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Pediatric Hematology and Oncology Volume 25, 2008 - Issue 5
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Articles

CHEMICAL AND FUNCTIONAL ANALYSIS OF GENERIC HYDROXYUREA FORMULATIONS

Virginia L. Harrod Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
, MD, PhD,
Thad Howard Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
, MS,
Miguel R. Abboud Department of Pediatrics, Children's Cancer Center of Lebanon, American University of Beirut Medical Center, Beirut, Lebanon
, MD,
Jane Hankins Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
, MD, MS,
Clarisse Lobo Hematology Institute of Rio de Janeiro (HEMORIO), Rio de Janeiro, Brazil
, MD &
Russell E. Ware Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
, MD, PhD
Pages 423-429 | Received 17 Nov 2007, Accepted 25 Mar 2008, Published online: 09 Jul 2009

REFERENCES

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  • Steinberg MH, Barton F, Castro O, et al. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment. JAMA 2003; 289: 1645–1651
  • Zimmerman SA, Schultz WH, Davis JS, et al. Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease. Blood 2004; 103: 2039–2045
  • Hankins JS, Ware RE, Rogers ZR, et al. Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study. Blood 2005; 106: 2269–2275
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  • Kinney TR, Helms RW, O’Branski EE, et al. Safety of hydroxyurea in children with sickle cell anemia: results of the HUG-KIDS study, a phase I/II trial. Pediatric Hydroxyurea Group. Blood 1999; 94: 1550–1554
  • Ware RE, Eggleston B, Redding-Lallinger R, et al. Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy. Blood 2002; 99: 10–14
  • WHO Expert Committee on Specifications for Pharmaceutical Preparations. WHO Technical Report Series, no. 902. 2002
  • Counterfeit Medicines. WHO Drug Information, Vol. 20, No. 1. 2006
  • Heeney MM, Whorton MR, Howard TA, Johnson CA, Ware RE. Chemical and functional analysis of hydroxyurea oral solutions. J Pediatr Hematol Oncol. 2004; 26: 179–184
  • Fabricius E, Rajewsky F. Determination of hydroxyurea in mammalian tissues and blood. Rev Eur Etud Clin Biol. 1971; 16: 679–683
  • Harrod VL, Abramova T, Howard TA, Ware RE. Modification of a colorimetric hydroxyurea assay using small serum volumes [abstract]. Pediatr Blood Cancer 2006; 46: 672

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