressor rumination and distraction on cortisol and C-reactive protein. Health Psychology, 33, 1606.
   PubMed Web of Science ®Google Scholar