Th17/Treg-related cytokine imbalance in sulfur mustard exposed and stable chronic obstructive pulmonary (COPD) patients: correlation with disease activity

Reference

• Anderson PD. Emergency management of chemical weapons injuries. J Pharm Pract 2012;25:61–68.
   PubMedGoogle Scholar
• Malhotra RC, Ganesan K, Sugendran K, Swamy RV. Chemistry and toxicology of sulphur mustard: a review. Defence Sci J 1999;49:97–116.
   Web of Science ®Google Scholar
• Shadboorestan A. Commentary on: a review on delayed toxic effects of sulfur mustard in Iranian veterans. Daru 2012;20:99.
   PubMed Web of Science ®Google Scholar
• Ghanei M, Harandi AA. Long term consequences from exposure to sulfur mustard: a review. Inhal Toxicol 2007;19:451–456.
   PubMed Web of Science ®Google Scholar
• Rowell M, Kehe K, Balszuweit F, Thiermann H. The chronic effects of sulfur mustard exposure. Toxicology 2009;263:9–11.
   PubMed Web of Science ®Google Scholar
• Ghazanfari T, Kariminia A, Yaraee R, et al. Long term impact of sulfur mustard exposure on peripheral blood mononuclear subpopulations–Sardasht-Iran Cohort Study (SICS). Int Immunopharmacol 2013;17:931–935.
   PubMed Web of Science ®Google Scholar
• Mansour Razavi S, Salamati P, Saghafinia M, Abdollahi M. A review on delayed toxic effects of sulfur mustard in Iranian veterans. Daru 2012;20:51.
   PubMed Web of Science ®Google Scholar
• Ghanei M, Harandi AA. Molecular and cellular mechanism of lung injuries due to exposure to sulfur mustard: a review. Inhal Toxicol 2011;23:363–371.
   PubMed Web of Science ®Google Scholar
• Hefazi M, Attaran D, Mahmoudi M, Balali-Mood M. Late respiratory complications of mustard gas poisoning in Iranian veterans. Inhal Toxicol 2005;17:587–592.
   PubMed Web of Science ®Google Scholar
• Chiarugi A, Moskowitz MA. Cell biology. PARP-1-a perpetrator of apoptotic cell death? Science 2002;297:200–201.
   PubMed Web of Science ®Google Scholar
• Tang FR, Loke WK. Sulfur mustard and respiratory diseases. Crit Rev Toxicol 2012;42:688–702.
   PubMed Web of Science ®Google Scholar
• Yaraee R, Ghazanfari T, Ebtekar M, et al. Alterations in serum levels of inflammatory cytokines (TNF, IL-1alpha, IL-1beta and IL-1Ra) 20 years after sulfur mustard exposure: Sardasht-Iran cohort study. Int Immunopharmacol 2009;9:1466–1470.
   PubMed Web of Science ®Google Scholar
• Imani S, Panahi Y, Salimian J, et al. Epigenetic: a missing paradigm in cellular and molecular pathways of sulfur mustard lung: a prospective and comparative study. Iran J Basic Med Sci 2015;18:723–736.
   PubMed Web of Science ®Google Scholar
• Aghanouri R, Ghanei M, Aslani J, et al. Fibrogenic cytokine levels in bronchoalveolar lavage aspirates 15 years after exposure to sulfur mustard. Am J Physiol Lung Cell Mol Physiol 2004;287:L1160–L1164.
   PubMed Web of Science ®Google Scholar
• Emad A, Emad Y. CD4/CD8 ratio and cytokine levels of the BAL fluid in patients with bronchiectasis caused by sulfur mustard gas inhalation. J Inflam 2007;4:2.
   Google Scholar
• Ghotbi L, Hassan Z. The immunostatus of natural killer cells in people exposed to sulfur mustard. Int Immunopharmacol 2002;2:981–985.
   PubMed Web of Science ®Google Scholar
• Ghasemi H, Ghazanfari T, Yaraee R, et al. Evaluation of relationship between the serum levels of inflammatory mediators and ocular injuries induced by sulfur mustard: Sardasht-Iran cohort study. Int Immunopharmacol 2009;9:1494–1498.
   PubMed Web of Science ®Google Scholar
• Emad A, Emad V. Elevated levels of MCP-1, MIP-alpha and MIP-1 beta in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis. Toxicology 2007;240:60–69.
   PubMed Web of Science ®Google Scholar
• Li H, Liu Q, Jiang Y, et al. Disruption of th17/treg balance in the sputum of patients with chronic obstructive pulmonary disease. Am J Med Sci 2015;349:392–397.
   PubMed Web of Science ®Google Scholar
• Wang H, Ying H, Wang S, et al. Imbalance of peripheral blood Th17 and Treg responses in patients with chronic obstructive pulmonary disease. Clin Respir J 2015;9:330–341.
   PubMed Web of Science ®Google Scholar
• Beriou G, Costantino CM, Ashley CW, et al. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 2009;113:4240–4249.
   PubMed Web of Science ®Google Scholar
• Murray LA, Chen Q, Kramer MS, et al. TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P. Int J Biochem Cell Biol 2011;43:154–162.
   PubMed Web of Science ®Google Scholar
• Wynn TA. IL-13 effector functions. Annu Rev Immunol 2003;21:425–456.
   PubMed Web of Science ®Google Scholar
• Imani S, Salimian J, Bozorgmehr M, et al. Assessment of Treg/Th17 axis role in immunopathogenesis of chronic injuries of mustard lung disease. J Recept Signal Transduct Res 2016;19:1–11.
   Google Scholar
• Galati D, De Martino M, Trotta A, et al. Peripheral depletion of NK cells and imbalance of the Treg/Th17 axis in idiopathic pulmonary fibrosis patients. Cytokine 2014;66:119–126.
   PubMed Web of Science ®Google Scholar
• Nistala K, Moncrieffe H, Newton KR, et al. Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum 2008;58:875–887.
   PubMed Web of Science ®Google Scholar
• Nistala K, Wedderburn LR. Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis. Rheumatology (Oxford) 2009;48:602–606.
   PubMed Web of Science ®Google Scholar
• Ji L, Zhan Y, Hua F, et al. The ratio of Treg/Th17 cells correlates with the disease activity of primary immune thrombocytopenia. PloS One 2012;7:e50909.
   PubMed Web of Science ®Google Scholar
• Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev 2014;13:668–677.
   PubMed Web of Science ®Google Scholar
• Panahi Y, Davoudi SM, Beiraghdar F, et al. Serum levels of interleukins 2, 4, 6, and 10 in veterans with chronic sulfur mustard-induced pruritus: a cross-sectional study. Skinmed 2013;11:205–209.
   PubMedGoogle Scholar
• Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007;176:532–555.
   PubMed Web of Science ®Google Scholar
• Standardization of Spirometry. American journal of respiratory and critical care medicine. 1994 American Thoracic Society (1995)
   Google Scholar
• Quanjer PH, Tammeling GJ, Cotes JE, et al. Lung volumes and forced ventilatory flows. Report working party standardization of lung function tests, European community for steel and coal. Official statement of the European respiratory society. Eur Respir J Suppl 1993;16:5–40.
   PubMedGoogle Scholar
• Livak KJST. Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C (T)) method. Methods 2001;25:402–408.
   PubMed Web of Science ®Google Scholar
• Zhao L, Yang J, Wang HP, Liu RY. Imbalance in the Th17/Treg and cytokine environment in peripheral blood of patients with adenocarcinoma and squamous cell carcinoma. Med Oncol 2013;30:461.
   PubMed Web of Science ®Google Scholar
• Chu S, Zhong X, Zhang J, et al. The expression of Foxp3 and ROR gamma t in lung tissues from normal smokers and chronic obstructive pulmonary disease patients. Int Immunopharmacol 2011;11:1780–1788.
   PubMed Web of Science ®Google Scholar
• Shi YH, Shi GC, Wan HY, et al. Coexistence of Th1/Th2 and Th17/Treg imbalances in patients with allergic asthma. Chin Med J 2011;124:1951–1956.
   PubMed Web of Science ®Google Scholar
• Wang H, Peng W, Weng Y, et al. Imbalance of Th17/Treg cells in mice with chronic cigarette smoke exposure. Int Immunopharmacol 2012;14:504–512.
   PubMed Web of Science ®Google Scholar
• Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol 2010;40:1830–1835.
   PubMed Web of Science ®Google Scholar
• Barczyk A, Pierzchala W, Sozanska E. Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med 2003;97:726–733.
   PubMed Web of Science ®Google Scholar
• Takanashi S, Hasegawa Y, Kanehira Y, et al. Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers. Eur Respir J 1999;14:309–314.
   PubMed Web of Science ®Google Scholar
• Hackett TL, Holloway R, Holgate ST, Warner JA. Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study. Respir Res 2008;9:47.
   PubMed Web of Science ®Google Scholar
• Prause O, Bozinovski S, Anderson GP, Linden A. Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways. Thorax 2004;59:313–317.
   PubMed Web of Science ®Google Scholar
• Chen Y, Thai P, Zhao YH, et al. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem 2003;278:17036–17043.
   PubMed Web of Science ®Google Scholar
• Barnes PJ. The cytokine network in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2009;41:631–638.
   PubMed Web of Science ®Google Scholar
• Vila J, Isaacs JD, Anderson AE. Regulatory T cells and autoimmunity. Curr Opin Hematol 2009;16:274–279.
   PubMed Web of Science ®Google Scholar
• Barcelo B, Pons J, Ferrer JM, et al. Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4 + CD25+ regulatory T-lymphocyte response to tobacco smoking. Eur Respir J 2008;31:555–562.
   PubMed Web of Science ®Google Scholar
• Chen JG, Lai W, Jiang Y. [Expression of Th17/Treg cell in patients with psoriasis arthritis and its clinical significance]. Zhongguo yi Xue ke Xue Yuan Xue Bao Acta Academiae Medicinae Sinicae. 2012;34:617–620.
   Google Scholar
• Zhang L, Yang XQ, Cheng J, et al. Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity. Clin Immunol 2010;135:108–117.
   PubMed Web of Science ®Google Scholar
• Catana CS, Berindan Neagoe I, Cozma V, et al. Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease. World J Gastroenterol 2015;21:5823–5830.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Wang Z, Deng L, et al. Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients with acute coronary syndrome. Clin Immunol 2015;157:65–77.
   PubMed Web of Science ®Google Scholar
• Dolff S, Quandt D, Feldkamp T, et al. Increased percentages of PD-1 on CD4+ T cells is associated with higher INF-γ production and altered IL-17 production in patients with systemic lupus erythematosus. Scand J Rheumatol 2014;43:307–313.
   PubMed Web of Science ®Google Scholar