Distinct pattern of peripheral lymphocyte subsets in Graves’ disease with persistency of anti-TSHR autoantibodies

References

• Menconi F, Marcocci C, Marino M. Diagnosis and classification of Graves' disease. Autoimmun Rev. 2014;13:398–402.
   PubMed Web of Science ®Google Scholar
• Bossowski A, Urban M, Stasiak-Barmuta A. Analysis of changes in the percentage of B (CD19) and T (CD3) lymphocytes, subsets CD4, CD8 and their memory (CD45RO), and naive (CD45RA) T cells in children with immune and non-immune thyroid diseases. J Pediatr Endocrinol Metab. 2003;16:63–70.
   PubMed Web of Science ®Google Scholar
• Zha B, Wang L, Liu X, et al. Decrease in proportion of CD19+ CD24(hi) CD27+ B cells and impairment of their suppressive function in Graves' disease. PLoS One. 2012;7:e49835.
   PubMed Web of Science ®Google Scholar
• van der Weerd K, Van Hagen PM, Schrijver B, et al. The peripheral blood compartment in patient with Graves' disease: activated T lymphocytes and increased transitional and pre-naive mature B lymphocytes. Clin Exp Immunol. 2013;174:256–264.
   PubMed Web of Science ®Google Scholar
• Horie I, Abiru N, Saitoh O, et al. Distinct role of T helper Type 17 immune response for Graves' hyperthyroidism in mice with different genetic backgrounds. Autoimmunity. 2011;44:159–165.
   PubMed Web of Science ®Google Scholar
• Pan D, Shin YH, Gopalakrishnan G, et al. Regulatory T cells in Graves' disease. Clin Endocrinol (Oxf). 2009;71:587–593.
   PubMed Web of Science ®Google Scholar
• Vitales-Noyola M, Ramos-Levi AM, Martinez-Hernandez R, et al. Pathogenic Th17 and Th22 cells are increased in patients with autoimmune thyroid disorders. Endocrine. 2017;57:409–417.
   PubMed Web of Science ®Google Scholar
• Appay V, van Lier RA, Sallusto F, et al. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A. 2008;73:975–983.
   PubMed Web of Science ®Google Scholar
• Maecker HT, McCoy JP, Nussenblatt R. Standardizing immunophenotyping for the Human Immunology Project. Nat Rev Immunol. 2012;12:191–200.
   PubMed Web of Science ®Google Scholar
• Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol. 2004;22:745–763.
   PubMed Web of Science ®Google Scholar
• Streitz M, Miloud T, Kapinsky M, et al. Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study. Transplant Res. 2013;2:17.
   PubMedGoogle Scholar
• Popadic D, Anegon I, Baeten D, et al. Predictive immunomonitoring – the COST ENTIRE initiative. Clin Immunol. 2013;147:23–26.
   PubMed Web of Science ®Google Scholar
• Teniente-Serra A, Grau-Lopez L, Mansilla MJ, et al. Multiparametric flow cytometric analysis of whole blood reveals changes in minor lymphocyte subpopulations of multiple sclerosis patients. Autoimmunity. 2016;49:219–228.
   PubMed Web of Science ®Google Scholar
• Armengol MP, Sabater L, Fernandez M, et al. Influx of recent thymic emigrants into autoimmune thyroid disease glands in humans. Clin Exp Immunol. 2008;153:338–350.
   PubMed Web of Science ®Google Scholar
• Teniente-Serra A, Hervas JV, Quirant-Sanchez B, et al. Baseline differences in minor lymphocyte subpopulations may predict response to fingolimod in relapsing-remitting multiple sclerosis patients. CNS Neurosci Ther. 2016;22:584–592.
   PubMed Web of Science ®Google Scholar
• Haines CJ, Giffon TD, Lu LS, et al. Human CD4+ T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function. J Exp Med. 2009;206:275–285.
   PubMed Web of Science ®Google Scholar
• Fujikawa M, Okamura K, Sato K, et al. Usefulness of surface phenotype study of intrathyroidal lymphocytes obtained by fine needle aspiration cytology in autoimmune thyroid disease and malignant lymphoma of the thyroid. Clin Endocrinol. 1998;49:191–196.
   PubMed Web of Science ®Google Scholar
• Iwatani Y, Hidaka Y, Matsuzuka F, et al. Intrathyroidal lymphocyte subsets, including unusual CD4+ CD8+ cells and CD3loTCR alpha beta lo/-CD4-CD8– cells, in autoimmune thyroid disease. Clin Exp Immunol. 1993;93:430–436.
   PubMed Web of Science ®Google Scholar
• Uchimura K, Itoh M, Yamamoto K, et al. The effects of CD40- and interleukin (IL-4)-activated CD23+ cells on the production of IL-10 by mononuclear cells in Graves' disease: the role of CD8+ cells. Clin Exp Immunol. 2002;128:308–312.
   PubMed Web of Science ®Google Scholar
• Tomer Y. Genetic susceptibility to autoimmune thyroid disease: past, present, and future. Thyroid. 2010;20:715–725.
   PubMed Web of Science ®Google Scholar
• Jilek S, Schluep M, Rossetti AO, et al. CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis. Clin Immunol. 2007;123:105–113.
   PubMed Web of Science ®Google Scholar
• Pender MP, Csurhes PA, Pfluger CM, et al. Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis. Mult Scler. 2014;20:1825–1832.
   PubMed Web of Science ®Google Scholar
• Skowera A, Ladell K, McLaren JE, et al. β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure. Diabetes. 2015;64:916–925.
   PubMed Web of Science ®Google Scholar
• Pender MP. CD8+ T-cell deficiency, Epstein–Barr virus infection, vitamin D deficiency, and steps to autoimmunity: a unifying hypothesis. Autoimmune Dis. 2012;2012:189096.
   PubMedGoogle Scholar
• Hill-Cawthorne GA, Button T, Tuohy O, et al. Long term lymphocyte reconstitution after alemtuzumab treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2012;83:298–304.
   PubMed Web of Science ®Google Scholar
• Rotondi M, Molteni M, Leporati P, et al. Autoimmune thyroid diseases in patients treated with alemtuzumab for multiple sclerosis: an example of selective anti-TSH-receptor immune response. Front Endocrinol (Lausanne). 2017;8:254.
   PubMed Web of Science ®Google Scholar
• Jones JL, Thompson SA, Loh P, et al. Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation. Proc Natl Acad Sci USA. 2013;110:20200–20205.
   PubMed Web of Science ®Google Scholar
• Parel Y, Chizzolini C. CD4+ CD8+ double positive (DP) T cells in health and disease. Autoimmun Rev. 2004;3:215–220.
   PubMed Web of Science ®Google Scholar
• Sala P, Tonutti E, Feruglio C, et al. Persistent expansions of CD4+ CD8+ peripheral blood T cells. Blood. 1993;82:1546–1552.
   PubMedGoogle Scholar
• Xie D, Hai B, Xie X, et al. Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme B (GrB), Foxp3, interleukin 17 (IL-17), at higher levels in Th1/Th2 cytokines. Cell Immunol. 2009;259:157–164.
   PubMed Web of Science ®Google Scholar
• Bossowski A, Moniuszko M, Dąbrowska M, et al. Lower proportions of CD4 + CD25(high) and CD4 + FoxP3, but not CD4 + CD25 + CD127(low) FoxP3(+)T cell levels in children with autoimmune thyroid diseases. Autoimmunity. 2013;46:222.
   PubMed Web of Science ®Google Scholar
• Mao C, Wang S, Xiao Y, et al. Impairment of regulatory capacity of CD4 + CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease. J Immunol. 2011;186:4734–4743.
   PubMed Web of Science ®Google Scholar
• Li C, Yuan J, Zhu YF, et al. Imbalance of Th17/Treg in different subtypes of autoimmune thyroid diseases. Cell Physiol Biochem. 2016;40:245–252.
   PubMedGoogle Scholar
• Qin J, Zhou J, Fan C, et al. Increased circulating Th17 but decreased CD4 + Foxp3+ Treg and CD19 + CD1dhiCD5+ Breg subsets in new-onset Graves' disease. Biomed Res Int. 2017;2017:8431838.
   PubMedGoogle Scholar
• Klatka M, Grywalska E, Partyka M, et al. Th17 and Treg cells in adolescents with Graves' disease. Impact of treatment with methimazole on these cell subsets. Autoimmunity. 2014;47:201–211.
   PubMed Web of Science ®Google Scholar
• Fountoulakis S, Vartholomatos G, Kolaitis N, et al. HLA-DR expressing peripheral T regulatory cells in newly diagnosed patients with different forms of autoimmune thyroid disease. Thyroid. 2008;18:1195–1200.
   PubMed Web of Science ®Google Scholar
• Marazuela M, Garcia-Lopez MA, Figueroa-Vega N, et al. Regulatory T cells in human autoimmune thyroid disease. J Clin Endocrinol Metab. 2006;91:3639–3646.
   PubMed Web of Science ®Google Scholar
• Nakano A, Watanabe M, Iida T, et al. Apoptosis-induced decrease of intrathyroidal CD4(+)CD25(+) regulatory T cells in autoimmune thyroid diseases. Thyroid. 2007;17:25–31.
   PubMed Web of Science ®Google Scholar
• Glick AB, Wodzinski A, Fu P, et al. Impairment of regulatory T-cell function in autoimmune thyroid disease. Thyroid. 2013;23:871–878.
   PubMed Web of Science ®Google Scholar