Bulk T-cell receptor sequencing confirms clonality in obstetric antiphospholipid syndrome and may as a potential biomarker

References

• Ünlü O, Zuily S, Erkan D. The clinical significance of antiphospholipid antibodies in systemic lupus erythematosus. Eur J Rheumatol. 2016;3(2):75–84.
   PubMed Web of Science ®Google Scholar
• Schreiber K, Hunt BJ. Managing antiphospholipid syndrome in pregnancy. Thromb Res. 2019;181 Suppl 1(Suppl 1):S41–S46.
   PubMedGoogle Scholar
• Garcia D, Erkan D. Diagnosis and management of the antiphospholipid syndrome. N Engl J Med. 2018;378(21):2010–2021.
   PubMed Web of Science ®Google Scholar
• Di Simone N, Di Nicuolo F, D'Ippolito S, et al. Antiphospholipid antibodies affect human endometrial angiogenesis. Biol Reprod. 2010;83(2):212–219. Epub 2010 Apr 14. PMID: 20393166.
   PubMed Web of Science ®Google Scholar
• D'Ippolito S, Di Simone N, Di Nicuolo F, et al. Antiphospholipid antibodies: effects on trophoblast and endothelial cells. Am J Reprod Immunol. 2007;58(2):150–158. PMID: 17631008.
   PubMed Web of Science ®Google Scholar
• Di Simone N, D'Ippolito S, Marana R, et al. Antiphospholipid antibodies affect human endometrial angiogenesis: protective effect of a synthetic peptide (TIFI) mimicking the phospholipid binding site of β(2) glycoprotein I. Am J Reprod Immunol. 2013; Oct70(4):299–308. Epub 2013 May 7. PMID: 23650919.
   PubMed Web of Science ®Google Scholar
• D'Ippolito S, Meroni PL, Koike T, et al. Obstetric antiphospholipid syndrome: a recent classification for an old defined disorder. Autoimmun Rev. 2014;13(9):901–908. Epub 2014 May 10. PMID: 24820522.
   PubMed Web of Science ®Google Scholar
• Meroni PL, Borghi MO, Grossi C, et al. Obstetric and vascular antiphospholipid syndrome: same antibodies but different diseases? Nat Rev Rheumatol. 2018; Jul14(7):433–440. PMID: 29891914.
   PubMed Web of Science ®Google Scholar
• D'Ippolito S, Barbaro G, Paciullo C, et al. Antiphospholipid syndrome in pregnancy: new and old pathogenetic mechanisms. Int J Mol Sci. 2023;24(4):3195. PMID: 36834614; PMCID: PMC9966557.
   PubMed Web of Science ®Google Scholar
• Knight JS, Branch DW, Ortel TL. Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management. BMJ. 2023;380:e069717.
   PubMedGoogle Scholar
• Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295–306.
   PubMed Web of Science ®Google Scholar
• Hattori N, Kuwana M, Kaburaki J, et al. T cells that are autoreactive to beta2-glycoprotein I in patients with antiphospholipid syndrome and healthy individuals. Arthritis Rheum. 2000;43(1):65–75.
   PubMedGoogle Scholar
• Krause I, Blank M, Levi Y, et al. Anti-idiotype immunomodulation of experimental anti-phospholipid syndrome via effect on Th1/Th2 expression. Clin Exp Immunol. 1999;117(1):190–197.
   PubMed Web of Science ®Google Scholar
• Yan H, Li B, Su R, et al. Preliminary study on the imbalance between Th17 and regulatory T cells in antiphospholipid syndrome. Front Immunol. 2022;13:873644.
   PubMed Web of Science ®Google Scholar
• Long Y, Li W, Feng J, et al. Follicular helper and follicular regulatory T cell subset imbalance is associated with higher activated B cells and abnormal autoantibody production in primary anti-phospholipid syndrome patients. Clin Exp Immunol. 2021;206(2):141–152.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Lin M, Hao X, et al. Imbalance of circulating CTLA4+ follicular helper and follicular regulatory T cells in obstetric antiphospholipid syndrome. Clin Exp Med. 2022;22(1):27–36.
   PubMed Web of Science ®Google Scholar
• Glanville J, Huang H, Nau A, et al. Identifying specificity groups in the T cell receptor repertoire. Nature. 2017;547(7661):94–98.
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang W, Zhao M, et al. T cell receptor β repertoires as novel diagnostic markers for systemic lupus erythematosus and rheumatoid arthritis. Ann Rheum Dis. 2019;78(8):1070–1078.
   PubMed Web of Science ®Google Scholar
• Rajewsky K. Immunology. The power of clonal selection. Nature. 1993;363(6426):208–208.
   PubMed Web of Science ®Google Scholar
• Hakim FT, Flomerfelt FA, Boyiadzis M, et al. Aging, immunity and cancer. Curr Opin Immunol. 2004;16(2):151–156.
   PubMed Web of Science ®Google Scholar
• Bonilla FA, Oettgen HC. Adaptive immunity. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S33–S40.
   PubMed Web of Science ®Google Scholar
• Nielsen SCA, Boyd SD. Human adaptive immune receptor repertoire analysis-Past, present, and future. Immunol Rev. 2018;284(1):9–23.
   PubMed Web of Science ®Google Scholar
• Woodsworth DJ, Castellarin M, Holt RA. Sequence analysis of T-cell repertoires in health and disease. Genome Med. 2013;5(10):98. Published 2013 Oct 30.
   PubMedGoogle Scholar
• Wu J, Pendegraft AH, Byrne-Steele M, et al. Expanded TCRβ CDR3 clonotypes distinguish crohn’s disease and ulcerative colitis patients. Mucosal Immunol. 2018;11(5):1487–1495.
   PubMed Web of Science ®Google Scholar
• Hanson AL, Nel HJ, Bradbury L, et al. Altered repertoire diversity and disease-associated clonal expansions revealed by T cell receptor immunosequencing in ankylosing spondylitis patients. Arthritis Rheumatol. 2020;72(8):1289–1302.
   PubMed Web of Science ®Google Scholar
• Barbhaiya M, Zuily S, Naden R, et al. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. Ann Rheum Dis. 2023;82(10):1258–1270.
   PubMed Web of Science ®Google Scholar
• Aringer M, Costenbader K, Daikh D, et al. 2019 European league against rheumatism/American college of rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019;78(9):1151–1159.
   PubMed Web of Science ®Google Scholar
• Ruiz-Irastorza G, Crowther M, Branch W, et al. Antiphospholipid syndrome. Lancet. 2010;376(9751):1498–1509.
   PubMed Web of Science ®Google Scholar
• Gandhi AA, Estes SK, Rysenga CE, et al. Understanding the pathophysiology of thrombotic APS through animal models. Int J Mol Sci. 2021;22(5):2588. Published 2021 Mar 4.
   PubMed Web of Science ®Google Scholar
• Green D. Pathophysiology of antiphospholipid syndrome. Thromb Haemost. 2022;122(7):1085–1095.
   PubMedGoogle Scholar
• de Jong A, Jabbari A, Dai Z, et al. High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata. JCI Insight. 2018;3(19):e121949. Published 2018 Oct 4.
   PubMed Web of Science ®Google Scholar
• Xiong H, Wang L, Jiang M, et al. Comprehensive assessment of T cell receptor β repertoire in Stevens-Johnson syndrome/toxic epidermal necrolysis patients using high-throughput sequencing. Mol Immunol. 2019;106:170–177.
   PubMed Web of Science ®Google Scholar
• Ye X, Wang Z, Ye Q, et al. High-Throughput sequencing-based analysis of T cell repertoire in lupus nephritis. Front Immunol. 2020;11:1618. Published 2020 Aug 6.
   PubMed Web of Science ®Google Scholar
• Pacholczyk R, Ignatowicz H, Kraj P, et al. Origin and T cell receptor diversity of Foxp3 + CD4 + CD25+ T cells. Immunity. 2006;25(2):249–259.
   PubMed Web of Science ®Google Scholar
• Aran A, Garrigós L, Curigliano G, et al. Evaluation of the TCR repertoire as a predictive and prognostic biomarker in cancer: diversity or clonality? Cancers (Basel). 2022;14(7):1771. Published 2022 Mar 31.
   PubMed Web of Science ®Google Scholar
• Schultheiß C, Paschold L, Simnica D, et al. Next-Generation sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease. Immunity. 2020;53(2):442–455.e4.
   PubMed Web of Science ®Google Scholar
• Zou J, Li B, Li D, et al. Comprehensive analysis of T-cell receptor repertoires reveals antigen-driven T-cell clusters in patients with behçet’s syndrome. Eur J Immunol. 2023;53(4):e2250181.
   PubMed Web of Science ®Google Scholar
• Xiong H, Ji L, Yang J, et al. Analysis of CD8+ TCRβ chain repertoire in peripheral blood of vitiligo via high-throughput sequencing. Mol Immunol. 2023;160:112–120.
   PubMed Web of Science ®Google Scholar