Impact of socio-behavioral measures implemented during the SARS-CoV-2 pandemic on the outcomes of febrile neutropenia episodes in pediatric cancer patients: a single center quasi-experimental pre-post study

References

• Bodey GP, Rodriguez V, Chang H-Y, Narboni G. Fever and infection in leukemic patients: a study of 494 consecutive patients. Cancer. 1978;41(4):1610–1622. doi:10.1002/1097-0142(197804)41:4<1610::AID-CNCR2820410452>3.0.CO;2-B.
   PubMedGoogle Scholar
• Arif T, Phillips RS. Updated systematic review and meta-analysis of the predictive value of serum biomarkers in the assessment and management of fever during neutropenia in children with cancer. Pediatr Blood Cancer. 2019;66(10):e27887. doi:10.1002/pbc.27887.
   PubMed Web of Science ®Google Scholar
• Mueller EL, Croop J, Carroll AE. Fever and neutropenia hospital discharges in children with cancer: A 2012 update. Pediatr Hematol Oncol. 2016;33(1):39–48. doi:10.3109/08880018.2015.1102998.
   PubMed Web of Science ®Google Scholar
• Talcott JA, Finberg R, Mayer RJ, Goldman L. The medical course of cancer patients with fever and neutropenia. Clinical identification of a low-risk subgroup at presentation. Arch Intern Med. 1988;148(12):2561–2568.
   PubMedGoogle Scholar
• Alexander SW, Wade KC, Hibberd PL, Parsons SK. Evaluation of risk prediction criteria for episodes of febrile neutropenia in children with cancer. J Pediatr Hematol Oncol. 2002;24(1):38–42.
   PubMed Web of Science ®Google Scholar
• Paolino J, Mariani J, Lucas A, et al. Outcomes of a clinical pathway for primary outpatient management of pediatric patients with low-risk febrile neutropenia. Pediatr Blood Cancer. 2019;66(7):e27679. doi:10.1002/pbc.27679.
   PubMed Web of Science ®Google Scholar
• Santolaya ME, Alvarez AM, Acuna M, et al. Efficacy and safety of withholding antimicrobial treatment in children with cancer, fever and neutropenia, with a demonstrated viral respiratory infection: a randomized clinical trial. Clin Microbiol Infect. 2017;23(3):173–178. doi:10.1016/j.cmi.2016.11.001.
   PubMed Web of Science ®Google Scholar
• Santolaya ME, Alvarez AM, Aviles CL, et al. Early hospital discharge followed by outpatient management versus continued hospitalization of children with cancer, fever, and neutropenia at low risk for invasive bacterial infection. J Clin Oncol. 2004;22(18):3784–3789. doi:10.1200/JCO.2004.01.078.
   PubMed Web of Science ®Google Scholar
• Mueller EL, Walkovich KJ, Mody R, Gebremariam A, Davis MM. Hospital discharges for fever and neutropenia in pediatric cancer patients: United States, 2009. BMC Cancer. 2015;15:388. doi:10.1186/s12885-015-1413-8.
   PubMedGoogle Scholar
• Baugh CW, Faridi MK, Mueller EL, Camargo CA, Jr., Pallin DJ. Near-universal hospitalization of US emergency department patients with cancer and febrile neutropenia. PLoS One. 2019;14(5):e0216835.
   PubMed Web of Science ®Google Scholar
• Mueller EL, Walkovich KJ, Yanik GA, Clark SJ. Variation in Management of Fever and Neutropenia Among Pediatric Patients With Cancer: A Survey of Providers in Michigan. Pediatr Hematol Oncol. 2015;32(5):331–340. doi:10.3109/08880018.2015.1036331.
   PubMed Web of Science ®Google Scholar
• Lehrnbecher T, Robinson P, Fisher B, et al. Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update. J Clin Oncol. 2017;35(18):2082–2094. doi:10.1200/JCO.2016.71.7017.
   PubMed Web of Science ®Google Scholar
• Zhu N, Zhang D, Wang W, China Novel Coronavirus Investigating and Research Team, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733. doi:10.1056/NEJMoa2001017.
   PubMed Web of Science ®Google Scholar
• Fauci AS, Lane HC, Redfield RR. Covid-19 - navigating the uncharted. N Engl J Med. 2020;382(13):1268–1269. doi:10.1056/NEJMe2002387.
   PubMed Web of Science ®Google Scholar
• Chiu NC, Chi H, Tai YL, et al. Impact of wearing masks, hand hygiene, and social distancing on influenza, enterovirus, and all-cause pneumonia during the coronavirus pandemic: retrospective national epidemiological surveillance study. J Med Internet Res. 2020;22(8):e21257.
   PubMed Web of Science ®Google Scholar
• Olsen SJ, Azziz-Baumgartner E, Budd AP, et al. Decreased influenza activity during the COVID-19 pandemic - United States, Australia, Chile, and South Africa, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(37):1305–1309. doi:10.15585/mmwr.mm6937a6.
   PubMed Web of Science ®Google Scholar
• Smith RN, Nolan JP. Central venous catheters. BMJ. 2013;347:f6570. doi:10.1136/bmj.f6570.
   PubMedGoogle Scholar
• Patient Safety Component Manual: Bloodstream Infection Event (Central Line-Associated Bloodstream Infection and Non-central Line Associated Bloodstream Infection). In (NHSN). NHSN, ed. Atlanta, GA: Centers for Disease Control and Prevention; 2021.
   Google Scholar
• Nesher L, Rolston KV. Neutropenic enterocolitis, a growing concern in the era of widespread use of aggressive chemotherapy. Clin Infect Dis. 2013;56(5):711–717. doi:10.1093/cid/cis998.
   PubMed Web of Science ®Google Scholar
• Danishyar A, Ashurst JV. Acute Otitis Media. Treasure Island (FL): StatPearls; 2021.
   Google Scholar
• Ki V, Rotstein C. Bacterial skin and soft tissue infections in adults: A review of their epidemiology, pathogenesis, diagnosis, treatment and site of care. Can J Infect Dis Med Microbiol. 2008;19(2):173–184. doi:10.1155/2008/846453.
   PubMed Web of Science ®Google Scholar
• Miller JM, Binnicker MJ, Campbell S, et al. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the infectious Diseases Society of America and the American Society for microbiology. Clin Infect Dis. 2018;67(6):813–816. doi:10.1093/cid/ciy584.
   PubMedGoogle Scholar
• Short SB, Marshall P, Miller N, Olmschenk D, Prigge K, Solyntjes L. Diagnosis and Treatment of Respiratory Illness in Children and Adults. In: Improvement IfCS. 2017. Bloomington, MN: Institute for Clinical Systems Improvement.
   Google Scholar
• Baden LR, Swaminathan S, Angarone M, Blouin G. NCCN clincal practice guidelines in oncology: Prevention and treatment of cancer related infections; 2016. https://oralcancerfoundation.org/wp-content/uploads/2016/09/infections.pdf.
   Google Scholar
• Taplitz RA, Kennedy EB, Flowers CR. Outpatient management of fever and neutropenia in adults treated for malignancy: American Society of clinical oncology and infectious diseases society of America Clinical Practice Guideline update summary. J Oncol Pract. 2018;14(4):250–255. doi:10.1200/JOP.18.00016.
   PubMed Web of Science ®Google Scholar
• Phillips B, Depani S, Morgan J. What do families want to improve in the management of paediatric febrile neutropenia during anti-cancer treatment? Report of a patient/public involvement group. BMJ Paediatr Open. 2019;3(1):e000398.
   PubMedGoogle Scholar
• Robinson PD, Lehrnbecher T, Phillips R, Dupuis LL, Sung L. Strategies for empiric management of pediatric fever and neutropenia in patients with cancer and hematopoietic stem-cell transplantation recipients: a systematic review of randomized trials. JCO. 2016;34(17):2054–2060. doi:10.1200/JCO.2015.65.8591.
   PubMed Web of Science ®Google Scholar
• Mintz K, Jardas E, Shah S, Grady C, Danis M, Wendler D. Enrolling minors in COVID-19 vaccine trials. Pediatrics. 2021;147(3). doi:10.1542/peds.2020-040717.
   PubMedGoogle Scholar
• Feldstein LR, Tenforde MW, Friedman KG, Overcoming COVID-19 Investigators, et al. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021;325(11):1074–1087. doi:10.1001/jama.2021.2091.
   PubMed Web of Science ®Google Scholar
• Son MBF, Murray N, Friedman K, Overcoming COVID-19 Investigators, et al. Multisystem inflammatory syndrome in children - initial therapy and outcomes. N Engl J Med. 2021;385(1):23–34. doi:10.1056/NEJMoa2102605.
   PubMed Web of Science ®Google Scholar
• Jenco M. Moderna testing COVID-19 vaccine in children under 12. American Academy of Pediatrics News; 2021. https://www.aappublications.org/news/2021/03/16/moderna-covid-trials-children-031621. Accessed March 29, 2021.
   Google Scholar
• Hills T, Kearns N, Kearns C, Beasley R. Influenza control during the COVID-19 pandemic. Lancet. 2020;396(10263):1633–1634. doi:10.1016/S0140-6736(20)32166-8.
   PubMed Web of Science ®Google Scholar
• Wee LEI, Conceicao EP, Tan JY, et al. Unintended consequences of infection prevention and control measures during COVID-19 pandemic. Am J Infect Control. 2021;49(4):469–477.
   PubMedGoogle Scholar