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Original Article

Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice

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Pages 176-184 | Received 24 Jan 2019, Accepted 25 Jun 2019, Published online: 19 Jul 2019

References

  • Knechtle SJ, Kwun J. Unique aspects of rejection and tolerance in liver transplantation. Semin Liver Dis. 2009;29:91–101.
  • Yokota S, Yoshida O, Ono Y, et al. Liver transplantation in the mouse: insights into liver immunobiology, tissue injury, and allograft tolerance. Liver Transpl. 2016;22:536–546.
  • Nickkholgh A, Maluf D. Emerging graft protective strategies in clinical liver transplantation. Expert Rev Gastroenterol Hepatol. 2017;11:623–631.
  • Xu L, Yin W, Sun R, et al. Kupffer cell-derived IL-10 plays a key role in maintaining humoral immune tolerance in hepatitis B virus-persistent mice. Hepatology. 2014;59:443–452.
  • Heymann F, Peusquens J, Ludwig-Portugall I, et al. Liver inflammation abrogates immunological tolerance induced by Kupffer cells. Hepatology. 2015;62:279–291.
  • Xuesong X, Menghao W, Jin-Zheng L, et al. Tauroursodeoxycholic acid alleviates hepatic ischemia reperfusion injury by suppressing the function of Kupffer cells in mice. Biomed Pharmacother. 2018;106:1271–1281.
  • Jiang L, Ke M, Yue S, et al. Blockade of Notch signaling promotes acetaminophen-induced liver injury. Immunol Res. 2017;65:739–749.
  • Wongchana W, Kongkavitoon P, Tangtanatakul P, et al. Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes. PLoS One. 2018;13:e0198609.
  • Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol. 2006;7:678–689.
  • Di IM, Del PB, Baldoni S, et al. NOTCH and graft-versus-host disease. Front Immunol. 2018;9:1825.
  • Shin HM, Tilahun ME, Cho OH, et al. NOTCH1 can initiate NF-kappaB activation via cytosolic interactions with components of the T cell signalosome. Front Immunol. 2014;5:249.
  • Yao L, Kan EM, Kaur C, et al. Notch-1 signaling regulates microglia activation via NF-κB pathway after hypoxic exposure in vivo and in vitro. PLoS One. 2013;8:e78439.
  • Lu L, Yue S, Jiang L, et al. Myeloid notch1 deficiency activates RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers. Hepatology. 2017;67:1041–1055.
  • Fargo KN, Aisen P, Albert M, et al. Report on the milestones for the US national plan to address Alzheimer's disease. Alzheimers Dement. 2014;10:S430–S452.
  • Nakamura K, Kageyama S, Yue S, et al. Heme oxygenase-1 regulates sirtuin-1-autophagy pathway in liver transplantation: from mouse to human. Am J Transplant. 2018;18:1110–1121.
  • Ke B, Shen XD, Zhang Y, et al. KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants. J Hepatol. 2013;59:1200–1207.
  • Geem D, Medina-Contreras O, Kim W, et al. Isolation and characterization of dendritic cells and macrophages from the mouse intestine. J Vis Exp. 2012;63:e4040.
  • Li PZ, Li JZ, Li M, et al. An efficient method to isolate and culture mouse Kupffer cells. Immunol Lett. 2014;158:52–56.
  • Dai Y, Wilson G, Huang B, et al. Silencing of Jagged1 inhibits cell growth and invasion in colorectal cancer. Cell Death Dis. 2014;5:e1170.
  • Li P, Liu H, Zhang Y, et al. Endotoxin tolerance inhibits degradation of tumor necrosis factor receptor-associated factor 3 by suppressing pellino 1 expression and the K48 ubiquitin ligase activity of cellular inhibitor of apoptosis protein 2. J Infect Dis. 2016;214:906–915.
  • Yan L, Wenfeng Z, Yao C, et al. Activation of PPARγ by curcumin protects mice from ischemia/reperfusion injury induced by orthotopic liver transplantation via modulating polarization of Kupffer cells. Int Immunopharmacol. 2018;62:270–276.
  • Wei S, Ding C, Liu Z, et al. Dysfunctional immunoregulation in human liver allograft rejection associated with compromised galectin-1/CD7 pathway function. Cell Death Dis. 2018;9:293.
  • Zhang S, Loch AJ, Radtke F, et al. Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways. Dev Dyn. 2013;242:678–686.
  • Schabbauer G, Matt U, Gunzl P, et al. Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia. J Immunol. 2010;185:468–476.
  • Dong ZW, Ren CG, Xia Y, et al. Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. J Hematol Oncol. 2014;7:17.
  • Cheng Y, Tian Y, Xia J, et al. The role of PTEN in regulation of hepatic macrophages activation and function in progression and reversal of liver fibrosis. Toxicol Appl Pharmacol. 2017;317:51–62.
  • Yue S, Rao J, Zhu J, et al. Myeloid PTEN deficiency protects livers from ischemia reperfusion injury by facilitating M2 macrophage differentiation. J Immunol. 2014;192:5343–5353.
  • Burke JE. Structural basis for regulation of phosphoinositide kinases and their involvement in human disease. Mol Cell. 2018;71:653–673.
  • Bilyy R, Stoika R. Search for novel cell surface markers of apoptotic cells. Autoimmunity. 2007;40:249–253.
  • Datta G, Fuller BJ, Davidson BR. Molecular mechanisms of liver ischemia reperfusion injury: insights from transgenic knockout models. World J Gastroenterol. 2013;19:1683–1698.
  • Luo SY, Li R, Le ZY, et al. Anfibatide protects against rat cerebral ischemia/reperfusion injury via TLR4/JNK/caspase-3 pathway. Eur J Pharmacol. 2017;807:127–137.
  • Stienstra R, Saudale F, Duval C, et al. Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. Hepatology. 2010;51:511–522.
  • van RN, Sanders A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods. 1994;174:83–93.
  • Sapir T, Levy T, Kozer N, et al. Notch activation by shootin1 opposing activities on 2 ubiquitin ligases. Cereb Cortex. 2018;28:3115–3128.
  • Tang G, Weng Z, Song J, et al. Reversal effect of Jagged1 signaling inhibition on CCl4-induced hepatic fibrosis in rats. Oncotarget. 2017;8:60778–60788.

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