IL1β, IL18, NFKB1 and IFNG gene interactions are associated with severity of rheumatoid arthritis: A pilot study

References

• McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365(23):2205–2219.
   PubMed Web of Science ®Google Scholar
• Brzustewicz E, Bryl E. The role of cytokines in the pathogenesis of rheumatoid arthritis – practical and potential application of cytokines as biomarkers and targets of personalized therapy. Cytokine. 2015;76(2):527–536.
   PubMed Web of Science ®Google Scholar
• Azizieh FY, Al Jarallah K, Shehab D, et al. Patterns of circulatory and peripheral blood mononuclear cytokines in rheumatoid arthritis. Rheumatol Int. 2017;37(10):1727–1734.
   PubMed Web of Science ®Google Scholar
• Kim EY, Moudgil KD. Immunomodulation of autoimmune arthritis by pro-inflammatory cytokines. Cytokine. 2017;98:87–96.
   PubMed Web of Science ®Google Scholar
• Yi Y-S. Role of inflammasomes in inflammatory autoimmune rheumatic diseases. Korean J Physiol Pharmacol. 2018;22(1):1.
   PubMed Web of Science ®Google Scholar
• Meyer PWA, Hodkinson B, Ally M, et al. Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis. Mediators Inflamm. 2010;2010:1–10.
   Google Scholar
• Addobbati C, da Cruz HLA, Adelino JE, et al. Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients. Inflamm Res. 2018;67(3):255–264.
   PubMed Web of Science ®Google Scholar
• Buchs N, di Giovine F, Silvestri T, et al. IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels. Genes Immun. 2001;2(4):222–228.
   PubMed Web of Science ®Google Scholar
• Joosten LAB, Radstake TRD, Lubberts E, et al. Association of interleukin-18 expression with enhanced levels of both interleukin-1 and tumor necrosis factor in knee synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum. 2003;48(2):339–347.
   PubMedGoogle Scholar
• Liu T, Zhang L, Joo D, et al. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2:17023.
   PubMed Web of Science ®Google Scholar
• Kopitar-Jerala N. The role of interferons in inflammation and inflammasome activation. Front Immunol. 2017;8:873.
   PubMed Web of Science ®Google Scholar
• Świerkot J, Nowak B, Czarny A, et al. The activity of JAK/STAT and NF-κB in patients with rheumatoid arthritis. Adv Clin Exp Med. 2016;25(4):709–717.
   PubMed Web of Science ®Google Scholar
• López-Mejías R, García-Bermúdez M, González-Juanatey C, et al. NFKB1-94ATTG ins/del polymorphism (rs28362491) is associated with cardiovascular disease in patients with rheumatoid arthritis. Atherosclerosis. 2012;224(2):426–429.
   PubMed Web of Science ®Google Scholar
• Bogunia-Kubik K, Wysoczańska B, Piątek D, et al. Significance of polymorphism and expression of miR-146a and NFkB1 genetic variants in patients with rheumatoid arthritis. Arch Immunol Ther Exp. 2016;64(S1):131–136.
   PubMedGoogle Scholar
• Angelo HD, Gomes Silva IIF, Oliveira RDR, et al. Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study: IL-18, IL-12B and IFN-γ gene polymorphisms and rheumatoid arthritis. Tissue Antigens. 2015;86(4):276–278.
   PubMedGoogle Scholar
• Pociot F, Mølvig J, Wogensen L, et al. A Taql polymorphism in the human interleukin-1β (IL-1β) gene correlates with IL-1β secretion in vitro. Eur J Clin Invest. 1992;22(6):396–402.
   PubMed Web of Science ®Google Scholar
• Giedraitis V, He B, Huang W-X, et al. Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J Neuroimmunol. 2001;112(1-2):146–152.
   PubMed Web of Science ®Google Scholar
• Li LL, Deng XF, Li JP, et al. Association of IL-18 polymorphisms with rheumatoid arthritis: a meta-analysis. Genet Mol Res. 2016;15(1):1–14.
   Web of Science ®Google Scholar
• Karban AS, Okazaki T, Panhuysen CIM, et al. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet. 2004;13(1):35–45.
   PubMed Web of Science ®Google Scholar
• Gębura K, Świerkot J, Wysoczańska B, et al. Polymorphisms within genes involved in regulation of the NF-κB pathway in patients with Rheumatoid Arthritis. Int J Mol Sci. 2017;18(7):1432.
   Web of Science ®Google Scholar
• Pravica V, Perrey C, Stevens A, et al. A single nucleotide polymorphism in the first intron of the human IFN-γ gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Hum Immunol. 2000;61(9):863–866.
   PubMed Web of Science ®Google Scholar
• Wei Z, Wenhao S, Yuanyuan M, et al. A single nucleotide polymorphism in the interferon-γ gene (IFNG + 874 T/A) is associated with susceptibility to tuberculosis. Oncotarget. 2017;8:50415–50429.
   PubMedGoogle Scholar
• Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31(3):315–324.
   PubMed Web of Science ®Google Scholar
• Smolen JS, Landewe R, Breedveld FC, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis. 2010;69(6):964–975.
   PubMed Web of Science ®Google Scholar
• Carmo Vasconcelos de Carvalho V, de Macêdo JL, de Lima CAD, et al. IFN-gamma and IL-12B polymorphisms in women with cervical intraepithellial neoplasia caused by human papillomavirus. Mol Biol Rep. 2012;39:7627–7634.
   PubMed Web of Science ®Google Scholar
• G RK, K MS, G KK, et al. Evaluation of Hs-CRP levels and interleukin 18 (–137G/C) promoter polymorphism in risk prediction of coronary artery disease in first degree relatives. PLoS One. 2015;10(3):e0120359.
   PubMed Web of Science ®Google Scholar
• Paz Aparicio J, Fernández Bances I, López-Anglada Fernández E, et al. The IL-1β (+3953 T/C) gene polymorphism associates to symptomatic lumbar disc herniation. Eur Spine J. 2011;20(S3):383–389.
   PubMedGoogle Scholar
• Faul F, Erdfelder E, Buchner A, et al. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149–1160.
   PubMed Web of Science ®Google Scholar
• El-Sayed EH, Saleh MH, Al-Shahaly MH, et al. IL-37 gene variant (rs3811047): a marker of disease activity in rheumatoid arthritis: a pilot study. Autoimmunity. 2018;51(8):378–385.
   PubMed Web of Science ®Google Scholar
• Han T-U, Lee H-S, Kang C, et al. Association of joint erosion with SLC22A4 gene polymorphisms inconsistently associated with rheumatoid arthritis susceptibility. Autoimmunity. 2015;48(5):313–317.
   PubMed Web of Science ®Google Scholar
• Domínguez-Pérez RA, Loyola-Rodriguez JP, Abud-Mendoza C, et al. Association of cytokines polymorphisms with chronic periodontitis and rheumatoid arthritis in a Mexican population. Acta Odontol Scand. 2017;75(4):243–248.
   PubMed Web of Science ®Google Scholar
• Shafia S, Dilafroze  , Sofi FA, et al. Rheumatoid arthritis and genetic variations in cytokine genes: a population-based study in Kashmir Valley. Immunol Invest. 2014;43:349–359.
   PubMed Web of Science ®Google Scholar
• Pawlik A, Kurzawski M, Drozdzik M, et al. Interleukin‐18 gene (IL18) promoter polymorphisms in patients with rheumatoid arthritis. Scand J Rheumatol. 2009;38(3):159–165.
   PubMed Web of Science ®Google Scholar
• Rueda B, Gonzalez-Gay MA, Mataran L, et al. Interleukin-18-promoter polymorphisms are not relevant in rheumatoid arthritis. Tissue Antigens. 2005;65(6):544–548.
   PubMedGoogle Scholar
• Viatte S, Plant D, Lunt M, et al. Investigation of rheumatoid arthritis genetic susceptibility markers in the early rheumatoid arthritis study further replicates the TRAF1 association with radiological damage. J Rheumatol. 2013;40(2):144–156.
   PubMed Web of Science ®Google Scholar
• Orozco G, Hinks A, Eyre S, et al. Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet. 2009;18(14):2693–2699.
   PubMed Web of Science ®Google Scholar