References
- Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and knee osteoarthritis: a review. JAMA. 2021;325(6):568–578.
- Abramoff B, Caldera FE. Osteoarthritis: pathology, diagnosis, and treatment options. Med Clin North Am. 2020;104(2):293–311.
- Loeser RF, Goldring SR, Scanzello CR, et al. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012;64(6):1697–1707.
- Krych AJ, Saris D, Stuart MJ, et al. Cartilage injury in the knee: assessment and treatment options. J Am Acad Orthop Surg. 2020;28(22):914–922.
- Borrelli JJ, Olson SA, Godbout C, et al. Understanding articular cartilage injury and potential treatments. J Orthop Trauma. 2019;33 Suppl 6(3):S6–S12.
- Charlier E, Deroyer C, Ciregia F, et al. Chondrocyte dedifferentiation and osteoarthritis (OA). Biochem Pharmacol. 2019;165:49–65.
- Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977.
- De Jong OG, Van Balkom BW, Schiffelers RM, et al. Extracellular vesicles: potential roles in regenerative medicine. Front Immunol. 2014;5:608.
- Zhang S, Chuah SJ, Lai RC, et al. MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity. Biomaterials. 2018;156:16–27.
- Wang Y, Yu D, Liu Z, et al. Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix. Stem Cell Res Ther. 2017;8(1):189.
- Cui J, Shibata Y, Zhu T, et al. Osteocytes in bone aging: advances, challenges, and future perspectives. Ageing Res Rev. 2022;77:101608.
- Karthik V, Guntur AR. Energy metabolism of osteocytes. Curr Osteoporos Rep. 2021;19(4):444–451.
- Wang Z, Zhao Z, Gao B, et al. Exosome mediated biological functions within skeletal microenvironment. Front Bioeng Biotechnol. 2022;10:953916.
- Li J, Guo Y, Chen Y-Y, et al. miR-124-3p increases in high glucose induced osteocyte-derived exosomes and regulates galectin-3 expression: a possible mechanism in bone remodeling alteration in diabetic periodontitis. FASEB J. 2020;34(11):14234–14249.
- Wang YY, Xia K, Wang ZX, et al. Osteocyte exosomes accelerate benign prostatic hyperplasia development. Mol Cell Endocrinol. 2021;531:111301.
- Stern AR, Stern MM, Van Dyke ME, et al. Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice. Biotechniques. 2012;52(6):361–373.
- Hwang HS, Park IY, Hong JI, et al. Comparison of joint degeneration and pain in male and female mice in DMM model of osteoarthritis. Osteoarthritis Cartilage. 2021;29(5):728–738.
- Huang H, Quan YY, Wang XP, et al. Gold nanoparticles of diameter 13 nm induce apoptosis in rabbit articular chondrocytes. Nanoscale Res Lett. 2016;11(1):249.
- Wang BW, Jiang Y, Yao ZL, et al. Aucubin protects chondrocytes against IL-1 beta-induced apoptosis in vitro and inhibits osteoarthritis in mice model. Drug Des Dev Ther. 2019;13:3529–3538.
- Danišovič L, Varga I, Polák S. Growth factors and chondrogenic differentiation of mesenchymal stem cells. Tissue Cell. 2012;44(2):69–73.
- Prein C, Beier F. ECM signaling in cartilage development and endochondral ossification. Curr Top Dev Biol. 2019;133:25–47.
- Bei HP, Hung PM, Yeung HL, et al. Bone-a-petite: engineering exosomes towards bone, osteochondral, and cartilage repair. Small. 2021;17(50):e2101741.
- Zhang Y, Wang X, Chen J, et al. Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis. J Nanobiotechnol. 2022;20(1):56.
- Kim YG, Choi J, Kim K. Mesenchymal stem cell-derived exosomes for effective cartilage tissue repair and treatment of osteoarthritis. Biotechnol J. 2020;15(12):e2000082.
- Lyu H, Xiao Y, Guo Q, et al. The role of bone-derived exosomes in regulating skeletal metabolism and extraosseous diseases. Front Cell Dev Biol. 2020;8:89.
- Qin Y, Peng Y, Zhao W, et al. Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: a novel mechanism in muscle-bone communication. J Biol Chem. 2017;292(26):11021–11033.
- Lv P-Y, Gao P-F, Tian G-J, et al. Osteocyte-derived exosomes induced by mechanical strain promote human periodontal ligament stem cell proliferation and osteogenic differentiation via the miR-181b-5p/PTEN/AKT signaling pathway. Stem Cell Res Ther. 2020;11(1):295.
- Zhu X, Chan YT, Yung P, et al. Subchondral bone remodeling: a therapeutic target for osteoarthritis. Front Cell Dev Biol. 2020;8:607764.
- Tu M, Yang M, Yu N, et al. Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis. Bone Res. 2019;7(1):29.
- Tan Y, Testa JR. DLX Genes: roles in development and cancer. Cancers (Basel). 2021;13(12):3005.
- Li H, Marijanovic I, Kronenberg MS, et al. Expression and function of Dlx genes in the osteoblast lineage. Dev Biol. 2008;316(2):458–470.
- Zhang J, Zhang W, Shi J, et al. Dlx2 overexpression enhanced accumulation of type II collagen and aggrecan by inhibiting MMP13 expression in mice chondrocytes. Biochem Biophys Res Commun. 2018;503(2):528–535.
- Cheng J, Li M, Bai R. The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies. Front Physiol. 2022;13:954454.
- Lories RJ, Corr M, Lane NE. To Wnt or not to Wnt: the bone and joint health dilemma. Nat Rev Rheumatol. 2013;9(6):328–339.
- Voskamp C, Koevoet WJLM, Somoza RA, et al. Enhanced chondrogenic capacity of mesenchymal stem cells after TNFalpha pre-treatment. Front Bioeng Biotechnol. 2020;8:658.
- Zeng X, Wang Y, Dong Q, et al. DLX2 activates Wnt1 transcription and mediates Wnt/beta-catenin signal to promote osteogenic differentiation of hBMSCs. Gene. 2020;744:144564.