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Case Reports

METHOTREXATE RECHALLENGE FOLLOWING DELAYED CLEARANCE AND LIFE-THREATENING TOXICITY

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Pages 119-121 | Received 17 Jan 2007, Accepted 31 Oct 2007, Published online: 09 Jul 2009

REFERENCES

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  • Bacci G, Ferrari S, Longhi A, et al. Delayed methotrexate clearance in osteosarcoma patients treated with multiagent regimens of neoadjuvant chemotherapy. Oncol Rep 2003; 10: 851–857
  • Joerger J M, Huitema A D, Van Den Bongard H J, et al. Determinants of the elimination of methotrexate and 7-hydroxy-methotrexate following high dose infusional therapy to cancer patients. Br J Clin Pharmacol 2006; 62: 71–80
  • Crom W R, Pratt C B, Green A A, et al. The effect of prior cisplatin therapy on the pharmacokinetics of high-dose methotrexate. J Clin Oncol 1984; 2: 655–661

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