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Research Article

Cucurbita moschata Duch. and its active component, β-carotene effectively promote the immune responses through the activation of splenocytes and macrophages

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Pages 319-326 | Received 16 Jan 2016, Accepted 14 Jun 2016, Published online: 29 Jun 2016

References

  • Jan SS, Liu DC, Dong XY, et al. Effects of chitosan and its derivative added to water on immunological enhancement and disease control. Immunotherapy 2012;4:697–701.
  • Jiang MH, Zhu L, Jiang JG. Immunoregulatory actions of polysaccharides from Chinese herbal medicine. Expert Opin Ther Targets 2010;14:1367–1402.
  • Zhao T, Feng Y, Li J, et al. Schisandra polysaccharide evokes immunomodulatory activity through TLR 4-mediated activation of macrophages. Int J Biol Macromol 2014;65:33–40.
  • Luft FC. Curbing the appetites of the big eaters. J Mol Med (Berl) 2008;86:351–352.
  • Neyestani TR, Woodward B. Blood concentrations of Th2-type immunoglobulins are selectively increased in weanling mice subjected to acute malnutrition. Exp Biol Med (Maywood) 2005;230:128–134.
  • Wang H, Actor JK, Indrigo J, et al. Asian and Siberian ginseng as a potential modulator of immune function: an in vitro cytokine study using mouse macrophages. Clin Chim Acta 2003;327:123–128.
  • Jeong HJ, Chung HS, Hong SH, et al. CancerB increases production of nitric oxide and tumor necrosis factor-alpha in peritoneal macrophages. Clin Chim Acta 2002;322:149–156.
  • Pannicke U, Baumann B, Fuchs S, et al. Deficiency of innate and acquired immunity caused by an IKBKB mutation. N Engl J Med 2013;369:2504–2514.
  • Yde P, Mengel B, Jensen MH, et al. Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue. BMC Syst Biol 2011;5:115.
  • Guan S, Feng H Song B, et al. Salidroside attenuates LPS-induced pro-inflammatory cytokine responses and improves survival in murine endotoxemia. Int Immunopharmacol 2011;11:2194–2199.
  • Stevenson DG, Eller FJ, Wang L, et al. Oil and tocopherol content and composition of pumpkin seed oil in 12 cultivars. J Agric Food Chem 2007;55:4005–4013.
  • Kim MY, Kim EJ, Kim YN, et al. Comparison of the chemical compositions and nutritive values of various pumpkin (Cucurbitaceae) species and parts. Nutr Res Pract 2012;6:21–27.
  • Makni M, Fetoui H, Gargouri NK, et al. Hypolipidemic and hepatoprotective effects of flax and pumpkin seed mixture rich in omega-3 and omega-6 fatty acids inhypercholesterolemic rats. Food Chem Toxicol 2008;46:3714–3720.
  • Zhang B, Huang H, Xie J, et al. Cucurmosin induces apoptosis of BxPC-3 human pancreatic cancer cells via inactivation of the EGFR signaling pathway. Oncol Rep 2012;27:891–897.
  • Wang C, Yu X, Cao Q, et al. Characterization of murine macrophages from bone marrow, spleen and peritoneum. BMC Immunol 2013;14:6.
  • Oh HA, Ryu JG, Cha WS, et al. Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model. Tang 2012;2:e9.
  • Tiron A, Vasilescu C. Role of the spleen in immunity. Immunologic consequences of splenectomy. Chirurgia (Bucur) 2008;103:255–263.
  • Semaeva E, Tenstad O, Skavland J, et al. Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation. J Immunol 2010;184:4547–4556.
  • Osada Y, Shimizu S, Kumagai T, et al. Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators. Int J Parasitol 2009;39:457–464.
  • An HJ, Rim HK, Jeong HJ, et al. Hot water extracts of Chlorella vulgaris improve immune function in protein-deficient weanling mice and immune cells. Immunopharmacol Immunotoxicol 2010;32:585–592.
  • Jeong HJ, Chung HS, An HJ, et al. The immune-enhancing effect of the herbal combination Bouum-Myunyuk-Dan. Biol Pharm Bull 2004;27:29–33.
  • Wu TT, Chen TL, Chen RM. Lipopolysaccharide triggers macrophage activation of inflammatory cytokine expression, chemotaxis, phagocytosis, and oxidative ability via a toll-like receptor 4-dependent pathway: validated by RNA interference. Toxicol Lett 2009;191:195–202.
  • Ma G, Khan SI, Benavides G, et al. Inhibition of NF-kappaB-mediated transcription and induction of apoptosis by melampolides and repandolides. Cancer Chemother Pharmacol 2007;60:35–43.
  • Koo HN, Hong SH, Seo HG, et al. Inulin stimulates NO synthesis via activation of PKC-alpha and protein tyrosine kinase, resulting in the activation of NF-kappaB by IFN-gamma-primed RAW 264.7 cells. J Nutr Biochem 2003;14:598–605.
  • Steinman RM, Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 2006;311:17–58.
  • Hajoui O, Janani R, Tulic M, et al. Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production. J Allergy Clin Immunol 2004;114:657–663.
  • Liao W, Lin JX, Leonard WJ. IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol 2011;23:598–604.
  • Shtrichman R, Samuel CE. The role of gamma interferon in antimicrobial immunity. Curr Opin Microbiol 2001;4:251–259.
  • Popa C, Netea MG, van Riel PL, et al. The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res 2007;48:751–762.
  • Kim HM, Shin HY, Jeong HJ, et al. Reduced IL-2 but elevated IL-4, IL-6, and IgE serum levels in patients with cerebral infarction during the acute stage. J Mol Neurosci 2000;14:191–196.
  • Castaño D, Barrera LF, Rojas M. Mycobacterium tuberculosis alters the differentiation of monocytes into macrophages in vitro. Cell Immunol 2011;268:60–67.
  • Kwak JH, Baek SH, Woo Y, et al. Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of natural killer cell activity and early inflammatory response (randomized, double-blinded, placebo-controlled trial). Nutr J 2012;11:53.
  • Lee SJ, Rim HK, Jung JY, et al. Immunostimulatory activity of polysaccharides from Cheonggukjang. Food Chem Toxicol 2013;59:476–484.
  • Khera TK, Dick AD, Nicholson LB. Mechanisms of TNFα regulation in uveitis: focus on RNA-binding proteins. Prog Retin Eye Res 2010;29:610–621.
  • Liu C, Leung M, Koon J, et al. Macrophage activation by polysaccharide biological response modifier isolated from Aloe vera L. var. I (Haw.) Berg. Int Immunopharmacol 2006;6:1634e41.
  • Kim MC, Lee GH, Kim SJ, et al. Immune-enhancing effect of Danggwibohyeoltang, an extract from Astragali Radix and Angelicae gigantis Radix, in vitro and in vivo. Immunopharmacol Immunotoxicol 2012;34:66–73.
  • Ren Z, He C, Fan Y, et al. Immune-enhancing activity of polysaccharides from Cyrtomium macrophyllum. Int J Biol Macromol 2014;70:590–595.

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