458
Views
16
CrossRef citations to date
0
Altmetric
Original Article

Isolates from normal human intestinal flora but not lactic acid bacteria exhibit 7α- and 7β-hydroxysteroid dehydrogenase activities

, , , , , & show all
Pages 195-201 | Published online: 11 Jul 2009

REFERENCES

  • Sutherland JD, Holdeman LV, Williams CN, Macdonald IA. Formation of urso- and ursodeoxy-cholic acids from primary bile acids by a Clostridium limosum soil isolate. J Lipid Res 1984; 25: 1084–9.
  • Bachrach WH, Hofmann AF. Ursodeoxycholic acid treatment of cholesterol cholelithiasis. Dig Dis Sci 1982; 24: 833–56.
  • Battezzati PM, Podda M, Bianchi FB, Naccarato R, Orlandi F, Surrenti C, et al. Ursodeoxycholic acid for symptomatic primary biliary cirrhosis. Preliminary analysis of double-blind multicentre trial. J Hepatol 1993; 17: 332–8.
  • Combes B, Carithers RL Jr, Maddrey WC, Lin D, McDonald MF, Wheeler DE, et al. A randomized, double-blind, placebo controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1995; 22: 759–66.
  • Wali RK, Stoiber D, Nguyen L, Hart J, Sitrin MD, Brasitus T, et al. Ursodeoxycholic acid inhibits the initiation and post-initiation phases of azoxymethane-induced colonic tumor development. Cancer Epidemiol Biomarkers Prey 2002; 11: 1316–21.
  • Oyama K, Shiota G, Ito H, Murawaki Y, Kawasaki H. Reduction of hepatocarcinogenesis by ursodeoxycholic acid in rats. Carcinogenesis 2002; 23: 885–92.
  • Medici A, Pedrini P, Bianchini E, Fantin G, Guerrini A, Natalini B, et al. 7a-OH epimerisation of bile acids via oxido-reduction with Xanthomonas maltophilia. Steroids 2002; 67: 51(56.
  • Edenharder R, Knaflic T. Epimerization of chenodeoxycholic acid to ursodeoxycholic acid by human intestinal lecithinase-lipase-negative Clostridia. J Lipid Res 1981; 22: 652–8.
  • Macdonald IA, Hutchison D, Forrest TP. Formation of urso-and ursodeoxy-cholic acids from primary bile acids by Clostridium absonum. J Lipid Res 1981; 22: 458–66.
  • Macdonald IA, Rochon YP, Hutchison DM, Holdeman LV. Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7,6 -hydroxysteroid dehydrogenase-elaborating Eu-bacterium aerofaciens strain cocultured with 7oc-hydroxysteroid dehydrogenase-elaborating organisms. Appl Environ Microbiol 1982; 44: 1187–95.
  • Aries V, Hill MJ. Degradation of steroids by intestinal bacteria, II. Enzymes catalysing the oxidoreduction of the 3a-, 7- and 12a-hydroxyl groups in cholic acid, and the dehydroxylation of the 7-hydroxyl group. Biochim Biophys Acta 1970; 202: 535–43.
  • Franklund CV, de Prada P, Hylemon PB. Purification and characterization of a microbial, NADP-dependent bile acid 7oc-hydroxysteroid dehydrogenase. J Biol Chem 1990; 265: 9842–9.
  • Skalhegg BA, Fausa O. Enzymatic determination of bile acids. The NADP-specific 7alpha-hydroxysteroid dehydrogenase from P testosteroni (ATCC 1996). Scand J Gastroenterol 1997; 12: 433–9.
  • Yoshimoto T, Higashi H, Kanatani A, Lin XS, Nagai H, Oyama H, et al. Cloning and sequencing of the 7a-hydro-xysteroid dehydrogenase gene from Escherichia coli HB101 and characterization of the expressed enzyme. J Bacteriol 1991; 173: 2173–9.
  • Baron SF, Franklund CV, Hylemon PB. Cloning, sequencing, and expression of the gene coding for bile acid 7a-hydroxyster-oid dehydrogenase from Eubacterium sp, strain VPI 12708. J Bacteriol 1991; 173: 4558–69.
  • Akao T, Akao T, Kobashi K. Purification and characterization of 7fl-hydroxysteroid dehydrogenase from Ruminococcus sp. of human intestine. J Biochem 1987; 102: 613–9.
  • Edenharder R, Pfutzner A, Hammann R. Characterization of NAD-dependent 3 alpha- and 3 beta-hydroxysteroid dehydro-genase and of NADP-dependent 7 beta-hydroxysteroid dehy-drogenase from Peptostreptococcus productus. Biochim Biophys Acta 1989; 1004: 230–8.
  • Masuda N, Oda H, Tanaka H. Purification and characteriza-tion of NADP-dependent 7 beta-hydroxysteroid dehydrogenase from Peptostreptococcus productus strain b-52. Biochim Bio-phys Acta 1983; 755: 65–9.
  • Owen RW. Faecal steroids and colorectal carcinogenesis. Scand J Gastroenterol 1997; 222: 76–82.
  • Bortolini O, Medici A, Poli S. Biotranformations on steroid nucleus of bile acids. Steroids 1997; 62: 564–77.
  • Fedorowski T, Salen G, Tint S, Mosbach E. Transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal bacteria. Gastroenterology 1979; 77: 1068–73.
  • White BA, Fricke RJ, Hylemon PB. 7fl-dehydroxylation of ursodeoxycholic acid by whole cells and cell extract of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 12708. J Lipid Res 1982; 23: 145–53.
  • Takamine F, Imamura T. Isolation and characterization of bile acid 7-dehydroxylating bacteria from human feces. Microbiol Immunol 1995; 39: 11–8.
  • Hungate RE. A roll tube method for cultivation of strict anaerobes. Methods Microbiol 1969; 3B: 117–32.
  • Mahony DE, Meier E, Macdonald IA, Holdeman LV. Bile salt degradation by nonfermentative clostridia. Appl Environ Microbiol 1977; 34: 419–23.
  • Eneroth P, Sjövall J. Extraction, purification, and chromato-graphic analysis of bile acids in biological materials. In: Nair PP, Kritchevsky D, eds. The Bile Acids: Chemistry, Physiology, and Metabolism, vol 1. New York: Plenum Press, 1971: 121–71.
  • Tanaka H, Doesburg K, Iwasaki T, Mierau I. Screening of lactic acid bacteria for bile salt hydrolase activity. J Dairy Sci 1999; 82: 2530–5.
  • Canzi E, Maconi E, Aragozzini F, Ferrari A. Cooperative 3-epimerization of chenodeoxycholic acid by Clostridium inno-cuum and Eubacterium lentum. Cliff Microbiol 1989; 18: 335–8.
  • Akao T, Akao T, Hattori M, Namba T, Kobashi K. Enzymes involved in the formation of 3 beta, 7 beta-dihydroxy-12-oxo-5 beta-cholanic acid from dehydrocholic acid by Ruminococcus sp. obtained from human intestine. Biochim Biophys Acta 1987; 921: 275–80.
  • Macdonald IA, Roach PD. Bile salt induction of 7- and 713-hydroxysteroid dehydrogenases in Clostridium absonum. Bio-chim Biophys Acta 1981; 665: 262–9.
  • Macdonald IA, Hutchison DM, Forrest TP, Bokkenhauser VD, Winter J, Holdeman LV. Metabolism of primary bile acids by Clostridium perfringens. J Steroid Biochem 1983; 18: 97–104.
  • Macdonald IA, White BA, Hylemon PB. Separation of 7 alpha- and 7 beta-hydroxysteroid dehydrogenase activities from Clostridium absonum ATCC# 27555 and cellular response of this organism to bile acid inducers. J Lipid Res 1983; 24: 1119–26.
  • Akao T, Akao T, Hattori M, Namba T, Kobashi K. 3 beta-hydroxysteroid dehydrogenase of Ruminococcus sp. from hu-man intestinal bacteria. J Biochem 1986; 99: 1425–31.
  • Invernizzi P, Setchell KD, Crosignani A, Battezzati PM, Larghi A, O'Connell NC, et al. Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-con-jugated species in patients with primary biliary cirrhosis. Hepatology 1999; 29: 320–7.
  • Fischer S, Neubrand M, Paumgartner G. Biotransformation of orally administered ursodeoxycholic acid in man as observed in gallbladder bile, serum and urine. Eur J Clin Invest 1993; 23: 28–36.
  • Lindor KD, Lacerda MA, Jorgensen RA, DeSotel CK, Batta AK, Salen G, et al. Relationship between biliary and serum bile acids and response to ursodeoxycholic acid in patients with primary biliary cirrhosis. Am J Gastroenterol 1998; 93: 1498–504.
  • Stiehl A, Raedsch R, Rudolph G. Ileal excretion of bile acids: comparison with biliary bile composition and effect of ursodeoxycholic acid treatment. Gastroenterology 1988; 94: 1201–6.
  • Yahiro K, Setoguchi T, Katsuki T. Effect of cecum and appendix on 7a-dehydroxylation and 713-epimerization of chenodeoxycholic acid in the rabbit. J Lipid Res 1980; 21: 215–22.
  • Aldini R, Roda A, Montagnani M, Polimeni C, Lenzi PL, Cerre C, et al. Hepatic uptake and intestinal absorption of bile acids in the rabbit. Eur J Clin Invest 1994; 24: 691–7.
  • Montagnani M, Aldini R, Roda A, Caruso ML, Gioacchini AM, Lenzi PL, et al. Species differences in hepatic bile acid uptake: comparative evaluation of taurocholate and tauroursodeoxycholate extraction in rat and rabbit. Comp Biochem Physiol A Physiol 1996; 113: 157–64.
  • Tanaka H, Doesburg K, Iwasaki T, Mierau I. Screening of lactic bacteria for bile salt hydrolase activity. J Dairy Sci 1998; 82: 2530–5.
  • Marteau P, Gerhardt MF, Myara A, Bouvier E, Trivin F, Rambaud JC. Metabolism of bile salts by alimentary bacteria during transit in the human small intestine. Microb Ecol Health Dis 1995; 8: 151–7.
  • Tannock GW, Tangerman A, Van Schalk A, McConnell MA. Deconjugation of bile acids by Lactobacilli in the mouse small bowel. App! Environ Microbiol 1994; 60: 3419–20.