REFERENCES
- Goodrich D W, Lee W H. Molecular characterisation of the retinoblastoma susceptibility gene. Biochim Biophys Acta.. 1993; 11555: 43–61
- Friend S H, Bernards R, Rogelj S, et al, A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 1986; 323: 643–646. [PUBMED], [INFOTRIEVE]
- Scholz R B, Kabisch H, Weber B. Studies of the RB1 gene and the p53 gene in human osteosarcomas. Ped Hem Oncol.. 1992; 9: 125–137
- Wadayama B, Toguchida J, Shimizu T, et al, Mutation spectrum of the retinoblastoma gene in osteosarcoma. Cancer Res.. 1994; 54: 3042–3048. [PUBMED], [INFOTRIEVE]
- Bookstein R, Rio P, Madreperla S A, et al, Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma. Proc Natl Acad Sci USA.. 1990; 87: 7762–7766. [PUBMED], [INFOTRIEVE]
- Baylin S B, Hermann J G, Graff J R, et al, Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res.. 1998; 72: 141–196. [PUBMED], [INFOTRIEVE]
- Esteller M, Sanchez-Cespedes M, Rosell R, et al, Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res.. 1999; 59: 67–70. [PUBMED], [INFOTRIEVE]
- Sakai T, Toguchida J, Ohtani N, et al, Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Am J Hum Genet.. 1991; 48: 880–888. [PUBMED], [INFOTRIEVE]
- Greger V, Debus N, Lohmann D, et al, Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma. Hum Genet.. 1994; 94: 491–496. [PUBMED], [INFOTRIEVE]
- Ohtani-Fujita N, Dryja T, Rapaport J M, et al, Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma. Cancer Genet Cytogenet.. 1997; 98: 43–49. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Ohtani-Fujita N, Fujita T, Aoike A, et al, CpG methylation inactivates the promoter activity of the human retinoblastoma tumor suppressor gene. Oncogene. 1993; 8: 1063–1067. [PUBMED], [INFOTRIEVE]
- Fuchs N, Winkler K. Osteosarcoma. Curr Opin Oncol.. 1993; 5: 667–671. [PUBMED], [INFOTRIEVE]
- Nakamura M, Yonekawa Y, Kleihues P, et al, Promoter hypermethylation of the RB1 gene in glioblastomas. Laboratory Investigation. 2001; 81: 77–82. [PUBMED], [INFOTRIEVE]
- Simpson D J, Hibberts N A, McNicol A M, et al, Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island. Cancer Research. 2000; 60: 1211–1216. [PUBMED], [INFOTRIEVE]
- Salzer-Kuntschik M, Brand G, Delling G. Bestimmung des morphologischen Regressionsgrades nach Chemotherapie bei malignen Knochentumoren. Pathologe. 1983; 4: 135–141. [PUBMED], [INFOTRIEVE]
- Sambrook J, Fritsch J, Maniatis T. Molecular Cloning: A Laboratory Manuel, ed. 2, Cold Spring Harbor, NY, Cold Spring Harbor Press. 1989
- Greger V, Kerst S, Messmer E, et al, Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet. 1989; 83: 155–158. [PUBMED], [INFOTRIEVE]
- McGee T L, Yandell D W, Dryja T P. Structure and partial genomic sequence of the human retinoblastoma susceptibility gene. Gene. 1989; 80: 119–128. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Belka C, Greger V, Zabel B, et al, No evidence for sequences structurally related to the RB1 gene in the human genome. Hum Genet. 1991; 86: 401–403. [PUBMED], [INFOTRIEVE]
- Toguchida J, McGee T L, Paterson J C, et al, Complete genomic sequence of the human retinoblastoma susceptibility gene. Genomics. 1993; 17: 535–543. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Esteller M, Corn P G, Baylin S B, et al, A gene hypermethylation profile of human cancer. Cancer Research. 2001; 61: 3225–3229. [PUBMED], [INFOTRIEVE]
- Feugeas O, Guriec N, Babin-Boilletot A, et al, Loss of heterozygositiy of the RB gene is a poor prognostic factor in patients with osteosarcoma. J. Clin. Oncol.. 1996; 14: 467–472. [PUBMED], [INFOTRIEVE]
- Stirzacker C, Millar D S, Paul C L, et al, Extensive DNA methylation spanning the RB promoter in retinoblastoma tumors. Cancer Res.. 1997; 57: 2229–2237
- Herman J G, Graff J R, Myöhänen S, et al, Methylation specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA. 1996; 93: 9821–9826. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Wu J, Issa J P, Herman J, et al, Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH3T3 cells. Proc Natl Acad Sci USA.. 1993; 90: 8891–8895. [PUBMED], [INFOTRIEVE]
- Bakin A V, Curran T. Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science.. 1999; 283: 387–390. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Belinsky S A, Nikula K J, Baylin S B, et al, Increased cytosine DNA methyltransferase activity is target-cell specific and an early event in lung cancer. Proc Natl Acad Sci USA.. 1996; 93: 4045–4050. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Belinsky S A, Nikula K J, Palmisano W A, et al, Aberrant methylation of p16 (INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci USA.. 1998; 95: 11891–11896. [CROSSREF], [PUBMED], [INFOTRIEVE]
- Antillon-Klussmann F, Garcia-Delgado M, Villa-Elizaga I, et al, Mutational activation of ras genes is absent in pediatric osteosarcoma. Cancer Genet Cytogenet. 1995; 79: 49–53. [CROSSREF], [PUBMED], [INFOTRIEVE]