- Gibson GR, Roberfroid MB. Dietary modulation of the human colonie microbiota: introducing the concept of prebiotics. J Nutr 1995; 125: 1401-12.
- Macfarlane GT, Gibson GR. Carbohydrate fermentation, energy transduction and gas metabolism in the human large intestine. In: Mackie RI, White BH, eds. Gastrointestinal microbiology. London: Chapman & Hall, 1997: 269-318.
- Gibson GR, Wang X. Regulatory effects of bifidobacteria on the growth of other colonie bacteria. J Appl Bacteriol 1994; 77: 412-20.
- Hudault S, Lievin V, Bernet-Camard M-F, Servin AL. Antagonistic activity exerted in vitro and in vivo by Lactobacillvs casei (Strain GG) against Salmonella typhimurium CS infection. Appl Environ Microbiol 1997; 63: 513-8.
- Jacobsen CN, Rosenfeldt Nielsen V, Hayford AE, Møller PL, Michaelsen KF, Pserregaard A, Sandström B, Tvede M, Jakobsen M. Screening of probiotic activities of forty-seven strains of Lactobacillus spp. By in vitro techniques and evaluation of the colonization ability of five selected strains in humans. Appl Environ Microbiol 1999; 65: 4949-56.
- Liévin V, Peiffer I, Hudault S, Rochat F, Brassart D, Neeser J-R, Servin AL. Bifidobacterium strains from resident infant human gastrointestinal microbiota exert antimicrobial activity. Gut 2000; 47: 646-52.
- McCracken VJ, Gaskins HR. Probiotics and the immune system. In: Tannock GW, ed. Probiotics a critical review. Wymondham: Horizon Scientific Press, 1999: 85-111.
- Tuomola EM, Ouwehand AC, Salminen SJ. The effect of probiotic bacteria on the adhesion of pathogens to human intestinal mucus. FEMS Immunol Med Microbiol 1999; 26: 137-42.
- Forestier C, De Champs C, Vatoux C, JoIy B. Probiotic activities of Lactobacillus casei rhamnosus: in vitro adherence to intestinal cells and antimicrobial properties. Res Microbiol 2001; 152: 167-73.
- Conway PL. Microbial ecology of the human large intestine. In: Gibson GR, Macfarlane GT, eds. Human colonie bacteria: role in nutrition, physiology and pathology. Boca Raton: CRC Press, 1995: 1-24.
- Roberfroid MB, Bornet F, Bouley C, Cummings JH. Colonie microbiota: Nutrition and Health Nutr Revs 1995; 53: 12730.
- Tannock GW. A fresh look at the intestinal microbiota. In: Tannock GW, ed. Probiotics a critical review. Wymondham: Horizon Scientific Press, 1999: 5-14.
- Steer T, Carpenter H, Tuohy K, Gibson GR. Perspectives on the role of the human gut microbiota in health and disease and its modulation by pro- and prebiotics. Nutr Res Revs 2000; 13: 229-54.
- Gibson GR, Berry-Ottaway P, Rastall RA. Prebiotics: new developments in functional foods. Oxford, UK: Chandos Publishing Limited, 2000.
- Salminen S, Salminen E. Lactulose, lactic acid bacteria, intestinal microecology and mucosal protection. Scand J Gastroenterol 1997; 32 (Suppl 222): 45-8.
- Clausen MR, Mortensen PB. Lactulose, disaccharides and colonie flora. Drugs 53; 930-942.
- Cummings JH, Bingham SA, Heaton KW, Eastwood MA. Fecal weight, colon cancer risk, and dietary intake of nonstarch polysaccharides (dietary fiber). Gastroenterol 1992; 103: 1783-9.
- Terada A, Hara H, Kataoka M, Mitsuoka T. Effect of lactulose on the composition and metabolic activity of the human faecal microbiota. Microb Ecol Health Dis 1992; 5: 43-50.
- Ballongue J, Schumann C, Quignon P. Effects of lactulose and lactitol on colonie microbiota and enzymatic activity. Scand J Gastroenterol 1997; 32: 41-4.
- Hirayama K, Rafter J. The role of lactic acid bacteria in colon cancer prevention: mechanistic considerations. Ant Van Leeuwenhoek 1999; 76: 391-4.
- Bolognani F, Rumney CJ, Rowland IR. Influence of carcinogen binding by lactic acid-producing bacteria on tissue distribution and in vivo mutagenicity of dietary carcinogens. Food Chem Toxicol 1997; 35: 535-45.
- Langendijk PS, Schut F, Jansen GJ, Raangs GW, Kamphuis GR, Wilkinson MHF, Welling GW. Quantitative fluorescent in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in faecal samples. Appl Environ Microbiol 1995; 61: 3069-75.
- Hartemink R, Rombouts FM. Comparison of media for the detection of bifidobacteria, lactobacilli and total anaerobes from faecal samples. J Microbiol Methods 1999; 36: 181-92.
- Wilson KH, Blitchington RB. Human colonie bacteria studied by ribosomal DNA sequence analysis. Appl Environ Microbiol 1996; 62: 2273-8.
- Suau A, Bonnet R, Sutren M, Godon J-J, Gibson GR, Collins MD, Doré J. Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. Appl Environ Microbiol 1999; 65: 4799-807.
- Beerens H. An elective and selective isolation medium for Bifidobacterium spp. Letts. Appl. Microbiol. 1990; 11: 155-7.
- Silvi S, Rumney CJ, Rowland IR. An assessment of three selective media for bifidobacteria in faeces. J Appl Bacteriol 1996; 81: 561-4.
- Hartemink R, Kok BJ, Weenk GH, Rombouts FM. Raffinose-Bifidobacterium (RB) agar, a new selective medium for bifidobacteria. J Microbiol Methods 1996; 27: 33-43.
- Manz W, Amann R, Ludwig W, Vancanneyt M, Schleifer K-H. Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment. Microbiol 1996; 142: 1097-106.
- Franks AH, Harmsen HJM, Raangs GC, Jansen GJ, Schut F, Welling GW. Variations of bacterial populations in human faeces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Appl Environ Microbiol 1998; 64: 3336-45.
- Harmsen HJM, Elfferich P, Schut F, Welling GW. A 16S rRNA-targeted probe for detection of lactobacilli and enterococci in faecal samples by fluorescent in situ hybridization. Microb Ecol Health Dis 1999a; 11: 3-12.
- Porter KG, Feig YS. The use of DAPI for identifying and counting aquatic microbiota. Limnol Oceanog 1980; 25: 9438.
- Harmsen HJM, Gibson GR, Elfferich P, Raangs GC, Wideboer-Veloo ACM, Argaiz A, Roberfroid MB, Welling GW. Comparison of viable cell counts and fluorescent in situ hybridization using specific rRNA-based probes for the quantification of human faecal bacteria. FEMS Microb Ecol 1999b; 183: 125-9.
- Tuohy KM, Finlay RK, Wynne AG, Gibson GR. A human volunteer study on the prebiotic effects of HP-inulin-faecal bacteria enumerated using fluorescent in situ hybridization (FISH). Anaerobe 2001a; 7: 113-8.
- Osswald K, Becker TW, Grimm M, Jahreis G, Pool-Zobel BL. Inter- and intra-individual variation of faecal watergenotoxicity in human colon cells. Mutat Res 2000; 472: 59-70.
- Augeron C, Laboisse CL. Emergence of permanently differentiated cell clones in a human colonie cancer cell line in culture after treatment with sodium butyrate. Cancer Res 1984; 44: 3961-9.
- Pool-Zobel BL, Abrahamse SL, Collins AR, Kark W, Gugler R, Oberreuther D, Siegel EG, Treptow-van Lishaut S, Rechkemmer G. Analysis of DNA strand breaks, oxidized bases and glutathione S-transferase Pl in human colon cells. Cancer Epidemiol Biomark Prev 1999; 8: 609-14.
- Rowland IR. Toxicology of the colon: role of the intestinal microbiota. In: Gibson GR, Macfarlane GT, eds. Human colonie bacteria: role in nutrition, physiology and pathology. Boca Raton: CRC Press, 1995: 155-74.
- Pool-Zobel BL, Neudecker C, Domizlaff I, Ji S, Schillinger U, Rumney C, Moretti M, Vilarini I, Scassellati-Sforzolini R, Rowland I. Lactobacillus- and Bifidobacterium -mediated antigenotoxicity in the colon of rats. Nutr Cancer 1996; 26: 365-80.
- Tuohy KM, Kolida S, Lustenberger AM, Gibson GR. The prebiotic effects of biscuits containing partially hydrolyzed guar gum and fructo-oligosaccharides-a human volunteer study. Brit J Nutr 2001b; 86: 341-8.
- Roberfroid MB, Van Loo JAE, Gibson GR. The bifidogenic nature of chicory inulin and its hydrolysis products. J Nutr 1998; 128: 11-9.
- Harmsen HJM, Raangs GC, He T, Degener JE, Welling GW. Extensive set of 16S rRNA-based probes for detection of bacteria in human feces. Appl Environ Microbiol 2002; 68: 2982-90.
Microbial Ecology in Health and Disease
Volume 14, 2002 - Issue 3
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Research Article
A Human Volunteer Study to Determine the Prebiotic Effects of Lactulose Powder on Human Colonic Microbiota
Kieran M. Tuohy Food Microbial Sciences Unit, School of Food Biosciences, The University of Reading, Reading, UK
, , Annett Klinder Department of Nutritional Toxicology, Institute of Nutrition, Friedrich-Schiller-University of Jena, Dornburger Strasse 25, 07743 Jena, Germany
, , &
Pages 165-173
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Published online: 11 Jul 2009
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