220
Views
4
CrossRef citations to date
0
Altmetric
Articles

Roles of regulatory T cells in the pathogenesis of pediatric aplastic anemia

, , , , , , , & show all
Pages 198-210 | Received 11 Oct 2018, Accepted 14 May 2019, Published online: 09 Jul 2019

References

  • Miano M, Dufour C. The diagnosis and treatment of aplastic anemia: a review. Int J Hematol. 2015;101(6):527–535. doi: 10.1007/s12185-015-1787-z.
  • Boddu PC, Kadia TM. Updates on the pathophysiology and treatment of aplastic anemia: a comprehensive review. Expert Rev Hematol. 2017;10(5):433–448. doi: 10.1080/17474086.2017.1313700.
  • Xing L, Liu C, Fu R, et al. CD8+ HLA− DR+ T cells are increased in patients with severe aplastic anemia. Mol Med Rep. 2014;10(3):1252–1258. doi: 10.3892/mmr.2014.2344.
  • Li JP, Zheng CL, Han ZC. Abnormal immunity and stem/progenitor cells in acquired aplastic anemia. Crit Rev Oncol Hematol. 2010;75(2):79–93. doi: 10.1016/j.critrevonc.2009.12.001.
  • Langier S, Sade K, Kivity S. Regulatory T cells: the suppressor arm of theimmune system. Autoimmun Rev. 2010;10(2):112–115. doi: 10.1016/j.autrev.2010.08.013.
  • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012;30(1):531–564. doi: 10.1146/annurev.immunol.25.022106.141623.
  • Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Tregs cells. J Exp Med. 2006;203(7):1701–1711. doi: 10.1084/jem.20060772.
  • Li X, Zheng Y. Regulatory T cell identity: formation and maintenance. Trends Immunol. 2015;36(6):344–353. doi: 10.1016/j.it.2015.04.006.
  • Li B, Greene MI. Special regulatory T- cell review: FOXP3 biochemistry in regulatory T cells-how diverse signals regulate suppression. Immunology 2008;123(1):17–19. doi: 10.1111/j.1365-2567.2007.02774.x.
  • Xiong Y, Ahmad S, Iwami D, Brinkman CC, Bromberg JS. T-bet regulates natural Treg afferent lymphatic migration and suppressive function. JI. 2016;196(6):2526–2540. doi: 10.4049/jimmunol.1502537.
  • Chaudhry A, Rudra D, Treuting P, et al. CD4+ regulatory T cells control TH17 response in a Stat3- dependent manner. Science 2009;326(5955):986–991. doi: 10.1126/science.1172702.
  • Solomou EE, Rezvani K, Mielke S, et al. Deficient CD4+ CD25+ FOXP3+ T regulatory cells in aplastic anemia. Blood 2007;110(5):1603–1606. doi: 10.1182/blood-2007-01-066258.
  • Kordasti S, Marsh J, Al-Khan S, et al. Functional characterization of CD4+ T cells in aplastic anemia. Blood 2012;119(9):2033–2043. doi: 10.1182/blood-2011-08-368308.
  • Shi J, Ge M, Lu S, et al. Instrinsic impairment of CD4+ CD25+ regulatory T cells in acquired aplastic anemia. Blood 2012;120(8):1624–1632. doi: 10.1182/blood-2011-11-390708.
  • Qi W, Ren Y, Fu R, Wang H, Liu C, Shao Z. Detection and significance of CD4+ CD25+ CD127dim regulatory T cells in individuals with severe aplastic anemia. Tjh. 2015;32(3):220–227. doi: 10.4274/tjh.2013.0410.
  • Yan L, Fu R, Liu H, et al. Abnormal quantity and function of regulatory T cells in peripheral blood of patients with severe aplastic anemia. Cell Immunol. 2015;296(2):95–105. doi: 10.1016/j.cellimm.2015.04.001.
  • Kordasti S, Costantini B, Seidl T, et al. Deep phenotyping of Tregs identifies an immune signature for idiopathicaplastic anemia and predicts response to treatment. Blood 2016;128(9):1193–1205. doi: 10.1182/blood-2016-03-703702.
  • Marsh JC, Ball SE, Cavenagh J, et al. Guidelines for the diagnosis and management of aplastic anemia. Br J Haematol. 2009;147(1):43–70. doi: 10.1111/j.1365-2141.2009.07842.x.
  • Demirkiran A, Hendrikx TK, Baan CC, et al. Impact of immunosuppressive drugs on CD4+ CD25+ FOXP3+ regulatory T cells: does in vitro evidence translate to the clinical setting? Transplantation 2008;85(6):783–789. doi: 10.1097/TP.0b013e318166910b.
  • Feng X, Kajigaya S, Solomou EE, et al. Rabbit ATG but not horse ATG promotes expansion of functional CD4+ CD25highFOXP3+ regulatory T cells in vitro. Blood 2008;111(7):3675–3683. doi: 10.1182/blood-2008-01-130146.
  • Dao AT, Yamazaki H, Takamatsu H, et al. Cyclosporine restores hematopoietic function by compensating for decreased Tregs in patients with pure red cell aplasia and acquired aplastic anemia. Ann Hematol. 2016;95(5):771–781. doi: 10.1007/s00277-016-2629-7.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.