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Articles

The yield of monitoring adenovirus in pediatric hematopoietic stem cell transplant patients

, , , , , , , , & show all
Pages 161-172 | Received 30 Oct 2018, Accepted 10 Apr 2019, Published online: 30 Apr 2019

References

  • Matthes-Martin S, Feuchtinger T, Shaw PJ, et al. European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4 (2011). Transpl Infect Dis. 2012;14(6):555–563. doi:10.1111/tid.12022.
  • Mynarek M, Ganzenmueller T, Mueller-Heine A, et al. Patient, virus, and treatment-related risk factors in pediatric adenovirus infection after stem cell transplantation: results of a routine monitoring program. Biol Blood Marrow Transplant. 2014;20(2):250–256. doi:10.1016/j.bbmt.2013.11.009.
  • Watson T, MacDonald D, Song X, et al. Risk factors for molecular detection of adenovirus in pediatric hematopoietic stem cell transplantation recipients. Biol Blood Marrow Transplant. 2012;18(8):1227–1234. doi:10.1016/j.bbmt.2012.01.013.
  • Kullberg-Lindh C, Mellgren K, Friman V, et al. Opportunistic virus DNA levels after pediatric stem cell transplantation: serostatus matching, anti-thymocyte globulin, and total body irradiation are additive risk factors: opportunistic viral infections after pediatric SCT. Transpl Infect Dis. 2011;13(2):122–130. doi:10.1111/j.1399-3062.2010.00564.x.
  • Öhrmalm L, Lindblom A, Omar H, et al. Evaluation of a surveillance strategy for early detection of adenovirus by PCR of peripheral blood in hematopoietic SCT recipients: incidence and outcome. Bone Marrow Transplant. 2011;46(2):267–272. doi:10.1038/bmt.2010.86.
  • Lion T, Kosulin K, Landlinger C, et al. Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation. Leukemia 2010;24(4):706–714. doi:10.1038/leu.2010.4.
  • Gustafson I, Lindblom A, Yun Z, et al. Quantification of adenovirus DNA in unrelated donor hematopoietic stem cell transplant recipients. J Clin Virol. 2008;43(1):79–85. doi:10.1016/j.jcv.2008.04.014.
  • Yusuf U, Hale GA, Carr J, et al. Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients. Transplantation 2006;81(10):1398–1404. doi:10.1097/01.tp.0000209195.95115.8e.
  • Walls T, Hawrami K, Ushiro-Lumb I, Shingadia D, Saha V, Shankar AG. Adenovirus infection after pediatric bone marrow transplantation: is treatment always necessary? Clin Infect Dis. 2005;40(9):1244–1249. doi:10.1086/429235.
  • Howard DS, Phillips GL, Reece DE, et al. Adenovirus infections in hematopoietic stem cell transplant recipients. Clin Infect Dis. 1999;29(6):1494–1501. doi:10.1086/313514.
  • George D, El-Mallawany NK, Jin Z, et al. Adenovirus infection in paediatric allogeneic stem cell transplantation recipients is a major independent factor for significantly increasing the risk of treatment related mortality: adenovirus in paediatric allogeneic stem cell transplant. Br J Haematol. 2012;156(1):99–108. doi:10.1111/j.1365-2141.2010.08468.x.
  • Kosulin K, Geiger E, Vécsei A, et al. Persistence and reactivation of human adenoviruses in the gastrointestinal tract. Clin Microbiol Infect. 2016;22(4):381.e1–381.e8. doi:10.1016/j.cmi.2015.12.013.
  • Garnett CT, Talekar G, Mahr JA, et al. Latent species C adenoviruses in human tonsil tissues. J Virol. 2009;83(6):2417–2428. doi:10.1128/JVI.02392-08.
  • Echavarria MS, Ray SC, Ambinder R, Dumler JS, Charache P. PCR detection of adenovirus in a bone marrow transplant recipient: hemorrhagic cystitis as a presenting manifestation of disseminated disease. J Clin Microbiol. 1999;37(3):686–689.
  • Robin M, Marque-Juillet S, Scieux C, et al. Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome. Haematologica 2007;92(9):1254–1257.
  • van Tol MJD, Kroes ACM, Schinkel J, et al. Adenovirus infection in paediatric stem cell transplant recipients: increased risk in young children with a delayed immune recovery. Bone Marrow Transplant. 2005;36(1):39–50. doi:10.1038/sj.bmt.1705003.
  • Lion T. Adenovirus Infections in immunocompetent and immunocompromised patients. Clin Microbiol Rev. 2014;27(3):441–462. doi:10.1128/CMR.00116-13.
  • Hiwarkar P, Gaspar HB, Gilmour K, et al. Impact of viral reactivations in the era of pre-emptive antiviral drug therapy following allogeneic haematopoietic SCT in paediatric recipients. Bone Marrow Transplant. 2013;48(6):803–808. doi:10.1038/bmt.2012.221.
  • Sandkovsky U, Vargas L, Florescu DF. Adenovirus: current epidemiology and emerging approaches to prevention and treatment. Curr Infect Dis Rep. 2014; 16(8):416. doi:10.1007/s11908-014-0416-y.
  • Echavarria M, Forman M, van Tol MJ, Vossen JM, Charache P, Kroes AC. Prediction of severe disseminated adenovirus infection by serum PCR. The Lancet. 2001;358(9279):384–385. doi:10.1016/S0140-6736(01)05580-5.
  • Schilham MW, Claas EC, van Zaane W, et al. High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation. Clin Infect Dis. 2002;35(5):526–532. doi:10.1086/341770.
  • Hiwarkar P, Kosulin K, Cesaro S, et al. Management of adenovirus infection in patients after haematopoietic stem cell transplantation: state-of-the-art and real-life current approach: a position statement on behalf of the Infectious Diseases Working Party of the European Society of Blood and Marrow Transplantation. Rev Med Virol. 2018;28(3):e1980. doi:10.1002/rmv.1980.
  • Feghoul L, Chevret S, Cuinet A, et al. Adenovirus infection and disease in paediatric haematopoietic stem cell transplant patients: clues for antiviral pre-emptive treatment. Clin Microbiol Infect. 2015;21(7):701–709. doi:10.1016/j.cmi.2015.03.011.
  • Srinivasan A, Klepper C, Sunkara A, et al. Impact of adenoviral stool load on adenoviremia in pediatric hematopoietic stem cell transplant recipients. Pediatr Infect Dis J. 2015;34(6):562–565. doi:10.1097/INF.0000000000000678.
  • Kosulin K, Berkowitsch B, Matthes S, et al. Intestinal adenovirus shedding before allogeneic stem cell transplantation is a risk factor for invasive infection post-transplant. EBioMedicine 2018;28:114–119. doi:10.1016/j.ebiom.2017.12.030.
  • Feuchtinger T, Lücke J, Hamprecht K, et al. Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation. Br J Haematol. 2005;128(4):503–509. doi:10.1111/j.1365-2141.2004.05331.x.
  • Bhadri VA, Lee-Horn L, Shaw PJ. Safety and tolerability of cidofovir in high-risk pediatric patients. Transpl Infect Dis. 2009;11(4):373–379. doi:10.1111/j.1399-3062.2009.00391.x.
  • Grimley MS, Chemaly RF, Englund JA, et al. Brincidofovir for asymptomatic adenovirus viremia in pediatric and adult allogeneic hematopoietic cell transplant recipients: a randomized placebo-controlled phase II trial. J Am Soc Blood Marrow Transplant. 2017;23(3):512–521. doi:10.1016/j.bbmt.2016.12.621.
  • Hiwarkar P, Amrolia P, Sivaprakasam P, et al. Brincidofovir is highly efficacious in controlling adenoviremia in pediatric recipients of hematopoietic cell transplant. Blood 2017;129(14):2033–2037. doi:10.1182/blood-2016-11-749721.
  • Leen AM, Christin A, Myers GD, et al. Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation. Blood 2009;114(19):4283–4292. doi:10.1182/blood-2009-07-232454.
  • Sarantis H, Johnson G, Brown M, Petric M, Tellier R. Comprehensive detection and serotyping of human adenoviruses by PCR and sequencing. J Clin Microbiol. 2004;42(9):3963–3969. doi:10.1128/JCM.42.9.3963-3969.2004.
  • Lindemans CA, Leen AM, Boelens JJ. How I treat adenovirus in hematopoietic stem cell transplant recipients. Blood 2010;116(25):5476–5485. doi:10.1182/blood-2010-04-259291.
  • Lion T. Molecular monitoring of adenovirus in peripheral blood after allogeneic bone marrow transplantation permits early diagnosis of disseminated disease. Blood 2003;102(3):1114–1120. doi:10.1182/blood-2002-07-2152.
  • Kampmann B, Cubitt D, Walls T, et al. Improved outcome for children with disseminated adenoviral infection following allogeneic stem cell transplantation. Br J Haematol. 2005;130(4):595–603. doi:10.1111/j.1365-2141.2005.05649.x.
  • Leruez-Ville M, Minard V, Lacaille F, et al. Real-time blood plasma polymerase chain reaction for management of disseminated adenovirus infection. Clin Infect Dis. 2004;38(1):45–52. doi:10.1086/380450.
  • Anderson EJ, Guzman-Cottrill JA, Kletzel M, et al. High-risk adenovirus-infected pediatric allogeneic hematopoietic progenitor cell transplant recipients and preemptive cidofovir therapy. Pediatr Transplant. 2008;12(2):219–227. doi:10.1111/j.1399-3046.2007.00851.x.
  • Sivaprakasam P, Carr TF, Coussons M, et al. Improved outcome from invasive adenovirus infection in pediatric patients after hemopoietic stem cell transplantation using intensive clinical surveillance and early intervention. J Pediatr Hematol Oncol. 2007;29(2):81–85. doi:10.1097/MPH.0b013e318030875e.
  • Kalpoe JS, Van P, der H, Barge RM, et al. Assessment of disseminated adenovirus infections using quantitative plasma PCR in adult allogeneic stem cell transplant recipients receiving reduced intensity or myeloablative conditioning. Eur J Haematol. 2007;78(4):314–321. doi:10.1111/j.1600-0609.2007.00821.x.
  • Omar H, Yun Z, Lewensohn, I et al. Poor outcome of adenovirus infections in adult hematopoietic stem cell transplant patients with sustained adenovirus viremia. Transpl Infect Dis. 2010;12(5):465–469. doi:10.1111/j.1399-3062.2010.00528.x.
  • Suparno C, Milligan DW, Moss PAH, Mautner V. Adenovirus infections in stem cell transplant recipients: recent developments in understanding of pathogenesis, diagnosis and management. Leuk Lymphoma. 2004;45(5):873–885. doi:10.1080/10428190310001628176.
  • Walls T, Hawrami K, Shingadia D, Ushiro-Lumb I, Shankar A. Polymerase chain reaction in the management of disseminated adenovirus infection after stem cell transplantation. Pediatr Infect Dis J. 2004;23(12):1167–1169. doi:10.1097/01.inf.0000145407.56083.89.
  • Tomblyn M, Chiller T, Einsele H, et al. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant. 2009;15(10):1143–1238. doi:10.1016/j.bbmt.2009.06.019.

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