643
Views
46
CrossRef citations to date
0
Altmetric
Articles

MONOTHERAPY WITH PIPERACILLIN/TAZOBACTAM VERSUS CEFEPIME AS EMPIRICAL THERAPY FOR FEBRILE NEUTROPENIA IN PEDIATRIC CANCER PATIENTS: A Randomized Comparison

, MD, , MD & , MD
Pages 177-186 | Received 20 May 2005, Accepted 02 Dec 2005, Published online: 09 Jul 2009

REFERENCES

  • Hughes W T, Armstrong D, Bodey G P, et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 2002; 34: 730–751, [PUBMED], [CSA]
  • Viscoli C, Castagnola E, Caniggia M, et al. Italian guidelines for the management of infectious complications in pediatric oncology: empirical antimicrobial therapy of febrile neutropenia. Oncology 1998; 55: 489–500, [PUBMED], [CROSSREF], [CSA]
  • Gaya H. Empirical therapy of infections in neutropenic patients. Br J Hematol. 1998; 101: 5–9, [CSA]
  • Klastersky J. Empirical antibiotic therapy in neutropenic cancer patients. Eur J Cancer 1993; 29: 6–10, [CSA]
  • Kebudi R, Gorgün O, Ayan I, Gurler N, Akici F, Toreci K. Randomized comparison of cefepime versus ceftazidime monotherapy for fever and neutropenia in children with solid tumors. Med Pedaitr Oncol. 2001; 36: 434–441, [CROSSREF], [CSA]
  • Hung K C, Chiu H H, Tseng Y C, et al. Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empirical therapy for neutropenic fever in children with malignancy. J Microbiol Immunol Infect 2003; 36: 254–259, [PUBMED], [CSA]
  • Düzova A, Kutluk T, Kanra G, et al. Monotherapy with meropenem versus combination therapy with piperacillin plus amikacin as empiric therapy for neutropenic fever in children with lymphoma and solid tumors. Turk J Pediatr 2001; 43: 105–109, [CSA]
  • Biron P, Fuhrmann C, Cure H, et al. Cefepime versus imipenem-cilastatin as emprical monotherapy in 400 febrile patients with short duration neutropenia. J Antimicrob Chemother 1998; 42: 511–518, [PUBMED], [CROSSREF], [CSA]
  • Ramphal R. Is monotherapy for febrile neutropenia still a viable alternative?. Clin Infect Dis. 1999; 29: 508–514, [PUBMED], [CSA]
  • Ramphal R, Gucalp R, Rotstein C, Cimino M, Oblon D. Clinical experince with single agent and combination regimens in the management of infection in the febrile neutropenic patient. Am J Med 1996; 100: 83S–89S, [PUBMED], [CROSSREF], [CSA]
  • Çorapçioglu F, Sarper N. Cefepime versus ceftazidime+amikacin as empirical therapy for febrile neutropenia in children with cancer: a prospective randomized trial of the treatment efficacy and cost. Pediatr Hematol Oncol. 2005; 22: 59–70, [CSA]
  • Gorschlüter M, Hahn C, Fixson A, et al. Piperacillin–tazobactam is more effective than ceftriaxone plus gentamicin in febrile neutropenic patient with hematological malignancies: a randomized comparison. Support Care Cancer 2003; 11: 362–370, [CSA]
  • Yamamura D, Gucalp R, Carlisle P, Cimino M, Roberts J, Rotstein C. Open randomized study of cefepime versus piperacillin-gentamicin for treatment of febrile neutropenic cancer patients. Antimicrob Agents Chemother. 1997; 41: 1704–1708, [PUBMED], [CSA]
  • Fleischhack G, Schmidt-Niemann M, Wulff B, et al. Piperacillin, beta-lactam inhibitor plus gentamicin as empirical therapy of a sequential regimen in febrile neutropenia of pediatric cancer patients. Support Care Cancer 2001; 9: 372–379, [PUBMED], [CROSSREF], [CSA]
  • Cometta A, Zinner S, De Bock R, et al. Piperacillin–tazobactam plus amikacin versus ceftazidime plus amikacin as empiric therapy for fever in granulucytopenic patients with cancer. Antimicrob Agents Chemoter 1995; 39: 445–452, [CSA]
  • Hess U, Böhme C, Rey K, Senn H J. Monotherapy with piperacillin/tazobactam versus combination therapy with ceftazidime plus amikacin as an empiric therapy for fever in neutropenic cancer patients. Support Care Cancer. 1998; 6: 402–409, [PUBMED], [CROSSREF], [CSA]
  • Del Favero A, Menichetti F, Martino P, et al. A multicenter, double-blind, placebo-controlled trial comparing piperacillin-tazobactam with and without amikacin as empiric therapy for febrile neutropenia. Clin Infect Dis 2001; 33: 1295–1301, [PUBMED], [CROSSREF], [CSA]
  • Le Guyader N, Auvrignon A, Vu-Thien H, Portier E, Tabone M D, Leverger G. Piperacillin–tazobactam and netilmicin as a safe and efficacious empirical treatment of febrile neutropenic children. Support Care Cancer. 2004; 12: 720–724, [PUBMED], [CROSSREF], [CSA]
  • Aksoylar S, Çetingül N, Kantar M, Karapinar D, Kavakli K, Kansoy S. Meropenem plus amikacin versus piperacillin–tazobactam plus netilmicin as empiric therapy for high-risk febrile neutropenia in children. Pediatr Hematol Oncol. 2004; 21: 115–123, [PUBMED], [CROSSREF], [CSA]
  • Kutluk T, Kurne O, Akyüz C, et al. Cefepime vs. meropenem as empirical therapy for neutropenic fever in children with lymphoma and solid tumors. Pediatr Blood Cancer 2004; 42: 284–286, [PUBMED], [CROSSREF], [CSA]
  • Mustafa M M, Carlson L, Tkaczewski I, McCracken G H, Jr, Buchanan G R. Comparative study of cefepime versus ceftazidime in the empiric treatment of pediatric cancer patients with fever and neutropenia. Pediatr Infect Dis J. 2001; 20: 362–369, [PUBMED], [CROSSREF], [CSA]
  • Dues J M, Siebor E, Pechinot A, Cordin X, Chamard-Neuwirth C, Kazmierczak A. In vitro antibacterial activity of piperacillin-tazobactam in combination with netilmicin or amikacin against Enterobacteriaceae resistant to amoxicillin. Pathol Biol. 1995; 43: 208–214, [CSA]
  • Thabaut A, Meyran M. In vitro activity of piperacillin-tazobactam on 224 isolats of P. aeruginosa according to beta-lactamase production. Pathol Biol 1991; 39: 361–366, [PUBMED], [CSA]
  • Arguedas A, Sifuentes-Osornio J, Loaiza C, Herrera M, Corrales J C, Mohs E. An open, multicenter clinical trial of piperacillin/tazobactam in the treatment of pediatric patients with intra-abdominal infections. J Chemother. 1996; 8: 130–136, [PUBMED], [CSA]
  • Cometta A, Kern W V, De Bock R, et al. Vancomycin versus placebo for treating persistent fever in patients with neutropenic cancer receiving piperacillin–tazobactam monotherapy. Clin Infect Dis 2003; 37: 382–389, [PUBMED], [CROSSREF], [CSA]
  • Kelsey S M, Weinhardt B, Pocock C E, Shaw E, Newland A C. Piperacillin/tazobactam plus gentamicin as empirical therapy for febrile neutropenic patients with hematological malignancy. J Chemother. 1992; 4: 281–285, [PUBMED], [CSA]
  • Bohme A, Shah P M, Stille W, Hoelzer D. Piperacillin/tazobactam versus cefepime as initial empirical antimicrobial therapy in febrile neutropenia patients: a prospective randomized pilot study. Eur J Met Res. 1998; 3: 324–330, [CSA]
  • Reed M D, Goldfarb C, Yamashita T S, Lemon E, Blumer J. Single-dose pharmacokinetics of piperacillin and tazobactam in infants and children. Antimicrob Agents Chemother. 1994; 38: 2817–2826, [PUBMED], [CSA]
  • Nürnberger W, Bönig H, Burdach S, Göbel U. Tolerability of piperacillin/tazobactam in children and adolescence after high dose radio/chemotherapy and autologous stem cell transplantation. Infection. 1998; 26: 65–67, [CSA]
  • Castagnola E, Paula D, Giacchino R, Rossi R, Viscoli C. Economic aspects of empiric antibiotic therapy for febrile neutropenia in children with cancer. Support Care Cancer. 1998; 6: 524–528, [PUBMED], [CROSSREF], [CSA]
  • Agaoglu L, Devecioglu O, Anak S, et al. Cost-effectiveness of cefepime + netilmicin or ceftazidime + amikacin or meropenem monotherapy in febrile neutropenic children with malignancy in Turkey. J Chemother 2001; 13: 281–287, [PUBMED], [CSA]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.