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Research Article

Vernonia cinerea L. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model

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Pages 94-102 | Received 17 Jul 2008, Accepted 12 Aug 2008, Published online: 17 Feb 2009

References

  • Ames, B.N. Dietary carcinogens and anticarcinogens: Oxygen radicals and degenerative diseases. Science 1983, 221, 1256–1264.
  • Stadtman, E.R. Protein oxidation and aging. Science 1992, 257, 1220–1224.
  • Sun, Y. Free radicals, antioxidant enzymes and carcinogenesis. Free Rad. Biol. Med. 1990, 8, 583–599.
  • Cerutti, P.A. Oxy-radicals and cancer. Lancet 1994, 344(8926) 862–863.
  • Wiseman, H.; Haliwell, B. Damage to DNA by reactive oxygen and nitrogen species: Role of inflammatory disease and progression to cancer. Biochem. J. 1996, 313, 17–29.
  • Sun, Y. Free radicals, antioxidant enzymes and carcinogenesis. Free Radic. Biol. Med. 1990, 8, 583–586.
  • Sheeja, K.; Shihab, P.K.; Kuttan, G. Antioxidant and anti-inflammatory activities of the plant Andographis paniculata Nees. Immunopharmacol. Immunotoxicol. 2006, 28, 129–140.
  • Mathew, S.; Kuttan, G.; Antioxidant and anti-inflammatory activities of Tinospora cordifolia and its usefulness in the amelioration of cyclophosphamide induced toxicity. J. Exp. Clin. Cancer Res. 1997, 16, 407–411.
  • Jose, J.K.; Kuttan, R. Antioxidant activity of Emblica officinalis Gaertn. J. Clin. Biochem. Nutr. 1995, 19, 63–70.
  • Guruvayoorappan, C.; Afira, A.H.; Kuttan, G. Antioxidant potential of Biophytum sensitivum Extract in vitro and in vivo. J. Basic Clin. Physiol. Pharmacol. 2006, 17, 255–167.
  • Hoult, J.R.S.; Paya, M. Pharmacological and biochemical actions of simple coumarins: Natural products with therapeutic potential. Gen. Pharmacol. 1996, 27, 713–722.
  • Linton, M.F.; Fazio, S. Macrophages, inflammation and artherosclerosis. Inter. J. Obesity 2003, 27, 535–540.
  • Eigler, A.; Sinha, B.; Hartmann, G.; Endress, S. Taming TNF: Strategies to restrain this proinflammatory cytokine. Immunol. Today 1997, 18, 487–492.
  • Whitcomb, D.C. Inflammation and cancer. V. Chronic pancreatisis and pancreatic cancer. Am. J. Physiol.: Gastro. Liver Physiol. 2004, 287, G315–G319.
  • Kuby, J. Immunology, 3rd ed.. New York: W. H. Freeman and Company, 1997.
  • Middleton, E. Jr.; Kandaswami, C. Potential health promoting properties of citrus flavanoids. Food Tech. 1994, 18, 115–120.
  • Hsu, Y.T. Study on the Chinese drugs used as a cancer remedy. J. S. E. Asian Res. 1967, 3, 63.
  • John, D. One hundred useful raw drugs of the Kani tribes of Trivandrum. Inter. J. Crude Drug Res. 1984, 1, 17–39.
  • Jain, S.P.; Puri, H.S. Ethanomedicinal plants of Jaunsar-Bawar hills (Uttar Pradesh) India. J. Ethnopharmacol. 1984, 12, 213–222.
  • Singh, V.K.; Ali, Z.A. Folk medicines of Aligarh (Uttar Pradesh) India. Fitoterapia 1989, LX, 483–490.
  • Bhattarai, N.K. Folk herbal medicines of Makawanpur district, Nepal. Inter. J. Pharmacog. 1991, 29, 284–295.
  • Bajpai, A.; Ohja, J.K.; Sant, H.R. Medicobotany of the Varanasi District, Inter. J. Pharmacog. 1995, 33, 172–176.
  • Graigner, C.R. Medicinal plants of Seychelles. J. Royal Soc. Health 1996, 116, 107–109.
  • Latha, R.M.; Geetha, T.; Varalakshmi, P. Effect of Vernonia cinerea less flower extract in adjuvant induced arthritis. Gen. Pharmacol. 1998, 31, 601–606.
  • Benoit, F.; Valentine, A.; Pelessier, Y.; Diafuoka, F.; Marion, C., et al. In vitro antimalarial activity of vegetal extracts used in West African traditional medicine. Am. J. Trop. Med. Hyg., 1996, 54, 67–71.
  • Alves, T.M,; ; Nagem, T.J.; ; de Carvalho, L.V.; ; Krettl, A.V.; ; Zani, C.L. et al. Antiplasmodial triterpene from Vernonia brasiliani. Planta Medica 1997, 63, 554–555.
  • Oketch-Rabah, H.A.; Brogger, C.S.; Frydenvang, K.; Dossagi, S.F. et al. Antiprotozoal properties of 16, 17 dihydro-brachycalyoxide from Vernonia brachycalyx. Planta Medica. 1998, 64, 559–562.
  • Abeysekera, A.M.; De Silva, K.Y.D.; De Silva, S.R.P.; Sirimanne, V.D.P.; Labadie, R.P.; Van der Berg, A.J.J. et al. Fitoterapia 1999, 70(3), 317.
  • Hall, I.H.; Lee, K.H.; Starnes, C.O.; Sumida, Y.; Wu Ry.; Waddell, T.G, et al. J. Pharm. Sci. 1979, 6, 537.
  • Jakupovic, J.; Banerjee, S.; Castro, V.; Bohlmann, F.; Schuster, A.; Msonthi, J.D, et al. Phytochemistry 1986, 25(6), 1359.
  • Mishra, T.N.; Singh, R.S.; Srivastava, R.; Pandey, H.S.; Prasad, C.; Singh, S. A new triterpenoid from Vernonia cinerea. Planta Med. 1993, 59(5), 458.
  • Yao-Haur Kuo; Yu-Jen Kuo; Ang-Su Yu; Ming-Der Wu. et al. Chem. Pharm. Bull. 2003, 51(4), 425–426.
  • McCord, J.M.; Fridovich, I. Superoxide dismutase enzyme function for erythrocaprein. J. Biochem. 1969, 244, 6049–6056.
  • Elizabeth, S.; Rao, M.N. Oxygen radical scavenging activity of curcumin. Int. J. Pharm. 1990, 58, 237–240.
  • Okhawa, H.; Oshishi, N.; Yagi, K. Assay for lipid peroxide in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 1979, 95, 351–358.
  • Green, L.C.; Wagner, D.A.; Glogowski, J.; Skipper, P.L.; Wishnok, J.S.; Tannenbaum, S.R. Analysis of nitrate and nitrite and (15N) nitrite in biological fluids. Anal. Biochem. 1982, 126, 131–138.
  • Lowry, O.H.; Rosenbrough, N.J.; Farr, A.L.; Randall, R.J. Protein measurement with folin phenol reagent. J. Biol. Chem. 1951, 193, 265–175.
  • Drabkins, D.L.; Austin, J.M. Spectrometric studies; spectrometric constants for common hemoglobin derivatives in human, dog and rabbit blood. J. Biol. Chem. 1932, 98, 719–733.
  • Aebi, H. Catalase estimation. In: Methods of enzymatic analysis. New York: Berg Meyer H.V. Verlag Chemic Ed., 1974, 673–684.
  • Moron, M.A.; De Pierre, J.W.; Manner Vick. B. Levels of glutathione, glutathione reductase and glutathine-S transferase in rat liver. Biochem. Biophys. Acta 1979, 582, 67–68.
  • Hafeman, D.G.; Sundae, R.A.; Houestra, W.G. Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J. Nutr. 1974, 247, 7130–7139.
  • Habig, W.H.; Pabst, M.J.; Jakoby, W.R. Glutathione-S transferase, the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 247, 7130–7139.
  • Racker, E. Glutathione reductase (liver and yeast). In: Sydney, P.C. and Nathen, O.K. eds., Methods of Enzymology. New York: Academic Press, 1955, 722–725.
  • Dwivedi, P.P.; Verma, A.S.; Ray, P.K. Induction of immune rejection of tumours by protein A in mice bearing transplantable solid tissue Dalton’s lymphoma tumours. Immunopharmacol. Immunotoxicol. 1992, 14, 105–128.
  • Langrange, P.H..; Mackaness, G.B.; Miller, T.E. Influence of dose and route of antigen injection on the immunological induction of T-Cells. J. Exp. Med. 1974, 139, 528–53.
  • Sreejayan.; Rao, M.N.A. Nitricoxide scavenging by curcuminoids. J. Pharm. Pharmacol. 1997, 49, 105–107.
  • Gupta, M.; Mazumder, U.K.; Kumar, R.S. Hepatoprotective role of Caesalpinia bonducella on paracetamol-induced hepatic damage in rats. Nat. Prod Sci. 2003, 9, 186–191.
  • Chance, B.; Greenstein, S.; Roughton, R.J.W. The mechanism of catalase action-steady state analysis. Arch Biochem Biophys. 1952, 37, 301–339.
  • Bruce, A.; Freeman, D.; James, C. Biology of disease-free radicals and tissue injury. Lab Invest. 1982, 47, 412–426.
  • Jakoby, W.B. Detoxification, conjugation and hydrolysis in liver biology and pathology. sourceIn: Aris, I.M. and Jackoby, W.B. eds. New York: Raven Press Inc. 1988, 375–385.
  • Meister, A. New aspects of glutathione biochemistry and transport selective alterations of glutathione metabolism. Nutr. Rev. 1984, 42, 397–410.
  • Nicotera, P.; Orrenius, S. Role of thiols in protection against biological reactive intermediates. Adv. Exp. Med. Biol. 1986, 197, 41–49.
  • Ohshima, H.; Bartsch, H. Chronic infections and inflammatory process as cancer risk factors: Possible role of nitric oxide in carcinogenesis. Mutat.Res. 1994, 305, 253–264.
  • Bakan, E.; Taysi, S.; Ploat, M.F.; Dalga, S.; Umudum, z.; Bakan, N.; Gumus, M. Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer. Jpn. J. Clin.Oncol. 2002, 32, 162–166.
  • Ray, G.; Husain, S.A. Oxidants, antioxidants and carcinogenesis. Indian J. Exp. Biol. 2002, 40, 1213–1232.
  • Roberfroid, M.B.; Viche, H. G.; Remacle, J. In: Testa D, ed. Advances in Drug Research. London: Academic Press, 1897.
  • Hiller, P.L.; Hodd, K.O.; Wilson, R.L. Antiinflammatory drugs: Protection of a bacteria virus as an in vitro biological measure of free radical activity. Chem. Biol. Interact. 1983, 17, 293–305.
  • Chen, G,; Goeddel, DV. TNF-R1 signalling: A beautiful pathway. Science 2002, 226, 1634–5.
  • Baret, A. Pharmacokinetic and anti-inflammatory properties in the rat of superoxide dismutase (CuSODs and MnSOD) from various species. Biochem. Pharmacol. 1984, 33, 2755.
  • Bragt, P.C.; Bansberg, J.I.; Bonta, I.L. Anti-inflammatory effects of free radical scavengers and antioxidants. Inflammation 1980, 4, 289–299.

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