5,063
Views
2
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

The metabolism of phenobarbital, a drug used for epilepsy, by intestinal flora, Bifidobacterium adolescentis and Bifidobacterium bifidum

, , &
Pages 32-37 | Received 23 May 2005, Published online: 11 Jul 2009

References

  • Macfarlane G, Gibson GR, Forberg CW, Cheng KJ, White BR, Cotta MA, . Biochemical activities and metabolic transformations. Gastrointestinal microbiology, RI Mackie, BA White, et al. Chapman & Hall, New York, NY 1997; 269–620
  • Heavey PM, Rowland IR. Gastrointestinal cancer. Best Pract Res Gastroenterol 2004; 18: 323–36
  • Goldin BR. Intestinal microflora: metabolism of drugs and carcinogens. Ann Med 1990; 22: 43–8
  • Lewis D. The CYP2 family: models, mutants, and interactions. Xenobiotica 1998; 28: 617–61
  • Meatherall R. GC/MS confirmation of barbiturates in blood and urine. J Forensic Sci 1997; 42: 1160–70
  • Moore WEC, Holdeman LV. Human fecal flora: the normal flora of 20 Japanese-Hawaiians. Appl Microbiol 1974; 27: 961–79
  • Fredrickson JK, Kostandarithes HM, Plymale AE, Daly MJ. Reduction of F(III), Cr(VI), U(VI), and Tc(VII) by Deinococcus radiodurans R1. Appl Environ Microbiol 2000; 66: 2006–11
  • John GH, Walls S, Keith R, Good-fox-Jones J, Tucker K, Abraham KJ. The presence of a cytochrome P450-like protein in the human intestinal microflora Eubacterium aerofaciens. Microb Ecol Hlth Dis 2001; 13: 3–8
  • Atkinson C, Frankenfeld CL, Lampe JW. Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health. Exp Biol Med 2005; 230: 155–70
  • Simons AL, Renouf M, Hendrich S, Murphy PA. Human gut microbial degradation of flavonoids: structure-function relationships. J Agric Food Chem 2005; 53: 4258–63
  • Sinha VR, Kumria R. Microbially triggered drug delivery to the colon. Eur J Pharm Sci 2003; 18: 3–18
  • Nugon-Baudon L, Rabot S, Flinois J-P, Lory S, Beaune Ph. Effects of the bacterial status of rats on the changes in some liver cytochrome P450 (EC 1.14.14.1) apoprotein consequent to a glucosinolate-rich diet Br J Nutr 1998;80:231–4.
  • May T, Jurgens U, Rambeck B, Schnabel R. Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy. Epilepsy Res 1999; 33: 57–65
  • Butler T. The metabolic hydroxylation of phenobarbital. J Pharmacol Exp Ther 1955; 116: 326–36