227
Views
4
CrossRef citations to date
0
Altmetric
Reports

Lipid Apheresis to Manage Severe Hypertriglyceridemia during Induction Therapy in a Child with Acute Lymphoblastic Leukemia

ORCID Icon, , , , , & show all
Pages 530-538 | Received 13 Feb 2020, Accepted 12 Apr 2020, Published online: 06 May 2020

References

  • Steinherz PG. Transient, severe hyperlipidemia in patients with acute lymphoblastic leukemia treated with prednisone and asparaginase. Cancer. 1994;74(12):3234–3239. doi:10.1002/1097-0142(19941215)74:12 < 3234::aid-cncr2820741224 > 3.0.co;2-1.
  • Finch ER, Smith CA, Yang W, et al. Asparaginase formulation impacts hypertriglyceridemia during therapy for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2020;67(1):e28040. doi:10.1002/pbc.28040.
  • Hinson A, Newbern D, Linardic CM. Asparaginase-induced hypertriglyceridemia presenting as pseudohyponatremia during leukemia treatment. Case Rep Pediatr. 2014;2014:1–5. doi:10.1155/2014/635740.
  • Parsons SK, Skapek SX, Neufeld EJ, et al. Asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia. Blood. 1997;89(6):1886–1895. doi:10.1182/blood.V89.6.1886.
  • Hoogerbrugge N, Jansen H, Hoogerbrugge PM. Transient hyperlipidemia during treatment of ALL with L-asparaginase is related to decreased lipoprotein lipase activity. Leukemia. 1997;11(8):1377–1379. doi:10.1038/sj.leu.2400703.
  • Bhojwani D, Darbandi R, Pei D, et al. Severe hypertriglyceridaemia during therapy for childhood acute lymphoblastic leukaemia. Eur J Cancer. 2014;50(15):2685–2694. doi:10.1016/j.ejca.2014.06.023.
  • Cohen H, Bielorai B, Harats D, et al. Conservative treatment of L-asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2010;54:703–706. doi:10.1002/pbc.22305.
  • Tong WH, Pieters R, Groot-Kruseman HA, de, et al. The toxicity of very prolonged courses of PEGasparaginase or Erwinia asparaginase in relation to asparaginase activity, with a special focus on dyslipidemia. Haematologica. 2014;99(11):1716–1721. doi:10.3324/haematol.2014.109413.
  • Cremer P, Lakomek M, Beck W, Prindull G. The effect of L-asparaginase on lipid metabolism during induction chemotherapy of childhood lymphoblastic leukaemia. Eur J Pediatr. 1988;147(1):64–67. doi:10.1007/BF00442614.
  • Dietel V, Bührdel P, Hirsch W, Körholz D, Kiess W. Cerebral sinus occlusion in a boy presenting with asparaginase-induced hypertriglyceridemia. Klin Padiatr. 2007;219(2):95–96. doi:10.1055/s-2007-921455.
  • Athanassiadou F, Kourti M, Papageorgiou T, Stamou M, Makedou A, Boufidou A. Severe hyperlipidemia in a child with acute lymphoblastic leukemia treated with L-asparaginase and prednisone. Pediatr Int. 2004;46(6):743–744. doi:10.1111/j.1442-200x.2004.01991.x.
  • Kropshofer G, Wehl G, Högler W, Meister B, Heitger A, Nussbaumer W. Plasmapheresis as treatment for transient iatrogenic severe hyperlipidemia in a child with leukemia. Med Pediatr Oncol. 2003;41(2):177–177. doi:10.1002/mpo.10067.
  • Solano-Páez P, Villegas JA, Colomer I, Gutierrez MD, Fernandez-Teijeiro A. L-Asparaginase and steroids-associated hypertriglyceridemia successfully treated with plasmapheresis in a child with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2011;33:e122–4. doi:10.1097/MPH.0b013e3181faf7a1.
  • Ridola V, Buonuomo PS, Maurizi P, et al. Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with plasmapheresis. Pediatr Blood Cancer. 2008;50(2):378–380. doi:10.1002/pbc.20986.
  • Zawitkowska J, Lejman M, Zaucha-Prażmo A, Sekuła N, Greczkowska-Chmiel T, Drabko K. Severe drug-induced hypertriglyceridemia treated with plasmapheresis in children with acute lymphoblastic leukemia. Transfus Apher Sci. 2019;58(5):634–637. doi:10.1016/j.transci.2019.08.025.
  • Morand A, Barlogis V, Rouby F, Reynaud R, Marrec C, Michel G. Hypertriglycéridémie majeure, découverte sur une pseudohyponatrémie, induite par la l-asparaginase dans le cadre du traitement d’une leucémie aiguë lymphoblastique B pédiatrique. Therapie. 2016; S0040–5957(16)30051-8. doi:10.2515/therapie/2015051.
  • Persson L, Harila-Saari A, Hed Myrberg I, Heyman M, Nilsson A, Ranta S. Hypertriglyceridemia during asparaginase treatment in children with acute lymphoblastic leukemia correlates with antithrombin activity in adolescents. Pediatr Blood Cancer. 2017;64(10):e26559. doi:10.1002/pbc.26559.
  • Berglund L, Brunzell JD, Goldberg AC, et al. Evaluation and treatment of hypertriglyceridemia: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(9):2969–2989. doi:10.1210/jc.2011-3213.
  • Hijiya N, van der Sluis IM. Asparaginase-associated toxicity in children with acute lymphoblastic leukemia. Leuk Lymphoma. 2016;57(4):748–757. doi:10.3109/10428194.2015.1101098.
  • Scherer J, Singh VP, Pitchumoni CS, Yadav D. Issues in hypertriglyceridemic pancreatitis: an update. J Clin Gastroenterol. 2014;48(3):195–203. doi:10.1097/01.mcg.0000436438.60145.5a.
  • Jain D, Zimmerschied J. Heparin and insulin for hypertriglyceridemia-induced pancreatitis: case report. ScientificWorldJournal. 2009;9:1230–1232. doi:10.1100/tsw.2009.142.
  • Witztum JL, Gaudet D, Freedman SD, et al. Volanesorsen and triglyceride levels in familial chylomicronemia syndrome. N Engl J Med. 2019;381(6):531–542. doi:10.1056/NEJMoa1715944.
  • Tong WH, Pieters R, van der Sluis IM. Successful management of extreme hypertriglyceridemia in a child with acute lymphoblastic leukemia by temporarily omitting dexamethasone while continuing asparaginase. Pediatr Blood Cancer. 2012;58(2):317–318. doi:10.1002/pbc.23266.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.