Agmatine ameliorates acetic acid-induced colitis in rats: involvement of nitrergic system

References

• Yasukawa K, Tokuda H, Tun X, et al. The detrimental effect of nitric oxide on tissue is associated with inflammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis. Free Rad Res. 2012;46:1427–1436.
   PubMed Web of Science ®Google Scholar
• Rezayat SM, Dehpour A-R, Motamed SM, et al. Foeniculum vulgare essential oil ameliorates acetic acid-induced colitis in rats through the inhibition of NF-kB pathway. Inflammopharmacol. 2018;26:851–859.
   PubMed Web of Science ®Google Scholar
• Khalili H, Chan SSM, Lochhead P, et al. The role of diet in the aetiopathogenesis of inflammatory bowel disease. Nature Rev Gastroenterol Hepatol. 2018;15(9):1.
   PubMed Web of Science ®Google Scholar
• Kankuri E, Vaali K, Knowles RG, et al. Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl) benzyl] acetamidine. J Pharmacol Exp Ther. 2001;298:1128–1132.
   PubMed Web of Science ®Google Scholar
• Vento P, Kiviluoto T, Järvinen HJ, et al. Changes in distribution of three isoforms of nitric oxide synthase in ulcerative colitis. Scand J Gastroenterol. 2001;36:180–189.
   PubMed Web of Science ®Google Scholar
• Moncada S, Palmer R, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev. 1991;43:109–142.
   PubMed Web of Science ®Google Scholar
• Miller MJ, Sandoval M. III. A molecular prelude to intestinal inflammation. Am J Physiol Gastroint Liver Physiol. 1999;276:G795–G799.
   PubMed Web of Science ®Google Scholar
• Lefer AM, Lefer DJ. II. Nitric oxide protects in intestinal inflammation. Am J Physiol Gastroint Liver Physiol. 1999;276:G572–G575.
   Web of Science ®Google Scholar
• Zingarelli B, Cuzzocrea S, Szabó C, et al. Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther. 1998;287:1048–1055.
   PubMed Web of Science ®Google Scholar
• Nakamura H, Tsukada H, Oya M, et al. Aminoguanidine has both an anti-inflammatory effect on experimental colitis and a proliferative effect on colonic mucosal cells. Scand J Gastroenterol. 1999;34:1117–1122.
   PubMed Web of Science ®Google Scholar
• Blanchard HS, Dernis-Labous E, Lamarque D, et al. Inducible nitric oxide synthase attenuates chronic colitis in human histocompatibility antigen HLA-B27/human beta2 microglobulin transgenic rats. Eur Cyt Network. 2001;12:111–118.
   PubMed Web of Science ®Google Scholar
• Hong S, Lee J, Kim C, et al. Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line. BMC Neurosci. 2007;8:81.
   PubMed Web of Science ®Google Scholar
• Sharawy MH, Abdelrahman RS, El-Kashef DH. Agmatine attenuates rhabdomyolysis-induced acute kidney injury in rats in a dose dependent manner. Life Sci. 2018;208:79–86.
   PubMed Web of Science ®Google Scholar
• Uzbay TI. The pharmacological importance of agmatine in the brain. Neurosci Biobehav Rev. 2012;36:502–519.
   PubMed Web of Science ®Google Scholar
• Li X, Liu Z, Jin H, et al. Agmatine protects against zymosan-induced acute lung injury in mice by inhibiting NF-κB-mediated inflammatory response. BioMed Res Int. 2014;2014:1.
   Google Scholar
• Rashidian A, Roohi P, Mehrzadi S, et al. Protective effect of Ocimum basilicum essential oil against acetic acid–induced colitis in rats. J Evid Based Complementary Altern Med. 2016;21:NP36–NP42.
   PubMedGoogle Scholar
• Deshmukh C, Veeresh B, Pawar A. Protective effect of Emblica officinalis fruit extract on acetic acid induced colitis in rats. J Herb Med Toxicol. 2010;4:83–87.
   Google Scholar
• Rashidian A, Muhammadnejad A, Dehpour A-R, et al. Atorvastatin attenuates TNBS-induced rat colitis: the involvement of the TLR4/NF-kB signaling pathway. Inflammopharmacol. 2016;24:109–118.
   PubMed Web of Science ®Google Scholar
• Khan I, Oriowo MA, Anim JT. Amelioration of experimental colitis by Na-H exchanger-1 inhibitor amiloride is associated with reversal of IL-1β and ERK mitogen-activated protein kinase. Scand J Gastroenterol. 2005;40:578–585.
   PubMed Web of Science ®Google Scholar
• Bradley PP, Priebat DA, Christensen RD, et al. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78:206–209.
   PubMed Web of Science ®Google Scholar
• Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 1998;11:155–168.
   PubMed Web of Science ®Google Scholar
• Hartmann RM, Morgan Martins MI, Tieppo J, et al. Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid. Dig Dis Sci. 2012;57:2038–2044.
   PubMed Web of Science ®Google Scholar
• Jurjus AR, Khoury NN, Reimund J-M. Animal models of inflammatory bowel disease. J Pharmacol Toxicol Methods. 2004;50:81–92.
   PubMedGoogle Scholar
• Gonzalez R, Rodriguez S, Romay C, et al. Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats. Pharmacol Res. 1999;39:55–59.
   PubMed Web of Science ®Google Scholar
• Sharon P, Stenson WF. Metabolism of arachidonic acid in acetic acid colitis in rats: similarity to human inflammatory bowel disease. Gastroenterology. 1985;88:55–63.
   PubMed Web of Science ®Google Scholar
• Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol. 2003;3:521.
   PubMed Web of Science ®Google Scholar
• Dionne S, Hiscott J, D'Agata I, et al. Quantitative PCR analysis of TNF-alpha and IL-1 beta mRNA levels in pediatric IBD mucosal biopsies . Dig Dis Sci. 1997;42:1557–1566.
   PubMed Web of Science ®Google Scholar
• Ordás I, Mould DR, Feagan BG, et al. Anti‐TNF monoclonal antibodies in inflammatory bowel disease: pharmacokinetics‐based dosing paradigms. Clin Pharmacol Ther. 2012;91:635–646.
   PubMed Web of Science ®Google Scholar
• Hong S, Park K, Kim CY, et al. Agmatine inhibits hypoxia-induced TNF-alpha release from cultured retinal ganglion cells. Biocell. 2008;32:201–205.
   PubMed Web of Science ®Google Scholar
• Hong S, Kim CY, Lee JE, et al. Agmatine protects cultured retinal ganglion cells from tumor necrosis factor-alpha-induced apoptosis. Life Sci. 2009;84:28–32.
   PubMed Web of Science ®Google Scholar
• Singer II, Kawka DW, Scott S, et al. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease. Gastroenterology. 1996;111:871–885.
   PubMed Web of Science ®Google Scholar
• Rachmilewitz D, Stamler JS, Bachwich D, et al. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Gut. 1995;36:718–723.
   PubMed Web of Science ®Google Scholar
• Kolios G, Valatas V, Ward SG. Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle. Immunology. 2004;113:427–437.
   PubMed Web of Science ®Google Scholar
• Guslandi M. Nitric oxide and inflammatory bowel diseases. Eur J Clin Invest. 1998;28:904–907.
   PubMed Web of Science ®Google Scholar
• McCafferty DM, Mudgett JS, Swain MG, et al. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology. 1997;112:1022–1027.
   PubMed Web of Science ®Google Scholar
• Pfeiffer C, Qiu B. Effects of chronic nitric oxide synthase inhibition on TNB‐induced colitis in rats. J Pharm Pharmacol. 1995;47:827–832.
   PubMed Web of Science ®Google Scholar
• Camuesco D, Comalada M, Rodríguez-Cabezas ME, et al. The intestinal anti-inflammatory effect of quercitrin is associated with an inhibition in iNOS expression. Br J Pharmacol. 2004;143:908–918.
   PubMed Web of Science ®Google Scholar
• Venkataranganna M, et al. NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS. World J Gastroenterol. 2007;13:1103.
   PubMed Web of Science ®Google Scholar
• Dong W-G, Mei Q, Yu J-P, et al. Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis. World J Gastroenterol. 2003;9:1307.
   PubMed Web of Science ®Google Scholar
• El-Kashef DH, El-Kenawi AE, Rahim MA, et al. Agmatine improves renal function in gentamicin-induced nephrotoxicity in rats. Can J Physiol Pharmacol. 2016;94:278–286.
   PubMed Web of Science ®Google Scholar
• Abe K, Abe Y, Saito H. Agmatine suppresses nitric oxide production in microglia. Brain Res. 2000;872:141–148.
   PubMed Web of Science ®Google Scholar