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Articles

Aplastic anemia in children: How good is immunosuppressive therapy?

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Pages 211-221 | Received 10 Dec 2018, Accepted 11 May 2019, Published online: 09 Jul 2019

References

  • Killick SB, Bown N, Cavenagh J, et al. British Society for Standards in Haematology. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol. 2016;172(2):187–207. doi: 10.1111/bjh.13853.
  • Samarasinghe S, Veys P, Vora A, Wynn R. Paediatric amendment to adult BSH guidelines for aplastic anaemia. Br J Haematol. 2018;180(2):201–205. doi: 10.1111/bjh.15066.
  • Rosenfeld SJ, Kimball J, Vining D, Young NS. Intensive immunosuppression with antithymocyte globulin and cyclosporine as treatment for severe acquired aplastic anemia. Blood 1995;85(11):3058–3065.
  • Frickhofen N, Rosenfeld SJ. Immunosuppressive treatment of aplastic anemia with antithymocyte globulin and cyclosporine. Semin Hematol. 2000;37(1):56–68. doi: 10.1053/shem.2000.0370056.
  • Rosenfeld S, Follmann D, Nunez O, Young NS. Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome. JAMA 2003;289(9):1130–1135.
  • Fuhrer M, Rampf U, Baumann I, et al. Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival. Blood 2005;106(6):2102–2104. doi: 10.1182/blood-2005-03-0874.
  • Locasciulli A, Oneto R, Bacigalupo A, et al. Severe aplastic anemia working party of the european blood and marrow transplant group. Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment in the last decade: a report from the European Group for Blood and Marrow Transplantation (EBMT). Haematologica 2007;92(1):11–18.
  • Pongtanakul B, Das PK, Charpentier K, Dror Y. Outcome of children with aplastic anemia treated with immunosuppressive therapy. Pediatr Blood Cancer. 2008;50(1):52–57. doi: 10.1002/pbc.21377.
  • Deyell RJ, Shereck EB, Milner RA, Schultz KR. Immunosuppressive therapy without hematopoietic growth factor exposure in pediatric acquired aplastic anemia. Pediatr Hematol Oncol. 2011;28(6):469–478. doi: 10.3109/08880018.2011.568043.
  • Sharma R, Chandra J, Sharma S, Pemde H, Singh V. Antithymocyte globulin and cyclosporine in children with aplastic anemia: a developing country experience. J PediatrHematolOncol. 2012;34:93–95. doi: 10.1097/MPH.0b013e31823c287b.
  • Chandra J, Naithani R, Ravi R, et al. Antithymocyte globulin and cyclosporin in children with acquired aplastic anemia. Indian J Pediatr. 2008;75(3):229–233. doi: 10.1007/s12098-008-0050-5.
  • Gupta V, Kumar A, Tilak V, Saini I, Bhatia B. Immunosuppressive therapy in aplastic anemia. Indian J Pediatr. 2012;79(12):1587–1591. doi: 10.1007/s12098-012-0691-2.
  • Ramzan M, Yadav SP, Zafar MS, Dinand V, Sachdeva A. Outcome of pediatric acquired aplastic anemia: a developing world experience. Pediatr Hematol Oncol. 2014;31(1):29–38. doi: 10.3109/08880018.2013.807898.
  • Samarasinghe S, Webb DK. How I manage aplastic anaemia in children. Br J Haematol. 2012;157(1):26–40. doi: 10.1111/j.1365-2141.2012.09058.x.
  • George B, Mathews V, Viswabandya A, Lakshmi KM, Srivastava A, Chandy M. Allogeneic hematopoietic stem cell transplantation is superior to immunosuppressive therapy in Indian children with aplastic anemia—a single-center analysis of 100 patients. PediatrHematolOncol 2010;27:122–131. doi: 10.3109/08880010903540542.
  • George B, Mathews V, Lakshmi KM, et al. The use of a fludarabine-based conditioning regimen in patients with severe aplastic anemia–a retrospective analysis from three Indian centers. Clin Transplant 2013;27(6):923–929. doi: 10.1111/ctr.12263.
  • Townsley DM, Scheinberg P, Winkler T, et al. Eltrombopag added to standard immunosuppression for aplastic anemia. N Engl J Med. 2017;376(16):1540–1550. doi: 10.1056/NEJMoa1613878.
  • Sreedharanunni S, Sachdeva MUS, Bose P, Varma N, Bansal D, Trehan A. Frequency of paroxysmal nocturnal hemoglobinuria clones by multiparametric flow cytometry in pediatric aplastic anemia patients of Indian ethnic origin. Pediatr Blood Cancer 2016;63(1):93–97. doi: 10.1002/pbc.25691.
  • Sachdeva MU, Varma N, Chandra D, Bose P, Malhotra P, Varma S. Multiparameter FLAER-based flow cytometry for screening of paroxysmal nocturnal hemoglobinuria enhances detection rates in patients with aplastic anemia. Ann Hematol. 2015;94(5):721–728. doi: 10.1007/s00277-014-2267-x.
  • Camitta BM, Rappeport JM, Parkman R, Nathan DG. Selection of patients for bone marrow transplantation in severe aplastic anemia. Blood 1975;45(3):355–363.
  • Camitta BM. What is the definition of cure for aplastic anemia?. Acta Haematol. 2000;103(1):16–18. doi: 10.1159/000040999.
  • Nair V, Sondhi V, Sharma A, Das S, Sharma S. Survival after immunosuppressive therapy in children with aplastic anemia. Indian Pediatr. 2012;49(5):371–376. doi: 10.1007/s13312-012-0086-5.
  • Tutelman PR, Aubert G, Milner RA, Dalal BI, Schultz KR, Deyell RJ. Paroxysmal nocturnal haemoglobinuria phenotype cells and leucocyte subset telomere length in childhood acquired aplastic anaemia. Br J Haematol. 2014;164(5):717–721. doi: 10.1111/bjh.12656.
  • Kulagin A, Lisukov I, Ivanova M, et al. Prognostic value of paroxysmal nocturnal haemoglobinuria clone presence in aplastic anaemia patients treated with combined immunosuppression: results of two-centre prospective study. Br J Haematol. 2014;164(4):546–554. doi: 10.1111/bjh.12661.
  • Scheinberg P, Marte M, Nunez O, Young NS. Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine. Haematologica 2010;95(7):1075–1080. doi: 10.3324/haematol.2009.017889.
  • Yoshida N, Yagasaki H, Takahashi Y, et al. Clinical impact of HLA-DR15, a minor population of paroxysmal nocturnal haemoglobinuria-type cells, and an aplastic anaemia-associated autoantibody in children with acquired aplastic anaemia. Br J Haematol. 2008;142(3):427–435. doi: 10.1111/j.1365-2141.2008.07182.x.
  • Shah S, Jain P, Shah K, et al. Immunosuppressive therapy for aplastic anemia: a single-center experience from western India. Ann Hematol. 2018;98:41–46. [Epub ahead of print] doi: 10.1007/s00277-018-3487-2.
  • Agarwal MB, Jijina F, Shah S, Malhotra P, Damodar S, Ross C. Safety and efficacy of indigenous equine antithymocyte globulin along with cyclosporine in subjects with acquired aplastic anemia. Indian J Hematol Blood Transfus. 2015;31(2):174–179. doi: 10.1007/s12288-014-0423-z.
  • Schrezenmeier H, Marin P, Raghavachar A, et al. Relapse of aplastic anaemia after immunosuppressive treatment: a report from the European Bone Marrow Transplantation Group SAA Working Party. Br J Haematol. 1993;85(2):371–377.
  • Bacigalupo A, Bruno B, Saracco P, et al. Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. European Group for Blood and Marrow Transplantation (EBMT) Working Party on Severe Aplastic Anemia and the GruppoItalianoTrapianti di Midolio Osseo (GITMO). Blood 2000;95:1931–1934.

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