Contribution of CD8+ T cells to inflammatory cytokine production in systemic sclerosis (SSc)

References

• Müller-Ladner, U., O. Distler, L. Ibba-Manneschi, et al. 2009. Mechanisms of vascular damage in systemic sclerosis. Autoimmunity 42: 597–595
   Web of Science ®Google Scholar
• Sakkas, L. I. 2005. New developments in the pathogenesis of systemic sclerosis. Autoimmunity 38: 113–116
   PubMed Web of Science ®Google Scholar
• Radstake, T. R., L. van Bon, J. Broen, et al. 2009. The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. PLoS One 4: e5903
   PubMed Web of Science ®Google Scholar
• Radstake, T. R., L. van Bon, J. Broen, et al. 2009. Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PLoS One 4: e5981
   Web of Science ®Google Scholar
• Kurzinski, K., K. S. Torok. 2011. Cytokine profiles in localized scleroderma and relationship to clinical features. Cytokine 55: 157–164
   PubMed Web of Science ®Google Scholar
• Baraut, J., L. Michel, F. Verrecchia, and D. Farge. 2010. Relationship between cytokine profiles and clinical outcomes in patients with systemic sclerosis. Autoimmun. Rev. 10: 65–73
   PubMed Web of Science ®Google Scholar
• Papp, G., I. F. Horvath, S. Barath, et al. 2011. Altered T-cell and regulatory cell repertoire in patients with diffuse cutaneous systemic sclerosis. Scand. J. Rheumatol. 40: 205–210
   PubMed Web of Science ®Google Scholar
• Fenoglio, D., F. Battaglia, A. Parodi, et al. 2011. Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis. Clin. Immunol. 139: 249–257
   PubMed Web of Science ®Google Scholar
• Mathian, A., C. Parizot, K. Dorgham, et al. 2012. Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions. Ann. Rheum. Dis. 71: 1227–1234
   PubMed Web of Science ®Google Scholar
• Fuschiotti, P., T. A. MedsgerJr, and P. A. Morel. 2009. Effector CD8+ T cells in systemic sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis. Arthritis. Rheum. 60: 1119–1128
   PubMed Web of Science ®Google Scholar
• Boin, F., F. M. Wigley, J. P. Schneck, et al. 2005. Evaluation of topoisomerase-1-specific CD8+ T-cell response in systemic sclerosis. Ann. N. Y. Acad. Sci. 1062: 137–145
   PubMed Web of Science ®Google Scholar
• Ercole, L. P., M. Malvezzi, A. C. Boaretti, et al. 2003. Analysis of lymphocyte subpopulations in systemic sclerosis. J. Investig. Allergol. Clin. Immunol. 13: 87–93
   PubMed Web of Science ®Google Scholar
• Atamas, S. P., V. V. Yurovsky, R. Wise, et al. 1999. Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis. Arthritis. Rheum. 42: 1168–1178
   PubMed Web of Science ®Google Scholar
• Kessel, A., I. Rosner, M. Rozenbaum, et al. 2004. Increased CD8+ T cell apoptosis in scleroderma is associated with low levels of NF-kappa B. J. Clin. Immunol. 24: 30–36
   PubMed Web of Science ®Google Scholar
• Gambichler, T., C. Tigges, B. Burkert, et al. 2010. Absolute count of T and B lymphocyte subsets is decreased in systemic sclerosis. Eur. J. Med. Res. 15: 44–46
   PubMed Web of Science ®Google Scholar
• Filaci, G., M. Fravega, D. Fenoglio, et al. 2004. Non-antigen specific CD8+ T suppressor lymphocytes. Clin. Exp. Med. 4: 86–92
   PubMed Web of Science ®Google Scholar
• Fergusson, J. R., V. M. Fleming, and P. Klenerman. 2011. CD161-expressing human T cells. Front. Immunol. 2: 1–7
   PubMed Web of Science ®Google Scholar
• Mitsuo, A., S. Morimoto, Y. Nakiri, et al. 2006. Decreased CD161 + CD8+ T cells in the peripheral blood of patients suffering from rheumatic diseases. Rheumatology (Oxford) 45: 1477–1484
   PubMed Web of Science ®Google Scholar
• Parel, Y., M. Aurrand-Lions, A. Scheja, et al. 2007. Presence of CD4 + CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis. Arthritis Rheum. 56: 3459–3467
   PubMed Web of Science ®Google Scholar
• Medsger, T. A. Jr., D. E. Ivanco, L. Kardava, et al. 2011. GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production. Arthritis Rheum. 63: 1738–1747
   PubMed Web of Science ®Google Scholar
• Fuschiotti, P. 2011. CD8+ T cells in systemic sclerosis. Immunol. Res. 50: 188–194
   PubMed Web of Science ®Google Scholar
• Fuschiotti, P., A. T. Larregina, J. Ho, et al. 2013. Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis. Arthritis Rheum. 65: 236–246
   PubMed Web of Science ®Google Scholar
• Hasegawa, M. S., and S. Sato. 2008. The roles of chemokines in leukocyte recruitment and fibrosis in systemic sclerosis. Front. Biosci. 13: 3637–3647
   PubMed Web of Science ®Google Scholar
• Truchetet, M. E., N. C. Brembilla, E. Montanari, et al. 2011. Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease. Arthritis Res. Ther. 13: R166
   PubMed Web of Science ®Google Scholar
• Tao, J., L. Li, Z. Tan, et al. 2011. Up-regulation of CC chemokine ligand 20 and its receptor CCR6 in the lesional skin of early systemic sclerosis. Eur. J. Dermatol. 21: 731–736
   PubMed Web of Science ®Google Scholar
• van den Hoogen, F., D. Khanna, J. Fransen, et al. 2013. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum. 65: 2737–2747
   PubMed Web of Science ®Google Scholar
• Hachulla, E., and D. Launay. 2011. Diagnosis and classification of systemic sclerosis. Clin. Rev. Allergy Immunol. 40: 78–83
   PubMed Web of Science ®Google Scholar
• Distler, J. H., A. Akhmetshina, G. Schett, and O. Distler. 2009. Monocyte chemoattractant proteins in the pathogenesis of systemic sclerosis. Rheumatology (Oxford) 48: 98–103
   PubMed Web of Science ®Google Scholar
• Kimmig, S., G. K. Przybylski, C. A. Schmidt, et al. 2002. Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J. Exp. Med. 195: 789–794
   PubMed Web of Science ®Google Scholar
• Fink, P. J. 2013. The biology of recent thymic emigrants. Annu. Rev. Immunol. 31: 31–50
   PubMed Web of Science ®Google Scholar
• Fujii, H., M. Hasegawa, K. Takehara, et al. 2002. Abnormal expression of intracellular cytokines and chemokine receptors in peripheral blood T lymphocytes from patients with systemic sclerosis. Clin. Exp. Immunol. 130: 548–556
   PubMed Web of Science ®Google Scholar
• Hickman, H. D., G. V. Reynoso, B. F. Ngudiankama, et al. 2015. CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells. Immunity 42: 524–537
   PubMed Web of Science ®Google Scholar
• Oghumu, S., C. A. Terrazas, S. Varikuti, et al. 2015. CXCR3 expression defines a novel subset of innate CD8+ T cells that enhance immunity against bacterial infection and cancer upon stimulation with IL-15. Faseb. J. 29: 1019–1028
   PubMed Web of Science ®Google Scholar
• Villarroel, V. A., N. Okiyama, G. Tsuji, et al. 2014. CXCR3-mediated skin homing of autoreactive CD8 T cells is a key determinant in murine graft-versus-host disease. J. Invest. Dermatol. 134: 1552–1560
   PubMed Web of Science ®Google Scholar
• Yaqub, A., L. Chung, K. E. Rieger, and D. F. Fiorentino. 2013. Localized cutaneous fibrosing disorders. Rheum. Dis. Clin. North Am. 39: 347–364
   PubMed Web of Science ®Google Scholar
• Oo, Y. H., V. Banz, D. Kavanagh, et al. 2012. CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. J. Hepatol. 57: 1044–1051
   PubMed Web of Science ®Google Scholar
• van der Waart, A. B., W. J. van der Velden, A. G. van Halteren, et al. 2012. Decreased levels of circulating IL17-producing CD161 + CCR6+ T cells are associated with graft-versus-host disease after allogeneic stem cell transplantation. Plos One 7: e50896
   Google Scholar
• Billerbeck, E., Y. H. Kang, L. Walker, et al. 2010. Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc. Natl. Acad. Sci. USA 107: 3006–3011
   PubMed Web of Science ®Google Scholar
• Wehrens, E. J., G. Mijnheer, C. L. Duurland, et al. 2011. Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells. Blood 118: 3538–3548
   PubMed Web of Science ®Google Scholar
• Xie, Y., Zhang, X., Wakasugi, S., et al. 2008. Immunohistochemical characterization of the cellular infiltrate in localized scleroderma. Int. J. Dermatol. 47: 438–442
   PubMed Web of Science ®Google Scholar
• Li, H., and A. Rostami. 2010. IL-9: basic biology, signaling pathways in CD4+ T cells and implications for autoimmunity. J. Neuroimmune Pharmacol. 5: 198–209
   PubMed Web of Science ®Google Scholar
• Visekruna, A., J. Ritter, T. Scholz, et al. 2013. Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation. Eur. J. Immunol. 43: 606–518
   PubMed Web of Science ®Google Scholar
• Nowak, E. C., and R. J. Noelle. 2010. Interleukin-9 as a T helper type 17 cytokine. Immunology 131: 169–173
   PubMed Web of Science ®Google Scholar
• Lu, Y., S. Hong, H. Li, et al. 2012. Th9 cells promote antitumor immune responses in vivo. J. Clin. Invest. 122: 4160–4171
   PubMed Web of Science ®Google Scholar
• Yanaba, K., A. Yoshizaki, Y. Asano, et al. 2011. Serum interleukin 9 levels are increased in patients with systemic sclerosis: association with lower frequency and severity of pulmonary fibrosis. J. Rheumatol. 38: 2193–2197
   PubMed Web of Science ®Google Scholar
• Macaulay, R., A. N. Akbar, and S. M. Henson. 2013. The role of the T cell in age-related inflammation. Age (Dordr) 35: 563–572
   PubMed Web of Science ®Google Scholar
• Mayerl, C., and M. Prelog. 2012. Immunosenescence and juvenile idiopathic arthritis. Autoimmun. Rev. 11: 297–300
   PubMed Web of Science ®Google Scholar
• Prelog, M., N. Schwarzenbrunner, M. Sailer-Höck, et al. 2008. Premature aging of the immune system in children with juvenile idiopathic arthritis. Arthritis Rheum. 58: 2153–2162
   PubMed Web of Science ®Google Scholar
• Prelog, M. 2006. Aging of the immune system: a risk factor for autoimmunity? Autoimmun. Rev. 5: 136–139
   PubMed Web of Science ®Google Scholar
• Moore, K. W., R. de Waal Malefyt, R. L. Coffman, and A. O'Garra. 2001. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19: 683–765
   PubMed Web of Science ®Google Scholar
• Fahey, L. M., and D. G. Brooks. 2010. Opposing positive and negative regulation of T cell activity during viral persistence. Curr. Opin. Immunol. 22: 348–354
   PubMed Web of Science ®Google Scholar
• Gravano, D. M., and K. K. Hoyer. 2013. Promotion and prevention of autoimmune disease by CD8+ T cells. J. Autoimmun. 45: 68–79
   PubMed Web of Science ®Google Scholar
• Masson, F., M. Ghisi, J. R. Groom, et al. 2014. Id2 represses E2A-mediated activation of IL-10 expression in T cells. Blood 123: 3420–3428
   PubMed Web of Science ®Google Scholar
• Herman, S., N. Zurgil, P. Langevitz, et al. 2008. Methotrexate selectively modulates TH1/TH2 balance in active rheumatoid arthritis patients. Clin. Exp. Rheumatol. 26: 317–323
   PubMed Web of Science ®Google Scholar
• Guggino, G., A. Giardina, A. Ferrante, et al. 2015. The in vitro addition of methotrexate and/or methylprednisolone determines peripheral reduction in Th17 and expansion of conventional Treg and of IL-10 producing Th17 lymphocytes in patients with early rheumatoid arthritis. Rheumatol. Int. 35: 171–175
   PubMed Web of Science ®Google Scholar
• Zhang, Z., P. Zhao, A. Li, et al. 2009. Effects of methotrexate on plasma cytokines and cardiac remodeling and function in postmyocarditis rats. Mediators Inflamm. 2009: 389720
   PubMed Web of Science ®Google Scholar
• Thomaz, M. A., S. C. Acedo, C. C. de Oliveira, et al. 2009. Methotrexate is effective in reactivated colitis and reduces inflammatory alterations in mesenteric adipose tissue during intestinal inflammation. Pharmacol. Res. 60: 341–346
   PubMed Web of Science ®Google Scholar
• Huang, B., Q. T. Wang, S. S. Song, et al. 2012. Combined use of etanercept and MTX restores CD4+/CD8+ ratio and Tregs in spleen and thymus in collagen-induced arthritis. Inflamm. Res. 61: 1229–1239
   PubMed Web of Science ®Google Scholar
• Zhang, S., Z. Shen, G. Hu, et al. 2009. Effects of endogenous glucocorticoids on allergic inflammation and T(H)1 /T(H)2 balance in airway allergic disease. Ann. Allergy Asthma Immunol. 103: 525–534
   PubMed Web of Science ®Google Scholar
• Muangchan, C., Canadian Scleroderma Research Group, Baron M, Pope J. 2013. The 15% rule in scleroderma: the frequency of severe organ complications in systemic sclerosis. A systematic review. J. Rheumatol. 40: 1545–1556
   PubMed Web of Science ®Google Scholar