HERC6 is upregulated in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and promotes the disease progression

References

• Fairhurst AM, Wandstrat AE, Wakeland EK. Systemic lupus erythematosus: multiple immunological phenotypes in a complex genetic disease. Adv Immunol. 2006;92:1–69.
   PubMed Web of Science ®Google Scholar
• Ghodke-Puranik Y, Niewold TB. Immunogenetics of systemic lupus erythematosus: a comprehensive review. J Autoimmun. 2015;64:125–136.
   PubMed Web of Science ®Google Scholar
• Liu A, La Cava A. Epigenetic dysregulation in systemic lupus erythematosus [review]. Autoimmunity. 2014;47(4):215–219.
   PubMed Web of Science ®Google Scholar
• Levy DM, Kamphuis S. Systemic lupus erythematosus in children and adolescents. Pediatr Clin North Am. 2012;59(2):345–364.
   PubMed Web of Science ®Google Scholar
• Luo Q, Zhang L, Fang L, et al. Circular RNAs hsa_circ_0000479 in peripheral blood mononuclear cells as novel biomarkers for systemic lupus erythematosus [research support, non-US gov’t]. Autoimmunity. 2020;53(3):167–176.
   PubMedGoogle Scholar
• Egner W. The use of laboratory tests in the diagnosis of SLE. J Clin Pathol. 2000;53(6):424–432.
   PubMed Web of Science ®Google Scholar
• Reveille JD. Predictive value of autoantibodies for activity of systemic lupus erythematosus. Lupus. 2004;13(5):290–297.
   PubMed Web of Science ®Google Scholar
• Sternhagen E, Bettendorf B, Lenert A, et al. The role of clinical features and serum biomarkers in identifying patients with incomplete lupus erythematosus at higher risk of transitioning to systemic lupus erythematosus: Current perspectives. J Inflamm Res. 2022;15:1133–1145.
   PubMed Web of Science ®Google Scholar
• Delves PJ, Martin SJ, Burton DR, et al. Roitt’s essential immunology. New Jersey: John Wiley & Sons; 2017.
   Google Scholar
• Kurki A, Kemppainen E, Laurikka P, et al. The use of peripheral blood mononuclear cells in celiac disease diagnosis and treatment. Expert Rev Gastroenterol Hepatol. 2021;15(3):305–316.
   PubMed Web of Science ®Google Scholar
• Sariko M, Maro A, Gratz J, et al. Evaluation of cytokines in peripheral blood mononuclear cell supernatants for the diagnosis of tuberculosis. J Inflamm Res. 2018;12:15–22.
   PubMed Web of Science ®Google Scholar
• Bokharaei-Salim F, Esteghamati A, Khanaliha K, et al. Evaluation of a PCR assay for diagnosis of toxoplasmosis in serum and peripheral blood mononuclear cell among HIV/AIDS patients. J Parasit Dis. 2020;44(1):159–165.
   PubMedGoogle Scholar
• Mohammadi S, Saghaeian-Jazi M, Sedighi S, et al. Immunomodulation in systemic lupus erythematosus: induction of M2 population in monocyte-derived macrophages by pioglitazone. Lupus. 2017;26(12):1318–1327.
   PubMed Web of Science ®Google Scholar
• Li F, Yang Y, Zhu X, et al. Macrophage polarization modulates development of systemic lupus erythematosus. Cell Physiol Biochem. 2015;37(4):1279–1288.
   PubMedGoogle Scholar
• Pickering MC, Botto M, Taylor PR, et al. Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv Immunol. 2000;76:227–324.
   PubMed Web of Science ®Google Scholar
• Katsiari CG, Liossis SN, Sfikakis PP. The pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus: a reappraisal. Semin Arthritis Rheum. 2010;39(6):491–503.
   PubMed Web of Science ®Google Scholar
• Alvarez-Rodriguez L, Martinez-Taboada V, Calvo-Alen J, et al. Altered Th17/treg ratio in peripheral blood of systemic lupus erythematosus but not primary antiphospholipid syndrome. Front Immunol. 2019;10:391.
   PubMed Web of Science ®Google Scholar
• Yang J, Yang X, Zou H, et al. Recovery of the immune balance between Th17 and regulatory T cells as a treatment for systemic lupus erythematosus. Rheumatology (Oxford). 2011;50(8):1366–1372.
   PubMed Web of Science ®Google Scholar
• Filaci G, Bacilieri S, Fravega M, et al. Impairment of CD8+ T suppressor cell function in patients with active systemic lupus erythematosus. J Immunol. 2001;166(10):6452–6457.
   PubMed Web of Science ®Google Scholar
• Dinesh RK, Skaggs BJ, La Cava A, et al. CD8+ tregs in lupus, autoimmunity, and beyond. Autoimmun Rev. 2010;9(8):560–568.
   PubMed Web of Science ®Google Scholar
• Sanchez-Tena S, Cubillos-Rojas M, Schneider T, et al. Functional and pathological relevance of HERC family proteins: a decade later. Cell Mol Life Sci. 2016;73(10):1955–1968.
   PubMed Web of Science ®Google Scholar
• Dastur A, Beaudenon S, Kelley M, et al. Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells. J Biol Chem. 2006;281(7):4334–4338.
   PubMed Web of Science ®Google Scholar
• Wong JJ, Pung YF, Sze NS, et al. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. Proc Natl Acad Sci U S A. 2006;103(28):10735–10740.
   PubMed Web of Science ®Google Scholar
• Ketscher L, Basters A, Prinz M, et al. mHERC6 is the essential ISG15 E3 ligase in the murine system. Biochem Biophys Res Commun. 2012;417(1):135–140.
   PubMed Web of Science ®Google Scholar
• Woolsey C, Jankeel A, Matassov D, et al. Immune correlates of postexposure vaccine protection against Marburg virus. Sci Rep. 2020;10(1):3071.
   PubMed Web of Science ®Google Scholar
• Zeng JC, Lin DZ, Yi LL, et al. BTLA exhibits immune memory for alphabeta T cells in patients with active pulmonary tuberculosis. Am J Transl Res. 2014;6(5):494–506.
   PubMed Web of Science ®Google Scholar
• Sun Y, Lu W, Du K, et al. microRNA and mRNA profiles in the amygdala are relevant to fear memory induced by physical or psychological stress. J Neurophysiol. 2019;122(3):1002–1022.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Nozawa K, Doe K, Uomori K, et al. Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus. Autoimmunity. 2017;50(4):241–246.
   PubMed Web of Science ®Google Scholar
• Bakshi J, Segura BT, Wincup C, et al. Unmet needs in the pathogenesis and treatment of systemic lupus erythematosus. Clin Rev Allergy Immunol. 2018;55(3):352–367.
   PubMed Web of Science ®Google Scholar
• Tas SW, Quartier P, Botto M, et al. Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells. Ann Rheum Dis. 2006;65(2):216–221.
   PubMed Web of Science ®Google Scholar
• Feng Y, Yang M, Wu H, et al. The pathological role of B cells in systemic lupus erythematosus: from basic research to clinical. Autoimmunity. 2020;53(2):56–64.
   PubMed Web of Science ®Google Scholar
• Garcia-Gonzalo FR, Rosa JL. The HERC proteins: functional and evolutionary insights. Cell Mol Life Sci. 2005;62(16):1826–1838.
   PubMed Web of Science ®Google Scholar
• Huibregtse JM, Scheffner M, Beaudenon S, et al. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci U S A. 1995;92(7):2563–2567.
   PubMed Web of Science ®Google Scholar
• Renault L, Nassar N, Vetter I, et al. The 1.7 a crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller. Nature. 1998;392(6671):97–101.
   PubMed Web of Science ®Google Scholar
• Nemergut ME, Mizzen CA, Stukenberg T, et al. Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B. Science. 2001;292(5521):1540–1543.
   PubMed Web of Science ®Google Scholar
• Hadjebi O, Casas-Terradellas E, Garcia-Gonzalo FR, et al. The RCC1 superfamily: from genes, to function, to disease. Biochim Biophys Acta. 2008;1783(8):1467–1479.
   PubMed Web of Science ®Google Scholar
• Oudshoorn D, van Boheemen S, Sanchez-Aparicio MT, et al. HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells. PLoS One. 2012;7(1):e29870.
   PubMed Web of Science ®Google Scholar
• Bolli R, Dawn B, Xuan YT. Role of the JAK-STAT pathway in protection against myocardial ischemia/reperfusion injury. Trends Cardiovasc Med. 2003;13(2):72–79.
   PubMed Web of Science ®Google Scholar
• Zhuo Q, Wei L, Yin X, et al. LncRNA ZNF667-AS1 alleviates rheumatoid arthritis by sponging miR-523-3p and inactivating the JAK/STAT signalling pathway. Autoimmunity. 2021;54(7):406–414.
   PubMed Web of Science ®Google Scholar
• Zhang LH, Jiang SZ, Guo X, et al. MiR-146b-5p targets IFI35 to inhibit inflammatory response and apoptosis via JAK1/STAT1 signalling in lipopolysaccharide-induced glomerular cells [research support, non-US gov’t]. Autoimmunity. 2021;54(7):430–438.
   PubMed Web of Science ®Google Scholar
• O’Shea JJ, Plenge R. JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity. 2012;36(4):542–550.
   PubMed Web of Science ®Google Scholar
• O’Shea JJ, Schwartz DM, Villarino AV, et al. The JAK-STAT pathway: impact on human disease and therapeutic intervention. Annu Rev Med. 2015;66:311–328.
   PubMed Web of Science ®Google Scholar
• Remmers EF, Plenge RM, Lee AT, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med. 2007;357(10):977–986.
   PubMed Web of Science ®Google Scholar
• Shao WH, Shu DH, Zhen Y, et al. Prion-like aggregation of mitochondrial antiviral signaling protein in lupus patients is associated with increased levels of type I interferon. Arthritis Rheumatol. 2016;68(11):2697–2707.
   PubMed Web of Science ®Google Scholar
• Liang Y, Xu WD, Peng H, et al. SOCS signaling in autoimmune diseases: molecular mechanisms and therapeutic implications. Eur J Immunol. 2014;44(5):1265–1275.
   PubMed Web of Science ®Google Scholar
• Sukka-Ganesh B, Larkin J, 3rd. Therapeutic potential for targeting the suppressor of cytokine signalling-1 pathway for the treatment of SLE. Scand J Immunol. 2016;84(5):299–309.
   PubMed Web of Science ®Google Scholar
• de la Varga Martinez R, Rodriguez-Bayona B, Anez GA, et al. Clinical relevance of circulating anti-ENA and anti-dsDNA secreting cells from SLE patients and their dependence on STAT-3 activation. Eur J Immunol. 2017;47(7):1211–1219.
   PubMed Web of Science ®Google Scholar
• Wang S, Yang N, Zhang L, et al. Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice. Lupus. 2010;19(10):1171–1180.
   PubMed Web of Science ®Google Scholar
• Lu LD, Stump KL, Wallace NH, et al. Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2. J Immunol. 2011;187(7):3840–3853.
   PubMed Web of Science ®Google Scholar
• Ripoll E, de Ramon L, Draibe Bordignon J, et al. JAK3-STAT pathway blocking benefits in experimental lupus nephritis. Arthritis Res Ther. 2016;18(1):134.
   PubMed Web of Science ®Google Scholar
• Wu T, Ye Y, Min SY, et al. Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid. Arthritis Rheumatol. 2014;66(11):3129–3139.
   PubMed Web of Science ®Google Scholar