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Original Article

Molecular Mimicry toBorrelia burgdorferi: Pathway to Autoimmunity?

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Pages 387-392 | Accepted 13 Apr 2004, Published online: 07 Jul 2009

References

  • Nocton, J.J. and Steere, AC. (1995) "Lyme disease", Adv. Intern. Med. 40, 69–117.
  • Stanek, G. and Strle, F. (2003) "Lyme borreliosis", Lancet 362, 1639–1647.
  • Nocton, J.J., Dressler, F., Rutledge, B.J., Rys, RN., Persing, D.H. and Steere, AC. (1994) "Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis", N. EngL J. Med. 330, 229–234.
  • Nocton, J.J., Bloom, B.J., Rutledge, B.J., Persing, D.H., Logigian, EL., Schmid, C.H. and Steere, AC. (1996) "Detection of Borrelia burgdorferi DNA by polymerase chain reaction in cerebrospinal fluid in Lyme neuroborreliosis", J. Infect. Dis. 174, 623–627.
  • Steere, AC., Schoen, R.T. and Taylor, E. (1987) "The clinical evolution of Lyme arthritis", Ann. Intern. Med. 107, 725–731.
  • Yang, L., Weis, J.H., Eichwald, E., Kolbert, CP., Persing, D.H. and Weis, J.J. (1994) "Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues", Infect. Immun. 62, 492–500.
  • Hirschfeld, M., Kirschning, C.J., Schwandner, R., Wesche, H., Weis, J.H., Wooten, R.M. and Weis, J.J. (1999) "Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2", J. Immunol. 163, 2382–2386.
  • Lien, E., Sellati, T.J., Yoshimura, A., Flo, T.H., Rawadi, G., Finberg, R.W., Carroll, J.D., Espevik, T., Ingalls, R.R., Radolf, J.D. and Golenbock, D.T. (1999) "Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products", J. Biol. Chem. 274, 33419–33425.
  • Rahn, D.W. and Malawista, S.E. (1991) "Lyme disease", West J. Med. 154, 706–714.
  • Barthold, S.W., Beck, D.S., Hansen, G.M., Terwilliger, GA. and Moody, K.D. (1990) "Lyme borreliosis in selected strains and ages of laboratory mice", J. Infect. Dis. 162, 133–138.
  • Barthold, S.W., Sidman, C.L. and Smith, AL. (1992) "Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency", Am. J. Trop. Med. Hyg. 47, 605–613.
  • Brown, C.R. and Reiner, SI. (1999) "Genetic control of experimental lyme arthritis in the absence of specific immunity", Infect. Immun. 67, 1967–1973.
  • Ruderman, EM., Kerr, J.S., Telford, SR., HI, Spielman, A., Glimcher, L.H. and Gravallese, E.M. (1995) "Early murine Lyme carditis has a macrophage predominance and is independent of major histocompatibility complex class II-CD4+T cell inter-actions", J. Infect. Dis. 171, 362–370.
  • Fikrig, E., Barthold, S.W., Chen, M., Chang, C.H. and Flavell, R.A. (1997) "Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class 11 and CD4+T cells", J. Immunol. 159, 5682–5686.
  • Malawista, SE., Barthold, S.W. and Persing, D.H. (1994) "Fate of Borrelia burgdorferi DNA in tissues of infected mice after antibiotic treatment", J. Infect. Dis. 170, 1312–1316.
  • Steere, A.C., Dwyer, E. and Winchester, R. (1990) "Association of chronic Lyme arthritis with HLA-DR4 and FILA-DR2 alleles", N. Engl. J. Med. 323, 219–223.
  • Steere, AC., Falk, B., Drouin, E.E., Baxter-Lowe, L.A., Hammer, J. and Nepom, G.T. (2003) "Binding of outer surface protein A and human lymphocyte function-associated antigen 1 peptides to HLA-DR molecules associated with antibiotic treatment-resistant Lyme arthritis", Arthritis Rheum. 48, 534–540.
  • Steere, A.C., Levin, RE., Molloy, P.J., Kalish, R.A., Abraham, J.H., HI, Liu, N.Y. and Schmid, C.H. (1994) "Treatment of Lyme arthritis", Arthritis Rheum. 37, 878–888.
  • Carlson, D., Hernandez, J., Bloom, B.J., Coburn, J., Aversa, J.M. and Steere, A.C. (1999) "Lack of Borrelia burgdorferi DNA in synovial samples from patients with antibiotic treatment-resistant Lyme arthritis", Arthritis Rheum. 42, 2705–2709.
  • Kalish, R.A., Leong, J.M. and Steere, A.C. (1993) "Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi", Infect. Immun. 61, 2774–2779.
  • Schwan, T.G., Piesman, J., Golde, W.T., Dolan, MC. and Rosa, RA. (1995) "Induction of an outer surface protein on Borrelia burgdorferi during tick feeding", Proc. Natl Acad. Sci. USA 92, 2909–2913.
  • de Silva, A.M., Telford, S.R., M, Brunet, L.R., Barthold, S.W. and Fikrig, E. (1996) "Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine", J. Exp. Med. 183, 271–275.
  • Fujinami, R.S. and Oldstone, M.B. (1985) "Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity", Science 230, 1043–1045.
  • Abbas, AK., Lichtman, A.H. and Pober, J.S. (2000) Cellular and Molecular Immunology (W.B. Saunders Company, Philadelphia, PA).
  • Bachmaier, K., Neu, N., de la Maza, L.M., Pal, S., Hessel, A. and Penninger, J.M. (1999) "Chlamydia infections and heart disease linked through antigenic mimicry", Science 283, 1335–1339.
  • Zhao, Z.S., Granucci, F., Yeh, L., Schaffer, RA. and Cantor, H. (1998) "Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection", Science 279, 1344–1347.
  • Gross, D.M., Forsthuber, T., Tary-Lehmann, M., Etling, C., Ito, K., Nagy, Z.A., Field, J.A., Steere, AC. and Huber, B.T. (1998) "Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis", Science 281, 703–706.
  • Kamradt, T., Lengl-Janssen, B., Strauss, AF., Barisal, G. and Steere, A.C. (1996) "Dominant recognition of a Borrelia burgdorferi outer surface protein A peptide by T helper cells in patients with treatment-resistant Lyme arthritis", Infect. Immun. 64, 1284–1289.
  • Kalish, R.S., Wood, J.A., Golde, W., Bernard, R., Davis, LE., Grimson, R.C., Coyle, P.K. and Luft, B.J. (2003) "Human T lymphocyte response to Borrelia burgdorferi infection: no correlation between human leukocyte function antigen type 1 peptide response and clinical status", J. Infect. Dis. 187, 102–108.
  • Chen, J., Field, J.A., Glickstein, L., Molloy, P.J., Huber, B.T. and Steere, A.C. (1999) "Association of antibiotic treatment-resistant Lyme arthritis with T cell responses to dominant epitopes of outer surface protein A of Borrelia burgdorferi", Arthritis Rheum. 42, 1813–1822.
  • Suk, K., Das, S., Sun, W., Jwang, B., Barthold, S.W., Flavell, R.A. and Fikrig, E. (1995) "Borrelia burgdorferi genes selectively expressed in the infected host", Proc. Natl Acad. Sci. USA 92, 4269–4273.
  • Zhang, JR., Hardham, J.M., Barbour, A.G. and Norris, S.J. (1997) "Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes", Cell 89,275–285.
  • Miller, J.C., von Lackum, K., Babb, K., McAlister, J.D. and Stevenson, B. (2003) "Temporal analysis of Borrelia burgdorferi Erp protein expression throughout the mammal-tick infectious cycle", Infect. Immun. 71, 6943–6952.
  • Hemmer, B., Gran, B., Zhao, Y, Marques, A., Pascal, J., Tzou, A., Kondo, T., Cortese, I., Bielekova, B., Straus, SE., McFarland, H.F., Houghten, R., Simon, R., Pinilla, C. and Martin, R. (1999) "Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease", Nat. Med. 5, 1375–1382.
  • Meyer, AL., Trollmo, C., Crawford, F., Marrack, P., Steere, AC., Huber, B.T., Kappler, J. and Hafler, D.A. (2000) "Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class 11 tetramers", Proc. Natl Acad. Sci. USA 97, 11433–11438.
  • Akin, E., Aversa, J. and Steere, A.C. (2001) "Expression of adhesion molecules in synovia of patients with treatment-resistant lyme arthritis", Infect. Immun. 69, 1774–1780.
  • Trollmo, C., Meyer, AL., Steere, AC., Hafler, D.A. and Huber, B.T. (2001) "Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha Lisa partial agonist for outer surface protein A-reactive T cells", J. Immunol. 166, 5286–5291.
  • Limbach, F.X., Jaulhac, B., Puechal, X., Monteil, H., Kuntz, J.L., Piemont, Y. and Sibilia, J. (2001) "Treatment resistant Lyme arthritis caused by Borrelia garinii", Ann. Rheum. Dis. 60, 284–286.
  • Dejmkova, H., Hulinska, D., Tegzova, D., Pavelka, K., Gatterova, J. and Vavrik, P. (2002) "Seronegative Lyme arthritis caused by Borrelia garinii", Clin. RheumatoL 21, 330–334.
  • Steere, AC., Gross, D., Meyer, A.L. and Huber, B.T. (2001) "Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis", J. Autoimmun. 16, 263–268.
  • Maier, B., Molinger, M., Cope, AY., Fugger, L., Schneider-Mergener, J., Sonderstrup, G., Kamradt, T. and Kramer, A. (2000) "Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells", Eur. J. Immunol. 30, 448–457.
  • Yang, L., Ma, Y., Schoenfeld, R., Griffiths, M., Eichwald, E., Araneo, B. and Weis, J.J. (1992) "Evidence for B-lymphocyte mitogen activity in Borrelia burgdorferi-infected mice", Infect. Immun. 60, 3033–3041.
  • McKisic, M.D. and Barthold, S.W. (2000) "T-cell-independent responses to Borrelia burgdorferi are critical for protective immunity and resolution of lyme disease", Infect. Immun. 68, 5190–5197.
  • Martin, R., Ortlauf, J., Sticht-Groh, V., Bogdahn, U., Goldmann, S.F. and Mertens, HG. (1988) "Borrelia burgdorferi-specific and autoreactive T-cell lines from cerebrospinal fluid in Lyme radiculomyelitis", Ann. NeuroL 24, 509–516.
  • Ramesh, G., Alvarez, AL., Roberts, E.D., Dennis, V.A., Lasater, B.L., Alvarez, X. and Philipp, M.T. (2003) "Pathogenesis of Lyme neuroborreliosis: Borrelia burgdorferi lipoproteins induce both proliferation and apoptosis in rhesus monkey astrocytes", Eur. J. Immunol. 33, 2539–2550.
  • Pachner, A.R., Cadavid, D., Shu, G., Dail, D., Pachner, S., Hodzic, E. and Barthold, S.W. (2001) "Central and peripheral nervous system infection, immunity, and inflammation in the NHP model of Lyme borreliosis", Ann. NeuroL 50, 330–338.
  • Roberts, E.D., Bohm, R.P., Jr., Cogswell, F.B., Lanners, H.N., Lowrie, R.C., Jr., Povinelli, L., Piesman, J. and Philipp, M.T. (1995) "Chronic lyme disease in the rhesus monkey", Lab. Invest. 72, 146–160.
  • Barthold, S.W., de Souza, M.S., Janotka, J.L., Smith, A.L. and Persing, D.H. (1993) "Chronic Lyme borreliosis in the laboratory mouse", Am. J. PathoL 143, 959–971.
  • Croke, C.L., Munson, EL., Lovrich, S.D., Christopherson, J.A., Remington, M.C., England, D.M., Callister, S.M. and Schell, R.F. (2000) "Occurrence of severe destructive lyme arthritis in hamsters vaccinated with outer surface protein A and challenged with Borrelia burgdorferi", Infect. Immun. 68, 658–663.
  • Lim, L.C., England, D.M., DuChateau, B.K., Glowacki, N.J., Creson, J.R., Lovrich, S.D., Callister, S.M., Jobe, D.A. and Schell, R.F. (1994) "Development of destructive arthritis in vaccinated hamsters challenged with Borrelia burgdorferi", Infect. Immun. 62, 2825–2833.
  • Lim, L.C., England, D.M., Glowacki, N.J., DuChateau, B.K. and Schell, R.F. (1995) "Involvement of CD4+ T lymphocytes in induction of severe destructive Lyme arthritis in inbred LSH hamsters", Infect. Immun. 63, 4818–4825.

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