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Autoimmunity Volume 52, 2019 - Issue 1
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Original Article

CD5+ B lymphocytes secrete IL-10 rather than TGF-β1 which control the immune response in autoimmune haemolytic anaemia/Evans syndrome

Manjun ZhaoDepartment of Hematology, General Hospital Tianjin Medical University, Tianjin, China; View further author information
,
Ningning DuanDepartment of Hematology, General Hospital Tianjin Medical University, Tianjin, China; View further author information
,
Yi WangDepartment of Hematology, General Hospital Tianjin Medical University, Tianjin, China; View further author information
,
Hongli ZhuDepartment of Hematology, Jining No. 1 People’s Hospital, Shandong, ChinaView further author information
,
Hong LiuDepartment of Hematology, General Hospital Tianjin Medical University, Tianjin, China; View further author information
,
Huaquan WangDepartment of Hematology, General Hospital Tianjin Medical University, Tianjin, China; View further author information
,
Limin XingDepartment of Hematology, General Hospital Tianjin Medical University, Tianjin, China; Correspondence[email protected]
View further author information
&
Zonghong ShaoDepartment of Hematology, General Hospital Tianjin Medical University, Tianjin, China; View further author information
 show all
Pages 12-20 | Received 11 Sep 2018, Accepted 28 Jan 2019, Published online: 20 Feb 2019

References

  • Fagiolo E, Toriani-Terenzi C. Mechanisms of immunological tolerance loss versus erythrocyte self-antigens and autoimmune hemolytic anemia. J Autoimmunity. 2003;36:199–204.
  • Limin X, Zonghong S, Rong F, et al. CD5+ B lymphocytes in the bone morrow of autoimmune hemocytopenia patients and its clinical significance. Chin J Pract Intern Med. 2005;25:39–41. Chinese.
  • Hongli Z, Wenyan X, Hong L, et al. Expression of activated molecules on CD5(+) B lymphocytes in autoimmune hemolytic anemia. J Int J Hematol. 2016;103:545–553.
  • Heine G, Drozdenko G, Grün JR, et al. Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts. Eur J Immunol. 2014;44:1615–1621.
  • Yohei I. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. J Blood. 2011;2:530–541.
  • Blair PA, Noreña LY, Flores-Borja F, et al. CD19(+) CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. J Immunity. 2010;32:129–140.
  • Group, Chinese Society of Hematology, Chinese Medical Association. [Chinese expert consensus on the diagnosis and treatment of autoimmune hemolytic anemia (2017) Red Blood Cell Disease (Anemia)]. Zhonghua Xue Ye Xue Za Zhi. 2017;38:265–267. Chinese.
  • Neff AT. Autoimmune hemolytic anemias. In: Greer JP, Foerster J, Lukens JN, et al., editors. Wintrobe’s clinical hematology. Philadelphia (PA): Lippincott Williams & Wilkins; 2004. p. 1157–1182.
  • Marti GE, Rawstron AC, Ghia P, et al. Diagnostic criteria for monoclonal B-cell lymphocytosis. J Br J Haematol. 2005;130:325–332.
  • Bouaziz JD, Calbo S, Maho-Vaillant M, et al. IL-10 produced by activated human B cells regulates CD4+ T-cell activation in vitro. Eur J Immunol. 2010;40:2686–2691.
  • Barcellini W, Clerici G, Montesano R, et al. In vitro quantification of anti-red blood cell antibody production in idiopathic autoimmune haemolytic anaemia: effect of mitogen and cytokine stimulation. J Br J Haematol. 2000;111:452–460.
  • Vuslat O, Piraye A, Fikret P, et al. B cells produce less IL-10, IL-6 and TNF-α in myasthenia gravis. J Autoimmunity. 2015;48 201–207.
  • Das A, Ellis G, Pallant C, et al. IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection. J Immunol. 2012;189:3925–3935.
  • Mauri C, Blair PA. Regulatory B cells in autoimmunity: developments and controversies. J Nature reviews. Rheumatology. 2010;6:636–643.
  • Geiger KD, Klein U, Bräuninger A, et al. CD5-positive B cells in healthy elderly humans are a polyclonal B cell population. Eur J Immunol. 2000;30:2918–2923.
  • Pallier A, Hillion S, Danger R, et al. Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype. J Kidney Int. 2010;78:503–513.
  • Le Texier L, Thebault P, Lavault A, et al. Long-term allograft tolerance is characterized by the accumulation of B cells exhibiting an inhibited profile. Am J Transplant. 2011;11:429–438.
  • Heinemann K, Wilde B, Hoerning A, et al. Decreased IL-10(+) regulatory B cells (Bregs) in lupus nephritis patients. J Scand J Rheumatol. 2016;45:312–316.
  • Furuzawa-Carballeda J, Hernández-Molina G, Lima G, et al. Peripheral regulatory cells immunophenotyping in primary Sjögren's syndrome: a cross-sectional study. Arthritis Res Ther. 2013;15:R68.
  • Gieni RS, Umetsu DT, Dekruyff RHJCI. Ly1-(CD5-) B cells produce interleukin (IL)-10. Cell Immunol. 1997;175:164–170.
  • Lee JH, Noh J, Noh G, et al. Allergen-specific transforming growth factor-β-producing CD19(+) CD5(+) regulatory B-cell (Br3) responses in human late eczematous allergic reactions to cow's milk. J Interferon Cytokine Res. 2011;31:441–449.
  • Noh WS, Choi G, Noh J, et al. Presence of Foxp3-expressing CD19(+) CD5(+) B cells in human peripheral blood mononuclear cells: human CD19(+) CD5(+) Foxp3(+) regulatory B cell (Breg). Immune Netw. 2010;10:247–249.
  • Ahmad E, Elgohary T, Ibrahim H. Naturally occurring regulatory T cells and interleukins 10 and 12 in the pathogenesis of idiopathic warm autoimmune hemolytic anemia. J Investig Allergol Clin Immunol. 2011;21:297.

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