Advanced search
Publication Cover
Pediatric Hematology and Oncology Volume 40, 2023 - Issue 4
Submit an article Journal homepage
204
Views
0
CrossRef citations to date
0
Altmetric
Brief Reports

Epigenetic age acceleration among survivors of pediatric medulloblastoma and primitive neuroectodermal tumor

Rachel D. Harrisa Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA;b Texas Children’s Hospital, Texas Children’s Cancer and Hematology Centers, Houston, Texas, USACorrespondence[email protected]
View further author information
,
Melissa A. Richarda Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA;b Texas Children’s Hospital, Texas Children’s Cancer and Hematology Centers, Houston, Texas, USAView further author information
,
Maria Monica J. Gramatgesa Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA;b Texas Children’s Hospital, Texas Children’s Cancer and Hematology Centers, Houston, Texas, USAORCID Iconhttps://orcid.org/0000-0002-0947-104XView further author information
ORCID Icon,
Kevin Wilhelma Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USAView further author information
,
Michael E. Scheurera Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA;b Texas Children’s Hospital, Texas Children’s Cancer and Hematology Centers, Houston, Texas, USAORCID Iconhttps://orcid.org/0000-0002-8379-6088View further author information
ORCID Icon,
Philip J. Lupoa Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA;b Texas Children’s Hospital, Texas Children’s Cancer and Hematology Centers, Houston, Texas, USAORCID Iconhttps://orcid.org/0000-0003-0978-5863View further author information
ORCID Icon &
Austin L. Browna Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas, USA;b Texas Children’s Hospital, Texas Children’s Cancer and Hematology Centers, Houston, Texas, USAORCID Iconhttps://orcid.org/0000-0001-5802-5073View further author information
ORCID Icon show all
Pages 407-411 | Received 19 May 2022, Accepted 06 Jul 2022, Published online: 21 Jul 2022

References

  • Ward E, DeSantis C, Robbins A, Kohler B, Jemal A. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin. 2014;64(2):83–103. doi:10.3322/caac.21219.
  • Packer RJ, Vezina G. Management of and prognosis with medulloblastoma: therapy at a crossroads. Arch Neurol. 2008;65(11):1419–1424. doi:10.1001/archneur.65.11.1419.
  • Armstrong GT, Liu Q, Yasui Y, et al. Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2009;101(13):946–958. doi:10.1093/jnci/djp148.
  • Ness KK, Krull KR, Jones KE, et al. Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort study. J Clin Oncol. 2013;31(36):4496–4503. doi:10.1200/JCO.2013.52.2268.
  • Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006;355(15):1572–1582. doi:10.1056/NEJMsa060185.
  • Burger S. The aging process. Sciences (New York). 1963;3(8):10–13. doi:10.1002/j.2326-1951.1963.tb00730.x.
  • Campisi J, Vijg J. Does damage to DNA and other macromolecules play a role in aging? If so, how? J Gerontol A Biol Sci Med Sci. 2009;64(2):175–178. doi:10.1093/gerona/gln065.
  • Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115. doi:10.1186/gb-2013-14-10-r115.
  • Qin N, Li Z, Song N, et al. Epigenetic age acceleration and chronic health conditions among adult survivors of childhood cancer. J Natl Cancer Inst. 2021;113(5):597–605. doi:10.1093/jnci/djaa147.
  • Gajjar A, Chintagumpala M, Ashley D, et al. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol. 2006;7(10):813–820. doi:10.1016/S1470-2045(06)70867-1.
  • Gajjar A, Robinson GW, Smith KS, et al. Outcomes by clinical and molecular features in children with medulloblastoma treated with risk-adapted therapy: results of an international phase III trial (SJMB03). J Clin Oncol. 2021;39(7):822–835. doi:10.1200/JCO.20.01372.
  • Perna L, Zhang Y, Mons U, Holleczek B, Saum KU, Brenner H. Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort. Clin Epigenet. 2016;8(1):1–7. doi:10.1186/s13148-016-0228-z.
  • Man T-K, Aubert G, Richard MA, et al. Short NK- and naïve T-cell telomere length is associated with thyroid cancer in childhood cancer survivors: a report from the childhood cancer survivor study. Cancer Epidemiol Biomarkers Prev. 2022;31(2):453–460. doi:10.1158/1055-9965.EPI-21-0791.
  • Song N, Li Z, Qin N, et al. Shortened leukocyte telomere length associates with an increased prevalence of chronic health conditions among survivors of childhood cancer: a report from the St. Jude Lifetime Cohort. Clin Cancer Res. 2020;26(10):2362–2371. doi:10.1158/1078-0432.CCR-19-2503.
  • Antwih DA, Gabbara KM, Lancaster WD, Ruden DM, Zielske SP. Radiation-induced epigenetic DNA methylation modification of radiation-response pathways. Epigenetics. 2013;8(8):839–848. doi:10.4161/epi.25498.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.