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Original Article

A Second Heavy Chain Permits Survival of High Affinity Autoreactive B Cells

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Pages 27-32 | Received 22 Jul 2003, Accepted 22 Aug 2003, Published online: 07 Jul 2009

References

  • Blackwell, T.K. and Alt, F.W. (1989) "Mechanism and develop-mental program of immunoglobulin gene rearrangement in mammals", Annu. Rev. Genet. 23, 605–636
  • Winfield, J.B., Faiferman, I. and Koffler, D. (1977) "Avidity of anti-DNA antibodies in serum and IgG glomerula eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis", J. Clin. Investig. 59, 90–96
  • Pearson, L. and Lightfoot, R.W. Jr. (1981) "Correlationof DNA-anti-DNA association rates with clinical activity in systemic lupus erythematosus (SLE)", J. Immunol. 126, 16–19
  • Tan, EM. (1989) "Antinucelar antibodies: diagnostic markers for autoimmune diseases and probes for cell biology", Adv. Immunol. 44, 93–151
  • Nemazee, D.A. and Burki, K. (1989) "Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes", Nature 337, 562–566
  • Erikson, J., Radic, M.Z., Camper, S.A., Hardy, R.R., Carmack, C. and Weigert, M. (1991) "Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice", Nature 349, 331–334
  • Hartley, S.B., Crosbie, J., Brink, R., Kantor, A.B., Basten, A. and Goodnow, C.C. (1991) "Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens", Nature 353, 765–769
  • Goodnow, C.C., Brink, R. and Adams, E. (1991) "Breakdown of self-tolerance in anergic B lymphocytes", Nature 352, 532–536
  • Goodnow, C.C., Crosbie, J., Adelstein, S., Lavoie, TB., Smith-Gill, S.J., Brink, R.A., et al. (1988) "Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice", Nature 334, 676–682
  • Shefner, R., Kleiner, G., Turken, A., Papazian, L. and Diamond, B. (1991) "A novel class of anti-DNA antibodies identified in BALB/c mice", J. Exp. Med. 173, 287–296
  • Offen, D., Spatz, L., Escowitz, H., Factor, S. and Diamond, B. (1992) "Induction of tolerance to an IgG autoantibody", Proc. Natl Acad. Sci. USA 89, 8332–8336
  • Iliev, A., Spatz, L., Ray, S. and Diamond, B. (1994) "Lack of allelic exclusion permits autoreactive B cells to escape deletion", J. Immunol. 153, 3551–3556
  • Spatz, L., Saenko, V., they, A., Jones, L., Geskin, L. and Diamond, B. (1997) "Light chain usage in anti-double-stranded DNA B cell subsets: role in cell fate determination", J. Exp. Med. 185, 1317
  • Bynoe, MS., Spatz, L. and Diamond, B. (1999) "Characterization of anti-DNA B cells that escape negative selection", Eur. J. Immunol. 29, 1304–1313
  • Kitamura, D., Roes, J., Kuhn, R. and Rajewsky, K. (1991) "A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene", Nature 350, 423–426
  • Chu, Y.P., Taylor, D., Yon, HG., Diamond, B. and Spatz, L. (2002) "Persistence of partially functional double stranded DNA binding B cells in mice transgenic for the IgM heavy chain of an anti-dsDNA antibody", Intl. Immunol. 14, 45–54
  • Kettleborough, CA., Saldanha, J., Ansell, K.H. and Bendig, (1993) "Optimization of primers for cloning libraries of mouse immunoglobulin genes using the polymerase chain reaction", Eur J. Immunol. 23, 206–211
  • Cooke, M.P., Heath, A.W., Shokat, KM., Zeng, Y, Finkelman, ED., Linsley, P.S., et al. (1994) "Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells", J. Exp. Med. 179, 425–438
  • Eris, J.M., Basten, A., Brink, R., Doherty, K., Kehry, M.R. and Hodgkin, RD. (1994) "Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions", Proc. Natl Acad. Sci. USA 91, 4392–4396
  • Mandik-Nayak, L., Seo, S., Eaton-Bassiri, A., Allman, D., Hardy, R.R. and Erikson, J. (2000) "Functional consequences of the developmental arrest and follicular exclusion of anti-double-stranded DNA B cells", J. Immunol. 164, 1161–1168
  • Eilat, D., Webster, D.M. and Rees, A.R. (1988) "V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW Fl mice", J. Immunol. 141, 1745–1753
  • Chen, C., Nagy, Z., Prak, E.L. and Weigert, M. (1995) "Inununoglobulin heavy chain gene replacement: a mechanism of receptor editing", Immunity 3, 747–755
  • Bertrand, FE., Golub, R. and Wu, G.E. (1998) "V(H) gene replacement occurs in the spleen and bone marrow of non-autoimmune quasi-monoclonal mice", Eur. J. Immunol. 28, 3362–3370
  • King, LB. and Monroe, J.G. (2000) "Immunobiology of the immature B cell: plasticity in the B-cell antigen receptor-induced response fine tunes negative selection", Immunol. Rev. 176, 86–104
  • Gay, D., Saunders, T., Camper, S. and Weigert, M. (1993) "Receptor editing: an approach by autoreactive B cells to escape tolerance", J. Exp. Med. 177, 999–1008
  • Radic, M.Z., Erikson, J., Litwin, S. and Weigert, M. (1993) "B lymphocytes may escape tolerance by revising their antigen receptors", J. Exp. Med. 177, 1165–1173
  • Tiegs, S.L., Russell, D.M. and Nemazee, D. (1993) "Receptor editing in self-reactive bone marrow B cells", J. Exp. Med. 177, 1009–1020
  • Hertz, M. and Nemazee, D. (1997) "B CR ligation induces receptor editing in IgM IgD — bone marrow B cells in vitro", Immunity 6, 429–436
  • Chen, C., Radic, M.Z., Erikson, J., Camper, S.A., Litwin, S., Hardy, R.R., et al. (1994) "Deletion and editing of B cells that express antibodies to DNA", J. Immunol. 152, 1970–1982

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