Gossypol induced apoptosis of polymorphonuclear leukocytes and monocytes: Involvement of mitochondrial pathway and reactive oxygen species

References

• Qiu, J.; Levin, L.R.; Buck, J.; Reidenberg, M.M. Different pathways of cell killing by gossypol enantiomers. Exp Biol Med. 2002, 227(6):398–401.
   Web of Science ®Google Scholar
• Sunilkumar, G.; Campbell, L.M.; Puckhaber, L.; Stipanovic, R.D.; Rathore, K.S. Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol. Proc Natl Acad Sci USA. 2006, 103(48):18054–9.
   PubMed Web of Science ®Google Scholar
• Van Poznak, C.; Seidman, A.D.; Reidenberg, M.M.; Moasser, M.M.; Sklarin, N.; Van Zee, K.; Borgen, P.; Gollub, M.; Bacotti, D.; Yao, T.J.; Bloch, R.; Ligueros, M.; Sonenberg, M.; Norton, L.; Hudis, C. Oral gossypol in the treatment of patients with refractory metastatic breast cancer: A phase I/II clinical trial. Breast Cancer Res Treat. 2001, 66(3):239–48.
   PubMed Web of Science ®Google Scholar
• Dodou, K.; Anderson, R.J.; Small, D.A.; Groundwater, P.W. Investigations on gossypol: Past and present developments. Expert Opin Investig Drugs. 2005, 14(11):1419–34.
   PubMed Web of Science ®Google Scholar
• Lei, X.; Chen, Y.; Du, G.; Yu, W.; Wang, X.; Qu, H.; Xia, B.; He, H.; Mao, J.; Zong, W.; Liao, X.; Mehrpour, M.; Hao, X.; Chen, Q. Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. FASEB J. 2006, 20(12):2147–9.
   PubMed Web of Science ®Google Scholar
• Vermeulen, K.; Van Bockstaele, D.R.; Berneman, Z.N. Apoptosis: Mechanisms and relevance in cancer. Ann Hematol. 2005, 84(10):627–39.
   PubMed Web of Science ®Google Scholar
• Ghobrial, I.M.; Witzig, T.E.; Adjei, A.A. Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin. 2005, 55(3):178–94.
   PubMed Web of Science ®Google Scholar
• Di Carlo, E.; Forni, G.; Lollini, P.; Colombo, M.P.; Modesti, A.; Musiani, P. The intriguing role of polymorphonuclear neutrophils in antitumor reactions. Blood. 2001, 97(2):339–45.
   PubMed Web of Science ®Google Scholar
• Ziegler-Heitbrock, L. The CD14+ CD16+ blood monocytes: Their role in infection and inflammation. J Leukoc Biol. 2007, 81(3): 584–92.
   PubMed Web of Science ®Google Scholar
• Weiner, R.S.; Mason R.R. Subfractionation of human blood monocyte subsets with Percoll. Exp Hematol. 1984, 12(10):800–4.
   PubMed Web of Science ®Google Scholar
• Hernandez-Flores, G.; Gomez-Contreras, P.C.; Dominguez-Rodriguez, J.R.; Lerma-Diaz, J.M.; Ortiz-Lazareno, P.C.; Cervantes-Munguia, R.; Sahagun-Flores, J.E.; Orbach-Arbouys, S.; Scott-Algara, D.; Bravo-Cuellar, A. Gamma-irradiation induced apoptosis in peritoneal macrophages by oxidative stress. Implications of antioxidants in caspase mitochondrial pathway. Anticancer Res. 2005, 25(6B):4091–100.
   PubMed Web of Science ®Google Scholar
• Dominguez-Rodriguez, J.R.; Chaparro-Huerta, V.; Hernandez-Flores, G.; Gomez-Contreras, P.C.; Lerma-Daz, J.M.; Ortiz-Lazareno, P.C.; Cervantes-Munguia, R.; Orbach-Arbouys, S.; Scott-Algara, D.; Cuellar, A.B. In vivo adriamycin-induced apoptosis in peritoneal murine macrophages: Partial participation of a caspase cascade. Anticancer Res. 2004, 24(5A):2689–96.
   PubMed Web of Science ®Google Scholar
• Bravo-Cuellar, A.; Balercia, G.; Levesque, J.P.; Liu, X.H.; Osculati, F.; Orbach-Arbouys, S. Enhanced activity of peritoneal cells after aclacinomycin injection: Effect of pretreatment with superoxide dismutase on aclacinomycin-induced cytological alterations and antitumoral activity. Cancer Res. 1989, 49(6):1578–86.
   PubMed Web of Science ®Google Scholar
• Ergun, U.; Yurtcu, E.; Ergun, M.A. Protective effect of ginkgo biloba against gossypol-induced apoptosis in human lymphocytes. Cell Biol Int. (2005), 29(8):717–20.
   PubMed Web of Science ®Google Scholar
• Yurtcu, E.; Ergun, M.A.; Menevse, A. Apoptotic effect of gossypol on human lymphocytes. Cell Biol Int. 2003, 27(9):791–4.
   PubMed Web of Science ®Google Scholar
• Yeow, W.S.; Baras, A.; Chua, A.; Nguyen, D.M.; Sehgal, S.S.; Schrump, D.S.; Nguyen, D.M. Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. J Thorac Cardiovasc Surg. 2006, 132(6):1356–62.
   PubMed Web of Science ®Google Scholar
• Faraci, F.M.; Didion, S.P. Vascular protection: superoxide dismutase isoforms in the vessel wall. Arterioscler Thromb, Vasc Biol. 2004, 24(8):1367–73.
   PubMed Web of Science ®Google Scholar
• Bravo-Cuellar, A.; Gomez-Contreras, P.C.; Lerma-Diaz, J.M.; Hernandez-Flores, G.; Dominguez-Rodriguez, J.R.; Ortiz-Lazareno, P.; Cervantes-Munguia, R.; Orbach-Arbouys, S. In vivo modification of adriamycin-induced apoptosis in L-5178Y lymphoma cell-bearing mice by (+)-alpha-tocopherol and superoxide dismutase. Cancer Lett. 2005, 229(1):59–65.
   PubMed Web of Science ®Google Scholar
• Kable, E.P.; Parsons, P.G. Potency, selectivity and cell cycle dependence of catechols in human tumor cells in vitro. Biochem Pharmacol. 1988, 37(9):1711–1715.
   PubMed Web of Science ®Google Scholar
• Tanphaichitr, N.; Namking, M.; Tupper, S.; Hansen, C.; Wong, PTT. Gossypol effects on the structure and dynamics of phospholipid bilayers: A FT-IR study. Chem Phys Lipids. 1995, 75:119–125.
   Web of Science ®Google Scholar
• Xu, L.; Yang, D.; Wang, S.; Tang, W.; Liu, M.; Davis, M.; Chen, J.; Rae, J.M.; Lawrence, T.; Lippman, M.E. (-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. Mol Cancer Ther. 2005, 4(2):197–205.
   PubMed Web of Science ®Google Scholar
• Samraj, A.K., Sohn, D.; Schulze-Osthoff, K.; Schmitz, I. Loss of caspase-9: Its activation and mitochondrial membrane depolarization. Mol Biol Cell. 2007, 18(1):84–93.
   PubMed Web of Science ®Google Scholar
• Jo, W.S.; Jeong, M.H.; Jin, Y.H.; Jang, J.Y.; Nam, B.H.; Son, S.H.; Choi, S.S.; Yoo, Y.H.; Kang, C.D.; Lee, J.D.; Jeong, S.J. Loss of mitochondrial membrane potential and caspase activation enhance apoptosis in irradiated K562 cells treated with herbimycin A. Int J Radiat Biol. 2005, 81(7):531–43.
   PubMed Web of Science ®Google Scholar
• Kroemer, G.; Galluzzi, L.; Brenner, C. Mitochondrial membrane permeabilization in cell death. Physiol Rev. 2007, 87:99–167.
   PubMed Web of Science ®Google Scholar
• Lerma-Diaz, J.M.; Hernandez-Flores, G.; Dominguez-Rodriguez, J.R.; Ortiz-Lazareno, P.C.; Gomez-Contreras, P.; Cervantes-Munguia, R.; Scott-Algara, D.; Aguilar-Lemarroy, A.; Jave-Suarez, L.F.; Bravo-Cuellar, A. In vivo and in vitro sensitization of leukemic cells to adriamycin-induced apoptosis by pentoxifylline. Involvement of caspase cascades and IkappaBalpha phosphorylation. Immunol Lett. 2006, 103(2):149–58.
   PubMed Web of Science ®Google Scholar
• Inman, G.J.; Allday, M.J. Apoptosis induced by TGF-beta 1 in Burkitt’s lymphoma cells is caspase 8 dependent but is death receptor independent. J Immunol. 2000, 165(5):2500–10.
   PubMed Web of Science ®Google Scholar
• Bauer, J.A.; Trask, D.K.; Kumar, B.; Los, G.; Castro, J.; Lee, J.S.; Chen, J.; Wang, S.; Bradford, C.R.; Carey, T.E. Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: Role of wild-type p53 and Bcl-xL. Mol Cancer Ther. 2005, 4(7):1096–104.
   PubMed Web of Science ®Google Scholar
• Green, D.R. Apoptotic Pathways: Ten minutes to dead. Cell. 2005, 121:671–674.
   PubMed Web of Science ®Google Scholar
• Goldstein, J.C.; Muñoz-Pinedo, C.; Ricci, J-E.; Adams, S.R.; Kelekar, A.; Schuler, M.; Tsien, R.Y; Green, D.R. Cytochrome c is released in a single step during apoptosis. Cell Death Differ. 2005, 12:453–462.
   PubMed Web of Science ®Google Scholar
• Oliver, C.L.; Miranda, M.B.; Shangary, S.; Land, S.; Wang, S.; Johnson, D.E. (-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance. Mol Cancer Ther. 2005, 4(1):23–31.
   PubMed Web of Science ®Google Scholar
• Mohammad, R.M.; Wang, S.; Aboukameel, A.; Chen, B.; Wu, X.; Chen, J.; Al-Katib, A. Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma. Mols Cancer Ther. 2005, 4(1): 13–21.
   PubMed Web of Science ®Google Scholar
• Mohammad, R.M.; Wang, S.; Banerjee, S.; Wu, X.; Chen, J.; Sarkar, F.H. Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. Pancreas. 2005, 31(4):317–24.
   PubMed Web of Science ®Google Scholar
• Oliver, C.L.; Bauer, J.A.; Wolter, K.G.; Ubell, M.L.; Narayan, A.; O’Connell, K.M.; Fisher, S.G.; Wang, S.; Wu, X.; Ji, M.; Carey, T.E.; Bradford, C.R. In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004, 10(22):7757–63.
   PubMed Web of Science ®Google Scholar
• Bouchier-Hayes, L.; Lartigue, L.; Newmeyer, D.D. Mitochondria: pharmacological manipulation of cell death. J Clin Invest. 2005, 115(10):2640–7.
   PubMed Web of Science ®Google Scholar
• Cheze, S.; Macro, M.; Reman, O.; Levaltier, X.; Penther, D.; Leporrier, M.; Troussard, X. Comparison of chemiluminescence and polynuclear neutrophil count after aplasia in hematologic malignancies. Pathol Biol. 1996, 44(8):705–9.
   PubMedGoogle Scholar
• Bravo-Cuellar, A.; Homo-Delarche, F.; Cabannes, J.; Orbach-Arbouys, S.. Enhanced activity of murine peritoneal cells after aclacinomycin injection: Characteristics of the enhanced respiratory burst. Cancer Res. 1988, 48(12):3440–4.
   PubMed Web of Science ®Google Scholar
• Cuellar, A.; Ramirez, J. Further studies on the mechanism of action of gossypol on mitochondrial membrane. Int J Biochem. 1993, 25(8):1149–1155.
   PubMedGoogle Scholar
• Dzhagalov, I.; St John, A.; He, Y.W. The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood. 2007, 109(4): 1620–6.
   PubMed Web of Science ®Google Scholar