A prospective study on the epidemiology and clinical significance of viral respiratory infections among pediatric oncology patients

References

• Bailey CL, Reilly AF, Rheingold SR. Infections in pediatric patients with hematologic malignancies. Semin Hematol. 2009;46(3):313–324. doi:10.1053/j.seminhematol.2009.03.010.
   PubMed Web of Science ®Google Scholar
• Katsimpardi K, Papadakis V, Pangalis A, et al. Infections in a pediatric patient cohort with acute lymphoblastic leukemia during the entire course of treatment. Support Care Cancer. 2006;14(3):277–284. doi:10.1007/s00520-005-0884-6.
   PubMed Web of Science ®Google Scholar
• Kuypers J, Campbell AP, Cent A, Corey L, Boeckh M. Comparison of conventional and molecular detection of respiratory viruses in hematopoietic cell transplant recipients. Transpl Infect Dis. 2009;11(4):298–303. doi:10.1111/j.1399-3062.2009.00400.x.
   PubMed Web of Science ®Google Scholar
• Lee JH, Jang J-H, Lee SH, et al. Respiratory viral infections during the first 28 days after transplantation in pediatric hematopoietic stem cell transplant recipients. Clin Transplant. 2012;26(5):736–740. doi:10.1111/j.1399-0012.2012.01607.x.
   PubMed Web of Science ®Google Scholar
• Fisher BT, Danziger-Isakov L, Sweet LR, et al. A multicenter consortium to define the epidemiology and outcomes of inpatient respiratory viral infections in pediatric hematopoietic stem cell transplant recipients. J Pediatric Infect Dis Soc. 2017;0(0):1–8. doi:10.1093/jpids/pix051.
   Google Scholar
• Renaud C, Campbell AP. Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients. Curr Opin Infect Dis. 2011;24(4):333–343. doi:10.1097/QCO.0b013e3283480440.
   PubMed Web of Science ®Google Scholar
• Kumar D, Humar A. Respiratory viral infections in transplant and oncology patients. Infect Dis Clin N Am. 2010;24(2):395–412. doi:10.1016/j.idc.2010.01.007.
   PubMed Web of Science ®Google Scholar
• Simon A, Schildgen O, Schuster F. Viral infections in paediatric patients receiving conventional cancer chemotherapy. Arch Dis Child. 2008;93(10):880–889. doi:10.1136/adc.2007.132225.
   PubMed Web of Science ®Google Scholar
• Martin ET, Kuypers J, Wald A, Englund JA. Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children. Influenza Other Respir Viruses. 2012;6(1):71–77. doi:10.1111/j.1750-2659.2011.00265.x.
   PubMed Web of Science ®Google Scholar
• Loria C, Domm JA, Halasa NB, et al. Human Rhinovirus C infections in pediatric hematology and oncology patients. Pediatr Transplant. 2015;19(1):94–100. doi:10.1111/petr.12383.
   PubMed Web of Science ®Google Scholar
• Chu HY, Renaud C, Ficken E, Thomson B, Kuypers J, Englund JA. Respiratory tract infections due to human metapneumovirus in immunocompromised children. J Pediatric Infect Dis Soc. 2014;3(4):286–293. doi:10.1093/jpids/piu100.
   PubMedGoogle Scholar
• de Vries JJC, Bredius RGM, van Rheenen PF, et al. Human bocavirus in an immunocompromised child presenting with severe diarrhea. J Clin Microbiol. 2009;47(4):1241–1243. doi:10.1128/JCM.01703-08.
   PubMed Web of Science ®Google Scholar
• Ali M, Baker J, Richardson S, Weitzman S, Allen U, Abla O. Human metapneumovirus (hMPV) infection in children with cancer. J Pediatr Hematol Oncol. 2013;35(6):444–446. doi:10.1097/MPH.0b013e31828ac89c.
   PubMed Web of Science ®Google Scholar
• Koskenvuo M, Möttönen M, Waris M, Allander T, Salmi T, Ruuskanen O. Human bocavirus in children with acute lymphoblastic leukemia. Eur J Pediatr. 2008;167(9):1011–1015. doi:10.1007/s00431-007-0631-8.
   PubMed Web of Science ®Google Scholar
• Asner SA, Science ME, Tran D, Smieja M, Merglen A, Mertz D. Clinical disease severity of respiratory viral co-infection versus single viral infection: a systematic review and meta-analysis. PLoS One. 2014;9(6):e99392. doi:10.1371/journal.pone.0099392.
   PubMed Web of Science ®Google Scholar
• Kouni S, Karakitsos P, Chranioti A, Theodoridou M, Chrousos G, Michos A. Evaluation of viral co-infections in hospitalized and non-hospitalized children with respiratory infections using microarrays. Clin Microbiol Infect. 2013;19(8):772–777. doi:10.1111/1469-0691.12015.
   PubMed Web of Science ®Google Scholar
• Hara M, Takao S. Five-year study of viral etiology and features of febrile respiratory tract infections with prolonged fever in Japanese pediatric outpatients. Pediatr Infect Dis J. 2017;36(12):e358–e360. doi:10.1097/INF.0000000000001729.
   PubMed Web of Science ®Google Scholar
• Torres JP, De la Maza V, Kors L, et al. Respiratory viral infections and coinfections in children with cancer, fever and neutropenia. Pediatr Infect Dis J. 2016;35(9):949–954. doi:10.1097/INF.0000000000001209.
   PubMed Web of Science ®Google Scholar
• Genomica S. CLART® PneumoVir Detection of Viruses Causative of Human Respiratory Infections via Genomic Identification for in Vitro Diagnosis. 2018.
   Google Scholar
• Srinivasan A, Gu Z, Smith T, et al. Prospective detection of respiratory pathogens in symptomatic children with cancer. Pediatr Infect Dis J 2013;32(3):e99–e104.
   PubMed Web of Science ®Google Scholar
• Christensen MS, Nielsen LP, Hasle H. Few but severe viral infections in children with cancer: a prospective RT-PCR and PCR-based 12-month study. Pediatr Blood Cancer. 2005;45(7):945–951. doi:10.1002/pbc.20469.
   PubMed Web of Science ®Google Scholar
• Benites ECA, Cabrini DP, Silva ACB, et al. Acute respiratory viral infections in pediatric cancer patients undergoing chemotherapy. J Pediatr (Rio J). 2014;90(4):370–376. doi:10.1016/j.jped.2014.01.006.
   PubMed Web of Science ®Google Scholar
• Söderman M, Rhedin S, Tolfvenstam T, et al. Frequent respiratory viral infections in children with febrile neutropenia - A prospective follow-up study. PLoS One. 2016;11(6):e0157398. doi:10.1371/journal.pone.0157398.
   PubMed Web of Science ®Google Scholar
• Torres J, Labraña Y, Ibañez C, et al. Frequency and clinical outcome of respiratory viral infections and mixed viral-bacterial infections in children with cancer, fever and neutropenia. Pediatr Infect Dis J. 2012;31(9):889–893. doi:10.1097/INF.0b013e31825c4b7e.
   PubMed Web of Science ®Google Scholar
• Koskenvuo M, Möttönen M, Rahiala J, et al. Respiratory viral infections in children with leukemia. Pediatr Infect Dis J. 2008;27(11):974–980. doi:10.1097/INF.0b013e31817b0799.
   PubMed Web of Science ®Google Scholar
• Lee J-T, Chang L-Y, Wang L-C, et al. Epidemiology of respiratory syncytial virus infection in northern Taiwan, 2001-2005 — seasonality, clinical characteristics, and disease burden. J Microbiol Immunol Infect. 2007;40(4):293–301.
   PubMedGoogle Scholar
• Mlinaric-Galinovic G, Tabain I, Kukovec T, et al. Analysis of biennial outbreak pattern of respiratory syncytial virus according to subtype (A and B) in the Zagreb region. Pediatr Int. 2012;54(3):331–335. doi:10.1111/j.1442-200X.2011.03557.x.
   PubMed Web of Science ®Google Scholar
• Moore HC, Jacoby P, Hogan AB, Blyth CC, Mercer GN. Modelling the seasonal epidemics of respiratory syncytial virus in young children. PLoS One. 2014;9(6):e100422. doi:10.1371/journal.pone.0100422.
   PubMed Web of Science ®Google Scholar
• El Saleeby CM, Somes GW, DeVincenzo JP, Gaur AH. Risk factors for severe respiratory syncytial virus disease in children with cancer: the importance of lymphopenia and young age. Pediatrics 2008;121(2):235–243. doi:10.1542/peds.2007-1102.
   PubMed Web of Science ®Google Scholar
• Mendoza Sanchez MC, Ruiz-Contreras J, Vivanco JL, et al. Respiratory virus infections in children with cancer or HIV infection. J Pediatr Hematol Oncol. 2006;28(3):154–159. doi:10.1097/01.mph.0000210061.96075.8e.
   PubMed Web of Science ®Google Scholar
• Rowlinson E, Dueger E, Taylor T, et al. Incidence and clinical features of respiratory syncytial virus infections in a population-based surveillance site in the Nile delta region. J Infect Dis.2013;208(suppl_3):S189–S196. doi:10.1093/infdis/jit457.
   PubMedGoogle Scholar
• Hakim H, Dallas R, Zhou Y, et al. Acute respiratory infections in children and adolescents with acute lymphoblastic leukemia. Cancer. 2016;122(5):798–805. doi:10.1002/cncr.29833.
   PubMed Web of Science ®Google Scholar
• Fazekas T, Eickhoff P, Rauch M, et al. Prevalence and clinical course of viral upper respiratory tract infections in immunocompromised pediatric patients with malignancies or after hematopoietic stem cell transplantation. J Pediatr Hematol Oncol. 2012;34(6):442–449. doi:10.1097/MPH.0b013e3182580bc8.
   PubMed Web of Science ®Google Scholar
• Pilger D, Cantarelli V, Amantea S, Leistner-Segal S. Detection of human bocavirus and human metapneumovirus by real-time PCR from patients with respiratory symptoms in Southern Brazil. Mem Inst Oswaldo Cruz. 2011;106(1):56–60.
   PubMed Web of Science ®Google Scholar
• Principi N, Piralla A, Zampiero A, et al. Bocavirus infection in otherwise healthy children with respiratory disease. PLoS One. 2015;10(8):e0135640. doi:10.1371/journal.pone.0135640.
   PubMed Web of Science ®Google Scholar
• Bosch A, Biesbroek G, Trzcinski K, Sanders E, Bogaert D. Viral and bacterial interactions in the upper respiratory tract. PLoS Pathog. 2013;9(1):e1003057. doi:10.1371/journal.ppat.1003057.
   PubMed Web of Science ®Google Scholar
• Castro Wagner J, Pyles RB, Miller AL, Nokso-Koivisto J, Loeffelholz MJ, Chonmaitree T. Determining persistence of bocavirus DNA in the respiratory tract of children by pyrosequencing. Pediatr Infect Dis J. 2016;35(5):471–476. doi:10.1097/INF.0000000000001058.
   PubMed Web of Science ®Google Scholar
• Martin ET, Kuypers J, McRoberts JP, Englund JA, Zerr DM. Human bocavirus 1 primary infection and shedding in infants. J Infect Dis. 2015;212(4):516–524. doi:10.1093/infdis/jiv044.
   PubMed Web of Science ®Google Scholar
• Petrie JG, Ohmit SE, Cowling BJ, et al. Influenza transmission in a cohort of households with children: 2010-2011. PLoS One. 2013;8(9):e75339. doi:10.1371/journal.pone.0075339.
   PubMed Web of Science ®Google Scholar
• Viboud C, Boëlle P-Y, Cauchemez S, et al. Risk factors of influenza transmission in households. Br J Gen Pract. 2004;54(506):684–689.
   PubMed Web of Science ®Google Scholar
• Ng S, Lopez R, Kuan G, et al. The timeline of influenza virus shedding in children and adults in a household transmission study of influenza in Managua, Nicaragua. Pediatr Infect Dis J. 2016;35(5):583–586. doi:10.1097/INF.0000000000001083.
   PubMed Web of Science ®Google Scholar
• Kersun LS, Reilly AF, Coffin SE, Sullivan KE. Protecting pediatric oncology patients from influenza. Oncologist. 2013;18(2):204–211. doi:10.1634/theoncologist.2012-0401.
   PubMed Web of Science ®Google Scholar
• Waghmare A, Campbell AP, Xie H, et al. Respiratory syncytial virus lower respiratory disease in hematopoietic cell transplant recipients: viral RNA detection in blood, antiviral treatment, and clinical outcomes. Clin Infect Dis. 2013;57(12):1731–1741. doi:10.1093/cid/cit639.
   PubMed Web of Science ®Google Scholar
• Seo S, Xie H, Campbell AP, et al. Parainfluenza virus lower respiratory tract disease after hematopoietic cell transplant: viral detection in the lung predicts outcome. Clin Infect Dis. 2014;58(10):1357–1368. doi:10.1093/cid/ciu134.
   PubMed Web of Science ®Google Scholar
• Santolaya ME, Alvarez AM, Acuna M, et al. Efficacy and safety of withholding antimicrobial treatment in children with cancer, fever and neutropenia, with a demonstrated viral respiratory infection: a randomized clinical trial. Clin Microbiol Infect. 2017;23(3):173–178. doi:10.1016/j.cmi.2016.11.001.
   PubMed Web of Science ®Google Scholar
• Miedema K, Tissing W, Abbink F, et al. Risk-adapted approach for fever and neutropenia in paediatric cancer patients-a national multicentre study. Eur J Cancer. 2016;53:16–24. doi:10.1016/j.ejca.2015.10.065.
   PubMed Web of Science ®Google Scholar
• Tran D, Science M, Dix D, et al. Pandemic (H1N1) 2009 influenza in Canadian pediatric cancer and hematopoietic stem cell transplant patients. Influenza Other Respir Viruses. 2012;6(6):e105–e113. doi:10.1111/j.1750-2659.2012.00352.x.
   PubMed Web of Science ®Google Scholar
• Engelhard D, Mohty B, de la Camara R, Cordonnier C, Ljungman P. European guidelines for prevention and management of influenza in hematopoietic stem cell transplantation and leukemia patients: summary of ECIL-4 (2011), on behalf of ECIL, a joint venture of EBMT, EORTC, ICHS, and ELN. Transpl Infect Dis. 2013;15(3):219–232. doi:10.1111/tid.12054.
   PubMed Web of Science ®Google Scholar
• von Lilienfeld-Toal M, Berger A, Christopeit M, et al. Community acquired respiratory virus infections in cancer patients: Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology. Eur J Cancer. 2016;67:200–212. doi:10.1016/j.ejca.2016.08.015.
   PubMed Web of Science ®Google Scholar
• Richardson L, Brite J, Del Castillo M, et al. Comparison of respiratory virus shedding by conventional and molecular testing methods in patients with haematological malignancy. Clin Microbiol Infect. 2016;22(4):380.e381–380.e387. doi:10.1016/j.cmi.2015.12.012.
   Web of Science ®Google Scholar
• Lo M, Lee G, Gunawardane N, Burchett S, Lachenauer C, Lehmann L. The impact of RSV, adenovirus, influenza, and parainfluenza infection in pediatric patients receiving stem cell transplant, solid organ transplant, or cancer chemotherapy. Pediatr Transplant. 2013;17(2):133–143. doi:10.1111/petr.12022.
   PubMed Web of Science ®Google Scholar
• Dignan FL, Clark A, Aitken C, et al. BCSH/BSBMT/UK clinical virology network guideline: diagnosis and management of common respiratory viral infections in patients undergoing treatment for haematological malignancies or stem cell transplantation. Br J Haematol. 2016;173(3):380–393. doi:10.1111/bjh.14027.
   PubMed Web of Science ®Google Scholar
• Bhatia S, Landier W, Shangguan M, et al. Non adherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: A report from the Children’s Oncology Group. J Clin Oncol. 2012;30(17):2094–2101. doi:10.1200/JCO.2011.38.9924.
   PubMed Web of Science ®Google Scholar
• Salez N, Vabret A, Leruez-Ville M, et al. Evaluation of four commercial multiplex molecular tests for the diagnosis of acute respiratory infections. PLoS One. 2015;10(6):e0130378. doi:10.1371/journal.pone.0130378.
   PubMed Web of Science ®Google Scholar